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Eosinophilia and neutropenia in patients with acute rhinopharyngitis in a health center in Peru: an analytical study.

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Title: Eosinophilia and neutropenia in patients with acute rhinopharyngitis in a health center in Peru: an analytical study.
Alternate Title: Eosinofilia y neutropenia en pacientes con rinofaringitis aguda de un centro de salud de Perú: un estudio analítico.
Eosinofilia e neutropenia em pacientes com rinofaringite aguda de um centro de saúde no Peru: um estudo analítico.
Authors: Guevara-Tirado, Alberto1 (AUTHOR) albertoguevara1986@gmail.com
Source: MedUNAB. abr-jul2024, Vol. 27 Issue 1, p10-16. 7p.
Subjects: EOSINOPHILIA, NEUTROPENIA, IMMUNITY, COMMON cold, ADULTS, RESPIRATORY infections, MINORS
Geographic Terms: PERU
Abstract (English): Introduction.: Eosinophils modulate innate and adaptive immunity. Their elevation may be associated with changes in neutrophil concentrations during acute upper respiratory1 tract infections. The objective was to analyze the association between eosinophilia and neutropenia in patients with acute rhinopharyngitis. Methodology.: Cross-sectional and analytical study, based on data from medical records of 526 patients from a polyclinic in the district of Villa el Salvador. Peru. Patients diagnosed with acute rhinopharyngitis who underwent a complete blood count were selected. Patients with chronic respiratory and hematologic diseases were excluded. Bivariate statistics with frequencies and percentages were performed, as well as crude and adjusted Odds Ratio tests using binary logistic regression. Results.: Minors with neutropenia had eosinophilia 5.52 times more often than those without neutropenia (OR=5.52; CI:95%=2.28-13.35; p=0.005). In adults it was 2.01 (OR=2.01; CI:95%=1.07-3.77; p=0.027). Discussion.: The findings could be attributed to the antiviral activity of eosinophils by mechanisms mediated by ribonucleases and neurotoxins, which require neutrophil-mediated activation in the presence of viral and bacterial infectious conditions. In turn, the greater strength of the association in minors could be due to the fact that their immune system is less mature than that of adults, who also take medication more frequently. Conclusions.: Neutropenia and eosinophilia were more strongly associated in patients with acute rhinopharyngitis, mainly in minors. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción.: Los eosinófilos modulan la inmunidad innata y adaptativa. Su elevación puede estar asociada a cambios en las concentraciones de neutrófilos durante la infección aguda de vías respiratorias superiores. El objetivo fue analizar la asociación entre eosinofilia y neutropenia en pacientes con rinofaringitis aguda. Metodología.: Estudio transversal y analítico, basado en datos de historias clínicas de 526 pacientes de un policlínico del distrito de Villa el Salvador, Perú. Fueron seleccionados pacientes diagnosticados por rinofaringitis aguda que se realizaron un hemograma completo. Se excluyó a pacientes con enfermedades respiratorias y hematológicas crónicas. Se realizó estadística bivariada con frecuencias y porcentajes, así como la prueba de Odds Ratio crudo y ajustado por regresión logística binaria. Resultados.: Los menores de edad con neutropenia tuvieron eosinofilia 5.52 veces más a menudo que aquellos sin neutropenia (OR=5.52; IC:95%=2.28-13.35; p=0.005). En adultos fue 2.01 (OR=2.01; IC:95%=1.07-3.77; p=0.027). Discusión.: Los hallazgos podrían atribuirse a la actividad antiviral de los eosinófilos por mecanismos mediados por ribonucleasas y neurotoxinas, los cuales requieren de la activación mediada por neutrófilos en presencia de cuadros infecciosos virales y bacterianos. A su vez, la mayor fuerza de asociación en menores de edad podría deberse a que su sistema inmunológico está en menor madurez que los adultos, quienes además se medican con mayor frecuencia. Conclusiones.: La neutropenia y la eosinofilia tuvieron una mayor fuerza de asociación en pacientes con rinofaringitis aguda, principalmente en menores de edad. [ABSTRACT FROM AUTHOR]
Abstract (Portuguese): Introdução.: Os eosinófilos modulam a imunidade inata e adaptativa. Sua elevação pode estar associada a alterações nas concentrações de neutrófilos durante infecção aguda do trato respiratório superior. O objetivo foi analisar a associação entre eosinofilia e neutropenia em pacientes com rinofaringite aguda. Metodologia.: Estudo transversal e analítico, baseado em dados de prontuários de 526 pacientes de urna policlínica do distrito de Villa el Salvador, Peru. Foram selecionados pacientes com diagnóstico de rinofaringite aguda e submetidos a hemograma completo. Foram excluídos pacientes com doenças respiratorias e hematológicas crónicas. Foram realizadas estatísticas bivariadas com frequências e porcentagens, bem como o teste Odds Ratio bruto e ajustado por regressão logística binária. Resultados.: Menores com neutropenia apresentaram eosinofilia 5.52 vezes mais frequentemente que aqueles sem neutropenia (OR-5.52; IC 95%=2.28-13.35; p=0.005). Nos adultos foi de 2.01 (OR=2.01; IC: 95%=1.07-3.77; p=0.027). Discussão.: Os achados podem ser atribuídos à atividade antiviral dos eosinófilos através de mecanismos mediados por ribonucleases e neurotoxinas, que requerem ativação mediada por neutrófilos na presença de condições infecciosas virais e bacterianas. Por sua vez, a maior força de associação nos menores pode ser devida ao fato do seu sistema imunitário ser menos maduro do que o dos adultos, que também tomam medicamentos com mais frequência. Conclusões.: Neutropenia e eosinofilia tiveram maior força de associação nos pacientes com rinofaringite aguda, principalmente nos menores. [ABSTRACT FROM AUTHOR]
Copyright of MedUNAB is the property of Universidad Autonoma de Bucaramanga, UNAB and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Eosinophilia and neutropenia in patients with acute rhinopharyngitis in a health center in Peru: an analytical study.
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  Data: Eosinofilia y neutropenia en pacientes con rinofaringitis aguda de un centro de salud de Perú: un estudio analítico.<br />Eosinofilia e neutropenia em pacientes com rinofaringite aguda de um centro de saúde no Peru: um estudo analítico.
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  Data: <searchLink fieldCode="AR" term="%22Guevara-Tirado%2C+Alberto%22">Guevara-Tirado, Alberto</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> albertoguevara1986@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22MedUNAB%22">MedUNAB</searchLink>. abr-jul2024, Vol. 27 Issue 1, p10-16. 7p.
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  Data: <searchLink fieldCode="DE" term="%22EOSINOPHILIA%22">EOSINOPHILIA</searchLink><br /><searchLink fieldCode="DE" term="%22NEUTROPENIA%22">NEUTROPENIA</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNITY%22">IMMUNITY</searchLink><br /><searchLink fieldCode="DE" term="%22COMMON+cold%22">COMMON cold</searchLink><br /><searchLink fieldCode="DE" term="%22ADULTS%22">ADULTS</searchLink><br /><searchLink fieldCode="DE" term="%22RESPIRATORY+infections%22">RESPIRATORY infections</searchLink><br /><searchLink fieldCode="DE" term="%22MINORS%22">MINORS</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22PERU%22">PERU</searchLink>
– Name: Abstract
  Label: Abstract (English)
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  Data: Introduction.: Eosinophils modulate innate and adaptive immunity. Their elevation may be associated with changes in neutrophil concentrations during acute upper respiratory1 tract infections. The objective was to analyze the association between eosinophilia and neutropenia in patients with acute rhinopharyngitis. Methodology.: Cross-sectional and analytical study, based on data from medical records of 526 patients from a polyclinic in the district of Villa el Salvador. Peru. Patients diagnosed with acute rhinopharyngitis who underwent a complete blood count were selected. Patients with chronic respiratory and hematologic diseases were excluded. Bivariate statistics with frequencies and percentages were performed, as well as crude and adjusted Odds Ratio tests using binary logistic regression. Results.: Minors with neutropenia had eosinophilia 5.52 times more often than those without neutropenia (OR=5.52; CI:95%=2.28-13.35; p=0.005). In adults it was 2.01 (OR=2.01; CI:95%=1.07-3.77; p=0.027). Discussion.: The findings could be attributed to the antiviral activity of eosinophils by mechanisms mediated by ribonucleases and neurotoxins, which require neutrophil-mediated activation in the presence of viral and bacterial infectious conditions. In turn, the greater strength of the association in minors could be due to the fact that their immune system is less mature than that of adults, who also take medication more frequently. Conclusions.: Neutropenia and eosinophilia were more strongly associated in patients with acute rhinopharyngitis, mainly in minors. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducción.: Los eosinófilos modulan la inmunidad innata y adaptativa. Su elevación puede estar asociada a cambios en las concentraciones de neutrófilos durante la infección aguda de vías respiratorias superiores. El objetivo fue analizar la asociación entre eosinofilia y neutropenia en pacientes con rinofaringitis aguda. Metodología.: Estudio transversal y analítico, basado en datos de historias clínicas de 526 pacientes de un policlínico del distrito de Villa el Salvador, Perú. Fueron seleccionados pacientes diagnosticados por rinofaringitis aguda que se realizaron un hemograma completo. Se excluyó a pacientes con enfermedades respiratorias y hematológicas crónicas. Se realizó estadística bivariada con frecuencias y porcentajes, así como la prueba de Odds Ratio crudo y ajustado por regresión logística binaria. Resultados.: Los menores de edad con neutropenia tuvieron eosinofilia 5.52 veces más a menudo que aquellos sin neutropenia (OR=5.52; IC:95%=2.28-13.35; p=0.005). En adultos fue 2.01 (OR=2.01; IC:95%=1.07-3.77; p=0.027). Discusión.: Los hallazgos podrían atribuirse a la actividad antiviral de los eosinófilos por mecanismos mediados por ribonucleasas y neurotoxinas, los cuales requieren de la activación mediada por neutrófilos en presencia de cuadros infecciosos virales y bacterianos. A su vez, la mayor fuerza de asociación en menores de edad podría deberse a que su sistema inmunológico está en menor madurez que los adultos, quienes además se medican con mayor frecuencia. Conclusiones.: La neutropenia y la eosinofilia tuvieron una mayor fuerza de asociación en pacientes con rinofaringitis aguda, principalmente en menores de edad. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Portuguese)
  Group: Ab
  Data: Introdução.: Os eosinófilos modulam a imunidade inata e adaptativa. Sua elevação pode estar associada a alterações nas concentrações de neutrófilos durante infecção aguda do trato respiratório superior. O objetivo foi analisar a associação entre eosinofilia e neutropenia em pacientes com rinofaringite aguda. Metodologia.: Estudo transversal e analítico, baseado em dados de prontuários de 526 pacientes de urna policlínica do distrito de Villa el Salvador, Peru. Foram selecionados pacientes com diagnóstico de rinofaringite aguda e submetidos a hemograma completo. Foram excluídos pacientes com doenças respiratorias e hematológicas crónicas. Foram realizadas estatísticas bivariadas com frequências e porcentagens, bem como o teste Odds Ratio bruto e ajustado por regressão logística binária. Resultados.: Menores com neutropenia apresentaram eosinofilia 5.52 vezes mais frequentemente que aqueles sem neutropenia (OR-5.52; IC 95%=2.28-13.35; p=0.005). Nos adultos foi de 2.01 (OR=2.01; IC: 95%=1.07-3.77; p=0.027). Discussão.: Os achados podem ser atribuídos à atividade antiviral dos eosinófilos através de mecanismos mediados por ribonucleases e neurotoxinas, que requerem ativação mediada por neutrófilos na presença de condições infecciosas virais e bacterianas. Por sua vez, a maior força de associação nos menores pode ser devida ao fato do seu sistema imunitário ser menos maduro do que o dos adultos, que também tomam medicamentos com mais frequência. Conclusões.: Neutropenia e eosinofilia tiveram maior força de associação nos pacientes com rinofaringite aguda, principalmente nos menores. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of MedUNAB is the property of Universidad Autonoma de Bucaramanga, UNAB and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: EOSINOPHILIA
        Type: general
      – SubjectFull: NEUTROPENIA
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