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The Relationship Between Menopausal Status and Depression in U.S. Women: Insights from the NHANES 2017–March 2020 Cross-Sectional Study.

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Title: The Relationship Between Menopausal Status and Depression in U.S. Women: Insights from the NHANES 2017–March 2020 Cross-Sectional Study.
Authors: Pei, Jiaojiao1, Chen, Jiao2, Liu, Ling3 liuling06180711@sina.com, Li, Mao4 lm552323002@126.com
Source: Actas Espanolas de Psiquiatria. 2025, Vol. 53 Issue 6, p1223-1236. 14p.
Subjects: PREMATURE ovarian failure, MENTAL depression, PHYSICAL activity, REPRODUCTIVE history, AMERICAN women, NATIONAL Health & Nutrition Examination Survey, MENOPAUSE
Geographic Terms: UNITED States
Abstract: Objective: This study harnessed cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2017–March 2020 to examine the relationship between menopausal status and depression among U.S. women. Methods: Data from NHANES 2017–March 2020 were used for this cross-sectional analysis. Robust statistical approaches, including univariate and multivariate logistic regression, were applied, and subgroup analyses were conducted to assess the stability of the findings. Results: Women with premature ovarian insufficiency (POI) and early menopause showed a higher likelihood of depression compared with non-menopausal women (POI: odds ratio (OR) = 1.59, 95% confidence interval (95% CI) = 1.07–2.35; Early menopause: OR = 1.71, 95% CI = 1.06– 2.76). Among these groups, women whose age at last delivery was under 35 years demonstrated an ever greater vulnerability to depression (POI: OR = 1.62, 95% CI = 1.07–2.43; Early menopause: OR = 1.83, 95% CI = 1.11–3.02). In postmenopausal women, moderate-intensity activity (≥150 minutes per week) was associated with increased odds of depressive symptoms (Overall moderate-to-vigorous physical activity: OR = 1.9, 95% CI = 1.08–3.34; moderateto-vigorous recreational activity: OR = 2.17, 95% CI = 1.06–4.44). This association was not statistically significant among postmenopausal women engaging in insufficient moderate-intensity physical activity. Conclusion: These findings support a significant association between POI and early menopause and depression in U.S. women, particularly among those whose age at last delivery was below 35 years. [ABSTRACT FROM AUTHOR]
Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: The Relationship Between Menopausal Status and Depression in U.S. Women: Insights from the NHANES 2017–March 2020 Cross-Sectional Study.
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  Data: <searchLink fieldCode="AR" term="%22Pei%2C+Jiaojiao%22">Pei, Jiaojiao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chen%2C+Jiao%22">Chen, Jiao</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Liu%2C+Ling%22">Liu, Ling</searchLink><relatesTo>3</relatesTo><i> liuling06180711@sina.com</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Mao%22">Li, Mao</searchLink><relatesTo>4</relatesTo><i> lm552323002@126.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Actas+Espanolas+de+Psiquiatria%22">Actas Espanolas de Psiquiatria</searchLink>. 2025, Vol. 53 Issue 6, p1223-1236. 14p.
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  Data: <searchLink fieldCode="DE" term="%22PREMATURE+ovarian+failure%22">PREMATURE ovarian failure</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink><br /><searchLink fieldCode="DE" term="%22PHYSICAL+activity%22">PHYSICAL activity</searchLink><br /><searchLink fieldCode="DE" term="%22REPRODUCTIVE+history%22">REPRODUCTIVE history</searchLink><br /><searchLink fieldCode="DE" term="%22AMERICAN+women%22">AMERICAN women</searchLink><br /><searchLink fieldCode="DE" term="%22NATIONAL+Health+%26+Nutrition+Examination+Survey%22">NATIONAL Health & Nutrition Examination Survey</searchLink><br /><searchLink fieldCode="DE" term="%22MENOPAUSE%22">MENOPAUSE</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22UNITED+States%22">UNITED States</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This study harnessed cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2017–March 2020 to examine the relationship between menopausal status and depression among U.S. women. Methods: Data from NHANES 2017–March 2020 were used for this cross-sectional analysis. Robust statistical approaches, including univariate and multivariate logistic regression, were applied, and subgroup analyses were conducted to assess the stability of the findings. Results: Women with premature ovarian insufficiency (POI) and early menopause showed a higher likelihood of depression compared with non-menopausal women (POI: odds ratio (OR) = 1.59, 95% confidence interval (95% CI) = 1.07–2.35; Early menopause: OR = 1.71, 95% CI = 1.06– 2.76). Among these groups, women whose age at last delivery was under 35 years demonstrated an ever greater vulnerability to depression (POI: OR = 1.62, 95% CI = 1.07–2.43; Early menopause: OR = 1.83, 95% CI = 1.11–3.02). In postmenopausal women, moderate-intensity activity (≥150 minutes per week) was associated with increased odds of depressive symptoms (Overall moderate-to-vigorous physical activity: OR = 1.9, 95% CI = 1.08–3.34; moderateto-vigorous recreational activity: OR = 2.17, 95% CI = 1.06–4.44). This association was not statistically significant among postmenopausal women engaging in insufficient moderate-intensity physical activity. Conclusion: These findings support a significant association between POI and early menopause and depression in U.S. women, particularly among those whose age at last delivery was below 35 years. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.62641/aep.v53i6.1998
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        Text: English
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      – SubjectFull: PREMATURE ovarian failure
        Type: general
      – SubjectFull: MENTAL depression
        Type: general
      – SubjectFull: PHYSICAL activity
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      – SubjectFull: REPRODUCTIVE history
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      – SubjectFull: AMERICAN women
        Type: general
      – SubjectFull: NATIONAL Health & Nutrition Examination Survey
        Type: general
      – SubjectFull: MENOPAUSE
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      – SubjectFull: UNITED States
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      – TitleFull: The Relationship Between Menopausal Status and Depression in U.S. Women: Insights from the NHANES 2017–March 2020 Cross-Sectional Study.
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              Text: 2025
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