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Perfil clínico de la demencia frontotemporal: serie de casos de un centro neurológico de referencia nacional en el Perú.

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Title: Perfil clínico de la demencia frontotemporal: serie de casos de un centro neurológico de referencia nacional en el Perú.
Alternate Title: Clinical profile of frontotemporal dementia: case series from a national reference neurological care center in Peru.
Authors: Castro-Suárez, Sheila1,2 sheila.castro-suarez@gbhi.org, Guevara-Silva, Erik1, Caparó-Zamalloa, César1, Álvarez-Toledo, Kelvin H.1, Meza-Vega, María1,3
Source: Archivos de Neurociencias. Jan-Mar2025, Vol. 30 Issue 1, p28-34. 7p.
Subjects: FRONTOTEMPORAL dementia, EXECUTIVE function, MENTAL illness, RETROSPECTIVE studies, APHASIA, DESCRIPTIVE statistics, NEUROLOGY, MEDICAL records, ACQUISITION of data, RESEARCH methodology, PARKINSONIAN disorders, SEMANTICS, DISEASE progression, MENTAL depression, SYMPTOMS
Geographic Terms: PERU
Abstract (English): Background: Frontotemporal dementia (FTD) is a clinical syndrome characterized by progressive deterioration of behavior, language, executive function and, occasionally, motor dysfunction. In Latin America, many FTD patients are underrecognized or are diagnosed late in their disease course. There is limited information on clinical aspects of FTD in the Peruvian population. Objective: To describe the clinical characteristics of patients with frontotemporal dementia (FTD) evaluated at a national neurology referral center in Peru. Method: Retrospective study. We reviewed 161 clinical records, of which 24 met the diagnosis of probable FTD, and descriptive analysis was performed for each of the variants of FTD. Results: Twelve cases of behavioral variant FTD, nine of primary progressive aphasia non-fluent variant, and three of the semantic variants were included. The most frequent symptom in behavioral variant FTD was executive dysfunction (92%), while forced speech and impaired naming (100%) were more frequent in primary progressive aphasia non-fluent variant and primary progressive aphasia semantic variant, respectively. Depression and parkinsonism were present in 45 and 38%, respectively. Conclusion: Behavioral variant FTD was the most frequent clinical syndrome, and lack of empathy was the least reported nuclear symptom in this variant. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Antecedentes: La demencia frontotemporal (DFT) es un síndrome clínico caracterizado por el deterioro progresivo del comportamiento, el lenguaje, la función ejecutiva y, ocasionalmente, de la función motora. En América Latina, muchos pacientes con DFT no son reconocidos o son diagnosticados tardíamente en el curso de la enfermedad. Existe información limitada sobre los aspectos clínicos de la DFT en la población peruana. Objetivo: Describir las características clínicas de los pacientes con DFT evaluados en un centro de referencia nacional de neurología en el Perú. Método: Estudio retrospectivo. Se revisaron 161 registros clínicos, de los cuales 24 cumplieron diagnóstico de DFT probable, se realizó el análisis descriptivo por cada una de las variantes de la DFT. Resultados: Se incluyeron 12 casos (50%) de demencia frontotemporal variante conductual (DFTvc), nueve de afasia progresiva primaria variante no fluente (APPvnf) y tres de la variante semántica (APPvs). El síntoma inicial más frecuente en la DFTvc fue la desinhibición temprana (50%), mientras el habla forzada (77.8%) y el deterioro en la denominación (100%) fueron más frecuentes en la APPvnf y APPvs respectivamente. La depresión y el parkinsonismo estaban presentes en el 45 y 38% respectivamente. Conclusión: La DFTvc fue el síndrome clínico más frecuente, la falta de empatía fue el síntoma nuclear menos reportado. [ABSTRACT FROM AUTHOR]
Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Perfil clínico de la demencia frontotemporal: serie de casos de un centro neurológico de referencia nacional en el Perú.
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  Data: Clinical profile of frontotemporal dementia: case series from a national reference neurological care center in Peru.
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  Data: <searchLink fieldCode="AR" term="%22Castro-Suárez%2C+Sheila%22">Castro-Suárez, Sheila</searchLink><relatesTo>1,2</relatesTo><i> sheila.castro-suarez@gbhi.org</i><br /><searchLink fieldCode="AR" term="%22Guevara-Silva%2C+Erik%22">Guevara-Silva, Erik</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Caparó-Zamalloa%2C+César%22">Caparó-Zamalloa, César</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Álvarez-Toledo%2C+Kelvin+H%2E%22">Álvarez-Toledo, Kelvin H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Meza-Vega%2C+María%22">Meza-Vega, María</searchLink><relatesTo>1,3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Archivos+de+Neurociencias%22">Archivos de Neurociencias</searchLink>. Jan-Mar2025, Vol. 30 Issue 1, p28-34. 7p.
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  Data: <searchLink fieldCode="DE" term="%22FRONTOTEMPORAL+dementia%22">FRONTOTEMPORAL dementia</searchLink><br /><searchLink fieldCode="DE" term="%22EXECUTIVE+function%22">EXECUTIVE function</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+illness%22">MENTAL illness</searchLink><br /><searchLink fieldCode="DE" term="%22RETROSPECTIVE+studies%22">RETROSPECTIVE studies</searchLink><br /><searchLink fieldCode="DE" term="%22APHASIA%22">APHASIA</searchLink><br /><searchLink fieldCode="DE" term="%22DESCRIPTIVE+statistics%22">DESCRIPTIVE statistics</searchLink><br /><searchLink fieldCode="DE" term="%22NEUROLOGY%22">NEUROLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+records%22">MEDICAL records</searchLink><br /><searchLink fieldCode="DE" term="%22ACQUISITION+of+data%22">ACQUISITION of data</searchLink><br /><searchLink fieldCode="DE" term="%22RESEARCH+methodology%22">RESEARCH methodology</searchLink><br /><searchLink fieldCode="DE" term="%22PARKINSONIAN+disorders%22">PARKINSONIAN disorders</searchLink><br /><searchLink fieldCode="DE" term="%22SEMANTICS%22">SEMANTICS</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+progression%22">DISEASE progression</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink><br /><searchLink fieldCode="DE" term="%22SYMPTOMS%22">SYMPTOMS</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22PERU%22">PERU</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Frontotemporal dementia (FTD) is a clinical syndrome characterized by progressive deterioration of behavior, language, executive function and, occasionally, motor dysfunction. In Latin America, many FTD patients are underrecognized or are diagnosed late in their disease course. There is limited information on clinical aspects of FTD in the Peruvian population. Objective: To describe the clinical characteristics of patients with frontotemporal dementia (FTD) evaluated at a national neurology referral center in Peru. Method: Retrospective study. We reviewed 161 clinical records, of which 24 met the diagnosis of probable FTD, and descriptive analysis was performed for each of the variants of FTD. Results: Twelve cases of behavioral variant FTD, nine of primary progressive aphasia non-fluent variant, and three of the semantic variants were included. The most frequent symptom in behavioral variant FTD was executive dysfunction (92%), while forced speech and impaired naming (100%) were more frequent in primary progressive aphasia non-fluent variant and primary progressive aphasia semantic variant, respectively. Depression and parkinsonism were present in 45 and 38%, respectively. Conclusion: Behavioral variant FTD was the most frequent clinical syndrome, and lack of empathy was the least reported nuclear symptom in this variant. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Antecedentes: La demencia frontotemporal (DFT) es un síndrome clínico caracterizado por el deterioro progresivo del comportamiento, el lenguaje, la función ejecutiva y, ocasionalmente, de la función motora. En América Latina, muchos pacientes con DFT no son reconocidos o son diagnosticados tardíamente en el curso de la enfermedad. Existe información limitada sobre los aspectos clínicos de la DFT en la población peruana. Objetivo: Describir las características clínicas de los pacientes con DFT evaluados en un centro de referencia nacional de neurología en el Perú. Método: Estudio retrospectivo. Se revisaron 161 registros clínicos, de los cuales 24 cumplieron diagnóstico de DFT probable, se realizó el análisis descriptivo por cada una de las variantes de la DFT. Resultados: Se incluyeron 12 casos (50%) de demencia frontotemporal variante conductual (DFTvc), nueve de afasia progresiva primaria variante no fluente (APPvnf) y tres de la variante semántica (APPvs). El síntoma inicial más frecuente en la DFTvc fue la desinhibición temprana (50%), mientras el habla forzada (77.8%) y el deterioro en la denominación (100%) fueron más frecuentes en la APPvnf y APPvs respectivamente. La depresión y el parkinsonismo estaban presentes en el 45 y 38% respectivamente. Conclusión: La DFTvc fue el síndrome clínico más frecuente, la falta de empatía fue el síntoma nuclear menos reportado. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.24875/ANC.M24000023
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      – Code: spa
        Text: Spanish
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        PageCount: 7
        StartPage: 28
    Subjects:
      – SubjectFull: FRONTOTEMPORAL dementia
        Type: general
      – SubjectFull: EXECUTIVE function
        Type: general
      – SubjectFull: MENTAL illness
        Type: general
      – SubjectFull: RETROSPECTIVE studies
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      – SubjectFull: APHASIA
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      – SubjectFull: DESCRIPTIVE statistics
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      – SubjectFull: NEUROLOGY
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      – SubjectFull: MEDICAL records
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      – SubjectFull: PARKINSONIAN disorders
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      – SubjectFull: SEMANTICS
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      – SubjectFull: SYMPTOMS
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      – SubjectFull: PERU
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      – TitleFull: Perfil clínico de la demencia frontotemporal: serie de casos de un centro neurológico de referencia nacional en el Perú.
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              Text: Jan-Mar2025
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