Bone metastasis patterns in solid cancers at a tertiary cancer center.
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| Title: | Bone metastasis patterns in solid cancers at a tertiary cancer center. |
|---|---|
| Alternate Title: | Patrones de metástasis ósea en cánceres sólidos en un centro oncológico terciario. |
| Authors: | Rosas, L. C.1,2, García-Ortega, D. Y.1,3, Clara-Altamirano, M. A.1,2 drmiguelclara@gmail.com, Martínez-Said, H.1,4, Villavicencio-Valencia, V.1,3, Meléndez-Fernández, A. P.1,3, González-Prieto, R. E.1,2, González-Álvarez, C.1,2, Cuellar-Hubbe, M.1,3 |
| Source: | Acta Ortopédica Mexicana. Nov/Dec2025, Vol. 39 Issue 6, p380-385. 6p. |
| Subjects: | BONE metastasis, METASTASIS, CANCER treatment, TUMORS, BONE resorption, OVERALL survival, PROGNOSIS |
| Abstract (English): | Introduction: Metastatic Bone Cancer (MBC) is the most common malignancy affecting the skeletal system. The cancers that most frequently metastasize to bone include breast, prostate, lung, kidney, and thyroid cancers (comprising 70% of cases). Metastatic patterns are classified as lytic, blastic, or mixed lesions, often affecting the axial skeleton. Materials and methods: this retrospective cohort study included patients with MBC treated between January 1, 2012, and December 31, 2022. Patients over 17 years of age with a diagnosis of solid neoplasia and evidence of metastatic bone disease confirmed by plain radiographs, computed tomography, magnetic resonance imaging, or PET-CT were included. Patients who died from causes unrelated to cancer and those who discontinued follow-up were excluded. Statistical analysis: we performed a descriptive analysis of demographic variables and used a Cox regression model, incorporating variables adapted to the model. Overall Survival (OS) was evaluated using the Kaplan-Meier method. Results: we analyzed data from 902 patients with a median age of 61 years. The majority were male (54.4%). Multiple lesions (three or more) were found in 49% of cases, primarily in the axial skeleton. Prostate cancer was the most common primary cancer (32%), while lytic lesions were most often associated with lung cancer (38%). Additionally, 153 patients (17%) had pathological fractures, 77% experienced pain secondary to Hypercalcemia of Malignancy (HCM), and 59% had metastases in organs other than bone. The median OS was 15 months. Conclusions: bone metastases are a poor prognostic factor in cancer patients and negatively impact quality of life. Identifying and understanding metastatic patterns is essential for developing effective therapeutic strategies and innovative treatments. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción: el cáncer óseo metastásico (MBC) es la neoplasia maligna más frecuente que afecta al sistema esquelético. Los cánceres que con mayor frecuencia metastatizan en los huesos son los de mama, próstata, pulmón, riñón y tiroides (que representan 70% de los casos). Los patrones metastásicos se clasifican en lesiones líticas, blásticas o mixtas, que a menudo afectan al esqueleto axial. Material y métodos: este estudio de cohorte retrospectivo incluyó a pacientes con MBC tratados entre el 1 de enero de 2012 y el 31 de diciembre de 2022. Se incluyeron pacientes mayores de 17 años con diagnóstico de neoplasia sólida y evidencia de enfermedad ósea metastásica confirmada mediante radiografías simples, tomografía computada, resonancia magnética o PET-TC. Se excluyeron los pacientes que fallecieron por causas no relacionadas con el cáncer y a los que interrumpieron el seguimiento. Análisis estadístico: realizamos un análisis descriptivo de las variables demográficas y utilizamos un modelo de regresión de Cox, incorporando variables adaptadas al modelo. La supervivencia general (SG) se evaluó mediante el método de Kaplan-Meier. Resultados: analizamos los datos de 902 pacientes con una mediana de edad de 61 años. La mayoría eran hombres (54.4%). Se encontraron lesiones múltiples (tres o más) en 49% de los casos, principalmente en el esqueleto axial. El cáncer de próstata fue el cáncer primario más frecuente (32%), mientras que las lesiones líticas se asociaron con mayor frecuencia al cáncer de pulmón (38%). Además, 153 pacientes (17%) presentaban fracturas patológicas, 77% experimentaba dolor secundario a hipercalcemia maligna (HCM) y 59% presentaba metástasis en órganos distintos de los huesos. La mediana de la SG fue de 15 meses. Conclusiones: las metástasis óseas son un factor de mal pronóstico en pacientes con cáncer y afectan negativamente a su calidad de vida. Identificar y comprender los patrones metastásicos es esencial para desarrollar estrategias terapéuticas eficaces y tratamientos innovadores. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 189501369 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bone metastasis patterns in solid cancers at a tertiary cancer center. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Patrones de metástasis ósea en cánceres sólidos en un centro oncológico terciario. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rosas%2C+L%2E+C%2E%22">Rosas, L. C.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22García-Ortega%2C+D%2E+Y%2E%22">García-Ortega, D. Y.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Clara-Altamirano%2C+M%2E+A%2E%22">Clara-Altamirano, M. A.</searchLink><relatesTo>1,2</relatesTo><i> drmiguelclara@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Martínez-Said%2C+H%2E%22">Martínez-Said, H.</searchLink><relatesTo>1,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Villavicencio-Valencia%2C+V%2E%22">Villavicencio-Valencia, V.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Meléndez-Fernández%2C+A%2E+P%2E%22">Meléndez-Fernández, A. P.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22González-Prieto%2C+R%2E+E%2E%22">González-Prieto, R. E.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22González-Álvarez%2C+C%2E%22">González-Álvarez, C.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cuellar-Hubbe%2C+M%2E%22">Cuellar-Hubbe, M.</searchLink><relatesTo>1,3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Ortopédica+Mexicana%22">Acta Ortopédica Mexicana</searchLink>. Nov/Dec2025, Vol. 39 Issue 6, p380-385. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22BONE+metastasis%22">BONE metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22METASTASIS%22">METASTASIS</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+treatment%22">CANCER treatment</searchLink><br /><searchLink fieldCode="DE" term="%22TUMORS%22">TUMORS</searchLink><br /><searchLink fieldCode="DE" term="%22BONE+resorption%22">BONE resorption</searchLink><br /><searchLink fieldCode="DE" term="%22OVERALL+survival%22">OVERALL survival</searchLink><br /><searchLink fieldCode="DE" term="%22PROGNOSIS%22">PROGNOSIS</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction: Metastatic Bone Cancer (MBC) is the most common malignancy affecting the skeletal system. The cancers that most frequently metastasize to bone include breast, prostate, lung, kidney, and thyroid cancers (comprising 70% of cases). Metastatic patterns are classified as lytic, blastic, or mixed lesions, often affecting the axial skeleton. Materials and methods: this retrospective cohort study included patients with MBC treated between January 1, 2012, and December 31, 2022. Patients over 17 years of age with a diagnosis of solid neoplasia and evidence of metastatic bone disease confirmed by plain radiographs, computed tomography, magnetic resonance imaging, or PET-CT were included. Patients who died from causes unrelated to cancer and those who discontinued follow-up were excluded. Statistical analysis: we performed a descriptive analysis of demographic variables and used a Cox regression model, incorporating variables adapted to the model. Overall Survival (OS) was evaluated using the Kaplan-Meier method. Results: we analyzed data from 902 patients with a median age of 61 years. The majority were male (54.4%). Multiple lesions (three or more) were found in 49% of cases, primarily in the axial skeleton. Prostate cancer was the most common primary cancer (32%), while lytic lesions were most often associated with lung cancer (38%). Additionally, 153 patients (17%) had pathological fractures, 77% experienced pain secondary to Hypercalcemia of Malignancy (HCM), and 59% had metastases in organs other than bone. The median OS was 15 months. Conclusions: bone metastases are a poor prognostic factor in cancer patients and negatively impact quality of life. Identifying and understanding metastatic patterns is essential for developing effective therapeutic strategies and innovative treatments. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción: el cáncer óseo metastásico (MBC) es la neoplasia maligna más frecuente que afecta al sistema esquelético. Los cánceres que con mayor frecuencia metastatizan en los huesos son los de mama, próstata, pulmón, riñón y tiroides (que representan 70% de los casos). Los patrones metastásicos se clasifican en lesiones líticas, blásticas o mixtas, que a menudo afectan al esqueleto axial. Material y métodos: este estudio de cohorte retrospectivo incluyó a pacientes con MBC tratados entre el 1 de enero de 2012 y el 31 de diciembre de 2022. Se incluyeron pacientes mayores de 17 años con diagnóstico de neoplasia sólida y evidencia de enfermedad ósea metastásica confirmada mediante radiografías simples, tomografía computada, resonancia magnética o PET-TC. Se excluyeron los pacientes que fallecieron por causas no relacionadas con el cáncer y a los que interrumpieron el seguimiento. Análisis estadístico: realizamos un análisis descriptivo de las variables demográficas y utilizamos un modelo de regresión de Cox, incorporando variables adaptadas al modelo. La supervivencia general (SG) se evaluó mediante el método de Kaplan-Meier. Resultados: analizamos los datos de 902 pacientes con una mediana de edad de 61 años. La mayoría eran hombres (54.4%). Se encontraron lesiones múltiples (tres o más) en 49% de los casos, principalmente en el esqueleto axial. El cáncer de próstata fue el cáncer primario más frecuente (32%), mientras que las lesiones líticas se asociaron con mayor frecuencia al cáncer de pulmón (38%). Además, 153 pacientes (17%) presentaban fracturas patológicas, 77% experimentaba dolor secundario a hipercalcemia maligna (HCM) y 59% presentaba metástasis en órganos distintos de los huesos. La mediana de la SG fue de 15 meses. Conclusiones: las metástasis óseas son un factor de mal pronóstico en pacientes con cáncer y afectan negativamente a su calidad de vida. Identificar y comprender los patrones metastásicos es esencial para desarrollar estrategias terapéuticas eficaces y tratamientos innovadores. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.35366/121817 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 380 Subjects: – SubjectFull: BONE metastasis Type: general – SubjectFull: METASTASIS Type: general – SubjectFull: CANCER treatment Type: general – SubjectFull: TUMORS Type: general – SubjectFull: BONE resorption Type: general – SubjectFull: OVERALL survival Type: general – SubjectFull: PROGNOSIS Type: general Titles: – TitleFull: Bone metastasis patterns in solid cancers at a tertiary cancer center. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rosas, L. C. – PersonEntity: Name: NameFull: García-Ortega, D. Y. – PersonEntity: Name: NameFull: Clara-Altamirano, M. A. – PersonEntity: Name: NameFull: Martínez-Said, H. – PersonEntity: Name: NameFull: Villavicencio-Valencia, V. – PersonEntity: Name: NameFull: Meléndez-Fernández, A. P. – PersonEntity: Name: NameFull: González-Prieto, R. E. – PersonEntity: Name: NameFull: González-Álvarez, C. – PersonEntity: Name: NameFull: Cuellar-Hubbe, M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov/Dec2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 23064102 Numbering: – Type: volume Value: 39 – Type: issue Value: 6 Titles: – TitleFull: Acta Ortopédica Mexicana Type: main |
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