Asociación entre signos y síntomas de aparición temprana en pacientes con la mortalidad por sepsis en un hospital de tercer nivel en Colombia.
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| Title: | Asociación entre signos y síntomas de aparición temprana en pacientes con la mortalidad por sepsis en un hospital de tercer nivel en Colombia. |
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| Alternate Title: | Association between early signs and symptoms and mortality from sepsis at a tertiary care hospital in Colombia. |
| Authors: | Alexánder Güezguan-Pérez, Jonathan1 alexander.guezguan@gmail.com, Camila Prieto-Vaca, Paula2, Felipe Salazar-Urbano, Andrés3, Rojas Salamanca, Ana Carolina3, Ortiz-Báez, Natalia3, Catalina Contreras-Niño, Liliana3, Daniela Muñoz-Torres, Laura4, Ascuntar-Ceballos, Johana5, Alberto Jaimes-Barragán, Fabián6 |
| Source: | Acta Medica Colombiana. ene-mar2025, Vol. 50 Issue 1, p1-9. 9p. |
| Subjects: | CHRONIC obstructive pulmonary disease, SYMPTOMS, LOGISTIC regression analysis, UNIVARIATE analysis, HEART beat |
| Abstract (English): | Introduction: sepsis is a potentially fatal unregulated host response to an infection, and early detection appears to reduce mortality. Method: a prospective cohort study at a tertiary care hospital in Colombia which enrolled 595 patients hospitalized for suspected infection between August 2021 and 2022. The study outcome was ICU mortality. Univariate and bivariate descriptions were made, and univariate logistic regression models were created to analyze the impact of signs and symptoms, constructing a multivariate logistic regression model. Results: among 595 patients, there was 14.3% ICU mortality, along with a mean age of 59 years and male predominance (53.8%). The most common comorbidities were diabetes (13.8%), chronic obstructive pulmonary disease (16.5%) and heart failure (11.4%). The most common symptoms were general malaise (87.7%) and dyspnea (25.8%). On univariate analysis, there were significant associations between dyspnea, altered mental status and heart rate, and a higher risk of mortality. However, these associations did not persist after adjusting for comorbidities. Conclusions: sepsis mortality is high and none of the early signs and symptoms were associated with mortality. These findings suggest the need for multicenter studies to validate early diagnostic systems in local settings. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción: la sepsis es una respuesta desregulada del huésped a una infección que puede ser mortal y su reconocimiento temprano parece disminuir la mortalidad. Métodos: estudio de cohorte prospectivo en un hospital de tercer nivel en Colombia, incluyó 595 pacientes hospitalizados por sospecha de infección entre agosto de 2021 y 2022. El desenlace evaluado fue la mortalidad en UCI, se realizó una descripción univariada y bivariada, posteriormente se realizaron modelos univariados de regresión logística para analizar el impacto de los signos y síntomas, construyendo un modelo multivariado de regresión logística. Resultados: entre 595 pacientes, se reportó una mortalidad de 14.3% en UCI y una media de edad de 59 años, con predominio masculino (53.8%). Las comorbilidades más comunes fueron diabetes (13.8%), enfermedad pulmonar obstructiva crónica (16.5%) e insuficiencia cardiaca (11.4%). Los síntomas más frecuentes incluyeron malestar general (87.7%) y disnea (25.8%). En el análisis univariado, se hallaron asociaciones significativas entre disnea, estado mental alterado y frecuencia cardiaca con un mayor riesgo de mortalidad. No obstante, estas asociaciones no se mantuvieron tras el ajuste por comorbilidades. Conclusiones: la mortalidad por sepsis es alta y ninguno de los signos o síntomas tempranos estuvo asociado con la mortalidad. Estos hallazgos sugieren la necesidad de estudios multicéntricos para validar sistemas de diagnóstico temprano en contextos locales. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Medica Colombiana is the property of Acta Medica Colombiana and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Items | – Name: Title Label: Title Group: Ti Data: Asociación entre signos y síntomas de aparición temprana en pacientes con la mortalidad por sepsis en un hospital de tercer nivel en Colombia. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Association between early signs and symptoms and mortality from sepsis at a tertiary care hospital in Colombia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alexánder+Güezguan-Pérez%2C+Jonathan%22">Alexánder Güezguan-Pérez, Jonathan</searchLink><relatesTo>1</relatesTo><i> alexander.guezguan@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Camila+Prieto-Vaca%2C+Paula%22">Camila Prieto-Vaca, Paula</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Felipe+Salazar-Urbano%2C+Andrés%22">Felipe Salazar-Urbano, Andrés</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Rojas+Salamanca%2C+Ana+Carolina%22">Rojas Salamanca, Ana Carolina</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ortiz-Báez%2C+Natalia%22">Ortiz-Báez, Natalia</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Catalina+Contreras-Niño%2C+Liliana%22">Catalina Contreras-Niño, Liliana</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Daniela+Muñoz-Torres%2C+Laura%22">Daniela Muñoz-Torres, Laura</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ascuntar-Ceballos%2C+Johana%22">Ascuntar-Ceballos, Johana</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Alberto+Jaimes-Barragán%2C+Fabián%22">Alberto Jaimes-Barragán, Fabián</searchLink><relatesTo>6</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Medica+Colombiana%22">Acta Medica Colombiana</searchLink>. ene-mar2025, Vol. 50 Issue 1, p1-9. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22CHRONIC+obstructive+pulmonary+disease%22">CHRONIC obstructive pulmonary disease</searchLink><br /><searchLink fieldCode="DE" term="%22SYMPTOMS%22">SYMPTOMS</searchLink><br /><searchLink fieldCode="DE" term="%22LOGISTIC+regression+analysis%22">LOGISTIC regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22UNIVARIATE+analysis%22">UNIVARIATE analysis</searchLink><br /><searchLink fieldCode="DE" term="%22HEART+beat%22">HEART beat</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction: sepsis is a potentially fatal unregulated host response to an infection, and early detection appears to reduce mortality. Method: a prospective cohort study at a tertiary care hospital in Colombia which enrolled 595 patients hospitalized for suspected infection between August 2021 and 2022. The study outcome was ICU mortality. Univariate and bivariate descriptions were made, and univariate logistic regression models were created to analyze the impact of signs and symptoms, constructing a multivariate logistic regression model. Results: among 595 patients, there was 14.3% ICU mortality, along with a mean age of 59 years and male predominance (53.8%). The most common comorbidities were diabetes (13.8%), chronic obstructive pulmonary disease (16.5%) and heart failure (11.4%). The most common symptoms were general malaise (87.7%) and dyspnea (25.8%). On univariate analysis, there were significant associations between dyspnea, altered mental status and heart rate, and a higher risk of mortality. However, these associations did not persist after adjusting for comorbidities. Conclusions: sepsis mortality is high and none of the early signs and symptoms were associated with mortality. These findings suggest the need for multicenter studies to validate early diagnostic systems in local settings. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción: la sepsis es una respuesta desregulada del huésped a una infección que puede ser mortal y su reconocimiento temprano parece disminuir la mortalidad. Métodos: estudio de cohorte prospectivo en un hospital de tercer nivel en Colombia, incluyó 595 pacientes hospitalizados por sospecha de infección entre agosto de 2021 y 2022. El desenlace evaluado fue la mortalidad en UCI, se realizó una descripción univariada y bivariada, posteriormente se realizaron modelos univariados de regresión logística para analizar el impacto de los signos y síntomas, construyendo un modelo multivariado de regresión logística. Resultados: entre 595 pacientes, se reportó una mortalidad de 14.3% en UCI y una media de edad de 59 años, con predominio masculino (53.8%). Las comorbilidades más comunes fueron diabetes (13.8%), enfermedad pulmonar obstructiva crónica (16.5%) e insuficiencia cardiaca (11.4%). Los síntomas más frecuentes incluyeron malestar general (87.7%) y disnea (25.8%). En el análisis univariado, se hallaron asociaciones significativas entre disnea, estado mental alterado y frecuencia cardiaca con un mayor riesgo de mortalidad. No obstante, estas asociaciones no se mantuvieron tras el ajuste por comorbilidades. Conclusiones: la mortalidad por sepsis es alta y ninguno de los signos o síntomas tempranos estuvo asociado con la mortalidad. Estos hallazgos sugieren la necesidad de estudios multicéntricos para validar sistemas de diagnóstico temprano en contextos locales. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Medica Colombiana is the property of Acta Medica Colombiana and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.36104/amc.2025.3828 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 9 StartPage: 1 Subjects: – SubjectFull: CHRONIC obstructive pulmonary disease Type: general – SubjectFull: SYMPTOMS Type: general – SubjectFull: LOGISTIC regression analysis Type: general – SubjectFull: UNIVARIATE analysis Type: general – SubjectFull: HEART beat Type: general Titles: – TitleFull: Asociación entre signos y síntomas de aparición temprana en pacientes con la mortalidad por sepsis en un hospital de tercer nivel en Colombia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alexánder Güezguan-Pérez, Jonathan – PersonEntity: Name: NameFull: Camila Prieto-Vaca, Paula – PersonEntity: Name: NameFull: Felipe Salazar-Urbano, Andrés – PersonEntity: Name: NameFull: Rojas Salamanca, Ana Carolina – PersonEntity: Name: NameFull: Ortiz-Báez, Natalia – PersonEntity: Name: NameFull: Catalina Contreras-Niño, Liliana – PersonEntity: Name: NameFull: Daniela Muñoz-Torres, Laura – PersonEntity: Name: NameFull: Ascuntar-Ceballos, Johana – PersonEntity: Name: NameFull: Alberto Jaimes-Barragán, Fabián IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: ene-mar2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 01202448 Numbering: – Type: volume Value: 50 – Type: issue Value: 1 Titles: – TitleFull: Acta Medica Colombiana Type: main |
| ResultId | 1 |
