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Neuroartropatía de Charcot en Argentina: estudio de cohorte en dos hospitales de tercer nivel.

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Title: Neuroartropatía de Charcot en Argentina: estudio de cohorte en dos hospitales de tercer nivel.
Alternate Title: Charcot neuroarthropathy in Argentina: cohort study in two tertiary-level hospitals.
Authors: Carro, Gabriela V.1 (AUTHOR) gabivcarro@yahoo.com.ar, Parise, Ana C.2 (AUTHOR), Rodriguez Rey, Gabriela1 (AUTHOR), Noli, María Laura1 (AUTHOR), Caporaso, Federico1 (AUTHOR), Angel, Miguel1 (AUTHOR), Fuentes, Mariana G.1 (AUTHOR), Cafruni, Virginia M.2 (AUTHOR), Santini Araujo, María Gala2 (AUTHOR)
Source: Medicina (Buenos Aires). jul/ago2025, Vol. 85 Issue 4, p672-681. 10p.
Subjects: DIABETES, CHARCOT joints, TERTIARY care, ULCERS, COHORT analysis, AMPUTATION
Geographic Terms: ARGENTINA
Abstract (English): Introduction: Charcot neuroarthropathy (CN) is a complication of diabetes that can lead to deformities and increase the risk of amputation. This study describes the characteristics and evolution of patients with CN in two hospitals in Argentina. Materials and Methods: A prospective cohort study was conducted on 83 patients with CN who were con secutively treated between August and December 2023 at the National Hospital Alejandro Posadas (HNAP) and the Italian Hospital of Buenos Aires (HIBA). Results: Of the patients, 69.8% (58) were male, with a mean age of 51.8 (12.5) years, and 78.3% (65) had type 2 diabetes. Active-phase CN was present in 50 (60.2%) of cases. The temperature difference between both feet was 2.5°C in the active phase vs. 0.3°C in the inactive phase (p<0.01). Ulcers were observed in 47% of patients, more frequently at HNAP (57.1%) than at HIBA (25.9%, p<0.01). Compared to HNAP, HIBA had a lower proportion of male patients, a higher prevalence of type 1 diabetes, and more patients undergoing dialysis. Patients were followed for a median of 223 days (168-248). Among the 39 patients with ulcers, 19 (48.7%) healed, 19 (48.7%) had persistent ulcers, and one (2.6%) required major amputa tion. The incidence density of new ulcers was 2.7% per month in patients without prior lesions. Discussion: CN is an underdiagnosed disease with severe consequences if not detected and treated early. This study provides valuable information on its pre sentation and characteristics, highlighting the need for prevention strategies and early diagnosis. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: La neuroartropatía de Charcot (NC) es una complicación de la diabetes que puede generar deformidades y aumenta el riesgo de amputación. Se describen las características y evolución de pacientes con NC en dos hospitales de Argentina. Material y métodos: Estudio de cohorte prospectivo en 83 pacientes con NC atendidos en forma consecutiva entre agosto y diciembre de 2023 en el Hospital Nacional Alejandro Posadas (HNAP) y en el Hospital Italiano de Buenos Aires (HIBA). Resultados: El 69.8% (58) fueron hombres, con una media de edad de 51.8 (12.5) años, el 78.3% (65) con diabetes tipo 2. Cincuenta (60.2%) casos estaba en fase activa. La temperatura diferencial entre ambos pies fue 2.5°C en la fase activa vs. 0.3°C en la inactiva, p<0.01. Se observaron úlceras en el 47% de los pacientes, más frecuentemente en el HNAP (57.1%) que en el HIBA (25.9%, p<0.01). El HIBA presentó menor proporción de hombres, mayor de diabetes tipo 1 y aquellos en diálisis. Los pacientes fueron seguidos durante una mediana de 223 días (168-248). De los 39 con lesión, cicatrizaron 19 (48.7%), presentaron persistencia de la misma 19 (48.7%) y uno requirió amputación mayor (2.6%). La densidad de incidencia de nuevas úlceras fue de 2.7% por mes en pacientes sin lesión. Discusión: La NC es una enfermedad subdiagnosticada, con graves implicancias si no se detecta y trata temprana mente. Este estudio aporta información relevante sobre su presentación y características, destacando la necesidad de estrategias de prevención y diagnóstico temprano. [ABSTRACT FROM AUTHOR]
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Neuroartropat&#237;a de Charcot en Argentina: estudio de cohorte en dos hospitales de tercer nivel.
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  Data: Charcot neuroarthropathy in Argentina: cohort study in two tertiary-level hospitals.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Carro%2C+Gabriela+V%2E%22&quot;&gt;Carro, Gabriela V.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; gabivcarro@yahoo.com.ar&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Parise%2C+Ana+C%2E%22&quot;&gt;Parise, Ana C.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rodriguez+Rey%2C+Gabriela%22&quot;&gt;Rodriguez Rey, Gabriela&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Noli%2C+Mar&#237;a+Laura%22&quot;&gt;Noli, Mar&#237;a Laura&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Caporaso%2C+Federico%22&quot;&gt;Caporaso, Federico&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Angel%2C+Miguel%22&quot;&gt;Angel, Miguel&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fuentes%2C+Mariana+G%2E%22&quot;&gt;Fuentes, Mariana G.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cafruni%2C+Virginia+M%2E%22&quot;&gt;Cafruni, Virginia M.&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Santini+Araujo%2C+Mar&#237;a+Gala%22&quot;&gt;Santini Araujo, Mar&#237;a Gala&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Medicina+%28Buenos+Aires%29%22&quot;&gt;Medicina (Buenos Aires)&lt;/searchLink&gt;. jul/ago2025, Vol. 85 Issue 4, p672-681. 10p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22DIABETES%22&quot;&gt;DIABETES&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CHARCOT+joints%22&quot;&gt;CHARCOT joints&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22TERTIARY+care%22&quot;&gt;TERTIARY care&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ULCERS%22&quot;&gt;ULCERS&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22COHORT+analysis%22&quot;&gt;COHORT analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22AMPUTATION%22&quot;&gt;AMPUTATION&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ARGENTINA%22&quot;&gt;ARGENTINA&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract (English)
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  Data: Introduction: Charcot neuroarthropathy (CN) is a complication of diabetes that can lead to deformities and increase the risk of amputation. This study describes the characteristics and evolution of patients with CN in two hospitals in Argentina. Materials and Methods: A prospective cohort study was conducted on 83 patients with CN who were con secutively treated between August and December 2023 at the National Hospital Alejandro Posadas (HNAP) and the Italian Hospital of Buenos Aires (HIBA). Results: Of the patients, 69.8% (58) were male, with a mean age of 51.8 (12.5) years, and 78.3% (65) had type 2 diabetes. Active-phase CN was present in 50 (60.2%) of cases. The temperature difference between both feet was 2.5&#176;C in the active phase vs. 0.3&#176;C in the inactive phase (p&lt;0.01). Ulcers were observed in 47% of patients, more frequently at HNAP (57.1%) than at HIBA (25.9%, p&lt;0.01). Compared to HNAP, HIBA had a lower proportion of male patients, a higher prevalence of type 1 diabetes, and more patients undergoing dialysis. Patients were followed for a median of 223 days (168-248). Among the 39 patients with ulcers, 19 (48.7%) healed, 19 (48.7%) had persistent ulcers, and one (2.6%) required major amputa tion. The incidence density of new ulcers was 2.7% per month in patients without prior lesions. Discussion: CN is an underdiagnosed disease with severe consequences if not detected and treated early. This study provides valuable information on its pre sentation and characteristics, highlighting the need for prevention strategies and early diagnosis. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
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  Data: Introducci&#243;n: La neuroartropat&#237;a de Charcot (NC) es una complicaci&#243;n de la diabetes que puede generar deformidades y aumenta el riesgo de amputaci&#243;n. Se describen las caracter&#237;sticas y evoluci&#243;n de pacientes con NC en dos hospitales de Argentina. Material y m&#233;todos: Estudio de cohorte prospectivo en 83 pacientes con NC atendidos en forma consecutiva entre agosto y diciembre de 2023 en el Hospital Nacional Alejandro Posadas (HNAP) y en el Hospital Italiano de Buenos Aires (HIBA). Resultados: El 69.8% (58) fueron hombres, con una media de edad de 51.8 (12.5) a&#241;os, el 78.3% (65) con diabetes tipo 2. Cincuenta (60.2%) casos estaba en fase activa. La temperatura diferencial entre ambos pies fue 2.5&#176;C en la fase activa vs. 0.3&#176;C en la inactiva, p&lt;0.01. Se observaron &#250;lceras en el 47% de los pacientes, m&#225;s frecuentemente en el HNAP (57.1%) que en el HIBA (25.9%, p&lt;0.01). El HIBA present&#243; menor proporci&#243;n de hombres, mayor de diabetes tipo 1 y aquellos en di&#225;lisis. Los pacientes fueron seguidos durante una mediana de 223 d&#237;as (168-248). De los 39 con lesi&#243;n, cicatrizaron 19 (48.7%), presentaron persistencia de la misma 19 (48.7%) y uno requiri&#243; amputaci&#243;n mayor (2.6%). La densidad de incidencia de nuevas &#250;lceras fue de 2.7% por mes en pacientes sin lesi&#243;n. Discusi&#243;n: La NC es una enfermedad subdiagnosticada, con graves implicancias si no se detecta y trata temprana mente. Este estudio aporta informaci&#243;n relevante sobre su presentaci&#243;n y caracter&#237;sticas, destacando la necesidad de estrategias de prevenci&#243;n y diagn&#243;stico temprano. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Text: Spanish
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      – SubjectFull: DIABETES
        Type: general
      – SubjectFull: CHARCOT joints
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      – SubjectFull: TERTIARY care
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      – SubjectFull: AMPUTATION
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      – SubjectFull: ARGENTINA
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      – TitleFull: Neuroartropatía de Charcot en Argentina: estudio de cohorte en dos hospitales de tercer nivel.
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