Impact of intravenous ferric carboxymaltose on physical performance and patient-reported outcomes in elderly patients with non-dialysis CKD, mild anemia, and iron deficiency: A pilot study.
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| Title: | Impact of intravenous ferric carboxymaltose on physical performance and patient-reported outcomes in elderly patients with non-dialysis CKD, mild anemia, and iron deficiency: A pilot study. |
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| Alternate Title: | Impacto de la carboximaltosa ferrica intravenosa en los resultados comunicados por los pacientes en ancianos con ERC sin diálisis, anemia leve y deficiencia de hierro: estudio piloto. |
| Authors: | Puchades, Maria Jesús1,2,3,4 majepu@uv.es, Casas, Juan5, Nuñez, Julio2,3,6, Gimenez-Civera, Elena1,3, Gonzales, Boris1,3, Montomoli, Marco1,3, Espriella, Rafael de la2,3,6, Gonzalez-Rico, Miguel1,3, Torregrosa, Isidro1,2,3, Peñ, Carlos J.3, Cases, Aleix6, Gorriz, Jose Luis1,2,3 |
| Source: | Nefrologia. Feb2026, Vol. 46 Issue 2, p1-7. 7p. |
| Subjects: | PATIENT reported outcome measures, IRON deficiency, KIDNEY failure, ANEMIA, PHYSICAL mobility, OLDER patients, IRON supplements, PILOT projects |
| Abstract (English): | Background: Iron deficiency (ID) is highly prevalent in chronic kidney disease (CKD) and it's associated with poorer quality of life (QoL) and functional capacity. Intravenous iron therapy is limited to CKD patients with ID and anemia to avoid/delay the need or reduce the dose of erythropoiesis-stimulating agents, according to guidelines. We hypothesized that treatment with IV iron in CKD patients with ID and borderline anemia may improve their physical performance and QoL, independently of its effects on hemoglobin. Methods: Prospective, single-arm study in CKD patients with ID and mild anemia. The 6-min walk test (6-MWT), Piper fatigue scale, Patient's global assessment (PGA) and QOL (EQ-5D) questionnaires were evaluated at baseline, and at weeks 1 and 4 after receiving IV ferric carboxymaltose. Changes in continuous endpoints and their longitudinal trajectories were estimated with linear mixed regression models (LMRMs). Results: Forty-one patients completed the study. The 6-MWT increased from 296 ± 101 m to 314 ± 106 m at week 1 (p < 0.01), and to 325 ± 111 meters at week 4 (p < 0.01). PGA, EQ-5D questionnaire and Piper Fatigue scale significantly improved at week 4 from baseline (p < 0.05), after adjustment in the last 2 variables. Hemoglobin levels did not increase significantly during the follow-up. Conclusions: IV ferric carboxymaltose (IV FCM) was associated with a significant short-term improvement in the 6-MWT in CKD patients with iron deficiency and mild anemia. PGA, EQ-5D and Piper Fatigue Scale also improved at 4 weeks. These findings suggest a potential short-term benefit of IV ferric carboxymaltose on physical performance and PROMs in this population, independent of hemoglobin changes; however, given the small sample size and absence of a control group, results should be interpreted with caution and considered hypothesis-generating. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Antecedentes: El déficit de hierro (DH) es altamente prevalente en la enfermedad renal crónica (ERC), y se asocia con una peor calidad de vida y capacidad funcional. Según las guías clínicas, el tratamiento con hierro intravenoso está limitado a los pacientes con ERC que presentan DH y anemia, con el objetivo de evitar o retrasar la necesidad de agentes estimulantes de la eritropoyesis, o reducir su dosis. Nuestra hipótesis fue que el tratamiento con hierro intravenoso en los pacientes con ERC, DH y anemia leve podría mejorar su rendimiento fisico y calidad de vida, independientemente de su efecto sobre la hemoglobina. Metodos: Estudio prospectivo, de un solo brazo, en los pacientes con ERC, ID y anemia leve. Se evaluaron el test de marcha de 6 min (6-MWT), la escala de fatiga de Piper, la evaluación global del paciente (PGA) y los cuestionarios de calidad de vida (EQ-5D) al inicio y en las semanas 1 y 4 tras la administración de carboximaltosa férrica intravenosa. Los cambios en los desenlaces continuos y sus trayectorias longitudinales se estimaron mediante modelos de regresión lineal mixta (LMRM). Resultados: Cuarenta y un pacientes completaron el estudio. La distancia recorrida en el 6-MWT aumentó de 296 101 a 314 106 men la semana 1 (p<0,01), ya 325 ± 111 men la semana 4 (p < 0,01). La PGA, el cuestionario EQ-5D y la escala de fatiga de Piper mejoraron significativamente en la semana 4 respecto al Inicio (p<0,05), tras ajustes en las dos últimas variables. Los niveles de hemoglobina no aumentaron significativamente durante el seguimiento. Conclusiones: La administración intravenosa de carboximaltosa férrica se asoció con una mejora significativa a corto plazo en el test de marcha de 6 minutos en pacientes con ERC e DH La PGA, el EQ-5D y la escala de fatiga de Piper también mostraron mejoría a las 4 semanas. Estos hallazgos respaldan el papel de la deficiencia de hierro en el deterioro del rendimiento físico en pacientes con ERC. [ABSTRACT FROM AUTHOR] |
| Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Items | – Name: Title Label: Title Group: Ti Data: Impact of intravenous ferric carboxymaltose on physical performance and patient-reported outcomes in elderly patients with non-dialysis CKD, mild anemia, and iron deficiency: A pilot study. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Impacto de la carboximaltosa ferrica intravenosa en los resultados comunicados por los pacientes en ancianos con ERC sin diálisis, anemia leve y deficiencia de hierro: estudio piloto. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Puchades%2C+Maria+Jesús%22">Puchades, Maria Jesús</searchLink><relatesTo>1,2,3,4</relatesTo><i> majepu@uv.es</i><br /><searchLink fieldCode="AR" term="%22Casas%2C+Juan%22">Casas, Juan</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Nuñez%2C+Julio%22">Nuñez, Julio</searchLink><relatesTo>2,3,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Gimenez-Civera%2C+Elena%22">Gimenez-Civera, Elena</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Gonzales%2C+Boris%22">Gonzales, Boris</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Montomoli%2C+Marco%22">Montomoli, Marco</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Espriella%2C+Rafael+de+la%22">Espriella, Rafael de la</searchLink><relatesTo>2,3,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Gonzalez-Rico%2C+Miguel%22">Gonzalez-Rico, Miguel</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Torregrosa%2C+Isidro%22">Torregrosa, Isidro</searchLink><relatesTo>1,2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Peñ%2C+Carlos+J%2E%22">Peñ, Carlos J.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cases%2C+Aleix%22">Cases, Aleix</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Gorriz%2C+Jose+Luis%22">Gorriz, Jose Luis</searchLink><relatesTo>1,2,3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nefrologia%22">Nefrologia</searchLink>. Feb2026, Vol. 46 Issue 2, p1-7. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22PATIENT+reported+outcome+measures%22">PATIENT reported outcome measures</searchLink><br /><searchLink fieldCode="DE" term="%22IRON+deficiency%22">IRON deficiency</searchLink><br /><searchLink fieldCode="DE" term="%22KIDNEY+failure%22">KIDNEY failure</searchLink><br /><searchLink fieldCode="DE" term="%22ANEMIA%22">ANEMIA</searchLink><br /><searchLink fieldCode="DE" term="%22PHYSICAL+mobility%22">PHYSICAL mobility</searchLink><br /><searchLink fieldCode="DE" term="%22OLDER+patients%22">OLDER patients</searchLink><br /><searchLink fieldCode="DE" term="%22IRON+supplements%22">IRON supplements</searchLink><br /><searchLink fieldCode="DE" term="%22PILOT+projects%22">PILOT projects</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Background: Iron deficiency (ID) is highly prevalent in chronic kidney disease (CKD) and it's associated with poorer quality of life (QoL) and functional capacity. Intravenous iron therapy is limited to CKD patients with ID and anemia to avoid/delay the need or reduce the dose of erythropoiesis-stimulating agents, according to guidelines. We hypothesized that treatment with IV iron in CKD patients with ID and borderline anemia may improve their physical performance and QoL, independently of its effects on hemoglobin. Methods: Prospective, single-arm study in CKD patients with ID and mild anemia. The 6-min walk test (6-MWT), Piper fatigue scale, Patient's global assessment (PGA) and QOL (EQ-5D) questionnaires were evaluated at baseline, and at weeks 1 and 4 after receiving IV ferric carboxymaltose. Changes in continuous endpoints and their longitudinal trajectories were estimated with linear mixed regression models (LMRMs). Results: Forty-one patients completed the study. The 6-MWT increased from 296 ± 101 m to 314 ± 106 m at week 1 (p < 0.01), and to 325 ± 111 meters at week 4 (p < 0.01). PGA, EQ-5D questionnaire and Piper Fatigue scale significantly improved at week 4 from baseline (p < 0.05), after adjustment in the last 2 variables. Hemoglobin levels did not increase significantly during the follow-up. Conclusions: IV ferric carboxymaltose (IV FCM) was associated with a significant short-term improvement in the 6-MWT in CKD patients with iron deficiency and mild anemia. PGA, EQ-5D and Piper Fatigue Scale also improved at 4 weeks. These findings suggest a potential short-term benefit of IV ferric carboxymaltose on physical performance and PROMs in this population, independent of hemoglobin changes; however, given the small sample size and absence of a control group, results should be interpreted with caution and considered hypothesis-generating. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Antecedentes: El déficit de hierro (DH) es altamente prevalente en la enfermedad renal crónica (ERC), y se asocia con una peor calidad de vida y capacidad funcional. Según las guías clínicas, el tratamiento con hierro intravenoso está limitado a los pacientes con ERC que presentan DH y anemia, con el objetivo de evitar o retrasar la necesidad de agentes estimulantes de la eritropoyesis, o reducir su dosis. Nuestra hipótesis fue que el tratamiento con hierro intravenoso en los pacientes con ERC, DH y anemia leve podría mejorar su rendimiento fisico y calidad de vida, independientemente de su efecto sobre la hemoglobina. Metodos: Estudio prospectivo, de un solo brazo, en los pacientes con ERC, ID y anemia leve. Se evaluaron el test de marcha de 6 min (6-MWT), la escala de fatiga de Piper, la evaluación global del paciente (PGA) y los cuestionarios de calidad de vida (EQ-5D) al inicio y en las semanas 1 y 4 tras la administración de carboximaltosa férrica intravenosa. Los cambios en los desenlaces continuos y sus trayectorias longitudinales se estimaron mediante modelos de regresión lineal mixta (LMRM). Resultados: Cuarenta y un pacientes completaron el estudio. La distancia recorrida en el 6-MWT aumentó de 296 101 a 314 106 men la semana 1 (p<0,01), ya 325 ± 111 men la semana 4 (p < 0,01). La PGA, el cuestionario EQ-5D y la escala de fatiga de Piper mejoraron significativamente en la semana 4 respecto al Inicio (p<0,05), tras ajustes en las dos últimas variables. Los niveles de hemoglobina no aumentaron significativamente durante el seguimiento. Conclusiones: La administración intravenosa de carboximaltosa férrica se asoció con una mejora significativa a corto plazo en el test de marcha de 6 minutos en pacientes con ERC e DH La PGA, el EQ-5D y la escala de fatiga de Piper también mostraron mejoría a las 4 semanas. Estos hallazgos respaldan el papel de la deficiencia de hierro en el deterioro del rendimiento físico en pacientes con ERC. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.nefro.2025.501418 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1 Subjects: – SubjectFull: PATIENT reported outcome measures Type: general – SubjectFull: IRON deficiency Type: general – SubjectFull: KIDNEY failure Type: general – SubjectFull: ANEMIA Type: general – SubjectFull: PHYSICAL mobility Type: general – SubjectFull: OLDER patients Type: general – SubjectFull: IRON supplements Type: general – SubjectFull: PILOT projects Type: general Titles: – TitleFull: Impact of intravenous ferric carboxymaltose on physical performance and patient-reported outcomes in elderly patients with non-dialysis CKD, mild anemia, and iron deficiency: A pilot study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Puchades, Maria Jesús – PersonEntity: Name: NameFull: Casas, Juan – PersonEntity: Name: NameFull: Nuñez, Julio – PersonEntity: Name: NameFull: Gimenez-Civera, Elena – PersonEntity: Name: NameFull: Gonzales, Boris – PersonEntity: Name: NameFull: Montomoli, Marco – PersonEntity: Name: NameFull: Espriella, Rafael de la – PersonEntity: Name: NameFull: Gonzalez-Rico, Miguel – PersonEntity: Name: NameFull: Torregrosa, Isidro – PersonEntity: Name: NameFull: Peñ, Carlos J. – PersonEntity: Name: NameFull: Cases, Aleix – PersonEntity: Name: NameFull: Gorriz, Jose Luis IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 02116995 Numbering: – Type: volume Value: 46 – Type: issue Value: 2 Titles: – TitleFull: Nefrologia Type: main |
| ResultId | 1 |
