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Evaluating the Impact of Age-Related Macular Degeneration on Seasonal Affective Disorder: A Retrospective Cohort Study in a Chinese Population.

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Title: Evaluating the Impact of Age-Related Macular Degeneration on Seasonal Affective Disorder: A Retrospective Cohort Study in a Chinese Population.
Authors: Yang, Weijia1, Jia, Jun1, Liu, Xu1, Wan, Pengfei1 pengfeiwan123@163.com
Source: Actas Espanolas de Psiquiatria. 2025, Vol. 53 Issue 5, p939-946. 8p.
Subjects: MACULAR degeneration, SEASONAL affective disorder, CHINESE people, VISION, PSYCHOLOGICAL factors, LIVING conditions, COHORT analysis, OCULAR manifestations of general diseases
Geographic Terms: CHINA
Abstract: Background: Age-related macular degeneration (AMD) usually affects the macular region of the retina, while seasonal affective disorder (SAD) is a complex mental disorder. However, the interaction between these two clinical conditions remains unexplored. Therefore, this study aimed to explore the influence of AMD on SAD and to assess the correlation of ocular pathology with lifestyle and mental health factors. Methods: This study recruited 158 AMD patients admitted to the Second Affiliated Hospital of Xi’an Medical University, China, between January 2020 and October 2023. Based on their affection status, the patients were divided into two groups: the SAD group (n = 58) and the nonSAD group (n = 100). Baseline characteristics, including blood pressure, hematological parameters, ocular parameters, and lifestyle factors, were compared between the two groups to evaluate the potential influence of AMD on SAD. Results: We observed specific differences in the family history of mental illness between the non-SAD and SAD groups (p < 0.001). However, the two groups’ other baseline characteristics, such as blood pressure and hematological parameters, were comparable (p > 0.05). Additionally, significant differences were also observed in central retinal thickness (CRT), choroidal thickness, lesion atrophy area, and macular volume between the two groups (p < 0.001). Moreover, intraocular pressure (IOP) did not reveal a significant difference between the two groups (p > 0.05). Compared with the SAD group, the non-SAD group had significantly better vision, longer exercise duration, sunlight exposure time, outdoor activity, and lower sedentary behavior (all p < 0.001). The logistic regression analysis indicated that increased macular volume (odds ratio (OR) = 3.054, p = 0.008) and sedentary behavior (OR = 4.382, p < 0.001) significantly increased SAD risk. Additionally, the absence of a family history of mental illness did not reach statistical significance (OR = 0.375, p = 0.129), but a specific correlation was still observed. Conclusion: This study shows a correlation between SAD and AMD. The significant differences in ocular pathological characteristics, lifestyle factors, and mental health status between the SAD and non-SAD groups suggest the crucial role of visual function and lifestyle in regulating mood and circadian rhythm in AMD patients. [ABSTRACT FROM AUTHOR]
Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Evaluating the Impact of Age-Related Macular Degeneration on Seasonal Affective Disorder: A Retrospective Cohort Study in a Chinese Population.
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  Data: Background: Age-related macular degeneration (AMD) usually affects the macular region of the retina, while seasonal affective disorder (SAD) is a complex mental disorder. However, the interaction between these two clinical conditions remains unexplored. Therefore, this study aimed to explore the influence of AMD on SAD and to assess the correlation of ocular pathology with lifestyle and mental health factors. Methods: This study recruited 158 AMD patients admitted to the Second Affiliated Hospital of Xi’an Medical University, China, between January 2020 and October 2023. Based on their affection status, the patients were divided into two groups: the SAD group (n = 58) and the nonSAD group (n = 100). Baseline characteristics, including blood pressure, hematological parameters, ocular parameters, and lifestyle factors, were compared between the two groups to evaluate the potential influence of AMD on SAD. Results: We observed specific differences in the family history of mental illness between the non-SAD and SAD groups (p &lt; 0.001). However, the two groups’ other baseline characteristics, such as blood pressure and hematological parameters, were comparable (p &gt; 0.05). Additionally, significant differences were also observed in central retinal thickness (CRT), choroidal thickness, lesion atrophy area, and macular volume between the two groups (p &lt; 0.001). Moreover, intraocular pressure (IOP) did not reveal a significant difference between the two groups (p &gt; 0.05). Compared with the SAD group, the non-SAD group had significantly better vision, longer exercise duration, sunlight exposure time, outdoor activity, and lower sedentary behavior (all p &lt; 0.001). The logistic regression analysis indicated that increased macular volume (odds ratio (OR) = 3.054, p = 0.008) and sedentary behavior (OR = 4.382, p &lt; 0.001) significantly increased SAD risk. Additionally, the absence of a family history of mental illness did not reach statistical significance (OR = 0.375, p = 0.129), but a specific correlation was still observed. Conclusion: This study shows a correlation between SAD and AMD. The significant differences in ocular pathological characteristics, lifestyle factors, and mental health status between the SAD and non-SAD groups suggest the crucial role of visual function and lifestyle in regulating mood and circadian rhythm in AMD patients. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=190365494
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        Value: 10.62641/aep.v53i5.1810
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        Text: English
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      – SubjectFull: SEASONAL affective disorder
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      – SubjectFull: OCULAR manifestations of general diseases
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      – SubjectFull: CHINA
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      – TitleFull: Evaluating the Impact of Age-Related Macular Degeneration on Seasonal Affective Disorder: A Retrospective Cohort Study in a Chinese Population.
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