Pancreatitis aguda secundaria a hipertrigliceridemia: reporte de caso.
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| Title: | Pancreatitis aguda secundaria a hipertrigliceridemia: reporte de caso. |
|---|---|
| Alternate Title: | Acute Pancreatitis Secondary to Hypertriglyceridemia: Case Report. |
| Authors: | Alejandra Agredo-Pineda, María1 mariaalejandraagredopineda@gmail.com, David Calle, Juan1, Belalcázar-González, Maikol2, Hernando Guevara-Tamayo, Saúl3, Álvarez-Echeverry, Ingrid4 |
| Source: | Revista Colombiana de Gastroenterología. ene-mar2025, Vol. 41 Issue 1, p78-83. 6p. |
| Subjects: | FREE fatty acids, LIPOPROTEIN lipase, GENE expression, BILIARY tract, INSULIN therapy |
| Abstract (English): | Acute pancreatitis is characterized by a reversible inflammatory process affecting the pancreas. The most common causes include biliary tract obstruction and alcohol consumption. However, between 4% and 10% of cases are linked to hypertriglyceridemia, with serum triglyceride levels exceeding 1,000 mg/dL. While the exact pathophysiology remains unclear, prevailing hypotheses suggest two main mechanisms: the direct toxic effect of free fatty acids on pancreatic tissue and vascular obstruction caused by chylomicrons due to reduced genetic expression of lipoprotein lipase (LPL). Treatment focuses on lowering triglyceride levels to below 500 mg/dL. Although few interventions have proven effective, insulin therapy and anticoagulation are generally recommended. This report presents the case of a young male patient diagnosed with acute pancreatitis associated with hypertriglyceridemia, along with a review of the underlying pathophysiology and management strategies for this condition. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): | La pancreatitis aguda se caracteriza por un proceso inflamatorio reversible del páncreas. Las causas más frecuentes son la obstrucción de la vía biliar y el consumo de alcohol. No obstante, 4% a 10% de los episodios están asociados a hipertrigliceridemia con niveles séricos superiores a 1000 mg/dL. Aunque la fisiopatología exacta no está claramente establecida, las hipótesis predominantes incluyen el efecto tóxico directo de los ácidos grasos libres sobre el tejido pancreático y la obstrucción vascular provocada por los quilomicrones debido a la reducción de la expresión genética de la lipoproteína lipasa (LPL). El tratamiento se enfoca en reducir los niveles de triglicéridos a menos de 500 mg/dL; pocas intervenciones han demostrado ser efectivas, pero se recomienda el uso de insulina y de anticoagulantes. Se presenta el caso clínico de un paciente masculino joven con pancreatitis aguda asociada a hipertrigliceridemia, y se realiza una revisión de la fisiopatología y del manejo de esta entidad. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Colombiana de Gastroenterología is the property of Asociacion Colombiana de Gastroenterologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 185145789 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pancreatitis aguda secundaria a hipertrigliceridemia: reporte de caso. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Acute Pancreatitis Secondary to Hypertriglyceridemia: Case Report. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alejandra+Agredo-Pineda%2C+María%22">Alejandra Agredo-Pineda, María</searchLink><relatesTo>1</relatesTo><i> mariaalejandraagredopineda@gmail.com</i><br /><searchLink fieldCode="AR" term="%22David+Calle%2C+Juan%22">David Calle, Juan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Belalcázar-González%2C+Maikol%22">Belalcázar-González, Maikol</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hernando+Guevara-Tamayo%2C+Saúl%22">Hernando Guevara-Tamayo, Saúl</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Álvarez-Echeverry%2C+Ingrid%22">Álvarez-Echeverry, Ingrid</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Colombiana+de+Gastroenterología%22">Revista Colombiana de Gastroenterología</searchLink>. ene-mar2025, Vol. 41 Issue 1, p78-83. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22FREE+fatty+acids%22">FREE fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22LIPOPROTEIN+lipase%22">LIPOPROTEIN lipase</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br /><searchLink fieldCode="DE" term="%22BILIARY+tract%22">BILIARY tract</searchLink><br /><searchLink fieldCode="DE" term="%22INSULIN+therapy%22">INSULIN therapy</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Acute pancreatitis is characterized by a reversible inflammatory process affecting the pancreas. The most common causes include biliary tract obstruction and alcohol consumption. However, between 4% and 10% of cases are linked to hypertriglyceridemia, with serum triglyceride levels exceeding 1,000 mg/dL. While the exact pathophysiology remains unclear, prevailing hypotheses suggest two main mechanisms: the direct toxic effect of free fatty acids on pancreatic tissue and vascular obstruction caused by chylomicrons due to reduced genetic expression of lipoprotein lipase (LPL). Treatment focuses on lowering triglyceride levels to below 500 mg/dL. Although few interventions have proven effective, insulin therapy and anticoagulation are generally recommended. This report presents the case of a young male patient diagnosed with acute pancreatitis associated with hypertriglyceridemia, along with a review of the underlying pathophysiology and management strategies for this condition. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Turkish) Group: Ab Data: La pancreatitis aguda se caracteriza por un proceso inflamatorio reversible del páncreas. Las causas más frecuentes son la obstrucción de la vía biliar y el consumo de alcohol. No obstante, 4% a 10% de los episodios están asociados a hipertrigliceridemia con niveles séricos superiores a 1000 mg/dL. Aunque la fisiopatología exacta no está claramente establecida, las hipótesis predominantes incluyen el efecto tóxico directo de los ácidos grasos libres sobre el tejido pancreático y la obstrucción vascular provocada por los quilomicrones debido a la reducción de la expresión genética de la lipoproteína lipasa (LPL). El tratamiento se enfoca en reducir los niveles de triglicéridos a menos de 500 mg/dL; pocas intervenciones han demostrado ser efectivas, pero se recomienda el uso de insulina y de anticoagulantes. Se presenta el caso clínico de un paciente masculino joven con pancreatitis aguda asociada a hipertrigliceridemia, y se realiza una revisión de la fisiopatología y del manejo de esta entidad. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Colombiana de Gastroenterología is the property of Asociacion Colombiana de Gastroenterologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.22516/25007440.1188 Languages: – Code: tur Text: Turkish PhysicalDescription: Pagination: PageCount: 6 StartPage: 78 Subjects: – SubjectFull: FREE fatty acids Type: general – SubjectFull: LIPOPROTEIN lipase Type: general – SubjectFull: GENE expression Type: general – SubjectFull: BILIARY tract Type: general – SubjectFull: INSULIN therapy Type: general Titles: – TitleFull: Pancreatitis aguda secundaria a hipertrigliceridemia: reporte de caso. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alejandra Agredo-Pineda, María – PersonEntity: Name: NameFull: David Calle, Juan – PersonEntity: Name: NameFull: Belalcázar-González, Maikol – PersonEntity: Name: NameFull: Hernando Guevara-Tamayo, Saúl – PersonEntity: Name: NameFull: Álvarez-Echeverry, Ingrid IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: ene-mar2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 01209957 Numbering: – Type: volume Value: 41 – Type: issue Value: 1 Titles: – TitleFull: Revista Colombiana de Gastroenterología Type: main |
| ResultId | 1 |
