Polineuropatías inmunomediadas.
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| Title: | Polineuropatías inmunomediadas. |
|---|---|
| Alternate Title: | Immune-mediated polyneuropathies. |
| Authors: | Cerezo, Silvia1 (AUTHOR), Expósito, Jesica1 (AUTHOR), Carrera, Laura1 (AUTHOR), Natera, Daniel1 (AUTHOR), Nascimento, Andrés1 (AUTHOR), Ortez, Carlos1 (AUTHOR) carlos.ortez@sjd.es |
| Source: | Medicina (Buenos Aires). 2025 Supplement 4, Vol. 85, p41-46. 6p. |
| Subjects: | GUILLAIN-Barre syndrome, ACUTE flaccid paralysis, CHRONIC inflammatory demyelinating polyradiculoneuropathy, THERAPEUTICS, POLYNEUROPATHIES, DIAGNOSIS |
| Abstract (English): | The Guillain-Barré syndrome (GBS) represents a group of immune-mediated peripheral polyneuropa thies, which are the most common cause of acute flaccid paralysis in clinical practice. Its most prevalent form is acute inflammatory demyelinating polyneuropathy (AIDP), though multiple variants are also recognized, such as axonal neuropathies (AMAN, AMSAN) and Miller- Fisher syndrome. Diagnosis remains primarily clinical, supported by findings in cerebrospinal fluid analysis, neurophysiological studies, and, in certain cases, specific serology. Early detection is crucial to prevent potentially fatal complications such as respiratory failure or severe dysautonomia. This article provides an updated review of the diagnostic and therapeutic approaches to GBS, emphasizing its pathophysiology, clinical manifesta tions, first-line therapeutic strategies, and emerging variants treatable with targeted immunotherapy. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El síndrome de Guillain-Barré (SGB) representa un grupo de polineuropatías periféricas inmunomediadas que constituyen la causa más frecuente de parálisis flá cida aguda en la práctica clínica. Su forma más común es la polirradiculoneuropatía inflamatoria desmielinizante aguda (AIDP), aunque se reconocen múltiples variantes, como las neuropatías axonales (AMAN, AMSAN) y el sín drome de Miller-Fisher. El diagnóstico continúa siendo clínico, apoyado por hallazgos en el líquido cefalorra quídeo, estudios neurofisiológicos y, en algunos casos, serología específica. Su detección precoz es crítica para evitar complicaciones potencialmente fatales, como insuficiencia respiratoria o disautonomía grave. Este artículo ofrece una revisión actualizada del abordaje diagnóstico y terapéutico del SGB, con especial énfasis en su fisiopatología, manifestaciones clínicas, y estrate gias terapéuticas de primera línea, así como en variantes emergentes tratables con inmunoterapia dirigida. [ABSTRACT FROM AUTHOR] |
| Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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