Glomerulonefritis por C3 en Colombia Respuesta a prednisona y micofenolato mofetilo en un caso clínico.
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| Title: | Glomerulonefritis por C3 en Colombia Respuesta a prednisona y micofenolato mofetilo en un caso clínico. |
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| Alternate Title: | C3 glomerulonephritis in Colombia The response to prednisone and mycophenolate mofetil in a clinical case. |
| Authors: | Andrés Berrocal-Martínez, Carlos1 carlos.berrocal@correounivalle.edu.co, Hernando Dominguez-Vinayo, Edgar2, Marina Mejía-Paz, Luz3,4, Maria Arrunategui-Ramirez, Ana5, María Zumaqué-Carrascal, Antonio6,7 |
| Source: | Acta Medica Colombiana. ene-mar2026, Vol. 51 Issue 1, p1-6. 6p. |
| Subjects: | GLOMERULONEPHRITIS, PREDNISONE, HEMATURIA, MYCOPHENOLIC acid, PROTEINURIA, ACUTE kidney failure, COMPLEMENT activation, NEPHROTIC syndrome |
| Abstract (English): | Introduction: C3 glomerulonephritis is a recent condition that consists of dysregulation of the alternative complement pathway, with subsequent hyperactivation and glomerular C3 deposits. Patients may present hematuria and proteinuria, nephrotic syndrome and, less often, acute kidney injury or rapidly progressive glomerulonephritis. Treatment is still unclear and is based mainly on international reports and series. Case presentation: we present the case of a young adult with nephrotic syndrome secondary to C3 glomerulonephritis who was treated with prednisone and mycophenolate mofetil with a partial clinical and biochemical response. Conclusion: C3 glomerulonephritis is a rare condition with no clearly established treatment options thus far, as shown in the presented case. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción: la glomerulonefritis por C3 es una entidad reciente que consiste en la desregulación de la vía alternativa del complemento, con la consiguiente hiperactivación y la presencia de depósitos glomerulares de C3. Los pacientes pueden presentarse con hematuria y proteinuria, síndrome nefrótico y, menos comúnmente, con injuria renal aguda o glomerulonefritis rápidamente progresiva. El tratamiento continúa siendo incierto y se basa principalmente en reportes y series internacionales. Presentación de caso: se presenta el caso de un adulto joven con síndrome nefrótico secundario a glomerulonefritis por C3, tratado con prednisona y micofenolato mofetilo con respuesta clínica y bioquímica parcial. Conclusión: la glomerulonefritis por C3 representa una entidad infrecuente, con opciones terapéuticas aún no claramente establecidas, como se evidencia en el caso presentado. [ABSTRACT FROM AUTHOR] |
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| Database: | MedicLatina |
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