Utilidad de alfa-dornasa en el tratamiento de atelectasias en recién nacidos en estado crítico.
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| Title: | Utilidad de alfa-dornasa en el tratamiento de atelectasias en recién nacidos en estado crítico. |
|---|---|
| Alternate Title: | Usefulness of dornase alpha in the treatment of atelectasis in critically ill newborns. |
| Authors: | Fernández-Méndez, Jacqueline1, Berumen-Lechuga, María Guadalupe2, Moreno-Álvarez, Óscar3, Ramírez-Valenzuela, Karla Leticia4, Molina-Pérez, Carlos José5 carlos.molinap@imss.gob.mx |
| Source: | Revista Mexicana de Pediatria. sep/oct2025, Vol. 92 Issue 5, p174-179. 6p. |
| Subjects: | ATELECTASIS, INTRATRACHEAL drug administration, ARTIFICIAL respiration, NEONATAL intensive care, RESPIRATORY therapy, NEONATOLOGY, RETROSPECTIVE studies, OXYGEN in the blood |
| Abstract (English): | Introduction: critically ill newborns on mechanical ventilation are at high risk of developing atelectasis due to the accumulation of viscous secretions. Dornase alpha has emerged as an adjunctive therapy to reduce the viscosity of secretions and improve lung function. Objective: to evaluate the clinical effect of dornase alpha administered intratracheally in newborns with refractory atelectasis who are receiving mechanical ventilation. Material and methods: this was a retrospective observational study of 29 neonates. Patients with persistent atelectasis (> 48 hours) despite physiotherapy were included. Dornase alpha was administered at a dose of 1 mg/m² every 12 hours. The fraction of inspired oxygen (FiO2), partial pressure of carbon dioxide (PaCO2), radiological resolution of atelectasis, and adverse effects were evaluated. Results: the median age at the start of treatment was eight days, and male patients predominated (58.6%). Significant improvements were observed in FiO2 (62.7 vs. 24.3%, p < 0.001), PaCO2 (64.2 vs. 49.3 mmHg, p < 0.001), and peak inspiratory pressure (17 vs. 12 cmH2O, p < 0.001). Radiological resolution was observed in most patients by the fifth day of treatment. No deaths were recorded. Conclusion: intratracheal dornase alpha appears to improve oxygenation in critically ill neonates with refractory atelectasis. Prospective randomized studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción: los recién nacidos (RN) críticamente enfermos bajo ventilación mecánica tienen alto riesgo de desarrollar atelectasias debido a la acumulación de secreciones viscosas. La alfa-dornasa ha surgido como terapia coadyuvante para reducir la viscosidad de las secreciones y mejorar la función pulmonar. Objetivo: evaluar el efecto clínico de la alfa-dornasa administrada por vía intratraqueal en RN con atelectasias refractarias, que se encuentran asistidos con ventilación mecánica. Material y métodos: estudio observacional y retrospectivo en 29 neonatos. Se incluyeron pacientes con atelectasias persistentes > 48 horas, a pesar de fisioterapia. La alfa-dornasa se administró en dosis de 1 mg/m² cada 12 horas. Se evaluó la fracción inspirada de oxígeno (FiO2), presión arterial de dióxido de carbono (PaCO2), resolución radiológica de atelectasias y los efectos adversos. Resultados: la mediana de edad al inicio del tratamiento fue de ocho días, predominaron pacientes masculinos (58.6%). Se observó mejoría significativa en FiO2 (62.7 vs 24.3%, p < 0.001), PaCO2 (64.2 vs 49.3 mmHg, p < 0.001) y presión inspiratoria pico (17 vs 12 cmH2O, p < 0.001). En la mayoría hubo resolución radiológica al quinto día del tratamiento. No se registraron muertes. Conclusión: la alfa-dornasa intratraqueal parece mejorar la oxigenación en neonatos críticamente enfermos con atelectasias refractarias. Se requieren estudios prospectivos aleatorizados para confirmar estos hallazgos. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Mexicana de Pediatria is the property of Sociedad Mexicana de Pediatria and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Items | – Name: Title Label: Title Group: Ti Data: Utilidad de alfa-dornasa en el tratamiento de atelectasias en recién nacidos en estado crítico. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Usefulness of dornase alpha in the treatment of atelectasis in critically ill newborns. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fernández-Méndez%2C+Jacqueline%22">Fernández-Méndez, Jacqueline</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Berumen-Lechuga%2C+María+Guadalupe%22">Berumen-Lechuga, María Guadalupe</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Moreno-Álvarez%2C+Óscar%22">Moreno-Álvarez, Óscar</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Ramírez-Valenzuela%2C+Karla+Leticia%22">Ramírez-Valenzuela, Karla Leticia</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Molina-Pérez%2C+Carlos+José%22">Molina-Pérez, Carlos José</searchLink><relatesTo>5</relatesTo><i> carlos.molinap@imss.gob.mx</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Mexicana+de+Pediatria%22">Revista Mexicana de Pediatria</searchLink>. sep/oct2025, Vol. 92 Issue 5, p174-179. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22ATELECTASIS%22">ATELECTASIS</searchLink><br /><searchLink fieldCode="DE" term="%22INTRATRACHEAL+drug+administration%22">INTRATRACHEAL drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22ARTIFICIAL+respiration%22">ARTIFICIAL respiration</searchLink><br /><searchLink fieldCode="DE" term="%22NEONATAL+intensive+care%22">NEONATAL intensive care</searchLink><br /><searchLink fieldCode="DE" term="%22RESPIRATORY+therapy%22">RESPIRATORY therapy</searchLink><br /><searchLink fieldCode="DE" term="%22NEONATOLOGY%22">NEONATOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22RETROSPECTIVE+studies%22">RETROSPECTIVE studies</searchLink><br /><searchLink fieldCode="DE" term="%22OXYGEN+in+the+blood%22">OXYGEN in the blood</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction: critically ill newborns on mechanical ventilation are at high risk of developing atelectasis due to the accumulation of viscous secretions. Dornase alpha has emerged as an adjunctive therapy to reduce the viscosity of secretions and improve lung function. Objective: to evaluate the clinical effect of dornase alpha administered intratracheally in newborns with refractory atelectasis who are receiving mechanical ventilation. Material and methods: this was a retrospective observational study of 29 neonates. Patients with persistent atelectasis (> 48 hours) despite physiotherapy were included. Dornase alpha was administered at a dose of 1 mg/m² every 12 hours. The fraction of inspired oxygen (FiO2), partial pressure of carbon dioxide (PaCO2), radiological resolution of atelectasis, and adverse effects were evaluated. Results: the median age at the start of treatment was eight days, and male patients predominated (58.6%). Significant improvements were observed in FiO2 (62.7 vs. 24.3%, p < 0.001), PaCO2 (64.2 vs. 49.3 mmHg, p < 0.001), and peak inspiratory pressure (17 vs. 12 cmH2O, p < 0.001). Radiological resolution was observed in most patients by the fifth day of treatment. No deaths were recorded. Conclusion: intratracheal dornase alpha appears to improve oxygenation in critically ill neonates with refractory atelectasis. Prospective randomized studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción: los recién nacidos (RN) críticamente enfermos bajo ventilación mecánica tienen alto riesgo de desarrollar atelectasias debido a la acumulación de secreciones viscosas. La alfa-dornasa ha surgido como terapia coadyuvante para reducir la viscosidad de las secreciones y mejorar la función pulmonar. Objetivo: evaluar el efecto clínico de la alfa-dornasa administrada por vía intratraqueal en RN con atelectasias refractarias, que se encuentran asistidos con ventilación mecánica. Material y métodos: estudio observacional y retrospectivo en 29 neonatos. Se incluyeron pacientes con atelectasias persistentes > 48 horas, a pesar de fisioterapia. La alfa-dornasa se administró en dosis de 1 mg/m² cada 12 horas. Se evaluó la fracción inspirada de oxígeno (FiO2), presión arterial de dióxido de carbono (PaCO2), resolución radiológica de atelectasias y los efectos adversos. Resultados: la mediana de edad al inicio del tratamiento fue de ocho días, predominaron pacientes masculinos (58.6%). Se observó mejoría significativa en FiO2 (62.7 vs 24.3%, p < 0.001), PaCO2 (64.2 vs 49.3 mmHg, p < 0.001) y presión inspiratoria pico (17 vs 12 cmH2O, p < 0.001). En la mayoría hubo resolución radiológica al quinto día del tratamiento. No se registraron muertes. Conclusión: la alfa-dornasa intratraqueal parece mejorar la oxigenación en neonatos críticamente enfermos con atelectasias refractarias. Se requieren estudios prospectivos aleatorizados para confirmar estos hallazgos. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Mexicana de Pediatria is the property of Sociedad Mexicana de Pediatria and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.35366/122096 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 6 StartPage: 174 Subjects: – SubjectFull: ATELECTASIS Type: general – SubjectFull: INTRATRACHEAL drug administration Type: general – SubjectFull: ARTIFICIAL respiration Type: general – SubjectFull: NEONATAL intensive care Type: general – SubjectFull: RESPIRATORY therapy Type: general – SubjectFull: NEONATOLOGY Type: general – SubjectFull: RETROSPECTIVE studies Type: general – SubjectFull: OXYGEN in the blood Type: general Titles: – TitleFull: Utilidad de alfa-dornasa en el tratamiento de atelectasias en recién nacidos en estado crítico. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fernández-Méndez, Jacqueline – PersonEntity: Name: NameFull: Berumen-Lechuga, María Guadalupe – PersonEntity: Name: NameFull: Moreno-Álvarez, Óscar – PersonEntity: Name: NameFull: Ramírez-Valenzuela, Karla Leticia – PersonEntity: Name: NameFull: Molina-Pérez, Carlos José IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: sep/oct2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00350052 Numbering: – Type: volume Value: 92 – Type: issue Value: 5 Titles: – TitleFull: Revista Mexicana de Pediatria Type: main |
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