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Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stages.

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Title: Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stages.
Alternate Title: Efecto de la ivermectina sobre larvas de Toxocara canis in vitro e in vivo en diferentes etapas migratorias.
Authors: Abou-El-Naga, Iman F.1 eman.abuelnaga@alexmed.edu.eg, El-Nassery, Suzanne M. F.1, El-Temsahy, Mona M.1
Source: Biomédica: Revista del Instituto Nacional de Salud. mar2026, Vol. 46 Issue 1, p128-140. 13p.
Subjects: IVERMECTIN, TOXOCARA, HISTOPATHOLOGY, IN vitro studies, LARVAE, SCANNING electron microscopy, IN vivo studies
Abstract (English): Introduction. Ivermectin has shown potent activity against various nematodes. Objective. Evaluation of the efficacy of ivermectin against Toxocara canis larvae. Materials and methods. In vitro assessment was conducted using larval migration inhibition test and scanning electron microscopy (SEM). In vivo, ivermectin was administered orally to mice at a single 0.2 mg/kg dose at 2 (group I), 7 (group II), or 15 days (group III) post-infection. Efficacy was evaluated through brain larval counts and histopathological examination of liver and brain. Results. In vitro, ivermectin at concentrations of 10 µg/ml and 100 µg/ml inhibited larval migration by 8.5% and 87%, respectively. SEM showed cuticular damage after 24 and 48 hours with 100 µg/ml ivermectin. In vivo, brain larval counts significantly decreased in groups I and II (22.67 ± 5.41 and 37.17 ± 5.98), with no significant reduction in group III (130.5 ± 9.01). Histopathology of the liver at four weeks post-infection in groups I and II revealed numerous granulomas with degenerated larvae. The brain showed a marked reduction in larval presence and inflammation in groups I and II, while group III findings were similar to those of the control group. Conclusion. Ivermectin is effective against T. canis larvae during early migratory stages but shows limited efficacy against late-stage larvae. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción. La ivermectina ha demostrado una potente actividad contra diversos nematodos. Objetivo. Evaluar la eficacia de la ivermectina contra las larvas de Toxocara canis. Materiales y métodos. La evaluación in vitro se realizó mediante la prueba de inhibición de la migración larval y microscopía electrónica de barrido. In vivo, se administró ivermectina por vía oral a ratones en una dosis única de 0,2 mg/kg a los 2 (grupo I), 7 (grupo II) o 15 días (grupo III) después de la infección. La eficacia se evaluó mediante el recuento larval en cerebro, y los exámenes histopatológicos del hígado y cerebro. Resultados. In vitro, la ivermectina en concentraciones de 10 µg/ml y 100 µg/ml inhibió la migración larval en el 8,5 y el 87 %, respectivamente. La microscopía electrónica de barrido mostró daño en la cutícula tras 24 y 48 horas con 100 µg/ml de ivermectina. In vivo, el recuento larval cerebral disminuyó significativamente en los grupos I y II (22,67 ± 5,41 y 37,17 ± 5,98), sin reducción significativa en el grupo III (130,5 ± 9,01). La histopatología hepática a las cuatro semanas después de la infección mostró numerosos granulomas con larvas degeneradas en los grupos I y II. El cerebro presentó una acentuada reducción de larvas e inflamación en los grupos I y II, mientras que los hallazgos del grupo III fueron similares a los del grupo control. Conclusión. La ivermectina es eficaz contra las larvas de T. canis durante las etapas migratorias tempranas, pero muestra una eficacia limitada en las etapas larvales tardías. [ABSTRACT FROM AUTHOR]
Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stages.
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  Data: Efecto de la ivermectina sobre larvas de Toxocara canis in vitro e in vivo en diferentes etapas migratorias.
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  Data: <searchLink fieldCode="AR" term="%22Abou-El-Naga%2C+Iman+F%2E%22">Abou-El-Naga, Iman F.</searchLink><relatesTo>1</relatesTo><i> eman.abuelnaga@alexmed.edu.eg</i><br /><searchLink fieldCode="AR" term="%22El-Nassery%2C+Suzanne+M%2E+F%2E%22">El-Nassery, Suzanne M. F.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22El-Temsahy%2C+Mona+M%2E%22">El-Temsahy, Mona M.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Biomédica%3A+Revista+del+Instituto+Nacional+de+Salud%22">Biomédica: Revista del Instituto Nacional de Salud</searchLink>. mar2026, Vol. 46 Issue 1, p128-140. 13p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22IVERMECTIN%22">IVERMECTIN</searchLink><br /><searchLink fieldCode="DE" term="%22TOXOCARA%22">TOXOCARA</searchLink><br /><searchLink fieldCode="DE" term="%22HISTOPATHOLOGY%22">HISTOPATHOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22IN+vitro+studies%22">IN vitro studies</searchLink><br /><searchLink fieldCode="DE" term="%22LARVAE%22">LARVAE</searchLink><br /><searchLink fieldCode="DE" term="%22SCANNING+electron+microscopy%22">SCANNING electron microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22IN+vivo+studies%22">IN vivo studies</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction. Ivermectin has shown potent activity against various nematodes. Objective. Evaluation of the efficacy of ivermectin against Toxocara canis larvae. Materials and methods. In vitro assessment was conducted using larval migration inhibition test and scanning electron microscopy (SEM). In vivo, ivermectin was administered orally to mice at a single 0.2 mg/kg dose at 2 (group I), 7 (group II), or 15 days (group III) post-infection. Efficacy was evaluated through brain larval counts and histopathological examination of liver and brain. Results. In vitro, ivermectin at concentrations of 10 µg/ml and 100 µg/ml inhibited larval migration by 8.5% and 87%, respectively. SEM showed cuticular damage after 24 and 48 hours with 100 µg/ml ivermectin. In vivo, brain larval counts significantly decreased in groups I and II (22.67 ± 5.41 and 37.17 ± 5.98), with no significant reduction in group III (130.5 ± 9.01). Histopathology of the liver at four weeks post-infection in groups I and II revealed numerous granulomas with degenerated larvae. The brain showed a marked reduction in larval presence and inflammation in groups I and II, while group III findings were similar to those of the control group. Conclusion. Ivermectin is effective against T. canis larvae during early migratory stages but shows limited efficacy against late-stage larvae. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducción. La ivermectina ha demostrado una potente actividad contra diversos nematodos. Objetivo. Evaluar la eficacia de la ivermectina contra las larvas de Toxocara canis. Materiales y métodos. La evaluación in vitro se realizó mediante la prueba de inhibición de la migración larval y microscopía electrónica de barrido. In vivo, se administró ivermectina por vía oral a ratones en una dosis única de 0,2 mg/kg a los 2 (grupo I), 7 (grupo II) o 15 días (grupo III) después de la infección. La eficacia se evaluó mediante el recuento larval en cerebro, y los exámenes histopatológicos del hígado y cerebro. Resultados. In vitro, la ivermectina en concentraciones de 10 µg/ml y 100 µg/ml inhibió la migración larval en el 8,5 y el 87 %, respectivamente. La microscopía electrónica de barrido mostró daño en la cutícula tras 24 y 48 horas con 100 µg/ml de ivermectina. In vivo, el recuento larval cerebral disminuyó significativamente en los grupos I y II (22,67 ± 5,41 y 37,17 ± 5,98), sin reducción significativa en el grupo III (130,5 ± 9,01). La histopatología hepática a las cuatro semanas después de la infección mostró numerosos granulomas con larvas degeneradas en los grupos I y II. El cerebro presentó una acentuada reducción de larvas e inflamación en los grupos I y II, mientras que los hallazgos del grupo III fueron similares a los del grupo control. Conclusión. La ivermectina es eficaz contra las larvas de T. canis durante las etapas migratorias tempranas, pero muestra una eficacia limitada en las etapas larvales tardías. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.7705/biomedica.7828
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: TOXOCARA
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      – SubjectFull: HISTOPATHOLOGY
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      – SubjectFull: IN vitro studies
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      – SubjectFull: LARVAE
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      – SubjectFull: SCANNING electron microscopy
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      – SubjectFull: IN vivo studies
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      – TitleFull: Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stages.
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              Text: mar2026
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