Perfil clínico de la demencia frontotemporal: serie de casos de un centro neurológico de referencia nacional en el Perú.

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Title:	Perfil clínico de la demencia frontotemporal: serie de casos de un centro neurológico de referencia nacional en el Perú.
Alternate Title:	Clinical profile of frontotemporal dementia: case series from a national reference neurological care center in Peru.
Authors:	Castro-Suárez, Sheila^1,2 sheila.castro-suarez@gbhi.org, Guevara-Silva, Erik¹, Caparó-Zamalloa, César¹, Álvarez-Toledo, Kelvin H.¹, Meza-Vega, María^1,3
Source:	Archivos de Neurociencias. Jan-Mar2025, Vol. 30 Issue 1, p28-34. 7p.
Subjects:	FRONTOTEMPORAL dementia, EXECUTIVE function, MENTAL illness, RETROSPECTIVE studies, APHASIA, DESCRIPTIVE statistics, NEUROLOGY, MEDICAL records, ACQUISITION of data, RESEARCH methodology, PARKINSONIAN disorders, SEMANTICS, DISEASE progression, MENTAL depression, SYMPTOMS
Geographic Terms:	PERU
Abstract (English):	Background: Frontotemporal dementia (FTD) is a clinical syndrome characterized by progressive deterioration of behavior, language, executive function and, occasionally, motor dysfunction. In Latin America, many FTD patients are underrecognized or are diagnosed late in their disease course. There is limited information on clinical aspects of FTD in the Peruvian population. Objective: To describe the clinical characteristics of patients with frontotemporal dementia (FTD) evaluated at a national neurology referral center in Peru. Method: Retrospective study. We reviewed 161 clinical records, of which 24 met the diagnosis of probable FTD, and descriptive analysis was performed for each of the variants of FTD. Results: Twelve cases of behavioral variant FTD, nine of primary progressive aphasia non-fluent variant, and three of the semantic variants were included. The most frequent symptom in behavioral variant FTD was executive dysfunction (92%), while forced speech and impaired naming (100%) were more frequent in primary progressive aphasia non-fluent variant and primary progressive aphasia semantic variant, respectively. Depression and parkinsonism were present in 45 and 38%, respectively. Conclusion: Behavioral variant FTD was the most frequent clinical syndrome, and lack of empathy was the least reported nuclear symptom in this variant. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Antecedentes: La demencia frontotemporal (DFT) es un síndrome clínico caracterizado por el deterioro progresivo del comportamiento, el lenguaje, la función ejecutiva y, ocasionalmente, de la función motora. En América Latina, muchos pacientes con DFT no son reconocidos o son diagnosticados tardíamente en el curso de la enfermedad. Existe información limitada sobre los aspectos clínicos de la DFT en la población peruana. Objetivo: Describir las características clínicas de los pacientes con DFT evaluados en un centro de referencia nacional de neurología en el Perú. Método: Estudio retrospectivo. Se revisaron 161 registros clínicos, de los cuales 24 cumplieron diagnóstico de DFT probable, se realizó el análisis descriptivo por cada una de las variantes de la DFT. Resultados: Se incluyeron 12 casos (50%) de demencia frontotemporal variante conductual (DFTvc), nueve de afasia progresiva primaria variante no fluente (APPvnf) y tres de la variante semántica (APPvs). El síntoma inicial más frecuente en la DFTvc fue la desinhibición temprana (50%), mientras el habla forzada (77.8%) y el deterioro en la denominación (100%) fueron más frecuentes en la APPvnf y APPvs respectivamente. La depresión y el parkinsonismo estaban presentes en el 45 y 38% respectivamente. Conclusión: La DFTvc fue el síndrome clínico más frecuente, la falta de empatía fue el síntoma nuclear menos reportado. [ABSTRACT FROM AUTHOR]
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Database:	MedicLatina

Description
Abstract:	Background: Frontotemporal dementia (FTD) is a clinical syndrome characterized by progressive deterioration of behavior, language, executive function and, occasionally, motor dysfunction. In Latin America, many FTD patients are underrecognized or are diagnosed late in their disease course. There is limited information on clinical aspects of FTD in the Peruvian population. Objective: To describe the clinical characteristics of patients with frontotemporal dementia (FTD) evaluated at a national neurology referral center in Peru. Method: Retrospective study. We reviewed 161 clinical records, of which 24 met the diagnosis of probable FTD, and descriptive analysis was performed for each of the variants of FTD. Results: Twelve cases of behavioral variant FTD, nine of primary progressive aphasia non-fluent variant, and three of the semantic variants were included. The most frequent symptom in behavioral variant FTD was executive dysfunction (92%), while forced speech and impaired naming (100%) were more frequent in primary progressive aphasia non-fluent variant and primary progressive aphasia semantic variant, respectively. Depression and parkinsonism were present in 45 and 38%, respectively. Conclusion: Behavioral variant FTD was the most frequent clinical syndrome, and lack of empathy was the least reported nuclear symptom in this variant. [ABSTRACT FROM AUTHOR]
ISSN:	10285938
DOI:	10.24875/ANC.M24000023