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Seroprevalencia de infección por SARS-CoV-2 en personal de salud del Gran Santa Fe (Argentina) durante la pandemia de COVID-19.

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Title: Seroprevalencia de infección por SARS-CoV-2 en personal de salud del Gran Santa Fe (Argentina) durante la pandemia de COVID-19.
Alternate Title: Seroprevalence of SARS-CoV-2 infection among healthcare personnel in Gran Santa Fe (Argentina) during the COVID-19 pandemic.
Authors: Nilva, Gabriela1, Wettstein, Magalí1, Márquez, Gonzalo1, Vera Garate, Ma. Verónica1, Barrientos, Triana1, Fernández, Hugo1, Zerbini, Elsa1, Montemaggiore, Sandra2, Camuzzi, Beatriz2, Perig, Liliana3, Cisterna, Silvina3, Degiovanni, Gabriela4, Rico, Marina5, Bertona, María Lilian6, Rey, Carolina7, Argaraña, Fernanda8, Rigo, Laura9, Ulmari, Liliana10, Kusznierz, Gabriela1 gabriela.nilva@gmail.com
Source: Revista Horizonte Médico. ene-mar2025, Vol. 25 Issue 1, p20-29. 10p.
Abstract (English): Objective: To estimate the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through antibody detection among healthcare personnel (HP) in Gran Santa Fe (Argentina) during virus sustained circulation and remission phases. Materials and methods: A longitudinal, population-based, seroepidemiological study was conducted. The target population consisted of HP working in second- and third-level public health centers in the Gran Santa Fe region. The sample comprised 600 active health workers, proportionally distributed across selected health centers. A self-administered questionnaire collected data on sociodemographic, occupational, clinical and exposure variables of interest. IgG and IgM antibodies to SARS-CoV-2 were detected from serum samples using indirect enzyme-linked immunoassays. Results: The prevalence of IgG antibodies to SARS-CoV-2 was 7.6 times higher during the virus circulation phase compared to the remission phase (2.1 % vs. 15.9 %, respectively), while no IgM antibodies were detected. Regarding the level of workplace exposure risk, the highest cumulative prevalence, 26.7 %, was observed in the high-risk group (workers in direct contact with patients and "assigned to the Intensive Care Unit [ICU]" or "assigned to the COVID-19 Area" or "assigned to the Emergency Department"). Nearly one-third of workers reported inconsistent use of recommended personal protective equipment (PPE), and fewer than 10 % reported full adherence to PPE guidelines, regardless of the level of exposure risk. The seroprevalence among HP who reported no symptoms since the beginning of the Aislamiento Social Preventivo y Obligatorio (Preventive and Mandatory Lockdown) was 12.3 % during the remission phase, compared to 10.0 % among HP with a history of negative RT-PCR results (p < 0.05). Conclusions: Complementing passive epidemiological surveillance with active serological surveillance using simple and cost-effective tests is important for accurately tailoring mitigation strategies in vulnerable populations such as HP. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Estimar la prevalencia de infección por el coronavirus del síndrome respiratorio agudo grave de tipo 2 (SARS-CoV-2) mediante la determinación de anticuerpos en Personal de Salud (PS) del Gran Santa Fe (Argentina), en una fase de circulación viral sostenida y una fase de remisión. Materiales y Métodos: Se realizó un estudio longitudinal, seroepidemiológico y de base poblacional. La población objetivo estuvo constituida por el PS que se desempeñó en establecimientos de salud del subsector público, de segundo y tercer nivel, dentro del Gran Santa Fe. El tamaño muestral fue de 600 trabajadores de la salud activos, distribuidos proporcionalmente entre los establecimientos de salud seleccionados. Se aplicó un cuestionario autoadministrado para obtener datos sobre variables sociolaborales, clínicas y de exposición de interés. La detección de anticuerpos IgG e IgM anti-SARS-CoV-2 se realizó a partir de muestras de suero, mediante ensayos inmunoenzimáticos indirectos. Resultados: La prevalencia de IgG anti-SARS-CoV-2 fue 7,6 veces mayor en la fase de circulación viral respecto a la fase de remisión (2,1 % vs. 15,9 %, respectivamente); no se detectó IgM. Respecto al nivel de riesgo de exposición en el ámbito laboral, la mayor prevalencia acumulada se registró en el grupo de alto riesgo (tiene contacto con pacientes y "trabaja en la Unidad de Cuidados Intensivos [UCI]" o "trabaja en Área COVID-19" o "trabaja en Emergencia"), con 26,7 % de casos reactivos. Casi un tercio de los trabajadores señaló no usar siempre los equipos de protección personal recomendados y menos del 10 % declaró haberlos usado en su totalidad, independientemente del nivel de riesgo de exposición. La seroprevalencia en PS que no reportó síntomas desde el inicio del Aislamiento Social Preventivo y Obligatorio fue del 12,3 % en la fase de remisión, y del 10,0 % en aquellos trabajadores con antecedente de resultado RT-PCR negativo (p < 0,05). Conclusiones: Complementar la vigilancia epidemiológica pasiva con la vigilancia serológica activa mediante ensayos sencillos y económicos es importante para adecuar eficazmente las estrategias de mitigación en poblaciones vulnerables como el PS. [ABSTRACT FROM AUTHOR]
Copyright of Revista Horizonte Médico is the property of Universidad de San Martin de Porres and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Seroprevalencia de infecci&#243;n por SARS-CoV-2 en personal de salud del Gran Santa Fe (Argentina) durante la pandemia de COVID-19.
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  Data: Seroprevalence of SARS-CoV-2 infection among healthcare personnel in Gran Santa Fe (Argentina) during the COVID-19 pandemic.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nilva%2C+Gabriela%22&quot;&gt;Nilva, Gabriela&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wettstein%2C+Magal&#237;%22&quot;&gt;Wettstein, Magal&#237;&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22M&#225;rquez%2C+Gonzalo%22&quot;&gt;M&#225;rquez, Gonzalo&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vera+Garate%2C+Ma%2E+Ver&#243;nica%22&quot;&gt;Vera Garate, Ma. Ver&#243;nica&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Barrientos%2C+Triana%22&quot;&gt;Barrientos, Triana&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fern&#225;ndez%2C+Hugo%22&quot;&gt;Fern&#225;ndez, Hugo&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zerbini%2C+Elsa%22&quot;&gt;Zerbini, Elsa&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Montemaggiore%2C+Sandra%22&quot;&gt;Montemaggiore, Sandra&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Camuzzi%2C+Beatriz%22&quot;&gt;Camuzzi, Beatriz&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Perig%2C+Liliana%22&quot;&gt;Perig, Liliana&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cisterna%2C+Silvina%22&quot;&gt;Cisterna, Silvina&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Degiovanni%2C+Gabriela%22&quot;&gt;Degiovanni, Gabriela&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rico%2C+Marina%22&quot;&gt;Rico, Marina&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bertona%2C+Mar&#237;a+Lilian%22&quot;&gt;Bertona, Mar&#237;a Lilian&lt;/searchLink&gt;&lt;relatesTo&gt;6&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rey%2C+Carolina%22&quot;&gt;Rey, Carolina&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Argara&#241;a%2C+Fernanda%22&quot;&gt;Argara&#241;a, Fernanda&lt;/searchLink&gt;&lt;relatesTo&gt;8&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rigo%2C+Laura%22&quot;&gt;Rigo, Laura&lt;/searchLink&gt;&lt;relatesTo&gt;9&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ulmari%2C+Liliana%22&quot;&gt;Ulmari, Liliana&lt;/searchLink&gt;&lt;relatesTo&gt;10&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kusznierz%2C+Gabriela%22&quot;&gt;Kusznierz, Gabriela&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; gabriela.nilva@gmail.com&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Revista+Horizonte+M&#233;dico%22&quot;&gt;Revista Horizonte M&#233;dico&lt;/searchLink&gt;. ene-mar2025, Vol. 25 Issue 1, p20-29. 10p.
– Name: Abstract
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  Data: Objective: To estimate the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through antibody detection among healthcare personnel (HP) in Gran Santa Fe (Argentina) during virus sustained circulation and remission phases. Materials and methods: A longitudinal, population-based, seroepidemiological study was conducted. The target population consisted of HP working in second- and third-level public health centers in the Gran Santa Fe region. The sample comprised 600 active health workers, proportionally distributed across selected health centers. A self-administered questionnaire collected data on sociodemographic, occupational, clinical and exposure variables of interest. IgG and IgM antibodies to SARS-CoV-2 were detected from serum samples using indirect enzyme-linked immunoassays. Results: The prevalence of IgG antibodies to SARS-CoV-2 was 7.6 times higher during the virus circulation phase compared to the remission phase (2.1 % vs. 15.9 %, respectively), while no IgM antibodies were detected. Regarding the level of workplace exposure risk, the highest cumulative prevalence, 26.7 %, was observed in the high-risk group (workers in direct contact with patients and &quot;assigned to the Intensive Care Unit [ICU]&quot; or &quot;assigned to the COVID-19 Area&quot; or &quot;assigned to the Emergency Department&quot;). Nearly one-third of workers reported inconsistent use of recommended personal protective equipment (PPE), and fewer than 10 % reported full adherence to PPE guidelines, regardless of the level of exposure risk. The seroprevalence among HP who reported no symptoms since the beginning of the Aislamiento Social Preventivo y Obligatorio (Preventive and Mandatory Lockdown) was 12.3 % during the remission phase, compared to 10.0 % among HP with a history of negative RT-PCR results (p &lt; 0.05). Conclusions: Complementing passive epidemiological surveillance with active serological surveillance using simple and cost-effective tests is important for accurately tailoring mitigation strategies in vulnerable populations such as HP. [ABSTRACT FROM AUTHOR]
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  Data: Objetivo: Estimar la prevalencia de infecci&#243;n por el coronavirus del s&#237;ndrome respiratorio agudo grave de tipo 2 (SARS-CoV-2) mediante la determinaci&#243;n de anticuerpos en Personal de Salud (PS) del Gran Santa Fe (Argentina), en una fase de circulaci&#243;n viral sostenida y una fase de remisi&#243;n. Materiales y M&#233;todos: Se realiz&#243; un estudio longitudinal, seroepidemiol&#243;gico y de base poblacional. La poblaci&#243;n objetivo estuvo constituida por el PS que se desempe&#241;&#243; en establecimientos de salud del subsector p&#250;blico, de segundo y tercer nivel, dentro del Gran Santa Fe. El tama&#241;o muestral fue de 600 trabajadores de la salud activos, distribuidos proporcionalmente entre los establecimientos de salud seleccionados. Se aplic&#243; un cuestionario autoadministrado para obtener datos sobre variables sociolaborales, cl&#237;nicas y de exposici&#243;n de inter&#233;s. La detecci&#243;n de anticuerpos IgG e IgM anti-SARS-CoV-2 se realiz&#243; a partir de muestras de suero, mediante ensayos inmunoenzim&#225;ticos indirectos. Resultados: La prevalencia de IgG anti-SARS-CoV-2 fue 7,6 veces mayor en la fase de circulaci&#243;n viral respecto a la fase de remisi&#243;n (2,1 % vs. 15,9 %, respectivamente); no se detect&#243; IgM. Respecto al nivel de riesgo de exposici&#243;n en el &#225;mbito laboral, la mayor prevalencia acumulada se registr&#243; en el grupo de alto riesgo (tiene contacto con pacientes y &quot;trabaja en la Unidad de Cuidados Intensivos [UCI]&quot; o &quot;trabaja en &#193;rea COVID-19&quot; o &quot;trabaja en Emergencia&quot;), con 26,7 % de casos reactivos. Casi un tercio de los trabajadores se&#241;al&#243; no usar siempre los equipos de protecci&#243;n personal recomendados y menos del 10 % declar&#243; haberlos usado en su totalidad, independientemente del nivel de riesgo de exposici&#243;n. La seroprevalencia en PS que no report&#243; s&#237;ntomas desde el inicio del Aislamiento Social Preventivo y Obligatorio fue del 12,3 % en la fase de remisi&#243;n, y del 10,0 % en aquellos trabajadores con antecedente de resultado RT-PCR negativo (p &lt; 0,05). Conclusiones: Complementar la vigilancia epidemiol&#243;gica pasiva con la vigilancia serol&#243;gica activa mediante ensayos sencillos y econ&#243;micos es importante para adecuar eficazmente las estrategias de mitigaci&#243;n en poblaciones vulnerables como el PS. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Revista Horizonte M&#233;dico is the property of Universidad de San Martin de Porres and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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