View in EDS PDF Full Text

Investigating the Role of Gut-Derived Neurotoxin TMAO in PTSD Risk Following Traumatic Brain Injury.

Saved in:
Bibliographic Details
Title: Investigating the Role of Gut-Derived Neurotoxin TMAO in PTSD Risk Following Traumatic Brain Injury.
Authors: He, Dongliang1, Kang, Qin2, Duan, Wei3, Li, Guilan1, He, Renli1, Liu, Xiaoping4 Lxp6171@126.com, Gong, Xianghao2 13973463333@163.com
Source: Actas Espanolas de Psiquiatria. 2025, Vol. 53 Issue 4, p730-741. 12p.
Subjects: POST-traumatic stress disorder, TRIMETHYLAMINE oxide, BLOOD serum analysis, BRAIN injuries, NEUROTOXIC agents, DISEASE risk factors, BIOMARKERS, MENTAL health
Abstract: Background: Post-traumatic stress disorder (PTSD), comorbid with traumatic brain injury (TBI), severely affects the mood state of patients. Trimethylamine Noxide (TMAO), one of the key intestinal flora metabolites, strongly correlates with TBI. This study aimed to explore the role of TMAO in the development of TBI-related PTSD and assess its predictive significance. Methods: This study included 120 TBI patients treated at the Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital between February 2022 and April 2024. The clinical data were obtained from the hospital’s medical record system. Patients were divided into a PTSD group (n = 56) and a non-PTSD group (n = 64) based on the post-traumatic stress disorder self-rating scale (PTSD-SS). Furthermore, patients in the PTSD group were divided into mild and severe subgroups. Blood samples were collected, and serum TMAO levels were assessed. Additionally, the correlation between TMAO levels, PTSD incidence, and PTSD severity was evaluated. The risk factors for PTSD comorbid with TBI and its severity were evaluated using univariate and multivariate logistic regression analyses. Finally, receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic effectiveness of TMAO as a predictive marker for PTSD. Results: Multivariate analysis showed that female gender, lower per capita monthly household income, depression, anxiety, and higher serum TMAO levels were significant risk factors for PTSD. Depression, anxiety, and higher serum TMAO levels were associated with severe PTSD, and higher per capita monthly household income and intracranial infection were protective factors. Serum TMAO levels were significantly higher in PTSD patients than in non-PTSD patients (p < 0.001), with its level profoundly elevated in severe PTSD patients than in mild PTSD patients. Furthermore, the correlation analysis revealed that TMAO was positively correlated with the severity of PTSD (r = 0.8582, p < 0.0001). ROC curve analysis indicated TMAO’s sensitivity of 67.86% and specificity of 93.75% for predicting PTSD, with an area under the curve (AUC) of 0.8175. Conclusion: Serum TMAO levels were significantly elevated in PTSD patients comorbid with TBI and were closely associated with PTSD severity. Furthermore, TMAO may aid in the early identification of high-risk, severe PTSD patients following TBI, thus helping to optimize intervention strategies. [ABSTRACT FROM AUTHOR]
Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: lth
DbLabel: MedicLatina
An: 188690555
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Investigating the Role of Gut-Derived Neurotoxin TMAO in PTSD Risk Following Traumatic Brain Injury.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22He%2C+Dongliang%22&quot;&gt;He, Dongliang&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kang%2C+Qin%22&quot;&gt;Kang, Qin&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Duan%2C+Wei%22&quot;&gt;Duan, Wei&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Guilan%22&quot;&gt;Li, Guilan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22He%2C+Renli%22&quot;&gt;He, Renli&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liu%2C+Xiaoping%22&quot;&gt;Liu, Xiaoping&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt;&lt;i&gt; Lxp6171@126.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gong%2C+Xianghao%22&quot;&gt;Gong, Xianghao&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;i&gt; 13973463333@163.com&lt;/i&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Actas+Espanolas+de+Psiquiatria%22&quot;&gt;Actas Espanolas de Psiquiatria&lt;/searchLink&gt;. 2025, Vol. 53 Issue 4, p730-741. 12p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22POST-traumatic+stress+disorder%22&quot;&gt;POST-traumatic stress disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22TRIMETHYLAMINE+oxide%22&quot;&gt;TRIMETHYLAMINE oxide&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BLOOD+serum+analysis%22&quot;&gt;BLOOD serum analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BRAIN+injuries%22&quot;&gt;BRAIN injuries&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22NEUROTOXIC+agents%22&quot;&gt;NEUROTOXIC agents&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22DISEASE+risk+factors%22&quot;&gt;DISEASE risk factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22BIOMARKERS%22&quot;&gt;BIOMARKERS&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22MENTAL+health%22&quot;&gt;MENTAL health&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Post-traumatic stress disorder (PTSD), comorbid with traumatic brain injury (TBI), severely affects the mood state of patients. Trimethylamine Noxide (TMAO), one of the key intestinal flora metabolites, strongly correlates with TBI. This study aimed to explore the role of TMAO in the development of TBI-related PTSD and assess its predictive significance. Methods: This study included 120 TBI patients treated at the Affiliated Hengyang Hospital of Hunan Normal University &amp; Hengyang Central Hospital between February 2022 and April 2024. The clinical data were obtained from the hospital’s medical record system. Patients were divided into a PTSD group (n = 56) and a non-PTSD group (n = 64) based on the post-traumatic stress disorder self-rating scale (PTSD-SS). Furthermore, patients in the PTSD group were divided into mild and severe subgroups. Blood samples were collected, and serum TMAO levels were assessed. Additionally, the correlation between TMAO levels, PTSD incidence, and PTSD severity was evaluated. The risk factors for PTSD comorbid with TBI and its severity were evaluated using univariate and multivariate logistic regression analyses. Finally, receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic effectiveness of TMAO as a predictive marker for PTSD. Results: Multivariate analysis showed that female gender, lower per capita monthly household income, depression, anxiety, and higher serum TMAO levels were significant risk factors for PTSD. Depression, anxiety, and higher serum TMAO levels were associated with severe PTSD, and higher per capita monthly household income and intracranial infection were protective factors. Serum TMAO levels were significantly higher in PTSD patients than in non-PTSD patients (p &lt; 0.001), with its level profoundly elevated in severe PTSD patients than in mild PTSD patients. Furthermore, the correlation analysis revealed that TMAO was positively correlated with the severity of PTSD (r = 0.8582, p &lt; 0.0001). ROC curve analysis indicated TMAO’s sensitivity of 67.86% and specificity of 93.75% for predicting PTSD, with an area under the curve (AUC) of 0.8175. Conclusion: Serum TMAO levels were significantly elevated in PTSD patients comorbid with TBI and were closely associated with PTSD severity. Furthermore, TMAO may aid in the early identification of high-risk, severe PTSD patients following TBI, thus helping to optimize intervention strategies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=188690555
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.62641/aep.v53i4.1885
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 730
    Subjects:
      – SubjectFull: POST-traumatic stress disorder
        Type: general
      – SubjectFull: TRIMETHYLAMINE oxide
        Type: general
      – SubjectFull: BLOOD serum analysis
        Type: general
      – SubjectFull: BRAIN injuries
        Type: general
      – SubjectFull: NEUROTOXIC agents
        Type: general
      – SubjectFull: DISEASE risk factors
        Type: general
      – SubjectFull: BIOMARKERS
        Type: general
      – SubjectFull: MENTAL health
        Type: general
    Titles:
      – TitleFull: Investigating the Role of Gut-Derived Neurotoxin TMAO in PTSD Risk Following Traumatic Brain Injury.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: He, Dongliang
      – PersonEntity:
          Name:
            NameFull: Kang, Qin
      – PersonEntity:
          Name:
            NameFull: Duan, Wei
      – PersonEntity:
          Name:
            NameFull: Li, Guilan
      – PersonEntity:
          Name:
            NameFull: He, Renli
      – PersonEntity:
          Name:
            NameFull: Liu, Xiaoping
      – PersonEntity:
          Name:
            NameFull: Gong, Xianghao
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 11399287
          Numbering:
            – Type: volume
              Value: 53
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Actas Espanolas de Psiquiatria
              Type: main
ResultId 1