Impacto de la obesidad en la evolución clínica de la neumonía adquirida en la comunidad en adolescentes.
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| Title: | Impacto de la obesidad en la evolución clínica de la neumonía adquirida en la comunidad en adolescentes. |
|---|---|
| Alternate Title: | Impact of obesity on the clinical course of community-acquired pneumonia in adolescents. |
| Authors: | Bock Alvarado, Skarleth Paola1,2,3 skarlethbocka@gmail.com, Mejía Carranza, Saidy Lizette2, Alvarado-Carías, Iving E.2,3,4, Cáceres López, César Andrés2 |
| Source: | Andes Pediatrica. Jan/Feb2026, Vol. 97 Issue 1, p112-122. 11p. |
| Subjects: | OBESITY, COMMUNITY-acquired pneumonia, PHARMACOKINETICS, TREATMENT effectiveness, TEENAGERS, HOSPITAL care, DISEASE progression, DYSPNEA |
| Abstract (English): | Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality in adolescents. This developmental stage involves physiological changes that affect lung structure and the immune response. Obesity, whose prevalence is steadily increasing in this population, adds clinical complexity, as it is considered a chronic, low-grade inflammatory condition that pre-exists the acute illness associated with respiratory dysfunction and metabolic alterations that can negatively impact the course of the disease. This review examines the impact of adolescence, obesity, and their combination on the clinical presentation, progression, and treatment of CAP. Available evidence suggests that obese adolescents experience more frequent respiratory symptoms, lower oxygen saturation, recurrent infections, increased need for respiratory support, intensive care unit admission, longer hospital stays, and higher associated costs. Furthermore, pharmacokinetic alterations specific to obese adolescents, such as changes in distribution volume, hepatic metabolism, and renal clearance, may lead to antimicrobial underdosing and increase the risk of treatment failure. Both obesity and adolescence significantly modify the clinical course of CAP, increasing its severity and complicating its management. A point of discussion is that most studies group together broad pediatric age ranges without analyzing the adolescent subgroup separately, limiting our understanding of their specific clinical characteristics. This review evaluates the available information to determine whether the combination of obesity and adolescence could define a distinctive clinical profile, characterized by specific physiological and metabolic features that warrant further investigation in studies specifically targeting this age group. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | La neumonía adquirida en la comunidad (NAC) constituye una causa significativa de morbimortalidad en adolescentes. Esta etapa presenta cambios fisiológicos que modifican la estructura pulmonar y la respuesta inmunitaria. La obesidad, cuya prevalencia va en aumento de forma sostenida en este grupo, añade complejidad clínica al considerarse un estado inflamatorio crónico de bajo grado preexistente a la enfermedad aguda asociado a disfunción ventilatoria y alteraciones metabólicas que pueden influir negativamente en la evolución de la enfermedad. Esta revisión examina el impacto de la adolescencia, la obesidad y su combinación en la presentación clínica, progresión y tratamiento de la NAC. La evidencia disponible sugiere que los adolescentes con obesidad presentan mayor frecuencia de síntomas respiratorios, desaturación, recurrencia de cuadros infecciosos, necesidad de soporte ventilatorio, ingreso a cuidados intensivos, estancia hospitalaria prolongada y aumento en los costos asociados. Además, las alteraciones farmacocinéticas propias de los adolescentes con obesidad, como cambios en el volumen de distribución, metabolismo hepático y aclaramiento renal, pueden favorecer la subdosificación de antimicrobianos y aumentar el riesgo de fracaso terapéutico. La obesidad y la adolescencia modifican de forma significativa el curso clínico de la NAC, incrementando su gravedad y dificultando su manejo. Un aspecto en discusión es que la mayoría de los estudios agrupa amplias franjas etarias pediátricas sin analizar de forma diferenciada al subgrupo adolescente, lo que limita la comprensión de sus particularidades clínicas. En esta revisión se evalúa la información disponible para evaluar si la confluencia de obesidad y adolescencia podrían configurar un perfil clínico distintivo, caracterizado por particularidades fisiológicas y metabólicas que amerita ser explorado en futuras investigaciones específicamente dirigidas a este grupo etario. [ABSTRACT FROM AUTHOR] |
| Copyright of Andes Pediatrica is the property of Revista Chilena de Pediatria and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 191677888 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Impacto de la obesidad en la evolución clínica de la neumonía adquirida en la comunidad en adolescentes. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Impact of obesity on the clinical course of community-acquired pneumonia in adolescents. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bock+Alvarado%2C+Skarleth+Paola%22">Bock Alvarado, Skarleth Paola</searchLink><relatesTo>1,2,3</relatesTo><i> skarlethbocka@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Mejía+Carranza%2C+Saidy+Lizette%22">Mejía Carranza, Saidy Lizette</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Alvarado-Carías%2C+Iving+E%2E%22">Alvarado-Carías, Iving E.</searchLink><relatesTo>2,3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cáceres+López%2C+César+Andrés%22">Cáceres López, César Andrés</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Andes+Pediatrica%22">Andes Pediatrica</searchLink>. Jan/Feb2026, Vol. 97 Issue 1, p112-122. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22OBESITY%22">OBESITY</searchLink><br /><searchLink fieldCode="DE" term="%22COMMUNITY-acquired+pneumonia%22">COMMUNITY-acquired pneumonia</searchLink><br /><searchLink fieldCode="DE" term="%22PHARMACOKINETICS%22">PHARMACOKINETICS</searchLink><br /><searchLink fieldCode="DE" term="%22TREATMENT+effectiveness%22">TREATMENT effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22TEENAGERS%22">TEENAGERS</searchLink><br /><searchLink fieldCode="DE" term="%22HOSPITAL+care%22">HOSPITAL care</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+progression%22">DISEASE progression</searchLink><br /><searchLink fieldCode="DE" term="%22DYSPNEA%22">DYSPNEA</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality in adolescents. This developmental stage involves physiological changes that affect lung structure and the immune response. Obesity, whose prevalence is steadily increasing in this population, adds clinical complexity, as it is considered a chronic, low-grade inflammatory condition that pre-exists the acute illness associated with respiratory dysfunction and metabolic alterations that can negatively impact the course of the disease. This review examines the impact of adolescence, obesity, and their combination on the clinical presentation, progression, and treatment of CAP. Available evidence suggests that obese adolescents experience more frequent respiratory symptoms, lower oxygen saturation, recurrent infections, increased need for respiratory support, intensive care unit admission, longer hospital stays, and higher associated costs. Furthermore, pharmacokinetic alterations specific to obese adolescents, such as changes in distribution volume, hepatic metabolism, and renal clearance, may lead to antimicrobial underdosing and increase the risk of treatment failure. Both obesity and adolescence significantly modify the clinical course of CAP, increasing its severity and complicating its management. A point of discussion is that most studies group together broad pediatric age ranges without analyzing the adolescent subgroup separately, limiting our understanding of their specific clinical characteristics. This review evaluates the available information to determine whether the combination of obesity and adolescence could define a distinctive clinical profile, characterized by specific physiological and metabolic features that warrant further investigation in studies specifically targeting this age group. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: La neumonía adquirida en la comunidad (NAC) constituye una causa significativa de morbimortalidad en adolescentes. Esta etapa presenta cambios fisiológicos que modifican la estructura pulmonar y la respuesta inmunitaria. La obesidad, cuya prevalencia va en aumento de forma sostenida en este grupo, añade complejidad clínica al considerarse un estado inflamatorio crónico de bajo grado preexistente a la enfermedad aguda asociado a disfunción ventilatoria y alteraciones metabólicas que pueden influir negativamente en la evolución de la enfermedad. Esta revisión examina el impacto de la adolescencia, la obesidad y su combinación en la presentación clínica, progresión y tratamiento de la NAC. La evidencia disponible sugiere que los adolescentes con obesidad presentan mayor frecuencia de síntomas respiratorios, desaturación, recurrencia de cuadros infecciosos, necesidad de soporte ventilatorio, ingreso a cuidados intensivos, estancia hospitalaria prolongada y aumento en los costos asociados. Además, las alteraciones farmacocinéticas propias de los adolescentes con obesidad, como cambios en el volumen de distribución, metabolismo hepático y aclaramiento renal, pueden favorecer la subdosificación de antimicrobianos y aumentar el riesgo de fracaso terapéutico. La obesidad y la adolescencia modifican de forma significativa el curso clínico de la NAC, incrementando su gravedad y dificultando su manejo. Un aspecto en discusión es que la mayoría de los estudios agrupa amplias franjas etarias pediátricas sin analizar de forma diferenciada al subgrupo adolescente, lo que limita la comprensión de sus particularidades clínicas. En esta revisión se evalúa la información disponible para evaluar si la confluencia de obesidad y adolescencia podrían configurar un perfil clínico distintivo, caracterizado por particularidades fisiológicas y metabólicas que amerita ser explorado en futuras investigaciones específicamente dirigidas a este grupo etario. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Andes Pediatrica is the property of Revista Chilena de Pediatria and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.32641/andespediatr.v97i1.5744 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 11 StartPage: 112 Subjects: – SubjectFull: OBESITY Type: general – SubjectFull: COMMUNITY-acquired pneumonia Type: general – SubjectFull: PHARMACOKINETICS Type: general – SubjectFull: TREATMENT effectiveness Type: general – SubjectFull: TEENAGERS Type: general – SubjectFull: HOSPITAL care Type: general – SubjectFull: DISEASE progression Type: general – SubjectFull: DYSPNEA Type: general Titles: – TitleFull: Impacto de la obesidad en la evolución clínica de la neumonía adquirida en la comunidad en adolescentes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bock Alvarado, Skarleth Paola – PersonEntity: Name: NameFull: Mejía Carranza, Saidy Lizette – PersonEntity: Name: NameFull: Alvarado-Carías, Iving E. – PersonEntity: Name: NameFull: Cáceres López, César Andrés IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan/Feb2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 24526045 Numbering: – Type: volume Value: 97 – Type: issue Value: 1 Titles: – TitleFull: Andes Pediatrica Type: main |
| ResultId | 1 |
