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Quality of cervical cancer screening in a Brazilian sample: cross-sectional study.

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Title: Quality of cervical cancer screening in a Brazilian sample: cross-sectional study.
Alternate Title: Calidad del tamizaje del cáncer de cuello uterino en una muestra brasileña: estudio transversal.
Qualidade do rastreamento do câncer de colo do útero em uma amostra brasileira: estudo transversal.
Authors: Serra Tochetto, Liane de Oliveira1 lianeserra@gmail.com, Brevidelli, Maria Meimei2 maria.brevidelli@docente.unip.br, Santos, Tainara Rodrigues1 tainara.rodrigues3sants@gmail.com, Almeida, Michelle Samora de1 michelle.samora@unifesp.br, De Domenico, Edvane Birelo Lopes1 domenico.edvane@unifesp.br
Source: Revista Cuidarte. May-Aug2025, Vol. 16 Issue 2, p2-12. 12p.
Subjects: EPITHELIAL cells, CROSS-sectional method, CERVIX uteri tumors, EARLY detection of cancer, CHI-squared test, QUANTITATIVE research, ODDS ratio, ATROPHY, PAP test, QUALITY assurance, SOCIODEMOGRAPHIC factors, INFLAMMATION, CONFIDENCE intervals
Geographic Terms: BRAZIL
Abstract (English): Introduction: In Pap test reports, sample quality is assessed based on the presence of squamous-columnar junction (SCJ) cells and atypia. Objectives: To assess the quality of Pap test samples by analyzing the frequency of SCJ cells in Pap test results and examining their association with sociodemographic, clinical, and professional-related variables. Materials and Methods: A cross-sectional study was conducted using 1.251 reports collected from primary healthcare facilities in São Paulo, SP, Brazil. The chi-square test was used to evaluate potential associations, and the test for equality of two proportions was used to compare responses to the same variable. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine the strength of associations. Results: Squamous epithelial cells were the most frequently observed, appearing alone in 50.80% of the samples, while the frequency of SCJ cells was 48.60%, significantly higher among women aged 25-39 years (p<0.001). The presence of inflammation (OR = 7.7; 95% CI: 1.00-50.00), bacilli (OR = 1.8; 95% CI: 1.40-2.20), and cytological atypia (OR = 4.6; 95% CI: 2.00-10.00) was more likely in samples containing SCJ cells. The absence of atrophy, the presence of moderate cytolysis, and red blood cells were significantly associated with the presence of SCJ cells. Discussion: The study demonstrated that SCJ cells were absent in most samples, which may compromise the quality of cervical cancer screening. Conclusion: The main indicators of sample quality in Pap test reports fell below recommended standards, particularly among women aged 40-59 years, revealing deficiencies in the quality of cervical cancer screening. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: En los informes de las pruebas de Papanicolaou, la calidad de las muestras se evalúa con base en la presencia de células de la unión escamocolumnar (UEC) y de atipias. Objetivos: Evaluar la calidad de las muestras recolectadas para pruebas de Papanicolaou analizando la frecuencia de células de la UEC en los resultados de citologías y examinar su asociación con variables sociodemográficas, clínicas y relacionadas con el profesional. Materiales y Métodos: Este estudio transversal utilizó 1.251 informes recolectados en unidades de atención primaria de salud en São Paulo, SP, Brasil. Se utilizó la prueba de chicuadrado para analizar asociaciones y la prueba de igualdad de dos proporciones para comparar respuestas de una misma variable. Las razones de probabilidad con intervalos de confianza (IC) de 95% se usaron para identificar la magnitud de las asociaciones. Resultados: Las células del epitelio escamoso fueron las más frecuentemente encontradas (50,80%), mientras que la frecuencia de células de la UEC fue del 48,60%, que fue significativamente mayor entre mujeres de 25 a 39 años (p<0,001). La presencia de inflamación (OR= 7,7; IC 95%; 1,00-50,00), bacilos (OR= 1,8; IC 95%: 1,40-2,20) y atipia citológica (OR= 4,6; IC 95%; 2,00-10,00) fue más probable en las muestras que contenían células SCJ. La ausencia de atrofia, citólisis moderada y glóbulos rojos se asociaron con la presencia de células SCJ con significación estadística. Discusión: El presente estudio demostró que las células SCJ no fueron predominantes en las muestras, lo que compromete la calidad del tamizaje de cáncer de cuello uterino. Conclusión: Los indicadores más importantes para determinar la calidad de las muestras en los informes de citología estuvieron por debajo de lo esperado, incluso en el grupo de mujeres de entre 40 y 59 años, lo que evidencia la calidad deficiencias del tamizaje del cáncer cervical. [ABSTRACT FROM AUTHOR]
Abstract (Portuguese): Introdução: Nos relatórios citopatológicos de exames de Papanicolau, a adequação das amostras é avaliada pela presença de células da junção escamo-colunar (JEC) e pela presença de atipias. Objetivos: Avaliar a qualidade das amostras coletadas em testes de Papanicolau considerando a frequência de células da JEC nos resultados de citologia e examinar a associação entre a frequência de células da JEC e variáveis sociodemográficas, clínicas e relacionadas aos profissionais. Materiais e Métodos: Foi realizado um estudo transversal utilizando 1.251 laudos coletados em unidades de atenção primária à saúde em São Paulo, SP, Brasil. Testes de qui-quadrado e de igualdade de duas proporções foram utilizados. Razões de chance com IC 95% foram usados para identificar a magnitude das associações. Resultados: Células do epitélio escamoso foram as mais frequentemente encontradas (50,80%), enquanto a frequência de células da JEC foi de 48,60%, sendo significativamente maior entre mulheres com idades entre 25 e 39 anos (p<0,001). A presença de inflamação, bacilos e atipia citológica foi OR= 7,7 vezes (IC 95%; 1,00-50,00), OR= 1,8 vezes (IC 95%: 1,40-2,20) e OR= 4,6 vezes (IC 95%; 2,00-10,00) mais provável, respectivamente, em amostras contendo células SCJ. A ausência de atrofia, citólise moderada e hemácias foram associadas à presença de células SCJ com significância estatística. Discussão: O presente estudo demonstrou que as células SCJ não foram predominantes nas amostras, o que compromete a qualidade do rastreamento do câncer cervical. Conclusão: Os indicadores mais importantes para determinar a adequação das amostras nos relatórios citopatológicos estavam abaixo do esperado, inclusive no grupo de mulheres entre 40 e 59 anos, evidenciando a qualidade insatisfatória do rastreamento do câncer cervical. [ABSTRACT FROM AUTHOR]
Copyright of Revista Cuidarte is the property of Universidad de Santander and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Quality of cervical cancer screening in a Brazilian sample: cross-sectional study.
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  Data: Calidad del tamizaje del c&#225;ncer de cuello uterino en una muestra brasile&#241;a: estudio transversal.&lt;br /&gt;Qualidade do rastreamento do c&#226;ncer de colo do &#250;tero em uma amostra brasileira: estudo transversal.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Serra+Tochetto%2C+Liane+de+Oliveira%22&quot;&gt;Serra Tochetto, Liane de Oliveira&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; lianeserra@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brevidelli%2C+Maria+Meimei%22&quot;&gt;Brevidelli, Maria Meimei&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;i&gt; maria.brevidelli@docente.unip.br&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Santos%2C+Tainara+Rodrigues%22&quot;&gt;Santos, Tainara Rodrigues&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; tainara.rodrigues3sants@gmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Almeida%2C+Michelle+Samora+de%22&quot;&gt;Almeida, Michelle Samora de&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; michelle.samora@unifesp.br&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22De+Domenico%2C+Edvane+Birelo+Lopes%22&quot;&gt;De Domenico, Edvane Birelo Lopes&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; domenico.edvane@unifesp.br&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Revista+Cuidarte%22&quot;&gt;Revista Cuidarte&lt;/searchLink&gt;. May-Aug2025, Vol. 16 Issue 2, p2-12. 12p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22EPITHELIAL+cells%22&quot;&gt;EPITHELIAL cells&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CROSS-sectional+method%22&quot;&gt;CROSS-sectional method&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CERVIX+uteri+tumors%22&quot;&gt;CERVIX uteri tumors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22EARLY+detection+of+cancer%22&quot;&gt;EARLY detection of cancer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CHI-squared+test%22&quot;&gt;CHI-squared test&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22QUANTITATIVE+research%22&quot;&gt;QUANTITATIVE research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ODDS+ratio%22&quot;&gt;ODDS ratio&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22ATROPHY%22&quot;&gt;ATROPHY&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22PAP+test%22&quot;&gt;PAP test&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22QUALITY+assurance%22&quot;&gt;QUALITY assurance&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22SOCIODEMOGRAPHIC+factors%22&quot;&gt;SOCIODEMOGRAPHIC factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22INFLAMMATION%22&quot;&gt;INFLAMMATION&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22CONFIDENCE+intervals%22&quot;&gt;CONFIDENCE intervals&lt;/searchLink&gt;
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– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction: In Pap test reports, sample quality is assessed based on the presence of squamous-columnar junction (SCJ) cells and atypia. Objectives: To assess the quality of Pap test samples by analyzing the frequency of SCJ cells in Pap test results and examining their association with sociodemographic, clinical, and professional-related variables. Materials and Methods: A cross-sectional study was conducted using 1.251 reports collected from primary healthcare facilities in S&#227;o Paulo, SP, Brazil. The chi-square test was used to evaluate potential associations, and the test for equality of two proportions was used to compare responses to the same variable. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine the strength of associations. Results: Squamous epithelial cells were the most frequently observed, appearing alone in 50.80% of the samples, while the frequency of SCJ cells was 48.60%, significantly higher among women aged 25-39 years (p&lt;0.001). The presence of inflammation (OR = 7.7; 95% CI: 1.00-50.00), bacilli (OR = 1.8; 95% CI: 1.40-2.20), and cytological atypia (OR = 4.6; 95% CI: 2.00-10.00) was more likely in samples containing SCJ cells. The absence of atrophy, the presence of moderate cytolysis, and red blood cells were significantly associated with the presence of SCJ cells. Discussion: The study demonstrated that SCJ cells were absent in most samples, which may compromise the quality of cervical cancer screening. Conclusion: The main indicators of sample quality in Pap test reports fell below recommended standards, particularly among women aged 40-59 years, revealing deficiencies in the quality of cervical cancer screening. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducci&#243;n: En los informes de las pruebas de Papanicolaou, la calidad de las muestras se eval&#250;a con base en la presencia de c&#233;lulas de la uni&#243;n escamocolumnar (UEC) y de atipias. Objetivos: Evaluar la calidad de las muestras recolectadas para pruebas de Papanicolaou analizando la frecuencia de c&#233;lulas de la UEC en los resultados de citolog&#237;as y examinar su asociaci&#243;n con variables sociodemogr&#225;ficas, cl&#237;nicas y relacionadas con el profesional. Materiales y M&#233;todos: Este estudio transversal utiliz&#243; 1.251 informes recolectados en unidades de atenci&#243;n primaria de salud en S&#227;o Paulo, SP, Brasil. Se utiliz&#243; la prueba de chicuadrado para analizar asociaciones y la prueba de igualdad de dos proporciones para comparar respuestas de una misma variable. Las razones de probabilidad con intervalos de confianza (IC) de 95% se usaron para identificar la magnitud de las asociaciones. Resultados: Las c&#233;lulas del epitelio escamoso fueron las m&#225;s frecuentemente encontradas (50,80%), mientras que la frecuencia de c&#233;lulas de la UEC fue del 48,60%, que fue significativamente mayor entre mujeres de 25 a 39 a&#241;os (p&lt;0,001). La presencia de inflamaci&#243;n (OR= 7,7; IC 95%; 1,00-50,00), bacilos (OR= 1,8; IC 95%: 1,40-2,20) y atipia citol&#243;gica (OR= 4,6; IC 95%; 2,00-10,00) fue m&#225;s probable en las muestras que conten&#237;an c&#233;lulas SCJ. La ausencia de atrofia, cit&#243;lisis moderada y gl&#243;bulos rojos se asociaron con la presencia de c&#233;lulas SCJ con significaci&#243;n estad&#237;stica. Discusi&#243;n: El presente estudio demostr&#243; que las c&#233;lulas SCJ no fueron predominantes en las muestras, lo que compromete la calidad del tamizaje de c&#225;ncer de cuello uterino. Conclusi&#243;n: Los indicadores m&#225;s importantes para determinar la calidad de las muestras en los informes de citolog&#237;a estuvieron por debajo de lo esperado, incluso en el grupo de mujeres de entre 40 y 59 a&#241;os, lo que evidencia la calidad deficiencias del tamizaje del c&#225;ncer cervical. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Portuguese)
  Group: Ab
  Data: Introdu&#231;&#227;o: Nos relat&#243;rios citopatol&#243;gicos de exames de Papanicolau, a adequa&#231;&#227;o das amostras &#233; avaliada pela presen&#231;a de c&#233;lulas da jun&#231;&#227;o escamo-colunar (JEC) e pela presen&#231;a de atipias. Objetivos: Avaliar a qualidade das amostras coletadas em testes de Papanicolau considerando a frequ&#234;ncia de c&#233;lulas da JEC nos resultados de citologia e examinar a associa&#231;&#227;o entre a frequ&#234;ncia de c&#233;lulas da JEC e vari&#225;veis sociodemogr&#225;ficas, cl&#237;nicas e relacionadas aos profissionais. Materiais e M&#233;todos: Foi realizado um estudo transversal utilizando 1.251 laudos coletados em unidades de aten&#231;&#227;o prim&#225;ria &#224; sa&#250;de em S&#227;o Paulo, SP, Brasil. Testes de qui-quadrado e de igualdade de duas propor&#231;&#245;es foram utilizados. Raz&#245;es de chance com IC 95% foram usados para identificar a magnitude das associa&#231;&#245;es. Resultados: C&#233;lulas do epit&#233;lio escamoso foram as mais frequentemente encontradas (50,80%), enquanto a frequ&#234;ncia de c&#233;lulas da JEC foi de 48,60%, sendo significativamente maior entre mulheres com idades entre 25 e 39 anos (p&lt;0,001). A presen&#231;a de inflama&#231;&#227;o, bacilos e atipia citol&#243;gica foi OR= 7,7 vezes (IC 95%; 1,00-50,00), OR= 1,8 vezes (IC 95%: 1,40-2,20) e OR= 4,6 vezes (IC 95%; 2,00-10,00) mais prov&#225;vel, respectivamente, em amostras contendo c&#233;lulas SCJ. A aus&#234;ncia de atrofia, cit&#243;lise moderada e hem&#225;cias foram associadas &#224; presen&#231;a de c&#233;lulas SCJ com signific&#226;ncia estat&#237;stica. Discuss&#227;o: O presente estudo demonstrou que as c&#233;lulas SCJ n&#227;o foram predominantes nas amostras, o que compromete a qualidade do rastreamento do c&#226;ncer cervical. Conclus&#227;o: Os indicadores mais importantes para determinar a adequa&#231;&#227;o das amostras nos relat&#243;rios citopatol&#243;gicos estavam abaixo do esperado, inclusive no grupo de mulheres entre 40 e 59 anos, evidenciando a qualidade insatisfat&#243;ria do rastreamento do c&#226;ncer cervical. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Revista Cuidarte is the property of Universidad de Santander and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.15649/cuidarte.4029
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 12
        StartPage: 2
    Subjects:
      – SubjectFull: EPITHELIAL cells
        Type: general
      – SubjectFull: CROSS-sectional method
        Type: general
      – SubjectFull: CERVIX uteri tumors
        Type: general
      – SubjectFull: EARLY detection of cancer
        Type: general
      – SubjectFull: CHI-squared test
        Type: general
      – SubjectFull: QUANTITATIVE research
        Type: general
      – SubjectFull: ODDS ratio
        Type: general
      – SubjectFull: ATROPHY
        Type: general
      – SubjectFull: PAP test
        Type: general
      – SubjectFull: QUALITY assurance
        Type: general
      – SubjectFull: SOCIODEMOGRAPHIC factors
        Type: general
      – SubjectFull: INFLAMMATION
        Type: general
      – SubjectFull: CONFIDENCE intervals
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      – SubjectFull: BRAZIL
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      – TitleFull: Quality of cervical cancer screening in a Brazilian sample: cross-sectional study.
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            – D: 01
              M: 05
              Text: May-Aug2025
              Type: published
              Y: 2025
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