View in EDS PDF Full Text

Cardiovascular deconditioning and hypertension risk in simulated microgravity: implications for long-duration missions.

Saved in:
Bibliographic Details
Title: Cardiovascular deconditioning and hypertension risk in simulated microgravity: implications for long-duration missions.
Alternate Title: Desacondicionamiento cardiovascular y riesgo de hipertensión en microgravedad simulada: Implicaciones para misiones de larga duración.
Authors: Aralov, Mirza1 aralovmirza1930@gmail.com, Obloqulova, Olima2 obloqulova.olima@bsmi.uz, Agzamova, Shoira3 shoira_agzamova@mail.ru, Toirova, Nargiza4 nargiza.toirova.83@mail.ru, Karimov, Rustambek5 rustambekwester@gmail.com, Marufjonova, Roxila6 roxila_marufjonova@tues.uz, Abdulxakimov, Arsen7 abdulhakimovarsen@gmail.com
Source: Revista Latinoamericana de Hipertensión. 2026, Vol. 21 Issue 2, p127-136. 10p.
Subjects: REDUCED gravity environments, EXERCISE therapy, HUMAN space flight, DIETARY supplements, HEMODYNAMICS, HYPERTENSION risk factors, ORTHOSTATIC intolerance, CARDIOVASCULAR diseases
Abstract (English): The primary health issue in long-duration missions i.e. space missions exists because astronauts lose their cardiovascular health through extended time spent in microgravity. The clinical trial research studied cardiovascular transformations and hypertension development risks which occurred under simulated microgravity conditions in Uzbekistan while it assessed how effective exercise and nutritional programs worked. The 36 healthy participants included males from two ethnic groups who participated in the study. The researchers assigned the participants to three different groups which included a control group an exercise group and an exercise group that received electrolyte and antioxidant supplements. The researchers conducted measurements of hemodynamic parameters and vascular function and cardiac structure and orthostatic tolerance at zero days and thirty days and sixty days and ninety days. The results indicated that control group members experienced a decrease in systolic blood pressure which reached 11.5% while their cardiac output dropped by 30.3% and their systemic vascular resistance showed an increase of 31.9%. The body experienced a plasma volume reduction of 28.8% and the left ventricular mass showed 13.7% atrophy. Endothelial function decreased flow-dependent dilation by 43.8% and arterial stiffness through pulse wave velocity which increased from 23.5% to 23.5%. The exercise plus supplement group showed significantly lower changes in all parameters while postural hypotension occurred in 33.3% of participants from that group, compared to 83.3% from the control group. The control group showed 5.8 minutes of slope endurance time, while the full intervention group demonstrated 16.5 minutes. The research found that Uzbek and Russian volunteers exhibited no differences in their physiological responses. The research demonstrates that combining regular exercise with electrolyte and antioxidant supplements, which protects astronauts during long-duration spaceflights, effectively reduces cardiovascular disuse while preventing postural hypotension in simulated microgravity research. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): El principal problema de salud en misiones de larga duración, es decir, misiones espaciales, se debe a que los astronautas pierden salud cardiovascular al pasar tiempo prolongado en microgravedad. El ensayo clínico estudió las transformaciones cardiovasculares y el riesgo de desarrollar hipertensión en condiciones de microgravedad simulada en Uzbekistán, al tiempo que evaluaba la eficacia de los programas de ejercicio y nutrición. Los 36 participantes sanos, incluidos hombres de dos grupos étnicos, participaron en el estudio. Los investigadores asignaron a los participantes a tres grupos diferentes: un grupo de control, un grupo de ejercicio y un grupo de ejercicio que recibió suplementos de electrolitos y antioxidantes. Se realizaron mediciones de parámetros hemodinámicos, función vascular, estructura cardíaca y tolerancia ortostática a los días cero, treinta, sesenta y noventa. Los resultados indicaron que los miembros del grupo de control experimentaron una disminución de la presión arterial sistólica del 11,5 %, mientras que su gasto cardíaco se redujo un 30,3 % y su resistencia vascular sistémica mostró un aumento del 31,9 %. El cuerpo experimentó una reducción del volumen plasmático del 28,8 % y la masa ventricular izquierda mostró una atrofia del 13,7 %. La función endotelial disminuyó la dilatación dependiente del flujo en un 43,8 % y la rigidez arterial, a través de la velocidad de la onda de pulso, aumentó del 23,5 % al 23,5 %. El grupo de ejercicio más suplementos mostró cambios significativamente menores en todos los parámetros, mientras que la hipotensión postural se presentó en el 33,3 % de los participantes de ese grupo, en comparación con el 83,3 % del grupo control. El grupo control mostró 5,8 minutos de resistencia en pendiente, mientras que el grupo de intervención completa mostró 16,5 minutos. La investigación encontró que los voluntarios uzbekos y rusos no mostraron diferencias en sus respuestas fisiológicas. La investigación demuestra que la combinación de ejercicio regular con suplementos de electrolitos y antioxidantes, que protege a los astronautas durante vuelos espaciales de larga duración, reduce eficazmente el desuso cardiovascular y previene la hipotensión postural en la investigación de microgravedad simulada. [ABSTRACT FROM AUTHOR]
Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: lth
DbLabel: MedicLatina
An: 192704275
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cardiovascular deconditioning and hypertension risk in simulated microgravity: implications for long-duration missions.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Desacondicionamiento cardiovascular y riesgo de hipertensión en microgravedad simulada: Implicaciones para misiones de larga duración.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Aralov%2C+Mirza%22">Aralov, Mirza</searchLink><relatesTo>1</relatesTo><i> aralovmirza1930@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Obloqulova%2C+Olima%22">Obloqulova, Olima</searchLink><relatesTo>2</relatesTo><i> obloqulova.olima@bsmi.uz</i><br /><searchLink fieldCode="AR" term="%22Agzamova%2C+Shoira%22">Agzamova, Shoira</searchLink><relatesTo>3</relatesTo><i> shoira_agzamova@mail.ru</i><br /><searchLink fieldCode="AR" term="%22Toirova%2C+Nargiza%22">Toirova, Nargiza</searchLink><relatesTo>4</relatesTo><i> nargiza.toirova.83@mail.ru</i><br /><searchLink fieldCode="AR" term="%22Karimov%2C+Rustambek%22">Karimov, Rustambek</searchLink><relatesTo>5</relatesTo><i> rustambekwester@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Marufjonova%2C+Roxila%22">Marufjonova, Roxila</searchLink><relatesTo>6</relatesTo><i> roxila_marufjonova@tues.uz</i><br /><searchLink fieldCode="AR" term="%22Abdulxakimov%2C+Arsen%22">Abdulxakimov, Arsen</searchLink><relatesTo>7</relatesTo><i> abdulhakimovarsen@gmail.com</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Revista+Latinoamericana+de+Hipertensión%22">Revista Latinoamericana de Hipertensión</searchLink>. 2026, Vol. 21 Issue 2, p127-136. 10p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22REDUCED+gravity+environments%22">REDUCED gravity environments</searchLink><br /><searchLink fieldCode="DE" term="%22EXERCISE+therapy%22">EXERCISE therapy</searchLink><br /><searchLink fieldCode="DE" term="%22HUMAN+space+flight%22">HUMAN space flight</searchLink><br /><searchLink fieldCode="DE" term="%22DIETARY+supplements%22">DIETARY supplements</searchLink><br /><searchLink fieldCode="DE" term="%22HEMODYNAMICS%22">HEMODYNAMICS</searchLink><br /><searchLink fieldCode="DE" term="%22HYPERTENSION+risk+factors%22">HYPERTENSION risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22ORTHOSTATIC+intolerance%22">ORTHOSTATIC intolerance</searchLink><br /><searchLink fieldCode="DE" term="%22CARDIOVASCULAR+diseases%22">CARDIOVASCULAR diseases</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: The primary health issue in long-duration missions i.e. space missions exists because astronauts lose their cardiovascular health through extended time spent in microgravity. The clinical trial research studied cardiovascular transformations and hypertension development risks which occurred under simulated microgravity conditions in Uzbekistan while it assessed how effective exercise and nutritional programs worked. The 36 healthy participants included males from two ethnic groups who participated in the study. The researchers assigned the participants to three different groups which included a control group an exercise group and an exercise group that received electrolyte and antioxidant supplements. The researchers conducted measurements of hemodynamic parameters and vascular function and cardiac structure and orthostatic tolerance at zero days and thirty days and sixty days and ninety days. The results indicated that control group members experienced a decrease in systolic blood pressure which reached 11.5% while their cardiac output dropped by 30.3% and their systemic vascular resistance showed an increase of 31.9%. The body experienced a plasma volume reduction of 28.8% and the left ventricular mass showed 13.7% atrophy. Endothelial function decreased flow-dependent dilation by 43.8% and arterial stiffness through pulse wave velocity which increased from 23.5% to 23.5%. The exercise plus supplement group showed significantly lower changes in all parameters while postural hypotension occurred in 33.3% of participants from that group, compared to 83.3% from the control group. The control group showed 5.8 minutes of slope endurance time, while the full intervention group demonstrated 16.5 minutes. The research found that Uzbek and Russian volunteers exhibited no differences in their physiological responses. The research demonstrates that combining regular exercise with electrolyte and antioxidant supplements, which protects astronauts during long-duration spaceflights, effectively reduces cardiovascular disuse while preventing postural hypotension in simulated microgravity research. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: El principal problema de salud en misiones de larga duración, es decir, misiones espaciales, se debe a que los astronautas pierden salud cardiovascular al pasar tiempo prolongado en microgravedad. El ensayo clínico estudió las transformaciones cardiovasculares y el riesgo de desarrollar hipertensión en condiciones de microgravedad simulada en Uzbekistán, al tiempo que evaluaba la eficacia de los programas de ejercicio y nutrición. Los 36 participantes sanos, incluidos hombres de dos grupos étnicos, participaron en el estudio. Los investigadores asignaron a los participantes a tres grupos diferentes: un grupo de control, un grupo de ejercicio y un grupo de ejercicio que recibió suplementos de electrolitos y antioxidantes. Se realizaron mediciones de parámetros hemodinámicos, función vascular, estructura cardíaca y tolerancia ortostática a los días cero, treinta, sesenta y noventa. Los resultados indicaron que los miembros del grupo de control experimentaron una disminución de la presión arterial sistólica del 11,5 %, mientras que su gasto cardíaco se redujo un 30,3 % y su resistencia vascular sistémica mostró un aumento del 31,9 %. El cuerpo experimentó una reducción del volumen plasmático del 28,8 % y la masa ventricular izquierda mostró una atrofia del 13,7 %. La función endotelial disminuyó la dilatación dependiente del flujo en un 43,8 % y la rigidez arterial, a través de la velocidad de la onda de pulso, aumentó del 23,5 % al 23,5 %. El grupo de ejercicio más suplementos mostró cambios significativamente menores en todos los parámetros, mientras que la hipotensión postural se presentó en el 33,3 % de los participantes de ese grupo, en comparación con el 83,3 % del grupo control. El grupo control mostró 5,8 minutos de resistencia en pendiente, mientras que el grupo de intervención completa mostró 16,5 minutos. La investigación encontró que los voluntarios uzbekos y rusos no mostraron diferencias en sus respuestas fisiológicas. La investigación demuestra que la combinación de ejercicio regular con suplementos de electrolitos y antioxidantes, que protege a los astronautas durante vuelos espaciales de larga duración, reduce eficazmente el desuso cardiovascular y previene la hipotensión postural en la investigación de microgravedad simulada. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista Latinoamericana de Hipertensión is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=192704275
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.5281/zenodo.19050222
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 127
    Subjects:
      – SubjectFull: REDUCED gravity environments
        Type: general
      – SubjectFull: EXERCISE therapy
        Type: general
      – SubjectFull: HUMAN space flight
        Type: general
      – SubjectFull: DIETARY supplements
        Type: general
      – SubjectFull: HEMODYNAMICS
        Type: general
      – SubjectFull: HYPERTENSION risk factors
        Type: general
      – SubjectFull: ORTHOSTATIC intolerance
        Type: general
      – SubjectFull: CARDIOVASCULAR diseases
        Type: general
    Titles:
      – TitleFull: Cardiovascular deconditioning and hypertension risk in simulated microgravity: implications for long-duration missions.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Aralov, Mirza
      – PersonEntity:
          Name:
            NameFull: Obloqulova, Olima
      – PersonEntity:
          Name:
            NameFull: Agzamova, Shoira
      – PersonEntity:
          Name:
            NameFull: Toirova, Nargiza
      – PersonEntity:
          Name:
            NameFull: Karimov, Rustambek
      – PersonEntity:
          Name:
            NameFull: Marufjonova, Roxila
      – PersonEntity:
          Name:
            NameFull: Abdulxakimov, Arsen
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: 2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 18564550
          Numbering:
            – Type: volume
              Value: 21
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Revista Latinoamericana de Hipertensión
              Type: main
ResultId 1