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An approximation to the prevalence of focal segmental glomerulosclerosis: A systematic review of world literature over the past 32 years.

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Title: An approximation to the prevalence of focal segmental glomerulosclerosis: A systematic review of world literature over the past 32 years.
Alternate Title: Una aproximacioń a la prevalencia de la glomeruloesclerosis focal y segmentaria: una revisioń sistemática de la literatura mundial durante los últimos 32 años.
Authors: Orizaga-de-la-Cruz, Citlalli1, Lagunas-Rangel, Francisco Alejandro2,3, Gómez-García, Anel4, Chávez-Valencia, Venice1,5 drvenicechv@gmail.com
Source: Nefrologia. Dec2025, Vol. 45 Issue 10, p1-16. 16p.
Subjects: FOCAL segmental glomerulosclerosis, DISEASE prevalence, EPIDEMIOLOGICAL research, KIDNEY glomerulus, EPIDEMIOLOGY, SPATIAL variation
Geographic Terms: SOUTH Asia, MIDDLE East
Abstract (English): Background: Focal segmental glomerulosclerosis (FSGS) is a histopathological lesion characterized by scarring in specific sections of some glomeruli, accompanied by podocyte injury. Worldwide, the prevalence of FSGS and its temporal trends have not been sufficiently studied. However, some reports suggest an increase in the frequency of FSGS in recent decades. Understanding the epidemiology of FSGS is crucial for clinicians to improve diagnosis and treatment. Objective: Thisstudy critically evaluates global prevalence trends of FSGS overthe past 32 years(1992–2024), highlighting variations between countries through a systematic review. Methods: A systematic search of Medline, Embase and ScienceDirect was conducted to identify relevant studies. The reliability of prevalence data was assessed by critical appraisal of selected publications. Results: The prevalence of FSGS varies significantly between regions. East Asian countries have a relatively low prevalence, with a mean around 7%. In contrast, countriesin South Asia, the Middle East and the Americas have a higher prevalence of around 18%. European countries show an intermediate prevalence of about 11%. African countries do not show a clear pattern, with high and low prevalence rates in different countries. Conclusions: The prevalence of FSGS differs by geographic region and ethnicity. While South Asian countries have maintained a consistently low prevalence, other regions have experienced an increase in FSGS cases over time. This study improves the understanding of global patterns of FSGS, providing valuable epidemiological insights for clinicians and researchers. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Antecedentes La glomeruloesclerosis focal y segmentaria (GEFS) es una lesión histopatológica caracterizada por la cicatrización en secciones específicas de algunos glomérulos, acompañada de lesión de podocitos. A nivel mundial, la prevalencia de la GEFS y sus tendencias temporales no han sido suficientemente estudiadas. Sin embargo, algunos informes sugieren un aumento en la frecuencia de la GEFS en las últimas décadas. Comprender la epidemiología de la GEFS es crucial para que los médicos mejoren el diagnóstico y el tratamiento. Objetivo Este estudio evalúa críticamente las tendencias de prevalencia mundial de FSGS en los últimos 32 años (1992-2024), destacando las variaciones entre países a través de una revisión sistemática. Métodos Se realizó una búsqueda sistemática en Medline, Embase y ScienceDirect para identificar estudios relevantes. La fiabilidad de los datos de prevalencia se evaluó mediante una evaluación crítica de publicaciones seleccionadas. Resultados La prevalencia de la GEFS varía significativamente de una región a otra. Los países de Asia Oriental tienen una prevalencia relativamente baja, con una media de alrededor del 7%. En contraste, los países del sur de Asia, Medio Oriente y las Américas tienen una mayor prevalencia, con un 18%. Los países europeos muestran una prevalencia intermedia de alrededor del 11%. Los países africanos no muestran un patrón claro, con tasas de prevalencia alta y bajas en diferentes países. Conclusiones La prevalencia de la GEFS difiere según la región geográfica y la etnia. Mientras que los países del sur de Asia han mantenido una prevalencia sistemáticamente baja, otras regiones han experimentado un aumento de los casos de GEFS a lo largo del tiempo. Este estudio mejora la comprensión de los patrones globales de FSGS, proporcionando información epidemiológica valiosa para médicos e investigadores. [ABSTRACT FROM AUTHOR]
Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: An approximation to the prevalence of focal segmental glomerulosclerosis: A systematic review of world literature over the past 32 years.
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  Data: Una aproximacioń a la prevalencia de la glomeruloesclerosis focal y segmentaria: una revisioń sistemática de la literatura mundial durante los últimos 32 años.
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  Data: <searchLink fieldCode="AR" term="%22Orizaga-de-la-Cruz%2C+Citlalli%22">Orizaga-de-la-Cruz, Citlalli</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lagunas-Rangel%2C+Francisco+Alejandro%22">Lagunas-Rangel, Francisco Alejandro</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Gómez-García%2C+Anel%22">Gómez-García, Anel</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Chávez-Valencia%2C+Venice%22">Chávez-Valencia, Venice</searchLink><relatesTo>1,5</relatesTo><i> drvenicechv@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Nefrologia%22">Nefrologia</searchLink>. Dec2025, Vol. 45 Issue 10, p1-16. 16p.
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  Data: <searchLink fieldCode="DE" term="%22FOCAL+segmental+glomerulosclerosis%22">FOCAL segmental glomerulosclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+prevalence%22">DISEASE prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22EPIDEMIOLOGICAL+research%22">EPIDEMIOLOGICAL research</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+glomerulus%22">KIDNEY glomerulus</searchLink><br /><searchLink fieldCode="DE" term="%22EPIDEMIOLOGY%22">EPIDEMIOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22SPATIAL+variation%22">SPATIAL variation</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22SOUTH+Asia%22">SOUTH Asia</searchLink><br /><searchLink fieldCode="DE" term="%22MIDDLE+East%22">MIDDLE East</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Focal segmental glomerulosclerosis (FSGS) is a histopathological lesion characterized by scarring in specific sections of some glomeruli, accompanied by podocyte injury. Worldwide, the prevalence of FSGS and its temporal trends have not been sufficiently studied. However, some reports suggest an increase in the frequency of FSGS in recent decades. Understanding the epidemiology of FSGS is crucial for clinicians to improve diagnosis and treatment. Objective: Thisstudy critically evaluates global prevalence trends of FSGS overthe past 32 years(1992–2024), highlighting variations between countries through a systematic review. Methods: A systematic search of Medline, Embase and ScienceDirect was conducted to identify relevant studies. The reliability of prevalence data was assessed by critical appraisal of selected publications. Results: The prevalence of FSGS varies significantly between regions. East Asian countries have a relatively low prevalence, with a mean around 7%. In contrast, countriesin South Asia, the Middle East and the Americas have a higher prevalence of around 18%. European countries show an intermediate prevalence of about 11%. African countries do not show a clear pattern, with high and low prevalence rates in different countries. Conclusions: The prevalence of FSGS differs by geographic region and ethnicity. While South Asian countries have maintained a consistently low prevalence, other regions have experienced an increase in FSGS cases over time. This study improves the understanding of global patterns of FSGS, providing valuable epidemiological insights for clinicians and researchers. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Antecedentes La glomeruloesclerosis focal y segmentaria (GEFS) es una lesión histopatológica caracterizada por la cicatrización en secciones específicas de algunos glomérulos, acompañada de lesión de podocitos. A nivel mundial, la prevalencia de la GEFS y sus tendencias temporales no han sido suficientemente estudiadas. Sin embargo, algunos informes sugieren un aumento en la frecuencia de la GEFS en las últimas décadas. Comprender la epidemiología de la GEFS es crucial para que los médicos mejoren el diagnóstico y el tratamiento. Objetivo Este estudio evalúa críticamente las tendencias de prevalencia mundial de FSGS en los últimos 32 años (1992-2024), destacando las variaciones entre países a través de una revisión sistemática. Métodos Se realizó una búsqueda sistemática en Medline, Embase y ScienceDirect para identificar estudios relevantes. La fiabilidad de los datos de prevalencia se evaluó mediante una evaluación crítica de publicaciones seleccionadas. Resultados La prevalencia de la GEFS varía significativamente de una región a otra. Los países de Asia Oriental tienen una prevalencia relativamente baja, con una media de alrededor del 7%. En contraste, los países del sur de Asia, Medio Oriente y las Américas tienen una mayor prevalencia, con un 18%. Los países europeos muestran una prevalencia intermedia de alrededor del 11%. Los países africanos no muestran un patrón claro, con tasas de prevalencia alta y bajas en diferentes países. Conclusiones La prevalencia de la GEFS difiere según la región geográfica y la etnia. Mientras que los países del sur de Asia han mantenido una prevalencia sistemáticamente baja, otras regiones han experimentado un aumento de los casos de GEFS a lo largo del tiempo. Este estudio mejora la comprensión de los patrones globales de FSGS, proporcionando información epidemiológica valiosa para médicos e investigadores. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.nefroe.2025.501404
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        Text: English
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      – SubjectFull: FOCAL segmental glomerulosclerosis
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      – SubjectFull: DISEASE prevalence
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      – SubjectFull: EPIDEMIOLOGICAL research
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      – SubjectFull: SOUTH Asia
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      – SubjectFull: MIDDLE East
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              Text: Dec2025
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