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Recomendaciones de un programa de optimización de tratamiento antibiótico sobre la duración del tratamiento antibiótico: eficacia de pautas cortas en el Servicio de Urgencias.

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Title: Recomendaciones de un programa de optimización de tratamiento antibiótico sobre la duración del tratamiento antibiótico: eficacia de pautas cortas en el Servicio de Urgencias.
Alternate Title: Recommendations from an antimicrobial stewardship program on the duration of antibiotic treatment: effectiveness of short-course regimens in the emergency department.
Authors: Martínez-de La Cruz, Paula1 paulamartinezdelacruz@gmail.com, Sánz-Márquez, Sira2, Valverde-Cánovas, José Francisco2, Hervás-Gómez, Rafael2, Martín-Segarra, Oriol2, Vegas-Serrano, Ana2, Velasco-Arribas, María2, Losa-García, Juan Emilio2, Moreno-Núñez, Leonor2
Source: Revista Española de Quimioterapia. Oct2025, Vol. 38 Issue 5, p420-425. 6p.
Subjects: TREATMENT duration, ANTIBIOTICS, ANTIMICROBIAL stewardship, TREATMENT effectiveness, INFECTION, DRUG side effects, HOSPITAL emergency services
Abstract (English): Introduction: Excessive duration of antibiotic treatment is associated with adverse events without improving clinical outcomes. The Emergency Department (ED) is a strategic location to implement Antibiotic Stewardship Programs (ASP). Our objective was to determine the effect of ASP recommendations on short antibiotic treatment regimens in patients with uncomplicated infections treated in the ED. Material and Methods: We conducted a quasi-experimental study comparing patients treated in the ED in September and October 2022 who were discharged with antibiotic treatment (control group) with those treated in November and December of the same year (intervention group). Recommendations regarding the appropriateness of antibiotic therapy were made in both groups, and regarding treatment duration only in the intervention group. A 30-day follow-up was performed to assess healing, readmissions due to infection, and adverse effects. Results: A total of 78 patients were included, 40 in the control group and 38 in the intervention group. The median duration of antibiotic treatment was significantly shorter in the intervention group (7.5 days, IQR: 7-10 vs 6 days, IQR: 5-7, p<0.001). Healing rates were similar in both groups (92.5% vs 97.4%, p = 0.616). Adverse effects were documented in 7 patients from the intervention group (18.4%). Conclusions: An ASP in the ED can shorten the duration of antibiotic treatment in patients with uncomplicated infections who are discharged, without affecting clinical outcomes, and without being associated with severe adverse effects, mortality, or readmissions due to infection. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: La duración excesiva del tratamiento antibiótico se asocia a eventos adversos sin mejorar la evolución clínica. El Servicio de Urgencias (SU) es un lugar estratégico para implementar Programas de Optimización de Tratamiento Antibiótico (PROA). Nuestro objetivo fue determinar el efecto de las recomendaciones de un PROA sobre pautas cortas de tratamiento antibiótico en pacientes con infecciones no complicadas atendidos en el SU. Material y métodos: Realizamos un estudio cuasiexperimental en el que se compararon los pacientes atendidos en septiembre y octubre de 2022 en SU que fueron dados de alta con tratamiento antibiótico (grupo control), con los atendidos en noviembre y diciembre del mismo año (grupo intervención). Se realizaron recomendaciones sobre la adecuación de la antibioterapia en ambos grupos, y sobre la duración solo en el grupo de intervención. Se realizó seguimiento a 30 días para valorar la curación, reingresos por infección y efectos adversos. Resultados: Se incluyeron 78 pacientes, 40 en el grupo control y 38 en el de intervención. La mediana de duración del tratamiento antibiótico fue significativamente más corta en el grupo de intervención (7,5 días; RIQ:7-10, vs. 6 días, RIQ:5-7 p<0,001). La curación fue similar en ambos grupos (92,5% vs 97,4% p = 0,616). Se documentaron efectos adversos en 7 pacientes del grupo de intervención (18,4%). Conclusiones: Un PROA en el SU puede acortar la duración del tratamiento antibiótico en los pacientes con infecciones no complicadas que son dados de alta, sin modificar la evolución clínica, asociarse a efectos adversos graves, mortalidad o reingreso por infección. [ABSTRACT FROM AUTHOR]
Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Recomendaciones de un programa de optimizaci&#243;n de tratamiento antibi&#243;tico sobre la duraci&#243;n del tratamiento antibi&#243;tico: eficacia de pautas cortas en el Servicio de Urgencias.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mart&#237;nez-de+La+Cruz%2C+Paula%22&quot;&gt;Mart&#237;nez-de La Cruz, Paula&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; paulamartinezdelacruz@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22S&#225;nz-M&#225;rquez%2C+Sira%22&quot;&gt;S&#225;nz-M&#225;rquez, Sira&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Valverde-C&#225;novas%2C+Jos&#233;+Francisco%22&quot;&gt;Valverde-C&#225;novas, Jos&#233; Francisco&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Herv&#225;s-G&#243;mez%2C+Rafael%22&quot;&gt;Herv&#225;s-G&#243;mez, Rafael&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mart&#237;n-Segarra%2C+Oriol%22&quot;&gt;Mart&#237;n-Segarra, Oriol&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vegas-Serrano%2C+Ana%22&quot;&gt;Vegas-Serrano, Ana&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Velasco-Arribas%2C+Mar&#237;a%22&quot;&gt;Velasco-Arribas, Mar&#237;a&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Losa-Garc&#237;a%2C+Juan+Emilio%22&quot;&gt;Losa-Garc&#237;a, Juan Emilio&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Moreno-N&#250;&#241;ez%2C+Leonor%22&quot;&gt;Moreno-N&#250;&#241;ez, Leonor&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;
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– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction: Excessive duration of antibiotic treatment is associated with adverse events without improving clinical outcomes. The Emergency Department (ED) is a strategic location to implement Antibiotic Stewardship Programs (ASP). Our objective was to determine the effect of ASP recommendations on short antibiotic treatment regimens in patients with uncomplicated infections treated in the ED. Material and Methods: We conducted a quasi-experimental study comparing patients treated in the ED in September and October 2022 who were discharged with antibiotic treatment (control group) with those treated in November and December of the same year (intervention group). Recommendations regarding the appropriateness of antibiotic therapy were made in both groups, and regarding treatment duration only in the intervention group. A 30-day follow-up was performed to assess healing, readmissions due to infection, and adverse effects. Results: A total of 78 patients were included, 40 in the control group and 38 in the intervention group. The median duration of antibiotic treatment was significantly shorter in the intervention group (7.5 days, IQR: 7-10 vs 6 days, IQR: 5-7, p&lt;0.001). Healing rates were similar in both groups (92.5% vs 97.4%, p = 0.616). Adverse effects were documented in 7 patients from the intervention group (18.4%). Conclusions: An ASP in the ED can shorten the duration of antibiotic treatment in patients with uncomplicated infections who are discharged, without affecting clinical outcomes, and without being associated with severe adverse effects, mortality, or readmissions due to infection. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducci&#243;n: La duraci&#243;n excesiva del tratamiento antibi&#243;tico se asocia a eventos adversos sin mejorar la evoluci&#243;n cl&#237;nica. El Servicio de Urgencias (SU) es un lugar estrat&#233;gico para implementar Programas de Optimizaci&#243;n de Tratamiento Antibi&#243;tico (PROA). Nuestro objetivo fue determinar el efecto de las recomendaciones de un PROA sobre pautas cortas de tratamiento antibi&#243;tico en pacientes con infecciones no complicadas atendidos en el SU. Material y m&#233;todos: Realizamos un estudio cuasiexperimental en el que se compararon los pacientes atendidos en septiembre y octubre de 2022 en SU que fueron dados de alta con tratamiento antibi&#243;tico (grupo control), con los atendidos en noviembre y diciembre del mismo a&#241;o (grupo intervenci&#243;n). Se realizaron recomendaciones sobre la adecuaci&#243;n de la antibioterapia en ambos grupos, y sobre la duraci&#243;n solo en el grupo de intervenci&#243;n. Se realiz&#243; seguimiento a 30 d&#237;as para valorar la curaci&#243;n, reingresos por infecci&#243;n y efectos adversos. Resultados: Se incluyeron 78 pacientes, 40 en el grupo control y 38 en el de intervenci&#243;n. La mediana de duraci&#243;n del tratamiento antibi&#243;tico fue significativamente m&#225;s corta en el grupo de intervenci&#243;n (7,5 d&#237;as; RIQ:7-10, vs. 6 d&#237;as, RIQ:5-7 p&lt;0,001). La curaci&#243;n fue similar en ambos grupos (92,5% vs 97,4% p = 0,616). Se documentaron efectos adversos en 7 pacientes del grupo de intervenci&#243;n (18,4%). Conclusiones: Un PROA en el SU puede acortar la duraci&#243;n del tratamiento antibi&#243;tico en los pacientes con infecciones no complicadas que son dados de alta, sin modificar la evoluci&#243;n cl&#237;nica, asociarse a efectos adversos graves, mortalidad o reingreso por infecci&#243;n. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Revista Espa&#241;ola de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.37201/req/040.2025
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      – Code: spa
        Text: Spanish
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      – SubjectFull: TREATMENT duration
        Type: general
      – SubjectFull: ANTIBIOTICS
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      – SubjectFull: ANTIMICROBIAL stewardship
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      – SubjectFull: TREATMENT effectiveness
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      – SubjectFull: INFECTION
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      – SubjectFull: DRUG side effects
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      – SubjectFull: HOSPITAL emergency services
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      – TitleFull: Recomendaciones de un programa de optimización de tratamiento antibiótico sobre la duración del tratamiento antibiótico: eficacia de pautas cortas en el Servicio de Urgencias.
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              Text: Oct2025
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