Condrosarcoma primario de mama: reporte de caso y revisión de la literatura.
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| Title: | Condrosarcoma primario de mama: reporte de caso y revisión de la literatura. |
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| Alternate Title: | Primary Breast Chondrosarcoma: A Case Report and Review of the Literature. |
| Authors: | Santiago-Sanabria, Leopoldo1 leopoldosantiagosanabria@comunidad.unam.mx, Llano-Tostado, Adrián2, Sanabria-Villegas, Luz del Carmen3, Iturralde-Rosas Priego, Paola4, Molina-Pérez, Carlos José5 |
| Source: | Revista de la Facultad de Medicina de la UNAM. mar/abr2026, Vol. 69 Issue 2, p39-51. 13p. |
| Subjects: | CHONDROSARCOMA, BREAST tumors, MAMMOGRAMS, RADIOTHERAPY, MASTECTOMY, TISSUE analysis, IMMUNOHISTOCHEMISTRY |
| Abstract (English): | Primary chondrosarcoma of the breast is an exceedingly rare neoplasm, with only a limited number of cases reported in international medical literature. In the present article, we describe the case of a 65-year-old woman with no relevant past medical history who presented to the breast clinic with a palpable breast mass of six months' duration. Mammography was requested as the initial imaging modality, revealing an irregular, spiculated, hyperdense mass located in the upper outer quadrant of the left breast. Complementary breast ultrasonography identified two irregular, spiculated nodules with a combined size of 2.2 cm. The lesion was classified as BI-RADS 5. Subsequently, a core needle biopsy was performed. Histological examination demonstrated a high-grade mesenchymal neoplasm characterized by marked cellularity, significant cytologic atypia, and the presence of chondrocytes with abundant eosinophilic cytoplasm, hyperchromatic pleomorphic nuclei, and anaplastic cells, findings consistent with a primary chondrosarcoma of the breast. Considering the histological grade and tumor size, the lesion was classified as stage II according to the breast sarcoma staging system. After discussion in a multidisciplinary breast tumor board, a total mastectomy was performed due to the aggressive nature of the tumor and its poor prognostic features. Adjuvant treatment with external beam radiotherapy directed to the chest wall was administered with the aim of achieving local disease control. During follow-up, the patient has remained free of recurrence during the 6 months following completion of treatment. Breast chondrosarcomas represent a rare spectrum of breast tumors that predominantly affect postmenopausal women. Clinically, they usually present as a palpable mass, underscoring the importance of diagnostic mammography and histological confirmation through biopsy. Immunohistochemical markers such as S100 protein and vimentin play a crucial role in reaching the diagnosis. The surgical approach remains the cornerstone of treatment. The role of adjuvant therapies remains controversial; therefore, treatment decisions should be individualized on a case-by-case basis. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | El condrosarcoma primario de la glándula mamaria es una neoplasia de muy baja incidencia, con escasos casos reportados en la literatura médica internacional. En el presente artículo se describe el caso de una mujer de 65 años, sin antecedentes personales relevantes, quien acudió a la clínica de mama por la presencia de un nódulo palpable de seis meses de evolución.Se solicitó mastografía como primer estudio de imagen, en donde se evidenció un nódulo irregular, de márgenes espiculados, hiperdenso, que se localizaba en el cuadrante superior externo de la glándula mamaria izquierda. En la ecografía mamaria complementaria se identificaron dos nódulos irregulares y espiculados, con un tamaño conjunto de 2.2 cm, al cual se le otorgó una categoría BI-RADS 5. Posteriormente, se realizó biopsia por aguja de corte, en donde en el estudio histológico se identificó una neoplasia mesenquimal de alto grado, caracterizada por una elevada celularidad con marcada atipia citológica y presencia de condrocitos con citoplasma acidófilo abundante, núcleos pleomórficos hipercromáticos y células anaplásicas, lo cuales fueron compatibles con un condrosarcoma primario de glándula mamaria. Tomando en cuenta el grado histológico y el tamaño tumoral, se clasificó en un estadio II según la clasificación de sarcomas de mama. Al exponer el caso al comité multidisciplinario de tumores de mama, se decidió realizar una mastectomía total dada la naturaleza agresiva de la lesión y el pronóstico desfavorable. Se otorgó tratamiento adyuvante mediante radioterapia de haz externo dirigida a la pared torácica con el objetivo de obtener control local de la enfermedad. En cuanto a la vigilancia, la paciente ha permanecido sin datos de recurrencia en los 6 meses posteriores al tratamiento.Estos tumores de la mama representan un espectro de baja incidencia que suelen afectar a mujeres en la postmenopausia. Generalmente en la clínica se presentan como un nódulo palpable, por lo que es imperativo solicitar una mastografía diagnóstica y realizar una biopsia para integrar el diagnóstico histológico. Existen marcadores inmunohistoquímicos como el S100 y la vimentina que auxilian al clínico a integrar dicho diagnóstico. El abordaje quirúrgico continúa siendo el pilar del tratamiento. Los tratamientos adyuvantes son controvertidos, por lo que debe individualizarse en cada caso. [ABSTRACT FROM AUTHOR] |
| Copyright of Revista de la Facultad de Medicina de la UNAM is the property of UNAM, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 192610030 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Condrosarcoma primario de mama: reporte de caso y revisión de la literatura. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Primary Breast Chondrosarcoma: A Case Report and Review of the Literature. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Santiago-Sanabria%2C+Leopoldo%22">Santiago-Sanabria, Leopoldo</searchLink><relatesTo>1</relatesTo><i> leopoldosantiagosanabria@comunidad.unam.mx</i><br /><searchLink fieldCode="AR" term="%22Llano-Tostado%2C+Adrián%22">Llano-Tostado, Adrián</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sanabria-Villegas%2C+Luz+del+Carmen%22">Sanabria-Villegas, Luz del Carmen</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Iturralde-Rosas+Priego%2C+Paola%22">Iturralde-Rosas Priego, Paola</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Molina-Pérez%2C+Carlos+José%22">Molina-Pérez, Carlos José</searchLink><relatesTo>5</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Revista+de+la+Facultad+de+Medicina+de+la+UNAM%22">Revista de la Facultad de Medicina de la UNAM</searchLink>. mar/abr2026, Vol. 69 Issue 2, p39-51. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22CHONDROSARCOMA%22">CHONDROSARCOMA</searchLink><br /><searchLink fieldCode="DE" term="%22BREAST+tumors%22">BREAST tumors</searchLink><br /><searchLink fieldCode="DE" term="%22MAMMOGRAMS%22">MAMMOGRAMS</searchLink><br /><searchLink fieldCode="DE" term="%22RADIOTHERAPY%22">RADIOTHERAPY</searchLink><br /><searchLink fieldCode="DE" term="%22MASTECTOMY%22">MASTECTOMY</searchLink><br /><searchLink fieldCode="DE" term="%22TISSUE+analysis%22">TISSUE analysis</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOHISTOCHEMISTRY%22">IMMUNOHISTOCHEMISTRY</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Primary chondrosarcoma of the breast is an exceedingly rare neoplasm, with only a limited number of cases reported in international medical literature. In the present article, we describe the case of a 65-year-old woman with no relevant past medical history who presented to the breast clinic with a palpable breast mass of six months' duration. Mammography was requested as the initial imaging modality, revealing an irregular, spiculated, hyperdense mass located in the upper outer quadrant of the left breast. Complementary breast ultrasonography identified two irregular, spiculated nodules with a combined size of 2.2 cm. The lesion was classified as BI-RADS 5. Subsequently, a core needle biopsy was performed. Histological examination demonstrated a high-grade mesenchymal neoplasm characterized by marked cellularity, significant cytologic atypia, and the presence of chondrocytes with abundant eosinophilic cytoplasm, hyperchromatic pleomorphic nuclei, and anaplastic cells, findings consistent with a primary chondrosarcoma of the breast. Considering the histological grade and tumor size, the lesion was classified as stage II according to the breast sarcoma staging system. After discussion in a multidisciplinary breast tumor board, a total mastectomy was performed due to the aggressive nature of the tumor and its poor prognostic features. Adjuvant treatment with external beam radiotherapy directed to the chest wall was administered with the aim of achieving local disease control. During follow-up, the patient has remained free of recurrence during the 6 months following completion of treatment. Breast chondrosarcomas represent a rare spectrum of breast tumors that predominantly affect postmenopausal women. Clinically, they usually present as a palpable mass, underscoring the importance of diagnostic mammography and histological confirmation through biopsy. Immunohistochemical markers such as S100 protein and vimentin play a crucial role in reaching the diagnosis. The surgical approach remains the cornerstone of treatment. The role of adjuvant therapies remains controversial; therefore, treatment decisions should be individualized on a case-by-case basis. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: El condrosarcoma primario de la glándula mamaria es una neoplasia de muy baja incidencia, con escasos casos reportados en la literatura médica internacional. En el presente artículo se describe el caso de una mujer de 65 años, sin antecedentes personales relevantes, quien acudió a la clínica de mama por la presencia de un nódulo palpable de seis meses de evolución.Se solicitó mastografía como primer estudio de imagen, en donde se evidenció un nódulo irregular, de márgenes espiculados, hiperdenso, que se localizaba en el cuadrante superior externo de la glándula mamaria izquierda. En la ecografía mamaria complementaria se identificaron dos nódulos irregulares y espiculados, con un tamaño conjunto de 2.2 cm, al cual se le otorgó una categoría BI-RADS 5. Posteriormente, se realizó biopsia por aguja de corte, en donde en el estudio histológico se identificó una neoplasia mesenquimal de alto grado, caracterizada por una elevada celularidad con marcada atipia citológica y presencia de condrocitos con citoplasma acidófilo abundante, núcleos pleomórficos hipercromáticos y células anaplásicas, lo cuales fueron compatibles con un condrosarcoma primario de glándula mamaria. Tomando en cuenta el grado histológico y el tamaño tumoral, se clasificó en un estadio II según la clasificación de sarcomas de mama. Al exponer el caso al comité multidisciplinario de tumores de mama, se decidió realizar una mastectomía total dada la naturaleza agresiva de la lesión y el pronóstico desfavorable. Se otorgó tratamiento adyuvante mediante radioterapia de haz externo dirigida a la pared torácica con el objetivo de obtener control local de la enfermedad. En cuanto a la vigilancia, la paciente ha permanecido sin datos de recurrencia en los 6 meses posteriores al tratamiento.Estos tumores de la mama representan un espectro de baja incidencia que suelen afectar a mujeres en la postmenopausia. Generalmente en la clínica se presentan como un nódulo palpable, por lo que es imperativo solicitar una mastografía diagnóstica y realizar una biopsia para integrar el diagnóstico histológico. Existen marcadores inmunohistoquímicos como el S100 y la vimentina que auxilian al clínico a integrar dicho diagnóstico. El abordaje quirúrgico continúa siendo el pilar del tratamiento. Los tratamientos adyuvantes son controvertidos, por lo que debe individualizarse en cada caso. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Revista de la Facultad de Medicina de la UNAM is the property of UNAM, Facultad de Medicina and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.22201/fm.24484865e.2026.69.2.05 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 13 StartPage: 39 Subjects: – SubjectFull: CHONDROSARCOMA Type: general – SubjectFull: BREAST tumors Type: general – SubjectFull: MAMMOGRAMS Type: general – SubjectFull: RADIOTHERAPY Type: general – SubjectFull: MASTECTOMY Type: general – SubjectFull: TISSUE analysis Type: general – SubjectFull: IMMUNOHISTOCHEMISTRY Type: general Titles: – TitleFull: Condrosarcoma primario de mama: reporte de caso y revisión de la literatura. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Santiago-Sanabria, Leopoldo – PersonEntity: Name: NameFull: Llano-Tostado, Adrián – PersonEntity: Name: NameFull: Sanabria-Villegas, Luz del Carmen – PersonEntity: Name: NameFull: Iturralde-Rosas Priego, Paola – PersonEntity: Name: NameFull: Molina-Pérez, Carlos José IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: mar/abr2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00261742 Numbering: – Type: volume Value: 69 – Type: issue Value: 2 Titles: – TitleFull: Revista de la Facultad de Medicina de la UNAM Type: main |
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