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Changes in the Nijmegen Questionnaire in severe asthma patients treated with dupilumab.

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Title: Changes in the Nijmegen Questionnaire in severe asthma patients treated with dupilumab.
Alternate Title: Cambios en el Cuestionario de Nijmegen en pacientes con asma grave que reciben dupilumab.
Authors: De Agrela-Mendes, Isamar1 isamardeagrela@gmail.com, Correa-Borit, Jorge1, Lopez, Valentin1, Ifrim, Mihaela1, Turiel, Carlos1, De Las Vecillas, Leticia1,2, Quirce, Santiago1,2,3, Dominguez-Ortega, Javier1,2,3
Source: Revista Alergia de Mexico. oct-dic2025, Vol. 72 Issue 4, p271-275. 5p.
Subjects: ASTHMA, DUPILUMAB, HYPERVENTILATION, ASTHMATICS, PATIENT monitoring, RETROSPECTIVE studies, QUESTIONNAIRES
Abstract (English): Objective: To assess changes in Nijmegen Questionnaire (NQ) scores in patients with severe asthma treated with dupilumab and their relationship with disease control. Methods: A retrospective study was conducted in patients with severe asthma treated with dupilumab. Epidemiological and clinical data were collected, as well as results of questionnaires: NQ, asthma control test (ACT) and Asthma Quality of Life Questionnaire (AQLQ), assessing the changes after one year of treatment. Results: A total of 18 patients were included, 12 males, with a median age of 54 years and a range between 27 and 67 years old. The median result of the NQ at the start of dupilumab was 15.5 points (1-34) and at 12 months was 7 points (0-35). Before treatment, five patients (27.77%) had a NQ greater than 23 points compatible with hyperventilation syndrome (HVS). The median ACT score was 19 (10-24) and at the 12-month control it was 23 (12-25). The median AQLQ was 5 points (3-7) at the start of dupilumab and 6.08 points (3.50-7) after 12 months of dupilumab. This study observed changes in NQ scores after 12 months of dupilumab treatment, irrespective of initial NQ scores. Conclusions: Incorporating the NQ into the assessment of biologic response in severe asthma may provide additional insights into patient monitoring. Proper management of comorbidities, including HVS, is essential for optimizing asthma outcomes, as uncontrolled comorbidities can confound asthma control. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Evaluar los cambios en las puntuaciones del Cuestionario de Nijmegen (CN) en pacientes con asma grave que reciben dupilumab y su relación con el control de la enfermedad. Métodos: Estudio retrospectivo llevado a cabo en pacientes con asma grave, tratados con dupilumab. Se recopilaron datos epidemiológicos y clínicos, así como los resultados de los cuestionarios CN, Test de Control del Asma (TCA) y Cuestionario de Calidad de Vida en Asma (AQLQ), evaluando los cambios tras un año de tratamiento. Resultados: Se incluyeron 18 pacientes (12 hombres y 6 mujeres), con mediana de edad de 54 años (rango: 27-67 años). La mediana del CN al inicio del tratamiento con dupilumab fue de 15.5 puntos (rango: 1-34) y a los 12 meses de 7 puntos (rango: 0-35). Antes del tratamiento, 5 (27.77%) pacientes reportaron una puntuación superior a 23 puntos del CN, compatible con síndrome de hiperventilación (SHV). La mediana de la puntuación ACT fue de 19 (10-24) y en el control a los 12 meses fue de 23 (12-25). La mediana de la puntuación AQLQ fue de 5 puntos (3-7) al inicio del tratamiento con dupilumab y de 6.08 puntos (3.50-7) luego de 12 meses de tratamiento. Se informaron cambios en las puntuaciones NQ después de 12 meses de tratamiento con dupilumab, independientemente de las puntuaciones iniciales del cuestionario. Conclusión: La incorporación del Cuestionario de Nijmegen en la evaluación de la respuesta al tratamiento con biológicos en pacientes con asma grave puede proporcionar información adicional para su seguimiento. El tratamiento adecuado de las comorbilidades, incluido el síndrome de hiperventilación (SHV), es decisivo para optimizar los desenlaces en el control del asma. [ABSTRACT FROM AUTHOR]
Copyright of Revista Alergia de Mexico is the property of Coleg. Mexicano de Inmunologia Clinica y Alergia A.C.; Soc. Lat. de Alergia, Asma e Inmunologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Changes in the Nijmegen Questionnaire in severe asthma patients treated with dupilumab.
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  Data: Cambios en el Cuestionario de Nijmegen en pacientes con asma grave que reciben dupilumab.
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  Data: <searchLink fieldCode="AR" term="%22De+Agrela-Mendes%2C+Isamar%22">De Agrela-Mendes, Isamar</searchLink><relatesTo>1</relatesTo><i> isamardeagrela@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Correa-Borit%2C+Jorge%22">Correa-Borit, Jorge</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lopez%2C+Valentin%22">Lopez, Valentin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ifrim%2C+Mihaela%22">Ifrim, Mihaela</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Turiel%2C+Carlos%22">Turiel, Carlos</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22De+Las+Vecillas%2C+Leticia%22">De Las Vecillas, Leticia</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Quirce%2C+Santiago%22">Quirce, Santiago</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Dominguez-Ortega%2C+Javier%22">Dominguez-Ortega, Javier</searchLink><relatesTo>1,2,3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Revista+Alergia+de+Mexico%22">Revista Alergia de Mexico</searchLink>. oct-dic2025, Vol. 72 Issue 4, p271-275. 5p.
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  Data: <searchLink fieldCode="DE" term="%22ASTHMA%22">ASTHMA</searchLink><br /><searchLink fieldCode="DE" term="%22DUPILUMAB%22">DUPILUMAB</searchLink><br /><searchLink fieldCode="DE" term="%22HYPERVENTILATION%22">HYPERVENTILATION</searchLink><br /><searchLink fieldCode="DE" term="%22ASTHMATICS%22">ASTHMATICS</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+monitoring%22">PATIENT monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22RETROSPECTIVE+studies%22">RETROSPECTIVE studies</searchLink><br /><searchLink fieldCode="DE" term="%22QUESTIONNAIRES%22">QUESTIONNAIRES</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective: To assess changes in Nijmegen Questionnaire (NQ) scores in patients with severe asthma treated with dupilumab and their relationship with disease control. Methods: A retrospective study was conducted in patients with severe asthma treated with dupilumab. Epidemiological and clinical data were collected, as well as results of questionnaires: NQ, asthma control test (ACT) and Asthma Quality of Life Questionnaire (AQLQ), assessing the changes after one year of treatment. Results: A total of 18 patients were included, 12 males, with a median age of 54 years and a range between 27 and 67 years old. The median result of the NQ at the start of dupilumab was 15.5 points (1-34) and at 12 months was 7 points (0-35). Before treatment, five patients (27.77%) had a NQ greater than 23 points compatible with hyperventilation syndrome (HVS). The median ACT score was 19 (10-24) and at the 12-month control it was 23 (12-25). The median AQLQ was 5 points (3-7) at the start of dupilumab and 6.08 points (3.50-7) after 12 months of dupilumab. This study observed changes in NQ scores after 12 months of dupilumab treatment, irrespective of initial NQ scores. Conclusions: Incorporating the NQ into the assessment of biologic response in severe asthma may provide additional insights into patient monitoring. Proper management of comorbidities, including HVS, is essential for optimizing asthma outcomes, as uncontrolled comorbidities can confound asthma control. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo: Evaluar los cambios en las puntuaciones del Cuestionario de Nijmegen (CN) en pacientes con asma grave que reciben dupilumab y su relación con el control de la enfermedad. Métodos: Estudio retrospectivo llevado a cabo en pacientes con asma grave, tratados con dupilumab. Se recopilaron datos epidemiológicos y clínicos, así como los resultados de los cuestionarios CN, Test de Control del Asma (TCA) y Cuestionario de Calidad de Vida en Asma (AQLQ), evaluando los cambios tras un año de tratamiento. Resultados: Se incluyeron 18 pacientes (12 hombres y 6 mujeres), con mediana de edad de 54 años (rango: 27-67 años). La mediana del CN al inicio del tratamiento con dupilumab fue de 15.5 puntos (rango: 1-34) y a los 12 meses de 7 puntos (rango: 0-35). Antes del tratamiento, 5 (27.77%) pacientes reportaron una puntuación superior a 23 puntos del CN, compatible con síndrome de hiperventilación (SHV). La mediana de la puntuación ACT fue de 19 (10-24) y en el control a los 12 meses fue de 23 (12-25). La mediana de la puntuación AQLQ fue de 5 puntos (3-7) al inicio del tratamiento con dupilumab y de 6.08 puntos (3.50-7) luego de 12 meses de tratamiento. Se informaron cambios en las puntuaciones NQ después de 12 meses de tratamiento con dupilumab, independientemente de las puntuaciones iniciales del cuestionario. Conclusión: La incorporación del Cuestionario de Nijmegen en la evaluación de la respuesta al tratamiento con biológicos en pacientes con asma grave puede proporcionar información adicional para su seguimiento. El tratamiento adecuado de las comorbilidades, incluido el síndrome de hiperventilación (SHV), es decisivo para optimizar los desenlaces en el control del asma. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista Alergia de Mexico is the property of Coleg. Mexicano de Inmunologia Clinica y Alergia A.C.; Soc. Lat. de Alergia, Asma e Inmunologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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