Modificación de electrodos-impresos con Azul de Prusia y enzima para el control de diabetes en sudor: Estudio preliminar de viabilidad.
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| Title: | Modificación de electrodos-impresos con Azul de Prusia y enzima para el control de diabetes en sudor: Estudio preliminar de viabilidad. |
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| Alternate Title: | Modification of screen-printed electrodes with Prussian Blue (PB) and enzyme for diabetes control in sweat: Preliminary feasibility study. |
| Authors: | Gutiérrez-Gutiérrez, Reyna1, Godínez-Dávalos, Bruno U.1, Salazar-Gastélum, Moisés I.1, Ricardo Cárdenas-Valdez, José1, Pérez-Sicairos, Sergio1, Beltrán-Gastélum, Mara1 mara.beltran@tectijuana.edu.mx |
| Source: | Revista Mexicana de Ingeniería Biomédica. 2026 Special Issue, Vol. 47, p1-17. 17p. |
| Subjects: | DIABETES, PRUSSIAN blue, BLOOD sugar monitoring, BODY fluids, MEDICAL technology, SCREEN process printing, ENZYMES, WEARABLE technology |
| Geographic Terms: | MEXICO |
| Abstract (English): | The prevalence of diabetes in Mexico has increased considerably over the past 20 years, thus increasing the need for the development of non-invasive and reliable glucose monitoring platforms. The present research focus on the development and evaluation of a novel non-invasive glucose monitor for the quantification of glucose levels in sweat. This platform is based on the use of screen-printed electrodes modified with a Prussian Blue (PB) electrochemical mediator and the glucose oxidase (GOx) enzyme to provide glucose specificity. Additionally, we present the design of a portable electronic device for generating the input signal and processing the analyte output signals. The system was evaluated in a 0.1 M phosphate buffered saline (PBS) solution supplemented with different physiologically relevant glucose concentrations. The results demonstrated that the PB mediator plays a key role in the detection of glucose, since the control electrode modified with the enzyme but lacking the PB mediator did not show trend, while the electrode modified with PB and enzyme showed a good correlation coefficient with analytical sensitivity of 0.0008 mA µM-1. This finding could revolutionize the field of glucose monitoring, facilitating more accessible and less invasive health technologies. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La prevalencia de diabetes en México ha aumentado considerablemente en los últimos 20 años, aumentando así la necesidad de desarrollar plataformas de monitoreo de glucosa no invasivas y confiables. La presente investigación se enfoca en el desarrollo y la evaluación de una novedosa plataforma de monitoreo no invasiva para la cuantificación de niveles de glucosa en el sudor. Dicha plataforma se basa en el uso de electrodos impresos modificados con un mediador electroquímico de Azul de Prusia (PB) y con una enzima altamente específica, como la glucosa-oxidasa (GOx). Adicionalmente, presentamos el diseño de un dispositivo electrónico portátil para la generación de la señal de perturbación y el procesamiento de las señales de respuesta del analito. El sistema se evaluó en una solución buffer de fosfato salino (PBS) 0.1 M, suministrada con diferentes concentraciones de glucosa adecuadas fisiológicamente. Los resultados demostraron que el mediador de PB desempeña un papel fundamental en la detección de glucosa, debido a que el electrodo modificado con la enzima, pero sin el mediador PB, no mostró tendencia, mientras que el electrodo modificado con PB y enzima presentó un buen coeficiente de correlación, con una sensibilidad analítica de 0.0008 mA µM-1. Este avance podría revolucionar el campo de la monitorización de la glucosa, facilitando tecnologías de salud más accesibles y menos invasivas. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista Mexicana de Ingeniería Biomédica is the property of Sociedad Mexicana de Ingenieria Biomedica, A.C. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 191315945 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Modificación de electrodos-impresos con Azul de Prusia y enzima para el control de diabetes en sudor: Estudio preliminar de viabilidad. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Modification of screen-printed electrodes with Prussian Blue (PB) and enzyme for diabetes control in sweat: Preliminary feasibility study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gutiérrez-Gutiérrez%2C+Reyna%22">Gutiérrez-Gutiérrez, Reyna</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Godínez-Dávalos%2C+Bruno+U%2E%22">Godínez-Dávalos, Bruno U.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Salazar-Gastélum%2C+Moisés+I%2E%22">Salazar-Gastélum, Moisés I.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ricardo+Cárdenas-Valdez%2C+José%22">Ricardo Cárdenas-Valdez, José</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pérez-Sicairos%2C+Sergio%22">Pérez-Sicairos, Sergio</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Beltrán-Gastélum%2C+Mara%22">Beltrán-Gastélum, Mara</searchLink><relatesTo>1</relatesTo><i> mara.beltran@tectijuana.edu.mx</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+Mexicana+de+Ingeniería+Biomédica%22">Revista Mexicana de Ingeniería Biomédica</searchLink>. 2026 Special Issue, Vol. 47, p1-17. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22DIABETES%22">DIABETES</searchLink><br /><searchLink fieldCode="DE" term="%22PRUSSIAN+blue%22">PRUSSIAN blue</searchLink><br /><searchLink fieldCode="DE" term="%22BLOOD+sugar+monitoring%22">BLOOD sugar monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22BODY+fluids%22">BODY fluids</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+technology%22">MEDICAL technology</searchLink><br /><searchLink fieldCode="DE" term="%22SCREEN+process+printing%22">SCREEN process printing</searchLink><br /><searchLink fieldCode="DE" term="%22ENZYMES%22">ENZYMES</searchLink><br /><searchLink fieldCode="DE" term="%22WEARABLE+technology%22">WEARABLE technology</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22MEXICO%22">MEXICO</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: The prevalence of diabetes in Mexico has increased considerably over the past 20 years, thus increasing the need for the development of non-invasive and reliable glucose monitoring platforms. The present research focus on the development and evaluation of a novel non-invasive glucose monitor for the quantification of glucose levels in sweat. This platform is based on the use of screen-printed electrodes modified with a Prussian Blue (PB) electrochemical mediator and the glucose oxidase (GOx) enzyme to provide glucose specificity. Additionally, we present the design of a portable electronic device for generating the input signal and processing the analyte output signals. The system was evaluated in a 0.1 M phosphate buffered saline (PBS) solution supplemented with different physiologically relevant glucose concentrations. The results demonstrated that the PB mediator plays a key role in the detection of glucose, since the control electrode modified with the enzyme but lacking the PB mediator did not show trend, while the electrode modified with PB and enzyme showed a good correlation coefficient with analytical sensitivity of 0.0008 mA µM-1. This finding could revolutionize the field of glucose monitoring, facilitating more accessible and less invasive health technologies. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La prevalencia de diabetes en México ha aumentado considerablemente en los últimos 20 años, aumentando así la necesidad de desarrollar plataformas de monitoreo de glucosa no invasivas y confiables. La presente investigación se enfoca en el desarrollo y la evaluación de una novedosa plataforma de monitoreo no invasiva para la cuantificación de niveles de glucosa en el sudor. Dicha plataforma se basa en el uso de electrodos impresos modificados con un mediador electroquímico de Azul de Prusia (PB) y con una enzima altamente específica, como la glucosa-oxidasa (GOx). Adicionalmente, presentamos el diseño de un dispositivo electrónico portátil para la generación de la señal de perturbación y el procesamiento de las señales de respuesta del analito. El sistema se evaluó en una solución buffer de fosfato salino (PBS) 0.1 M, suministrada con diferentes concentraciones de glucosa adecuadas fisiológicamente. Los resultados demostraron que el mediador de PB desempeña un papel fundamental en la detección de glucosa, debido a que el electrodo modificado con la enzima, pero sin el mediador PB, no mostró tendencia, mientras que el electrodo modificado con PB y enzima presentó un buen coeficiente de correlación, con una sensibilidad analítica de 0.0008 mA µM-1. Este avance podría revolucionar el campo de la monitorización de la glucosa, facilitando tecnologías de salud más accesibles y menos invasivas. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista Mexicana de Ingeniería Biomédica is the property of Sociedad Mexicana de Ingenieria Biomedica, A.C. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.17488/RMIB.47.SI-TAIH.1521 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 17 StartPage: 1 Subjects: – SubjectFull: DIABETES Type: general – SubjectFull: PRUSSIAN blue Type: general – SubjectFull: BLOOD sugar monitoring Type: general – SubjectFull: BODY fluids Type: general – SubjectFull: MEDICAL technology Type: general – SubjectFull: SCREEN process printing Type: general – SubjectFull: ENZYMES Type: general – SubjectFull: WEARABLE technology Type: general – SubjectFull: MEXICO Type: general Titles: – TitleFull: Modificación de electrodos-impresos con Azul de Prusia y enzima para el control de diabetes en sudor: Estudio preliminar de viabilidad. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gutiérrez-Gutiérrez, Reyna – PersonEntity: Name: NameFull: Godínez-Dávalos, Bruno U. – PersonEntity: Name: NameFull: Salazar-Gastélum, Moisés I. – PersonEntity: Name: NameFull: Ricardo Cárdenas-Valdez, José – PersonEntity: Name: NameFull: Pérez-Sicairos, Sergio – PersonEntity: Name: NameFull: Beltrán-Gastélum, Mara IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 01 Text: 2026 Special Issue Type: published Y: 2026 Identifiers: – Type: issn-print Value: 01889532 Numbering: – Type: volume Value: 47 Titles: – TitleFull: Revista Mexicana de Ingeniería Biomédica Type: main |
| ResultId | 1 |
