Ecuación para determinación del modelo homeostático de insulino-resistencia: estudio binacional.
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| Title: | Ecuación para determinación del modelo homeostático de insulino-resistencia: estudio binacional. |
|---|---|
| Alternate Title: | Equation for determining the homeostatic model of insulin-resistance: binational study. |
| Authors: | Guevara-Tirado, Alberto1 albertoguevara1986@gmail.com |
| Source: | Revista del Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo. jul-sep2025, Vol. 18 Issue 3, p1-15. 15p. |
| Subjects: | INSULIN resistance, INSULIN, VENEZUELANS, STATISTICAL models, EQUILIBRIUM, GLUCOSE, MEXICANS |
| Abstract (English): | Introduction: The evaluation of the homeostatic model gives results close to the gold standard (hyperin-sulinemic-euglycemic clamp). Objective: To develop an equation to determine the homeostatic model of insulin resistance. Material and methods: Analytical and cross-sectional study of secondary databases of 2004 Venezuelan adults and another of 4363 Mexicans. The variables were: homeostatic model of insulin resistance (HOMA-2), basal insulin, basal glucose. Multiple linear regression, scatter plot, and student t test were used. Results: The regression equation was - 0.694+(0.138*basal insulin)+(0.009*basal glucose), where HOMA2- IR increases 0.138 for each U/mL of insulin and increases 0.009 for each mg/dL of basal glucose. The R2 value was 0.983 (Venezuelan database), indicating that 98% of the change in HOMA2-IR can be explained by the model based on basal insulin and glucose. The equation was applied to the Mexican adult database (n=4363), obtaining a coefficient of determination R2 of 0.897, implying that 90% of the variation in HOMA2-IR from the clinical calculator can be explained by HOMA2-IR from the regression equation. With a HOMA2-IR cut-off point of 2, lipid, glycemia, insulinemia, waist circumference, BMI, and blood pressure values were higher in the presence of HOMA2-IR levels ≥2 in the Venezuelan and Mexican databases. Conclusions: The regression equation to determine HOMA2-IR based on basal insulin and glucose is close to the HOMA2-IR clinical calculator. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción: El modelo homeostático de resistencia a la insulina (HOMA2-IR) es una herramienta útil para estimar la sensibilidad a la insulina, con buena correlación respecto al estándar de oro (pinza euglucémica-hiperinsulinémica). Objetivo: Desarrollar una ecuación que permita estimar el valor de HOMA2-IR a partir de insulina y glucosa basales, sin necesidad de utilizar software especializado. Material y métodos: Estudio analítico transversal basado en datos secundarios de 2004 adultos venezolanos y 4363 mexicanos. Se emplearon regresión lineal múltiple, gráficos de dispersión y prueba t de Student. Las variables incluidas fueron insulina basal (µU/mL), glucosa basal (mg/dL) y HOMA2-IR calculado por software. Resultados: En la muestra venezolana se obtuvo la siguiente ecuación: HOMA2-IR = −0.694 + (0.138 × insulina basal) + (0.009 × glucosa basal), con un coeficiente de determinación R² = 0.983. Al aplicar la ecuación en la muestra mexicana, se obtuvo un R² = 0.897, lo que indica una alta capacidad explicativa en ambas poblaciones. Al establecer un punto de corte de HOMA2-IR ≥2, se observaron mayores niveles de lípidos, glucosa, insulina, circunferencia de cintura, índice de masa corporal y presión arterial en ambos grupos poblacionales. Conclusión: La ecuación desarrollada permite estimar de forma precisa el valor de HOMA2-IR a partir de parámetros fácilmente obtenibles, representando una alternativa práctica y accesible a la calculadora clínica. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista del Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo is the property of Cuerpo Medico del Hospital Nacional Almanzor Aguinaga Asenjo and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Ecuación para determinación del modelo homeostático de insulino-resistencia: estudio binacional. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Equation for determining the homeostatic model of insulin-resistance: binational study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Guevara-Tirado%2C+Alberto%22">Guevara-Tirado, Alberto</searchLink><relatesTo>1</relatesTo><i> albertoguevara1986@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+del+Cuerpo+Médico+del+Hospital+Nacional+Almanzor+Aguinaga+Asenjo%22">Revista del Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo</searchLink>. jul-sep2025, Vol. 18 Issue 3, p1-15. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22INSULIN+resistance%22">INSULIN resistance</searchLink><br /><searchLink fieldCode="DE" term="%22INSULIN%22">INSULIN</searchLink><br /><searchLink fieldCode="DE" term="%22VENEZUELANS%22">VENEZUELANS</searchLink><br /><searchLink fieldCode="DE" term="%22STATISTICAL+models%22">STATISTICAL models</searchLink><br /><searchLink fieldCode="DE" term="%22EQUILIBRIUM%22">EQUILIBRIUM</searchLink><br /><searchLink fieldCode="DE" term="%22GLUCOSE%22">GLUCOSE</searchLink><br /><searchLink fieldCode="DE" term="%22MEXICANS%22">MEXICANS</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction: The evaluation of the homeostatic model gives results close to the gold standard (hyperin-sulinemic-euglycemic clamp). Objective: To develop an equation to determine the homeostatic model of insulin resistance. Material and methods: Analytical and cross-sectional study of secondary databases of 2004 Venezuelan adults and another of 4363 Mexicans. The variables were: homeostatic model of insulin resistance (HOMA-2), basal insulin, basal glucose. Multiple linear regression, scatter plot, and student t test were used. Results: The regression equation was - 0.694+(0.138*basal insulin)+(0.009*basal glucose), where HOMA2- IR increases 0.138 for each U/mL of insulin and increases 0.009 for each mg/dL of basal glucose. The R2 value was 0.983 (Venezuelan database), indicating that 98% of the change in HOMA2-IR can be explained by the model based on basal insulin and glucose. The equation was applied to the Mexican adult database (n=4363), obtaining a coefficient of determination R2 of 0.897, implying that 90% of the variation in HOMA2-IR from the clinical calculator can be explained by HOMA2-IR from the regression equation. With a HOMA2-IR cut-off point of 2, lipid, glycemia, insulinemia, waist circumference, BMI, and blood pressure values were higher in the presence of HOMA2-IR levels ≥2 in the Venezuelan and Mexican databases. Conclusions: The regression equation to determine HOMA2-IR based on basal insulin and glucose is close to the HOMA2-IR clinical calculator. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción: El modelo homeostático de resistencia a la insulina (HOMA2-IR) es una herramienta útil para estimar la sensibilidad a la insulina, con buena correlación respecto al estándar de oro (pinza euglucémica-hiperinsulinémica). Objetivo: Desarrollar una ecuación que permita estimar el valor de HOMA2-IR a partir de insulina y glucosa basales, sin necesidad de utilizar software especializado. Material y métodos: Estudio analítico transversal basado en datos secundarios de 2004 adultos venezolanos y 4363 mexicanos. Se emplearon regresión lineal múltiple, gráficos de dispersión y prueba t de Student. Las variables incluidas fueron insulina basal (µU/mL), glucosa basal (mg/dL) y HOMA2-IR calculado por software. Resultados: En la muestra venezolana se obtuvo la siguiente ecuación: HOMA2-IR = −0.694 + (0.138 × insulina basal) + (0.009 × glucosa basal), con un coeficiente de determinación R² = 0.983. Al aplicar la ecuación en la muestra mexicana, se obtuvo un R² = 0.897, lo que indica una alta capacidad explicativa en ambas poblaciones. Al establecer un punto de corte de HOMA2-IR ≥2, se observaron mayores niveles de lípidos, glucosa, insulina, circunferencia de cintura, índice de masa corporal y presión arterial en ambos grupos poblacionales. Conclusión: La ecuación desarrollada permite estimar de forma precisa el valor de HOMA2-IR a partir de parámetros fácilmente obtenibles, representando una alternativa práctica y accesible a la calculadora clínica. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista del Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo is the property of Cuerpo Medico del Hospital Nacional Almanzor Aguinaga Asenjo and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.35434/rcmhnaaa.2025.183.2674 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 15 StartPage: 1 Subjects: – SubjectFull: INSULIN resistance Type: general – SubjectFull: INSULIN Type: general – SubjectFull: VENEZUELANS Type: general – SubjectFull: STATISTICAL models Type: general – SubjectFull: EQUILIBRIUM Type: general – SubjectFull: GLUCOSE Type: general – SubjectFull: MEXICANS Type: general Titles: – TitleFull: Ecuación para determinación del modelo homeostático de insulino-resistencia: estudio binacional. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Guevara-Tirado, Alberto IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: jul-sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 22255109 Numbering: – Type: volume Value: 18 – Type: issue Value: 3 Titles: – TitleFull: Revista del Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo Type: main |
| ResultId | 1 |
