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Allergic comorbidities among inborn errors of immunity in children attended in a high-complexity center in Cali, Colombia.

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Title: Allergic comorbidities among inborn errors of immunity in children attended in a high-complexity center in Cali, Colombia.
Alternate Title: Comorbilidades alérgicas en pacientes pediátricos con errores innatos de la inmunidad atendidos en un centro de alta complejidad en Cali, Colombia.
Authors: Triviño-Arias, Jacobo1, Martínez-Betancur, Sofia1, Arias-Valderrama, Oriana1,2, Guzmán, Tania M.1, Pablo Diaz-Solórsano, Juan1, Medina, Diego3, Franco, Alexis3, Patiño, Jaime4, Marsela Pérez, Paola4, Pachajoa, Harry5, Olaya-Hernández, Manuela6 vanessa.cabrera.gu@javerianacali.edu.co
Source: Revista Alergia de Mexico. oct-dic2025, Vol. 72 Issue 4, p290-295. 6p.
Subjects: ALLERGIES, COMORBIDITY, INTERDISCIPLINARY research, CHILD patients, PRIMARY immunodeficiency diseases, RHINITIS, ATOPIC dermatitis, ASTHMA
Geographic Terms: CALI (Colombia)
Abstract (English): Objective: To describe the clinical characteristics of allergic diseases (AD) as comorbidities--distinct from primary atopic diseases (PAD)--in pediatric patients diagnosed with IEI. Methods: An observational and retrospective study was made. We included pediatric population diagnosed with IEI and allergic comorbidity between 2013-2023. The diagnosis was done considering the criteria from the ESID and IUIS-2022. We performed a descriptive analysis of the variables (frequencies/percentages). For qualitative variables, we used OR to obtain the probability of occurrence of allergic sensitization among patients with AD and IEI. Every analysis was performed with the software R Studio version 3.2.2. Results: There were 366 patients with diagnosis of IEI, 238 had concomitant AD. 59.6% were males. Mean age was 5 years. 84% had antibody-specific deficiencies, 8% combined immunodeficiencies associated to well-defined syndromes, 2.9% congenital defects in phagocytes, 2.5% combined-immunodeficiencies, 1.7% autoinflammatory diseases, and 0.8% defects in intrinsic and innate immunity. The distribution of the ADs was asthma 48.7%, rhinitis 18.9%, atopic-dermatitis 15.1%, food-allergy 8.4%, acute urticaria 5%, and chronic urticaria 3.8%. Conclusion: Allergic diseases are increasingly recognized as key indicators for early IEI diagnosis. These conditions may coexist without representing PAD, emphasizing the need for comprehensive care. Recognizing this heterogeneity supports a multidisciplinary approach to improve early detection and management of IEI. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Describir las características clínicas de las enfermedades alérgicas (EA) como comorbilidades --distintas de las enfermedades atópicas primarias (EAP)-- en pacientes pediátricos con diagnóstico de errores innatos de la inmunidad (IEI). Métodos: Estudio observacional y retrospectivo, efectuado en una población pediátrica con diagnóstico de IEI y comorbilidad alérgica, atendidos entre 2013 y 2023. El diagnóstico se basó en los criterios de ESID y IUIS-2022. Se realizó un análisis descriptivo de variables (frecuencias/porcentajes). Para las variables cualitativas se utilizó razón de momios (OR), con la intención de estimar la probabilidad de sensibilización alérgica. Los análisis se realizaron con R Studio versión 3.2.2. Resultados: Se registraron 366 pacientes con IEI y de estos 238 manifestaron EA concomitante (59.6% hombres; edad media: 5 años). Los tipos de IEI más frecuentes fueron las deficiencias específicas de anticuerpos (84%), seguidas por inmunodeficiencias combinadas asociadas a síndromes (8%), defectos congénitos de fagocitos (2.9%), inmunodeficiencias combinadas (2.5%), enfermedades autoinflamatorias (1.7%) y defectos de inmunidad innata (0.8%). Las EA incluyeron asma (48.7%), rinitis (18.9%), dermatitis atópica (15.1%), alergia alimentaria (8.4%), urticaria aguda (5%) y urticaria crónica (3.8%). Conclusión: Las EA son un signo de alerta cada vez más reconocido para la detección temprana de IEI. Su coexistencia, sin ser necesariamente EAP, destaca la necesidad de un abordaje integral y multidisciplinario. [ABSTRACT FROM AUTHOR]
Copyright of Revista Alergia de Mexico is the property of Coleg. Mexicano de Inmunologia Clinica y Alergia A.C.; Soc. Lat. de Alergia, Asma e Inmunologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Allergic comorbidities among inborn errors of immunity in children attended in a high-complexity center in Cali, Colombia.
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  Data: Comorbilidades alérgicas en pacientes pediátricos con errores innatos de la inmunidad atendidos en un centro de alta complejidad en Cali, Colombia.
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  Data: <searchLink fieldCode="JN" term="%22Revista+Alergia+de+Mexico%22">Revista Alergia de Mexico</searchLink>. oct-dic2025, Vol. 72 Issue 4, p290-295. 6p.
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  Data: <searchLink fieldCode="DE" term="%22ALLERGIES%22">ALLERGIES</searchLink><br /><searchLink fieldCode="DE" term="%22COMORBIDITY%22">COMORBIDITY</searchLink><br /><searchLink fieldCode="DE" term="%22INTERDISCIPLINARY+research%22">INTERDISCIPLINARY research</searchLink><br /><searchLink fieldCode="DE" term="%22CHILD+patients%22">CHILD patients</searchLink><br /><searchLink fieldCode="DE" term="%22PRIMARY+immunodeficiency+diseases%22">PRIMARY immunodeficiency diseases</searchLink><br /><searchLink fieldCode="DE" term="%22RHINITIS%22">RHINITIS</searchLink><br /><searchLink fieldCode="DE" term="%22ATOPIC+dermatitis%22">ATOPIC dermatitis</searchLink><br /><searchLink fieldCode="DE" term="%22ASTHMA%22">ASTHMA</searchLink>
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  Label: Abstract (English)
  Group: Ab
  Data: Objective: To describe the clinical characteristics of allergic diseases (AD) as comorbidities--distinct from primary atopic diseases (PAD)--in pediatric patients diagnosed with IEI. Methods: An observational and retrospective study was made. We included pediatric population diagnosed with IEI and allergic comorbidity between 2013-2023. The diagnosis was done considering the criteria from the ESID and IUIS-2022. We performed a descriptive analysis of the variables (frequencies/percentages). For qualitative variables, we used OR to obtain the probability of occurrence of allergic sensitization among patients with AD and IEI. Every analysis was performed with the software R Studio version 3.2.2. Results: There were 366 patients with diagnosis of IEI, 238 had concomitant AD. 59.6% were males. Mean age was 5 years. 84% had antibody-specific deficiencies, 8% combined immunodeficiencies associated to well-defined syndromes, 2.9% congenital defects in phagocytes, 2.5% combined-immunodeficiencies, 1.7% autoinflammatory diseases, and 0.8% defects in intrinsic and innate immunity. The distribution of the ADs was asthma 48.7%, rhinitis 18.9%, atopic-dermatitis 15.1%, food-allergy 8.4%, acute urticaria 5%, and chronic urticaria 3.8%. Conclusion: Allergic diseases are increasingly recognized as key indicators for early IEI diagnosis. These conditions may coexist without representing PAD, emphasizing the need for comprehensive care. Recognizing this heterogeneity supports a multidisciplinary approach to improve early detection and management of IEI. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo: Describir las características clínicas de las enfermedades alérgicas (EA) como comorbilidades --distintas de las enfermedades atópicas primarias (EAP)-- en pacientes pediátricos con diagnóstico de errores innatos de la inmunidad (IEI). Métodos: Estudio observacional y retrospectivo, efectuado en una población pediátrica con diagnóstico de IEI y comorbilidad alérgica, atendidos entre 2013 y 2023. El diagnóstico se basó en los criterios de ESID y IUIS-2022. Se realizó un análisis descriptivo de variables (frecuencias/porcentajes). Para las variables cualitativas se utilizó razón de momios (OR), con la intención de estimar la probabilidad de sensibilización alérgica. Los análisis se realizaron con R Studio versión 3.2.2. Resultados: Se registraron 366 pacientes con IEI y de estos 238 manifestaron EA concomitante (59.6% hombres; edad media: 5 años). Los tipos de IEI más frecuentes fueron las deficiencias específicas de anticuerpos (84%), seguidas por inmunodeficiencias combinadas asociadas a síndromes (8%), defectos congénitos de fagocitos (2.9%), inmunodeficiencias combinadas (2.5%), enfermedades autoinflamatorias (1.7%) y defectos de inmunidad innata (0.8%). Las EA incluyeron asma (48.7%), rinitis (18.9%), dermatitis atópica (15.1%), alergia alimentaria (8.4%), urticaria aguda (5%) y urticaria crónica (3.8%). Conclusión: Las EA son un signo de alerta cada vez más reconocido para la detección temprana de IEI. Su coexistencia, sin ser necesariamente EAP, destaca la necesidad de un abordaje integral y multidisciplinario. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Revista Alergia de Mexico is the property of Coleg. Mexicano de Inmunologia Clinica y Alergia A.C.; Soc. Lat. de Alergia, Asma e Inmunologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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