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Asociación de las plaquetas con la falla orgánica múltiple en pacientes sépticos.

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Title: Asociación de las plaquetas con la falla orgánica múltiple en pacientes sépticos.
Alternate Title: Association of platelets with multiple organic failure in septic patients.
Authors: Bocanegra-Alegría, Emiliano1, Bravo-Santibáñez, Edgar1 edgarsantibaez@hotmail.com, Berenice Márquez-Torres, Claudia2
Source: Revista Medica del IMSS. mar/abr2026, Vol. 64 Issue 2, p1-7. 7p.
Subjects: BLOOD platelets, MULTIPLE organ failure, THROMBOSIS, PROGNOSIS, SEPSIS, THROMBOCYTOPENIA, INTENSIVE care units, ACUTE kidney failure
Abstract (English): Background: Sepsis is a proinflammatory and procoagulant condition; platelet abnormalities constitute the main alteration, with thrombocytopenia being the most prevalent. This variation is due to multiple mechanisms, primarily the formation of microcirculatory thrombi, which leads to increased consumption. A potential association between decreased platelet counts and poor prognosis has been previously described. Objective: To establish the association between platelet counts and multiple organ failure (MOF) in septic patients in the intensive care unit. Material and methods: A single-center, cross-sectional, retrospective study including patients older than 18 years with a diagnosis of sepsis, with or without MOF, excluding those with COVID-19. Serum platelet levels were collected upon admission to the intensive care unit. The Mann-Whitney U test, ROC curve analysis, and binary logistic regression were used. Results: A total of 93 septic patients were included (46.2% with MOF). Those with MOF had lower platelet counts (149 vs. 217.5 × 10^9/L; p = 0.003), with 174 × 10^9/L identified as the best cutoff point (AUC 0.710). Platelets were also associated with MOF (OR 8.53; p = 0.003); however, in the multivariable analysis, acute kidney injury was the main factor associated with MOF (OR 27.8; p = 0.001). Conclusions: A decrease in platelet count is a risk factor associated with MOF in septic patients in the intensive care unit. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: la sepsis es una patología proinflamatoria y procoagulante; las alteraciones plaquetarias constituyen la principal afección, siendo la trombocitopenia la más prevalente. Esta variación se debe a múltiples mecanismos, principalmente a la formación de trombos en la microcirculación, lo que provoca un incremento en el consumo. Previamente, se ha descrito la posible asociación entre la disminución en la cifra de plaquetas y un mal pronóstico. Objetivo: establecer la asociación de las cifras de plaquetas con la falla orgánica múltiple (FOM) en pacientes sépticos en la terapia intensiva. Material y métodos: estudio unicéntrico, transversal y retrospectivo, que incluyó a mayores de 18 años con diagnóstico de sepsis, con o sin FOM, y excluyó a pacientes con COVID-19. Se recabaron los niveles séricos de plaquetas al ingreso a la terapia intensiva. Se utilizaron la prueba U de Mann-Whitney, la curva ROC y la regresión logística binaria. Resultados: se incluyó un total de 93 pacientes sépticos (46.2% con FOM). Aquellos con FOM presentaron un menor número de plaquetas (149 vs. 217.5 × 10^9/L; p = 0.003), siendo 174 × 10^9/L el mejor punto de corte (AUC 0.710). Asimismo, las plaquetas se asociaron con la FOM (RM 8.53; p = 0.003); sin embargo, en el análisis múltiple, la lesión renal aguda fue el principal factor asociado con FOM (RM 27.8; p = 0.001). Conclusiones: la disminución en la cifra de plaquetas es un factor de riesgo asociado con la FOM en pacientes sépticos en la terapia intensiva. [ABSTRACT FROM AUTHOR]
Copyright of Revista Medica del IMSS is the property of Direccion de Prestaciones Medicas - IMSS and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Asociación de las plaquetas con la falla orgánica múltiple en pacientes sépticos.
– Name: TitleAlt
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  Data: Association of platelets with multiple organic failure in septic patients.
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  Data: <searchLink fieldCode="AR" term="%22Bocanegra-Alegría%2C+Emiliano%22">Bocanegra-Alegría, Emiliano</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bravo-Santibáñez%2C+Edgar%22">Bravo-Santibáñez, Edgar</searchLink><relatesTo>1</relatesTo><i> edgarsantibaez@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Berenice+Márquez-Torres%2C+Claudia%22">Berenice Márquez-Torres, Claudia</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Revista+Medica+del+IMSS%22">Revista Medica del IMSS</searchLink>. mar/abr2026, Vol. 64 Issue 2, p1-7. 7p.
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  Data: <searchLink fieldCode="DE" term="%22BLOOD+platelets%22">BLOOD platelets</searchLink><br /><searchLink fieldCode="DE" term="%22MULTIPLE+organ+failure%22">MULTIPLE organ failure</searchLink><br /><searchLink fieldCode="DE" term="%22THROMBOSIS%22">THROMBOSIS</searchLink><br /><searchLink fieldCode="DE" term="%22PROGNOSIS%22">PROGNOSIS</searchLink><br /><searchLink fieldCode="DE" term="%22SEPSIS%22">SEPSIS</searchLink><br /><searchLink fieldCode="DE" term="%22THROMBOCYTOPENIA%22">THROMBOCYTOPENIA</searchLink><br /><searchLink fieldCode="DE" term="%22INTENSIVE+care+units%22">INTENSIVE care units</searchLink><br /><searchLink fieldCode="DE" term="%22ACUTE+kidney+failure%22">ACUTE kidney failure</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Background: Sepsis is a proinflammatory and procoagulant condition; platelet abnormalities constitute the main alteration, with thrombocytopenia being the most prevalent. This variation is due to multiple mechanisms, primarily the formation of microcirculatory thrombi, which leads to increased consumption. A potential association between decreased platelet counts and poor prognosis has been previously described. Objective: To establish the association between platelet counts and multiple organ failure (MOF) in septic patients in the intensive care unit. Material and methods: A single-center, cross-sectional, retrospective study including patients older than 18 years with a diagnosis of sepsis, with or without MOF, excluding those with COVID-19. Serum platelet levels were collected upon admission to the intensive care unit. The Mann-Whitney U test, ROC curve analysis, and binary logistic regression were used. Results: A total of 93 septic patients were included (46.2% with MOF). Those with MOF had lower platelet counts (149 vs. 217.5 × 10^9/L; p = 0.003), with 174 × 10^9/L identified as the best cutoff point (AUC 0.710). Platelets were also associated with MOF (OR 8.53; p = 0.003); however, in the multivariable analysis, acute kidney injury was the main factor associated with MOF (OR 27.8; p = 0.001). Conclusions: A decrease in platelet count is a risk factor associated with MOF in septic patients in the intensive care unit. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducción: la sepsis es una patología proinflamatoria y procoagulante; las alteraciones plaquetarias constituyen la principal afección, siendo la trombocitopenia la más prevalente. Esta variación se debe a múltiples mecanismos, principalmente a la formación de trombos en la microcirculación, lo que provoca un incremento en el consumo. Previamente, se ha descrito la posible asociación entre la disminución en la cifra de plaquetas y un mal pronóstico. Objetivo: establecer la asociación de las cifras de plaquetas con la falla orgánica múltiple (FOM) en pacientes sépticos en la terapia intensiva. Material y métodos: estudio unicéntrico, transversal y retrospectivo, que incluyó a mayores de 18 años con diagnóstico de sepsis, con o sin FOM, y excluyó a pacientes con COVID-19. Se recabaron los niveles séricos de plaquetas al ingreso a la terapia intensiva. Se utilizaron la prueba U de Mann-Whitney, la curva ROC y la regresión logística binaria. Resultados: se incluyó un total de 93 pacientes sépticos (46.2% con FOM). Aquellos con FOM presentaron un menor número de plaquetas (149 vs. 217.5 × 10^9/L; p = 0.003), siendo 174 × 10^9/L el mejor punto de corte (AUC 0.710). Asimismo, las plaquetas se asociaron con la FOM (RM 8.53; p = 0.003); sin embargo, en el análisis múltiple, la lesión renal aguda fue el principal factor asociado con FOM (RM 27.8; p = 0.001). Conclusiones: la disminución en la cifra de plaquetas es un factor de riesgo asociado con la FOM en pacientes sépticos en la terapia intensiva. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista Medica del IMSS is the property of Direccion de Prestaciones Medicas - IMSS and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.5281/zenodo.17537616
    Languages:
      – Code: spa
        Text: Spanish
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      – SubjectFull: BLOOD platelets
        Type: general
      – SubjectFull: MULTIPLE organ failure
        Type: general
      – SubjectFull: THROMBOSIS
        Type: general
      – SubjectFull: PROGNOSIS
        Type: general
      – SubjectFull: SEPSIS
        Type: general
      – SubjectFull: THROMBOCYTOPENIA
        Type: general
      – SubjectFull: INTENSIVE care units
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      – SubjectFull: ACUTE kidney failure
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      – TitleFull: Asociación de las plaquetas con la falla orgánica múltiple en pacientes sépticos.
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              Text: mar/abr2026
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