Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe.
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| Title: | Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe. |
|---|---|
| Alternate Title: | El estrés oxidativo y la inflamación en las anomalías metabólicas y la afectación renal en sujetos prediabéticos de toda Europa. |
| Authors: | Mas-Fontao, Sebastián1,2,3 smas@fjd.es, Civantos, Esther1,3, Boukichou-Abdelkader, Nisa4,5, Soto-Catalan, Manuel1,2, Romeo-Colas, Marta1, Marco, Arantxa1, Gomez-Guerrero, Carmen1,2, Moreno, Juan Antonio6,7, Tuomilehto, Jaakko8,9,10, Gabriel, Rafael4,5,11, Egido, Jesús1,2 jegido@quironsalud.es |
| Source: | Nefrologia. Mar2025, Vol. 45 Issue 3, p238-248. 11p. |
| Subjects: | PREDIABETIC state, TYPE 2 diabetes, OXIDATIVE stress, CHRONIC kidney failure, FATTY liver |
| Abstract (English): | Background: Studying the mechanisms Involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe. Methods:In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein - CRP; Interleukin 6 - IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement. Results:Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid profile, and fatty liver index. In particular, both types of biomarkers were associated with components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied. Conclusion:These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggests that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Antecedentes: El estudio de los mecanismos implicados en la transición de la prediabetes a la diabetes y sus complicaciones asociadas, como la enfermedad renal, es un tema de gran interés. Este estudio se centra en la identificación de biomarcadores eficaces para la detección precoz de la afectación renal, evaluando moléculas asociadas al estrés oxidativo e inflamación en individuos prediabéticos de varios países europeos. Métodos:En muestras de plasma de individuos prediabéticos, incluidos en el estudio ePREDICE, se determinaron biomarcadores de estrés oxidativo (AOPP) e inflamación (proteína C reactiva, IL-6) y se correlacionaron con datos antropométricos y bioquímicos, evaluando su potencial en el diagnóstico precoz de la disfunción renal. Resultados:Entre los 967 sujetos con prediabetes, 94 presentaban algún signo de afectación renal, como albuminuria, hiperfiltración o hipofiltración. Se identificaron variaciones significativas entre los biomarcadores de estrés oxidativo e inflamatorios (cuartiles superiores e inferior del AOPP, PCR e IL-6) y parámetros relacionados como la presión arterial, el metabolismo glucémico, el perfil lipídico y el índice de hígado graso. En particular, ambos biomarcadores estaban bien relacionados con los componentes del síndrome metabólico. Existieron asociaciones significativas entre la AOPP y la PCR, y la presencia de albuminuria, pero no con la función renal. En general, la PCR fue mejor biomarcador que la IL-6 para la mayoría de los parámetros estudiados. Conclusiones:Estos resultados subrayan las importantes conexiones entre estrés oxidativo e inflamación con las anomalías metabólicas ligadas al estado prediabético y sus complicaciones como el hígado graso y la afectación renal. Aunque es necesario confirmar estos datos, nuestro estudio sugiere que los AOPP y la PCR podrían ser biomarcadores de interés en la predicción del riesgo de pérdida de la función renal en los sujetos con prediabetes. [ABSTRACT FROM AUTHOR] |
| Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 183502712 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: El estrés oxidativo y la inflamación en las anomalías metabólicas y la afectación renal en sujetos prediabéticos de toda Europa. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mas-Fontao%2C+Sebastián%22">Mas-Fontao, Sebastián</searchLink><relatesTo>1,2,3</relatesTo><i> smas@fjd.es</i><br /><searchLink fieldCode="AR" term="%22Civantos%2C+Esther%22">Civantos, Esther</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Boukichou-Abdelkader%2C+Nisa%22">Boukichou-Abdelkader, Nisa</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Soto-Catalan%2C+Manuel%22">Soto-Catalan, Manuel</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Romeo-Colas%2C+Marta%22">Romeo-Colas, Marta</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Marco%2C+Arantxa%22">Marco, Arantxa</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gomez-Guerrero%2C+Carmen%22">Gomez-Guerrero, Carmen</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Moreno%2C+Juan+Antonio%22">Moreno, Juan Antonio</searchLink><relatesTo>6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Tuomilehto%2C+Jaakko%22">Tuomilehto, Jaakko</searchLink><relatesTo>8,9,10</relatesTo><br /><searchLink fieldCode="AR" term="%22Gabriel%2C+Rafael%22">Gabriel, Rafael</searchLink><relatesTo>4,5,11</relatesTo><br /><searchLink fieldCode="AR" term="%22Egido%2C+Jesús%22">Egido, Jesús</searchLink><relatesTo>1,2</relatesTo><i> jegido@quironsalud.es</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nefrologia%22">Nefrologia</searchLink>. Mar2025, Vol. 45 Issue 3, p238-248. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22PREDIABETIC+state%22">PREDIABETIC state</searchLink><br /><searchLink fieldCode="DE" term="%22TYPE+2+diabetes%22">TYPE 2 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22OXIDATIVE+stress%22">OXIDATIVE stress</searchLink><br /><searchLink fieldCode="DE" term="%22CHRONIC+kidney+failure%22">CHRONIC kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22FATTY+liver%22">FATTY liver</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Background: Studying the mechanisms Involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe. Methods:In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein - CRP; Interleukin 6 - IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement. Results:Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid profile, and fatty liver index. In particular, both types of biomarkers were associated with components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied. Conclusion:These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggests that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Antecedentes: El estudio de los mecanismos implicados en la transición de la prediabetes a la diabetes y sus complicaciones asociadas, como la enfermedad renal, es un tema de gran interés. Este estudio se centra en la identificación de biomarcadores eficaces para la detección precoz de la afectación renal, evaluando moléculas asociadas al estrés oxidativo e inflamación en individuos prediabéticos de varios países europeos. Métodos:En muestras de plasma de individuos prediabéticos, incluidos en el estudio ePREDICE, se determinaron biomarcadores de estrés oxidativo (AOPP) e inflamación (proteína C reactiva, IL-6) y se correlacionaron con datos antropométricos y bioquímicos, evaluando su potencial en el diagnóstico precoz de la disfunción renal. Resultados:Entre los 967 sujetos con prediabetes, 94 presentaban algún signo de afectación renal, como albuminuria, hiperfiltración o hipofiltración. Se identificaron variaciones significativas entre los biomarcadores de estrés oxidativo e inflamatorios (cuartiles superiores e inferior del AOPP, PCR e IL-6) y parámetros relacionados como la presión arterial, el metabolismo glucémico, el perfil lipídico y el índice de hígado graso. En particular, ambos biomarcadores estaban bien relacionados con los componentes del síndrome metabólico. Existieron asociaciones significativas entre la AOPP y la PCR, y la presencia de albuminuria, pero no con la función renal. En general, la PCR fue mejor biomarcador que la IL-6 para la mayoría de los parámetros estudiados. Conclusiones:Estos resultados subrayan las importantes conexiones entre estrés oxidativo e inflamación con las anomalías metabólicas ligadas al estado prediabético y sus complicaciones como el hígado graso y la afectación renal. Aunque es necesario confirmar estos datos, nuestro estudio sugiere que los AOPP y la PCR podrían ser biomarcadores de interés en la predicción del riesgo de pérdida de la función renal en los sujetos con prediabetes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.nefro.2024.10.003 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 238 Subjects: – SubjectFull: PREDIABETIC state Type: general – SubjectFull: TYPE 2 diabetes Type: general – SubjectFull: OXIDATIVE stress Type: general – SubjectFull: CHRONIC kidney failure Type: general – SubjectFull: FATTY liver Type: general Titles: – TitleFull: Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mas-Fontao, Sebastián – PersonEntity: Name: NameFull: Civantos, Esther – PersonEntity: Name: NameFull: Boukichou-Abdelkader, Nisa – PersonEntity: Name: NameFull: Soto-Catalan, Manuel – PersonEntity: Name: NameFull: Romeo-Colas, Marta – PersonEntity: Name: NameFull: Marco, Arantxa – PersonEntity: Name: NameFull: Gomez-Guerrero, Carmen – PersonEntity: Name: NameFull: Moreno, Juan Antonio – PersonEntity: Name: NameFull: Tuomilehto, Jaakko – PersonEntity: Name: NameFull: Gabriel, Rafael – PersonEntity: Name: NameFull: Egido, Jesús IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 02116995 Numbering: – Type: volume Value: 45 – Type: issue Value: 3 Titles: – TitleFull: Nefrologia Type: main |
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