Papiloma invertido sinonasal: características clínicas, radiológicas y quirúrgicas para el manejo integral del paciente.
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| Title: | Papiloma invertido sinonasal: características clínicas, radiológicas y quirúrgicas para el manejo integral del paciente. |
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| Alternate Title: | Sinonasal Inverted Papilloma: Clinical, Radiological, and Surgical Features for Comprehensive Patient Management. |
| Authors: | Rodrigo Quezada-Martínez, José1 jrquezada172@gmail.com, Vargas-Aguayo, Alejandro2 |
| Source: | Revista de la Facultad de Medicina de la UNAM. nov/dic2025, Vol. 68 Issue 6, p31-39. 9p. |
| Subjects: | PAPILLOMA, ENDOSCOPIC surgery, BENIGN tumors, RESPIRATORY obstructions, DIAGNOSTIC imaging, SQUAMOUS cell carcinoma, POSTOPERATIVE care |
| Abstract (English): | The sinonasal inverted papilloma (SNIP) is a benign tumor that represents about 5% of sinus neoplasms; it typically shows a locally aggressive growth pattern that tends to erode bone, be recurrent, and on average 5-15% of these cases may have a malignant transformation to squamous cell carcinoma (SCC). Although it is usually unilateral, up to 30% can be of multicentric origin. Its importance lies in the fact that, retrospectively, patients diagnosed with rhinosinusal polyposis actually had inverted papilloma, hence the importance of suspecting the tumor when there is unilateral rhinosinusal polyposis. Despite the existence of a complex and multifactorial etiology, there are several associations with SNIP. Some of these are human papillomavirus (HPV), smoking, welding smoke and organic solvents used in occupational exposures, as well as mutations in the epidermal growth factor receptor (EGFR), which could be involved, although the information is still controversial. The most commonly recorded symptomatology has been unilateral nasal obstruction, epistaxis, rhinorrhea and pain, with nasal obstruction being the predominant symptom. Imaging studies are fundamental, especially computed axial tomography (CT) with millimetric slices, since it allows identification of the site of origin (osteitis or hyperostosis) of the tumor, as well as surgical planning. Magnetic resonance imaging (MRI) is unnecessary as a routine study. Comprehensive diagnosis involves meticulous clinical examination, endoscopic examination and histopathology to confirm the diagnosis. The main treatment is endoscopic surgery, as this has been shown to have lower recurrence rates compared to an open approach. Surgical resection must imperatively be aggressive. It is important to emphasize postoperative follow-up, since late recurrences have been reported; follow-up should be at least 5 years, and adequately documented. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El papiloma invertido sinonasal (SNIP) es un tumor benigno que representa alrededor del 5% de las neoplasias de senos paranasales; típicamente presenta un patrón de crecimiento localmente agresivo que tiende a erosionar el hueso, ser recurrente y, en promedio, entre 5-15% de estos casos pueden tener una transformación maligna a carcinoma de células escamosas (SCC). Aunque suele ser unilateral, hasta en 30% puede ser de origen multicéntrico. Su importancia radica en que, retrospectivamente, pacientes diagnosticados con poliposis rinosinusal tenían en realidad papiloma invertido; de ahí la relevancia de sospechar este tumor cuando exista poliposis rinosinusal unilateral. A pesar de existir una etiología compleja y multifactorial, se han descrito diversas asociaciones con el SNIP; algunas de estas son el virus del papiloma humano (VPH), tabaquismo, humo de soldadura y disolventes orgánicos utilizados en exposiciones ocupacionales, así como mutaciones en el factor de crecimiento epidérmico (EGF), que podrían estar involucradas, aunque la información todavía es controversial. La sintomatología más comúnmente registrada ha sido obstrucción nasal unilateral, epistaxis, rinorrea y dolor, siendo la obstrucción nasal el síntoma predominante. Los estudios de imagen son fundamentales, en especial la tomografía axial computarizada (TAC) por cortes milimétricos, ya que permite identificar el sitio de origen (osteítis o hiperostosis) del tumor, así como la planeación quirúrgica. La resonancia magnética (RM) es innecesaria como estudio de rutina. El diagnóstico integral implica un examen clínico meticuloso, exploración endoscópica y un examen por histopatología que confirme el diagnóstico. El tratamiento principal es la cirugía endoscópica, ya que esta ha demostrado tener tasas de recurrencia más bajas en comparación con un abordaje abierto. La resección quirúrgica debe ser, imperativamente, agresiva. Es importante enfatizar el seguimiento posquirúrgico, ya que se han reportado recurrencias tardías; se recomienda un seguimiento mínimo de 5 años, así como documentarlo adecuadamente. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista de la Facultad de Medicina de la UNAM is the property of UNAM, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Papiloma invertido sinonasal: características clínicas, radiológicas y quirúrgicas para el manejo integral del paciente. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Sinonasal Inverted Papilloma: Clinical, Radiological, and Surgical Features for Comprehensive Patient Management. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rodrigo+Quezada-Martínez%2C+José%22">Rodrigo Quezada-Martínez, José</searchLink><relatesTo>1</relatesTo><i> jrquezada172@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Vargas-Aguayo%2C+Alejandro%22">Vargas-Aguayo, Alejandro</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+de+la+Facultad+de+Medicina+de+la+UNAM%22">Revista de la Facultad de Medicina de la UNAM</searchLink>. nov/dic2025, Vol. 68 Issue 6, p31-39. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22PAPILLOMA%22">PAPILLOMA</searchLink><br /><searchLink fieldCode="DE" term="%22ENDOSCOPIC+surgery%22">ENDOSCOPIC surgery</searchLink><br /><searchLink fieldCode="DE" term="%22BENIGN+tumors%22">BENIGN tumors</searchLink><br /><searchLink fieldCode="DE" term="%22RESPIRATORY+obstructions%22">RESPIRATORY obstructions</searchLink><br /><searchLink fieldCode="DE" term="%22DIAGNOSTIC+imaging%22">DIAGNOSTIC imaging</searchLink><br /><searchLink fieldCode="DE" term="%22SQUAMOUS+cell+carcinoma%22">SQUAMOUS cell carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22POSTOPERATIVE+care%22">POSTOPERATIVE care</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: The sinonasal inverted papilloma (SNIP) is a benign tumor that represents about 5% of sinus neoplasms; it typically shows a locally aggressive growth pattern that tends to erode bone, be recurrent, and on average 5-15% of these cases may have a malignant transformation to squamous cell carcinoma (SCC). Although it is usually unilateral, up to 30% can be of multicentric origin. Its importance lies in the fact that, retrospectively, patients diagnosed with rhinosinusal polyposis actually had inverted papilloma, hence the importance of suspecting the tumor when there is unilateral rhinosinusal polyposis. Despite the existence of a complex and multifactorial etiology, there are several associations with SNIP. Some of these are human papillomavirus (HPV), smoking, welding smoke and organic solvents used in occupational exposures, as well as mutations in the epidermal growth factor receptor (EGFR), which could be involved, although the information is still controversial. The most commonly recorded symptomatology has been unilateral nasal obstruction, epistaxis, rhinorrhea and pain, with nasal obstruction being the predominant symptom. Imaging studies are fundamental, especially computed axial tomography (CT) with millimetric slices, since it allows identification of the site of origin (osteitis or hyperostosis) of the tumor, as well as surgical planning. Magnetic resonance imaging (MRI) is unnecessary as a routine study. Comprehensive diagnosis involves meticulous clinical examination, endoscopic examination and histopathology to confirm the diagnosis. The main treatment is endoscopic surgery, as this has been shown to have lower recurrence rates compared to an open approach. Surgical resection must imperatively be aggressive. It is important to emphasize postoperative follow-up, since late recurrences have been reported; follow-up should be at least 5 years, and adequately documented. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El papiloma invertido sinonasal (SNIP) es un tumor benigno que representa alrededor del 5% de las neoplasias de senos paranasales; típicamente presenta un patrón de crecimiento localmente agresivo que tiende a erosionar el hueso, ser recurrente y, en promedio, entre 5-15% de estos casos pueden tener una transformación maligna a carcinoma de células escamosas (SCC). Aunque suele ser unilateral, hasta en 30% puede ser de origen multicéntrico. Su importancia radica en que, retrospectivamente, pacientes diagnosticados con poliposis rinosinusal tenían en realidad papiloma invertido; de ahí la relevancia de sospechar este tumor cuando exista poliposis rinosinusal unilateral. A pesar de existir una etiología compleja y multifactorial, se han descrito diversas asociaciones con el SNIP; algunas de estas son el virus del papiloma humano (VPH), tabaquismo, humo de soldadura y disolventes orgánicos utilizados en exposiciones ocupacionales, así como mutaciones en el factor de crecimiento epidérmico (EGF), que podrían estar involucradas, aunque la información todavía es controversial. La sintomatología más comúnmente registrada ha sido obstrucción nasal unilateral, epistaxis, rinorrea y dolor, siendo la obstrucción nasal el síntoma predominante. Los estudios de imagen son fundamentales, en especial la tomografía axial computarizada (TAC) por cortes milimétricos, ya que permite identificar el sitio de origen (osteítis o hiperostosis) del tumor, así como la planeación quirúrgica. La resonancia magnética (RM) es innecesaria como estudio de rutina. El diagnóstico integral implica un examen clínico meticuloso, exploración endoscópica y un examen por histopatología que confirme el diagnóstico. El tratamiento principal es la cirugía endoscópica, ya que esta ha demostrado tener tasas de recurrencia más bajas en comparación con un abordaje abierto. La resección quirúrgica debe ser, imperativamente, agresiva. Es importante enfatizar el seguimiento posquirúrgico, ya que se han reportado recurrencias tardías; se recomienda un seguimiento mínimo de 5 años, así como documentarlo adecuadamente. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista de la Facultad de Medicina de la UNAM is the property of UNAM, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.22201/fm.24484865e.2025.68.6.04 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 9 StartPage: 31 Subjects: – SubjectFull: PAPILLOMA Type: general – SubjectFull: ENDOSCOPIC surgery Type: general – SubjectFull: BENIGN tumors Type: general – SubjectFull: RESPIRATORY obstructions Type: general – SubjectFull: DIAGNOSTIC imaging Type: general – SubjectFull: SQUAMOUS cell carcinoma Type: general – SubjectFull: POSTOPERATIVE care Type: general Titles: – TitleFull: Papiloma invertido sinonasal: características clínicas, radiológicas y quirúrgicas para el manejo integral del paciente. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rodrigo Quezada-Martínez, José – PersonEntity: Name: NameFull: Vargas-Aguayo, Alejandro IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: nov/dic2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00261742 Numbering: – Type: volume Value: 68 – Type: issue Value: 6 Titles: – TitleFull: Revista de la Facultad de Medicina de la UNAM Type: main |
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