The impact of intravenous ibuprofen-paracetamol vs. ketorolac-paracetamol on coagulation and inflammation: implications for analgesia in hypertensive patients undergoing surgery.
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| Title: | The impact of intravenous ibuprofen-paracetamol vs. ketorolac-paracetamol on coagulation and inflammation: implications for analgesia in hypertensive patients undergoing surgery. |
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| Alternate Title: | El impacto de ibuprofeno-paracetamol intravenoso vs. ketorolaco-paracetamol en la coagulación y la inflamación: implicaciones para la analgesia en pacientes hipertensos sometidos a cirugía. |
| Authors: | Maarif, Muhammad Khaerul1 khaerulmaarif19@yahoo.com, Takdir Musba, A. M.2 takdir1974@yahoo.com, Datu, Madonna D.3 madonnadatu6@gmail.com, Gaus, Syafruddin3 udhingaus@hotmail.com, Wirawan, Nur Surya2 acoanestesi@yahoo.com, Adil, Andi3 adil_zanetti@yahoo.co.id |
| Source: | Revista Latinoamericana de Hipertensión. 2025, Vol. 20 Issue 8, p615-621. 7p. |
| Subjects: | BLOOD coagulation, INFLAMMATION, ANALGESIA, HYPERTENSION, ACETAMINOPHEN, KETOROLAC, IBUPROFEN, GYNECOLOGIC surgery |
| Abstract (English): | Postoperative pain following gynecological surgery continues to pose a significant clinical challenge, as many patients still experience moderate-to-severe pain with standard treatments. The potential for complications like bleeding further underscores the need for optimized analgesic strategies that balance efficacy with safety. This study evaluated two multimodal regimens: intravenous ibuprofen-paracetamol versus ketorolacparacetamol, comparing their impact on pain intensity, coagulation parameters, and interleukin-6 (IL-6) levels. In a double-blind randomized trial involving 40 patients, both combinations provided equivalent and effective pain control, with no significant difference in pain scores or clotting time observed between the groups. However, a key finding was that the ketorolac-based regimen caused a significant prolongation of bleeding time at 24 and 48 hours post-surgery. Conversely, the ibuprofen-based combination demonstrated a stronger anti-inflammatory effect, resulting in significantly lower levels of the proinflammatory cytokine IL-6. Consequently, while both regimens are effective for analgesia, the choice between them should be influenced by the patient's risk profile; ketorolac may pose a greater bleeding risk, whereas ibuprofen may offer superior control of the surgical inflammatory response. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El dolor posoperatorio tras cirugía ginecológica sigue representando un desafío clínico significativo, ya que muchas pacientes aún experimentan dolor de moderado a intenso con los tratamientos estándar. La posibilidad de complicaciones, como el sangrado, subraya aún más la necesidad de estrategias analgésicas optimizadas que equilibren eficacia y seguridad. Este estudio evaluó dos regímenes multimodales: ibuprofeno-paracetamol intravenoso versus ketorolaco-paracetamol, comparando su impacto en la intensidad del dolor, los parámetros de coagulación y los niveles de interleucina-6 (IL-6). En un ensayo aleatorizado doble ciego con 40 pacientes, ambas combinaciones proporcionaron un control del dolor equivalente y efectivo, sin observarse diferencias significativas en las puntuaciones de dolor ni en el tiempo de coagulación entre los grupos. Sin embargo, un hallazgo clave fue que el régimen basado en ketorolaco provocó una prolongación significativa del tiempo de sangrado a las 24 y 48 horas posoperatorias. Por el contrario, la combinación basada en ibuprofeno demostró un efecto antiinflamatorio más potente, resultando en niveles significativamente más bajos de la citocina proinflamatoria IL-6. En consecuencia, si bien ambos regímenes son eficaces para la analgesia, la elección entre ellos debe depender del perfil de riesgo del paciente; el ketorolaco puede suponer un mayor riesgo de sangrado, mientras que el ibuprofeno puede ofrecer un mejor control de la respuesta inflamatoria quirúrgica. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 188614629 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The impact of intravenous ibuprofen-paracetamol vs. ketorolac-paracetamol on coagulation and inflammation: implications for analgesia in hypertensive patients undergoing surgery. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: El impacto de ibuprofeno-paracetamol intravenoso vs. ketorolaco-paracetamol en la coagulación y la inflamación: implicaciones para la analgesia en pacientes hipertensos sometidos a cirugía. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Maarif%2C+Muhammad+Khaerul%22">Maarif, Muhammad Khaerul</searchLink><relatesTo>1</relatesTo><i> khaerulmaarif19@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Takdir+Musba%2C+A%2E+M%2E%22">Takdir Musba, A. M.</searchLink><relatesTo>2</relatesTo><i> takdir1974@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Datu%2C+Madonna+D%2E%22">Datu, Madonna D.</searchLink><relatesTo>3</relatesTo><i> madonnadatu6@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Gaus%2C+Syafruddin%22">Gaus, Syafruddin</searchLink><relatesTo>3</relatesTo><i> udhingaus@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Wirawan%2C+Nur+Surya%22">Wirawan, Nur Surya</searchLink><relatesTo>2</relatesTo><i> acoanestesi@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Adil%2C+Andi%22">Adil, Andi</searchLink><relatesTo>3</relatesTo><i> adil_zanetti@yahoo.co.id</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Latinoamericana+de+Hipertensión%22">Revista Latinoamericana de Hipertensión</searchLink>. 2025, Vol. 20 Issue 8, p615-621. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22BLOOD+coagulation%22">BLOOD coagulation</searchLink><br /><searchLink fieldCode="DE" term="%22INFLAMMATION%22">INFLAMMATION</searchLink><br /><searchLink fieldCode="DE" term="%22ANALGESIA%22">ANALGESIA</searchLink><br /><searchLink fieldCode="DE" term="%22HYPERTENSION%22">HYPERTENSION</searchLink><br /><searchLink fieldCode="DE" term="%22ACETAMINOPHEN%22">ACETAMINOPHEN</searchLink><br /><searchLink fieldCode="DE" term="%22KETOROLAC%22">KETOROLAC</searchLink><br /><searchLink fieldCode="DE" term="%22IBUPROFEN%22">IBUPROFEN</searchLink><br /><searchLink fieldCode="DE" term="%22GYNECOLOGIC+surgery%22">GYNECOLOGIC surgery</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Postoperative pain following gynecological surgery continues to pose a significant clinical challenge, as many patients still experience moderate-to-severe pain with standard treatments. The potential for complications like bleeding further underscores the need for optimized analgesic strategies that balance efficacy with safety. This study evaluated two multimodal regimens: intravenous ibuprofen-paracetamol versus ketorolacparacetamol, comparing their impact on pain intensity, coagulation parameters, and interleukin-6 (IL-6) levels. In a double-blind randomized trial involving 40 patients, both combinations provided equivalent and effective pain control, with no significant difference in pain scores or clotting time observed between the groups. However, a key finding was that the ketorolac-based regimen caused a significant prolongation of bleeding time at 24 and 48 hours post-surgery. Conversely, the ibuprofen-based combination demonstrated a stronger anti-inflammatory effect, resulting in significantly lower levels of the proinflammatory cytokine IL-6. Consequently, while both regimens are effective for analgesia, the choice between them should be influenced by the patient's risk profile; ketorolac may pose a greater bleeding risk, whereas ibuprofen may offer superior control of the surgical inflammatory response. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El dolor posoperatorio tras cirugía ginecológica sigue representando un desafío clínico significativo, ya que muchas pacientes aún experimentan dolor de moderado a intenso con los tratamientos estándar. La posibilidad de complicaciones, como el sangrado, subraya aún más la necesidad de estrategias analgésicas optimizadas que equilibren eficacia y seguridad. Este estudio evaluó dos regímenes multimodales: ibuprofeno-paracetamol intravenoso versus ketorolaco-paracetamol, comparando su impacto en la intensidad del dolor, los parámetros de coagulación y los niveles de interleucina-6 (IL-6). En un ensayo aleatorizado doble ciego con 40 pacientes, ambas combinaciones proporcionaron un control del dolor equivalente y efectivo, sin observarse diferencias significativas en las puntuaciones de dolor ni en el tiempo de coagulación entre los grupos. Sin embargo, un hallazgo clave fue que el régimen basado en ketorolaco provocó una prolongación significativa del tiempo de sangrado a las 24 y 48 horas posoperatorias. Por el contrario, la combinación basada en ibuprofeno demostró un efecto antiinflamatorio más potente, resultando en niveles significativamente más bajos de la citocina proinflamatoria IL-6. En consecuencia, si bien ambos regímenes son eficaces para la analgesia, la elección entre ellos debe depender del perfil de riesgo del paciente; el ketorolaco puede suponer un mayor riesgo de sangrado, mientras que el ibuprofeno puede ofrecer un mejor control de la respuesta inflamatoria quirúrgica. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.5281/zenodo.17113732 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 615 Subjects: – SubjectFull: BLOOD coagulation Type: general – SubjectFull: INFLAMMATION Type: general – SubjectFull: ANALGESIA Type: general – SubjectFull: HYPERTENSION Type: general – SubjectFull: ACETAMINOPHEN Type: general – SubjectFull: KETOROLAC Type: general – SubjectFull: IBUPROFEN Type: general – SubjectFull: GYNECOLOGIC surgery Type: general Titles: – TitleFull: The impact of intravenous ibuprofen-paracetamol vs. ketorolac-paracetamol on coagulation and inflammation: implications for analgesia in hypertensive patients undergoing surgery. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Maarif, Muhammad Khaerul – PersonEntity: Name: NameFull: Takdir Musba, A. M. – PersonEntity: Name: NameFull: Datu, Madonna D. – PersonEntity: Name: NameFull: Gaus, Syafruddin – PersonEntity: Name: NameFull: Wirawan, Nur Surya – PersonEntity: Name: NameFull: Adil, Andi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 18564550 Numbering: – Type: volume Value: 20 – Type: issue Value: 8 Titles: – TitleFull: Revista Latinoamericana de Hipertensión Type: main |
| ResultId | 1 |
