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Vitamin D and nutritional support in patients with heart failure: effect on circulating cytokines.

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Title: Vitamin D and nutritional support in patients with heart failure: effect on circulating cytokines.
Authors: Herrera-Martínez, Aura D.1,2 aurita.dhm@gmail.com, Muñoz-Jiménez, Concepción1,2, Romo, Ana Navas1,3, Aguilera, José López1,4, Gálvez Moreno, María Ángeles1,2, Molina Puerta, María José1,2, Roger, Aurora Jurado1,3
Source: Journal of Osteoporosis & Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (Spanish edition). oct-dic2025, Vol. 17 Issue 4, p139-145. 7p.
Subjects: HEART failure, CYTOKINES, DIETARY supplements, INFLAMMATION, DIET therapy, TREATMENT effectiveness, MEDITERRANEAN diet, VITAMIN D
Abstract: Background: heart failure (HF) is recognized as a highly state of inflammation. Increased circulating levels of cytokines have been previously reported and generally associated with worse clinical outcomes. In this context, the modulation of inflammation-related parameters seems to be a reasonable therapeutic option for improving the clinical course of the disease. Aim: to compare changes in circulating cytokines and clinical progression of patients with HF when calcifediol supplementation is administered along with Mediterranean diet alone or with Mediterranean diet and 2 hypercaloric, hyperproteic oral nutritional supplements (ONS) enriched with eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) fatty acids. Patients and methods: 25-hydoxi-vitamin D (25OHvitD) and circulating cytokines (IL-6, IL-8, IL-10, IP-10, MCP-1) were determined at baseline and after 24 weeks of nutritional support in a cohort of 38 patients previously included in an open label, controlled clinical tiral; briefly patients were randomized to receive calcifediol plus Mediterranean Diet (control group) vs calcifediol plus Mediterranean Diet and ONS (intervention group). Epidemiological, clinical, anthropometric, and biochemical evaluation was also performed. Results: 25OHVitD insufficiency was observed in 58.3 % of patients. Patients from the intervention group exhibited higher increase in serum 25OHVitD, higher decrease in ferritin, C-reactive protein (C-RP), IL-8, IL-6 and IP-10; although 25OHVitD levels positively correlated at baseline with body cell mass and the phase angle (p < 0.05) they did not correlate with serum ferritin, C-RP or the circulating evaluated interleukins. Any associations were observed between serum 25OHVitD and left ventricular ejection fraction (LVEF) or the N-terminal pro-brain natriuretic peptide (NT-proBNP). An age-, sex- and 25OHvitD adjusted multivariate analysis showed that the only cytokine associated with increased mortality in patients with HF was MCP-1 (OR 1.01, 95 %CI, 1.01-1.02), which was not modulated in the intervention or the control group after 24-weeks of treatment. Conclusion: although the combination of calcifediol, Mediterranean diet and hypercaloric, hyperproteic, EPA and DHA enriched ONS with decreased serum levels of inflammation related parameters (C-RP) and ferritin, as well as circulating cytokines, 25OHvitD levels were not correlated with these inflammation markers or the clinical progression of patients (mortality and new hospital admissions). [ABSTRACT FROM AUTHOR]
Copyright of Journal of Osteoporosis & Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (Spanish edition) is the property of Ibanez y Plaza and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Vitamin D and nutritional support in patients with heart failure: effect on circulating cytokines.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: heart failure (HF) is recognized as a highly state of inflammation. Increased circulating levels of cytokines have been previously reported and generally associated with worse clinical outcomes. In this context, the modulation of inflammation-related parameters seems to be a reasonable therapeutic option for improving the clinical course of the disease. Aim: to compare changes in circulating cytokines and clinical progression of patients with HF when calcifediol supplementation is administered along with Mediterranean diet alone or with Mediterranean diet and 2 hypercaloric, hyperproteic oral nutritional supplements (ONS) enriched with eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) fatty acids. Patients and methods: 25-hydoxi-vitamin D (25OHvitD) and circulating cytokines (IL-6, IL-8, IL-10, IP-10, MCP-1) were determined at baseline and after 24 weeks of nutritional support in a cohort of 38 patients previously included in an open label, controlled clinical tiral; briefly patients were randomized to receive calcifediol plus Mediterranean Diet (control group) vs calcifediol plus Mediterranean Diet and ONS (intervention group). Epidemiological, clinical, anthropometric, and biochemical evaluation was also performed. Results: 25OHVitD insufficiency was observed in 58.3 % of patients. Patients from the intervention group exhibited higher increase in serum 25OHVitD, higher decrease in ferritin, C-reactive protein (C-RP), IL-8, IL-6 and IP-10; although 25OHVitD levels positively correlated at baseline with body cell mass and the phase angle (p &lt; 0.05) they did not correlate with serum ferritin, C-RP or the circulating evaluated interleukins. Any associations were observed between serum 25OHVitD and left ventricular ejection fraction (LVEF) or the N-terminal pro-brain natriuretic peptide (NT-proBNP). An age-, sex- and 25OHvitD adjusted multivariate analysis showed that the only cytokine associated with increased mortality in patients with HF was MCP-1 (OR 1.01, 95 %CI, 1.01-1.02), which was not modulated in the intervention or the control group after 24-weeks of treatment. Conclusion: although the combination of calcifediol, Mediterranean diet and hypercaloric, hyperproteic, EPA and DHA enriched ONS with decreased serum levels of inflammation related parameters (C-RP) and ferritin, as well as circulating cytokines, 25OHvitD levels were not correlated with these inflammation markers or the clinical progression of patients (mortality and new hospital admissions). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Journal of Osteoporosis &amp; Mineral Metabolism / Revista de Osteoporosis y Metabolismo Mineral (Spanish edition) is the property of Ibanez y Plaza and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=190926529
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.20960/RevOsteoporosMetabMiner.00081
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 139
    Subjects:
      – SubjectFull: HEART failure
        Type: general
      – SubjectFull: CYTOKINES
        Type: general
      – SubjectFull: DIETARY supplements
        Type: general
      – SubjectFull: INFLAMMATION
        Type: general
      – SubjectFull: DIET therapy
        Type: general
      – SubjectFull: TREATMENT effectiveness
        Type: general
      – SubjectFull: MEDITERRANEAN diet
        Type: general
      – SubjectFull: VITAMIN D
        Type: general
    Titles:
      – TitleFull: Vitamin D and nutritional support in patients with heart failure: effect on circulating cytokines.
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              Text: oct-dic2025
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              Y: 2025
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