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Diabetes Mellitus tipo 2 y riesgo de cáncer de ovario en Loja 2000-2017: Un estudio de casos y controles.

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Title: Diabetes Mellitus tipo 2 y riesgo de cáncer de ovario en Loja 2000-2017: Un estudio de casos y controles.
Alternate Title: Type 2 diabetes mellitus and risk of ovarian cancer in Loja 2000-2017: A case-control study.
Authors: del Carmen Ludeña Gonzalez, Lucía1 lcludena2@utpl.edu.ec
Source: Revista Medicina. 2025, Vol. 25 Issue 1, p42-46. 5p.
Subjects: DISEASE risk factors, TYPE 2 diabetes, CONVENIENCE sampling (Statistics), OVARIAN cancer, MULTIVARIATE analysis
Abstract (English): Introduction: Ovarian cancer is one of the first deadly malignant neoplasms afflict women. Factors such as type 2 diabetes (T2D) or obesity have been associated with the risk of having ovarian cancer; however, research correlating metabolic problems with ovarian cancer risk is lacking. Objective: Evaluate the risk association between T2D and ovarian cancer. Methodology: Study of cases and controls ratio 1:1. The participants with histopathological diagnosis of ovarian cancer were the eligible cases, and the controls were chosen by a convenience sample of the initial base of patients who underwent a gynecological echo at a tertiary hospital. The exposure of interest was type 2 diabetes mellitus. ORs were calculated using logistic regression. Results: A total of 270 participants were evaluated (135 per arm). In the group of women with DM2, an OR of 6.1 (95% CI 2.47-15.32) was observed as a risk factor for ovarian cancer. In the multivariate analysis adjusted for confounding factors, obesity (OR 2.6; 95% CI 1.15-6.16) and DM2 (OR 4.9; 95% CI 1.89 - 12.79) remained as independent risk factors for ovarian cancer. Conclusions: In our study, DM2 behaves as a risk factor for ovarian cancer. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: El cáncer de ovario es una de las principales neoplasias malignas mortales que aquejan a las mujeres. Factores como diabetes mellitus tipo 2 (DM2) u obesidad se han asociado con el riesgo de tener cáncer de ovario. Sin embargo, faltan investigaciones que correlacionen los problemas metabólicos con el riesgo de cáncer de ovario.Objetivo: Evaluar la asociación de riesgo entre DM2 y cáncer de ovario. Metodología: Estudio de casos y controles, razón 1:1. Los participantes con diagnóstico histopatológico de cáncer de ovario fueron los casos elegibles y los controles fueron elegidos por un muestreo de conveniencia de la base inicial de pacientes que se realizaron un eco ginecológico en un hospital de tercer nivel. La exposición de interés fue la DM2. Los OR se calcularon mediante el uso de regresión logística. Resultados: Se evaluó un total de 270 participantes (135 por brazo). En el grupo de mujeres con DM2 se observó un OR de 6,1 (IC 95% 2,47- 15,32) como factor de riesgo de cáncer de ovario. En el análisis multivariante ajustado por factores de confusión, la obesidad (OR 2,6; IC 95% 1,15-6,16) y la DM2 (OR 4,9; IC 95% 1,89 - 12,79) permanecieron como factores de riesgo independientes de cáncer de ovario. Conclusión: En la muestra estudiada, la DM2 se comporta como un factor de riesgo de cáncer de ovario. [ABSTRACT FROM AUTHOR]
Copyright of Revista Medicina is the property of Revista Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Diabetes Mellitus tipo 2 y riesgo de cáncer de ovario en Loja 2000-2017: Un estudio de casos y controles.
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  Data: Type 2 diabetes mellitus and risk of ovarian cancer in Loja 2000-2017: A case-control study.
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  Data: <searchLink fieldCode="AR" term="%22del+Carmen+Ludeña+Gonzalez%2C+Lucía%22">del Carmen Ludeña Gonzalez, Lucía</searchLink><relatesTo>1</relatesTo><i> lcludena2@utpl.edu.ec</i>
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  Data: <searchLink fieldCode="JN" term="%22Revista+Medicina%22">Revista Medicina</searchLink>. 2025, Vol. 25 Issue 1, p42-46. 5p.
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  Data: <searchLink fieldCode="DE" term="%22DISEASE+risk+factors%22">DISEASE risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22TYPE+2+diabetes%22">TYPE 2 diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22CONVENIENCE+sampling+%28Statistics%29%22">CONVENIENCE sampling (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22OVARIAN+cancer%22">OVARIAN cancer</searchLink><br /><searchLink fieldCode="DE" term="%22MULTIVARIATE+analysis%22">MULTIVARIATE analysis</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction: Ovarian cancer is one of the first deadly malignant neoplasms afflict women. Factors such as type 2 diabetes (T2D) or obesity have been associated with the risk of having ovarian cancer; however, research correlating metabolic problems with ovarian cancer risk is lacking. Objective: Evaluate the risk association between T2D and ovarian cancer. Methodology: Study of cases and controls ratio 1:1. The participants with histopathological diagnosis of ovarian cancer were the eligible cases, and the controls were chosen by a convenience sample of the initial base of patients who underwent a gynecological echo at a tertiary hospital. The exposure of interest was type 2 diabetes mellitus. ORs were calculated using logistic regression. Results: A total of 270 participants were evaluated (135 per arm). In the group of women with DM2, an OR of 6.1 (95% CI 2.47-15.32) was observed as a risk factor for ovarian cancer. In the multivariate analysis adjusted for confounding factors, obesity (OR 2.6; 95% CI 1.15-6.16) and DM2 (OR 4.9; 95% CI 1.89 - 12.79) remained as independent risk factors for ovarian cancer. Conclusions: In our study, DM2 behaves as a risk factor for ovarian cancer. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducción: El cáncer de ovario es una de las principales neoplasias malignas mortales que aquejan a las mujeres. Factores como diabetes mellitus tipo 2 (DM2) u obesidad se han asociado con el riesgo de tener cáncer de ovario. Sin embargo, faltan investigaciones que correlacionen los problemas metabólicos con el riesgo de cáncer de ovario.Objetivo: Evaluar la asociación de riesgo entre DM2 y cáncer de ovario. Metodología: Estudio de casos y controles, razón 1:1. Los participantes con diagnóstico histopatológico de cáncer de ovario fueron los casos elegibles y los controles fueron elegidos por un muestreo de conveniencia de la base inicial de pacientes que se realizaron un eco ginecológico en un hospital de tercer nivel. La exposición de interés fue la DM2. Los OR se calcularon mediante el uso de regresión logística. Resultados: Se evaluó un total de 270 participantes (135 por brazo). En el grupo de mujeres con DM2 se observó un OR de 6,1 (IC 95% 2,47- 15,32) como factor de riesgo de cáncer de ovario. En el análisis multivariante ajustado por factores de confusión, la obesidad (OR 2,6; IC 95% 1,15-6,16) y la DM2 (OR 4,9; IC 95% 1,89 - 12,79) permanecieron como factores de riesgo independientes de cáncer de ovario. Conclusión: En la muestra estudiada, la DM2 se comporta como un factor de riesgo de cáncer de ovario. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista Medicina is the property of Revista Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.23878/medicina.v25i1.1193
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      – Code: spa
        Text: Spanish
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        PageCount: 5
        StartPage: 42
    Subjects:
      – SubjectFull: DISEASE risk factors
        Type: general
      – SubjectFull: TYPE 2 diabetes
        Type: general
      – SubjectFull: CONVENIENCE sampling (Statistics)
        Type: general
      – SubjectFull: OVARIAN cancer
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      – SubjectFull: MULTIVARIATE analysis
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      – TitleFull: Diabetes Mellitus tipo 2 y riesgo de cáncer de ovario en Loja 2000-2017: Un estudio de casos y controles.
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              Text: 2025
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