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Bilateral atypical femoral fractures caused by long-term use of bisphosphonate treatment in postmenopausal osteoporosis.

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Title: Bilateral atypical femoral fractures caused by long-term use of bisphosphonate treatment in postmenopausal osteoporosis.
Alternate Title: Fracturas femorales atípicas bilaterales causadas por uso prolongado de tratamiento con bifosfonato en osteoporosis postmenopáusica.
Authors: Jasqui-Remba, S.1 drsjasqui@gmail.com, Grobeisen-Levin, S.1,2, Jasqui-Romano, S.1,3, Rodríguez-Rejón, G.1
Source: Acta Ortopédica Mexicana. Nov/Dec2025, Vol. 39 Issue 6, p401-404. 4p.
Subjects: FEMORAL fractures, DIPHOSPHONATES, OSTEOPOROSIS, INTRAMEDULLARY fracture fixation, OSTEOPOROSIS in women, TREATMENT duration, BONE remodeling, PATIENT monitoring
Abstract (English): This paper presents two cases of bilateral atypical femoral fractures in postmenopausal women who underwent prolonged bisphosphonate therapy for osteoporosis. Both patients, aged 83 and 76, experienced fractures after long-term bisphosphonate treatment, highlighting concerns about suppressed bone turnover. Each case was treated with intramedullary nailing, and bisphosphonates were discontinued in favor of alternative therapies. These cases underscore the risks of atypical femoral fractures linked to extended bisphosphonate use, emphasizing the need for careful patient monitoring and further research to optimize osteoporosis treatment strategies and prevent such complications. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Este artículo presenta dos casos de fracturas femorales atípicas bilaterales en mujeres posmenopáusicas con tratamiento prolongado con bifosfonatos para la osteoporosis. Ambas pacientes, de 83 y 76 años, sufrieron fracturas tras un tratamiento prolongado con bifosfonatos, lo que pone de manifiesto la preocupación que suscita la supresión del recambio óseo. En ambos casos, la reducción de las fracturas fue mediante colocación de clavos intramedulares y se suspendió el tratamiento con bifosfonatos cambiando el manejo por terapias alternativas. Estos casos dan relevancia a los riesgos de fracturas femorales atípicas relacionadas con el uso prolongado de bifosfonatos, y subrayan la necesidad de un seguimiento cuidadoso de los pacientes y de más investigación para optimizar las estrategias de tratamiento de la osteoporosis y prevenir tales complicaciones. [ABSTRACT FROM AUTHOR]
Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Bilateral atypical femoral fractures caused by long-term use of bisphosphonate treatment in postmenopausal osteoporosis.
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  Data: Fracturas femorales atípicas bilaterales causadas por uso prolongado de tratamiento con bifosfonato en osteoporosis postmenopáusica.
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  Data: <searchLink fieldCode="AR" term="%22Jasqui-Remba%2C+S%2E%22">Jasqui-Remba, S.</searchLink><relatesTo>1</relatesTo><i> drsjasqui@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Grobeisen-Levin%2C+S%2E%22">Grobeisen-Levin, S.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Jasqui-Romano%2C+S%2E%22">Jasqui-Romano, S.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Rodríguez-Rejón%2C+G%2E%22">Rodríguez-Rejón, G.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Ortopédica+Mexicana%22">Acta Ortopédica Mexicana</searchLink>. Nov/Dec2025, Vol. 39 Issue 6, p401-404. 4p.
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  Data: <searchLink fieldCode="DE" term="%22FEMORAL+fractures%22">FEMORAL fractures</searchLink><br /><searchLink fieldCode="DE" term="%22DIPHOSPHONATES%22">DIPHOSPHONATES</searchLink><br /><searchLink fieldCode="DE" term="%22OSTEOPOROSIS%22">OSTEOPOROSIS</searchLink><br /><searchLink fieldCode="DE" term="%22INTRAMEDULLARY+fracture+fixation%22">INTRAMEDULLARY fracture fixation</searchLink><br /><searchLink fieldCode="DE" term="%22OSTEOPOROSIS+in+women%22">OSTEOPOROSIS in women</searchLink><br /><searchLink fieldCode="DE" term="%22TREATMENT+duration%22">TREATMENT duration</searchLink><br /><searchLink fieldCode="DE" term="%22BONE+remodeling%22">BONE remodeling</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+monitoring%22">PATIENT monitoring</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: This paper presents two cases of bilateral atypical femoral fractures in postmenopausal women who underwent prolonged bisphosphonate therapy for osteoporosis. Both patients, aged 83 and 76, experienced fractures after long-term bisphosphonate treatment, highlighting concerns about suppressed bone turnover. Each case was treated with intramedullary nailing, and bisphosphonates were discontinued in favor of alternative therapies. These cases underscore the risks of atypical femoral fractures linked to extended bisphosphonate use, emphasizing the need for careful patient monitoring and further research to optimize osteoporosis treatment strategies and prevent such complications. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Este artículo presenta dos casos de fracturas femorales atípicas bilaterales en mujeres posmenopáusicas con tratamiento prolongado con bifosfonatos para la osteoporosis. Ambas pacientes, de 83 y 76 años, sufrieron fracturas tras un tratamiento prolongado con bifosfonatos, lo que pone de manifiesto la preocupación que suscita la supresión del recambio óseo. En ambos casos, la reducción de las fracturas fue mediante colocación de clavos intramedulares y se suspendió el tratamiento con bifosfonatos cambiando el manejo por terapias alternativas. Estos casos dan relevancia a los riesgos de fracturas femorales atípicas relacionadas con el uso prolongado de bifosfonatos, y subrayan la necesidad de un seguimiento cuidadoso de los pacientes y de más investigación para optimizar las estrategias de tratamiento de la osteoporosis y prevenir tales complicaciones. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Ortopédica Mexicana is the property of Sociedad Mexicana de Ortopedia, AC and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=189501372
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        Value: 10.35366/121820
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 4
        StartPage: 401
    Subjects:
      – SubjectFull: FEMORAL fractures
        Type: general
      – SubjectFull: DIPHOSPHONATES
        Type: general
      – SubjectFull: OSTEOPOROSIS
        Type: general
      – SubjectFull: INTRAMEDULLARY fracture fixation
        Type: general
      – SubjectFull: OSTEOPOROSIS in women
        Type: general
      – SubjectFull: TREATMENT duration
        Type: general
      – SubjectFull: BONE remodeling
        Type: general
      – SubjectFull: PATIENT monitoring
        Type: general
    Titles:
      – TitleFull: Bilateral atypical femoral fractures caused by long-term use of bisphosphonate treatment in postmenopausal osteoporosis.
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              M: 11
              Text: Nov/Dec2025
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              Y: 2025
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