View in EDS PDF Full Text

Epidemiology of pituitary tumors treated by gamma knife radiosurgery in Mexico: a single-center study.

Saved in:
Bibliographic Details
Title: Epidemiology of pituitary tumors treated by gamma knife radiosurgery in Mexico: a single-center study.
Alternate Title: Epidemiología de los tumores hipofisarios tratados con radiocirugía con bisturí gamma en México: un estudio de un solo centro.
Authors: Jimenez-Ruiz, Amado1 dr.amadojimenez@gmail.com, García-Grimshaw, Miguel2, Valerdi-Contreras, Lorena3, Anaya-Silva, Israel3, Cuevas-Solórzano, Abel4, Gutiérrez-Castillo, Alejandro5, Torres-Mora, Cristina3, Ruiz-Sandoval, José L.1
Source: Revista Mexicana de Neurociencia. May/Jun2025, Vol. 26 Issue 3, p79-83. 5p.
Subjects: PITUITARY tumors, VISUAL fields, INTRACRANIAL tumors, TUMOR growth, MEXICANS
Abstract (English): Objective: Pituitary adenomas (PAs) represent the second most common intracranial tumors usually treated with surgery. Total resection is rare, so adjuvant radiosurgery is often indicated to control tumor growth. This study aims to describe a cohort of Mexican patients treated with Gamma Knife Radiosurgery (GKR) for PA over 17 years in a single center. Methods: The records of adult patients treated with GKR for PA at San Javier Hospital in Guadalajara, Mexico, from 1998 to 2015 were retrospectively reviewed. The analyzed factors included tumor imaging characteristics, visual field abnormalities, prior treatment, and radiographical improvement after radiosurgery. Results: This study included 111 patients (70 females, median age 39.5 years, [IQR: 33-51]). The median tumor volume was 3.55 cm3 (2.14-6.82), and the median diameter was 0.95 mm (0.5-1.4). We found an abnormal visual field pre-GKR in 33 (29%) patients. The most common type of tumor was prolactinoma (43%). The median dose of radiation was 21 Grays (16-25). Forty-five (39.5%) patients had radiographic improvement. The variables associated with significant radiographic improvement were having a normal pre-treatment visual field campimetry (p = 0.03; odds ratio [OR] = 2.4 [95% confidence interval (CI), 1.05-5.48]) and the absence of chiasmatic extension (p = 0.03; OR = 2.66 [95% CI, 1.06-6.99]) which are essential to anticipate and improve outcomes in patients with pituitary tumors. Conclusions: GKR was safe and valuable for the volumetric control of PA. Nearly half the patients had radiographic improvement without reported adverse effects (different from hormonal deficiencies) within a median follow-up of 12 months. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Los adenomas pituitarios representan el segundo tumor intracraneal más frecuente y usualmente son tratados mediante cirugía y radiocirugía. El objetivo de esta cohorte es describir el uso de radiocirugía con bisturí de rayos gamma en México. Métodos: Se realizó una revisión retrospectiva de pacientes tratados mediante radiocirugía con bisturí de rayos gamma en el Hospital San Javier en Guadalajara, México de 1998 al 2015. Las variantes analizadas incluían las características imagenológicas del tumor, las anormalidades del campo visual previo al tratamiento y la mejoría radiográfica posterior a la radiocirugía. Resultados: En total 111 pacientes fueron incluidos (70 mujeres, edad media 39.5 años [IQR: 33-51]) en este estudio. El volumen promedio del tumor fue 3.55 cm3 (2.14-6.82) y el diámetro de 0.95 mm (0.5-1.4). Encontramos alteraciones del campo visual previo a la radiocirugía en 33 pacientes (29%). La dosis promedio de radiación fue 21 Gy (16-25). Se observó una mejoría radiológica en 55 pacientes (39.5%); las variables asociadas con esta mejoría fueron un campo visual por campimetría normal previo al procedimiento (p = 0.03; OR 2.4 [95% CI, 1.05-5.48]) y la ausencia de extensión tumoral al quiasma óptico (p = 0.03; OR 2.66 [95% CI, 1.06-6.99]); los cuáles son esenciales para anticipar y mejorar los resultados a futuro con este tipo de ciurgía. Conclusiones: La radiocirugía con bisturí de rayos gamma fue segura y demostró utilidad en el control volumétrico de adenomas pituitarios. El 39.5% de los pacientes obtuvieron una mejoría radiológica sin reporte de efectos adversos, diferentes a deficiencias hormonales, en un seguimiento a 12 meses. [ABSTRACT FROM AUTHOR]
Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: lth
DbLabel: MedicLatina
An: 186002024
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Epidemiology of pituitary tumors treated by gamma knife radiosurgery in Mexico: a single-center study.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Epidemiología de los tumores hipofisarios tratados con radiocirugía con bisturí gamma en México: un estudio de un solo centro.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Jimenez-Ruiz%2C+Amado%22">Jimenez-Ruiz, Amado</searchLink><relatesTo>1</relatesTo><i> dr.amadojimenez@gmail.com</i><br /><searchLink fieldCode="AR" term="%22García-Grimshaw%2C+Miguel%22">García-Grimshaw, Miguel</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Valerdi-Contreras%2C+Lorena%22">Valerdi-Contreras, Lorena</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Anaya-Silva%2C+Israel%22">Anaya-Silva, Israel</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cuevas-Solórzano%2C+Abel%22">Cuevas-Solórzano, Abel</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Gutiérrez-Castillo%2C+Alejandro%22">Gutiérrez-Castillo, Alejandro</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Torres-Mora%2C+Cristina%22">Torres-Mora, Cristina</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ruiz-Sandoval%2C+José+L%2E%22">Ruiz-Sandoval, José L.</searchLink><relatesTo>1</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Revista+Mexicana+de+Neurociencia%22">Revista Mexicana de Neurociencia</searchLink>. May/Jun2025, Vol. 26 Issue 3, p79-83. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22PITUITARY+tumors%22">PITUITARY tumors</searchLink><br /><searchLink fieldCode="DE" term="%22VISUAL+fields%22">VISUAL fields</searchLink><br /><searchLink fieldCode="DE" term="%22INTRACRANIAL+tumors%22">INTRACRANIAL tumors</searchLink><br /><searchLink fieldCode="DE" term="%22TUMOR+growth%22">TUMOR growth</searchLink><br /><searchLink fieldCode="DE" term="%22MEXICANS%22">MEXICANS</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective: Pituitary adenomas (PAs) represent the second most common intracranial tumors usually treated with surgery. Total resection is rare, so adjuvant radiosurgery is often indicated to control tumor growth. This study aims to describe a cohort of Mexican patients treated with Gamma Knife Radiosurgery (GKR) for PA over 17 years in a single center. Methods: The records of adult patients treated with GKR for PA at San Javier Hospital in Guadalajara, Mexico, from 1998 to 2015 were retrospectively reviewed. The analyzed factors included tumor imaging characteristics, visual field abnormalities, prior treatment, and radiographical improvement after radiosurgery. Results: This study included 111 patients (70 females, median age 39.5 years, [IQR: 33-51]). The median tumor volume was 3.55 cm3 (2.14-6.82), and the median diameter was 0.95 mm (0.5-1.4). We found an abnormal visual field pre-GKR in 33 (29%) patients. The most common type of tumor was prolactinoma (43%). The median dose of radiation was 21 Grays (16-25). Forty-five (39.5%) patients had radiographic improvement. The variables associated with significant radiographic improvement were having a normal pre-treatment visual field campimetry (p = 0.03; odds ratio [OR] = 2.4 [95% confidence interval (CI), 1.05-5.48]) and the absence of chiasmatic extension (p = 0.03; OR = 2.66 [95% CI, 1.06-6.99]) which are essential to anticipate and improve outcomes in patients with pituitary tumors. Conclusions: GKR was safe and valuable for the volumetric control of PA. Nearly half the patients had radiographic improvement without reported adverse effects (different from hormonal deficiencies) within a median follow-up of 12 months. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo: Los adenomas pituitarios representan el segundo tumor intracraneal más frecuente y usualmente son tratados mediante cirugía y radiocirugía. El objetivo de esta cohorte es describir el uso de radiocirugía con bisturí de rayos gamma en México. Métodos: Se realizó una revisión retrospectiva de pacientes tratados mediante radiocirugía con bisturí de rayos gamma en el Hospital San Javier en Guadalajara, México de 1998 al 2015. Las variantes analizadas incluían las características imagenológicas del tumor, las anormalidades del campo visual previo al tratamiento y la mejoría radiográfica posterior a la radiocirugía. Resultados: En total 111 pacientes fueron incluidos (70 mujeres, edad media 39.5 años [IQR: 33-51]) en este estudio. El volumen promedio del tumor fue 3.55 cm3 (2.14-6.82) y el diámetro de 0.95 mm (0.5-1.4). Encontramos alteraciones del campo visual previo a la radiocirugía en 33 pacientes (29%). La dosis promedio de radiación fue 21 Gy (16-25). Se observó una mejoría radiológica en 55 pacientes (39.5%); las variables asociadas con esta mejoría fueron un campo visual por campimetría normal previo al procedimiento (p = 0.03; OR 2.4 [95% CI, 1.05-5.48]) y la ausencia de extensión tumoral al quiasma óptico (p = 0.03; OR 2.66 [95% CI, 1.06-6.99]); los cuáles son esenciales para anticipar y mejorar los resultados a futuro con este tipo de ciurgía. Conclusiones: La radiocirugía con bisturí de rayos gamma fue segura y demostró utilidad en el control volumétrico de adenomas pituitarios. El 39.5% de los pacientes obtuvieron una mejoría radiológica sin reporte de efectos adversos, diferentes a deficiencias hormonales, en un seguimiento a 12 meses. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=186002024
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.24875/RMN.24000022
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 79
    Subjects:
      – SubjectFull: PITUITARY tumors
        Type: general
      – SubjectFull: VISUAL fields
        Type: general
      – SubjectFull: INTRACRANIAL tumors
        Type: general
      – SubjectFull: TUMOR growth
        Type: general
      – SubjectFull: MEXICANS
        Type: general
    Titles:
      – TitleFull: Epidemiology of pituitary tumors treated by gamma knife radiosurgery in Mexico: a single-center study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jimenez-Ruiz, Amado
      – PersonEntity:
          Name:
            NameFull: García-Grimshaw, Miguel
      – PersonEntity:
          Name:
            NameFull: Valerdi-Contreras, Lorena
      – PersonEntity:
          Name:
            NameFull: Anaya-Silva, Israel
      – PersonEntity:
          Name:
            NameFull: Cuevas-Solórzano, Abel
      – PersonEntity:
          Name:
            NameFull: Gutiérrez-Castillo, Alejandro
      – PersonEntity:
          Name:
            NameFull: Torres-Mora, Cristina
      – PersonEntity:
          Name:
            NameFull: Ruiz-Sandoval, José L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May/Jun2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 16655044
          Numbering:
            – Type: volume
              Value: 26
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Revista Mexicana de Neurociencia
              Type: main
ResultId 1