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Radioterapia intraoperatoria para metástasis cerebrales: experiencia en Argentina.

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Title: Radioterapia intraoperatoria para metástasis cerebrales: experiencia en Argentina.
Alternate Title: Intraoperative radiotherapy for brain metastases: an experience in Argentina.
Authors: Saavedra Azcona, Tomás1 (AUTHOR) tomas.saavedra@hospitalitaliano.org.ar, Plou, Pedro L.1 (AUTHOR), Paolinelli, Pablo1 (AUTHOR), Casto, Florencia B.1 (AUTHOR), Jungberg, Ezequiel1 (AUTHOR), Tilano, Nicolás1 (AUTHOR), Pazos, Joan Sebastian1 (AUTHOR), Blettler, William1 (AUTHOR), Garategui, Gustavo L.1 (AUTHOR), Ajler, Pablo M.1 (AUTHOR)
Source: Medicina (Buenos Aires). ene/feb2026, Vol. 86 Issue 1, p260-265. 6p.
Subjects: INTRAOPERATIVE radiotherapy, BRAIN metastasis, NON-small-cell lung carcinoma, SURGICAL excision, RADIOTHERAPY, STEREOTACTIC radiosurgery, COLORECTAL cancer
Geographic Terms: ARGENTINA
Abstract (English): Postoperative stereotactic radiosurgery or hypofrac tionated radiotherapy represent the standard local ad juvant treatment modality after surgical resection of single brain metastases. Intraoperative radiotherapy (IORT) offers the advantage of delivering an ablative dose during the same surgical procedure, avoiding delays and allowing early reinitiation of systemic therapies. This work describes our first national experience with IORT, with preliminary results from a case series. The series included three male patients diagnosed with a single supratentorial brain metastasis (two right frontal and one left temporal), with surgical indication due to mass effect or diagnostic need (pathology analysis) and who met criteria for IORT. The primary tumors were colorectal carcinoma in one case and non-small cell lung cancer in two cases. In our experience, we documented no cases of local recurrence at follow-up, nor evidence of radionecrosis or leptomeningeal dissemination, the patients were alive at the close of the analysis and with out central nervous system disease progression. IORT resulted feasible and safe, with encouraging preliminary results, which, with future studies, could consolidate it as an alternative to the traditional regimen of surgery plus postoperative radiotherapy. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): La radiocirugía estereotáctica o radioterapia hipo fraccionada postoperatorias representan la modalidad estándar de adyuvancia local tras la resección quirúr gica de metástasis cerebrales únicas. La radioterapia intraoperatoria (IORT) ofrece la ventaja de aplicar una dosis ablativa durante el mismo acto quirúrgico, evitando retrasos y permitiendo reinicio temprano de terapias sistémicas. Este trabajo describe nuestra primera experiencia nacional con IORT, con los resul tados preliminares de una serie de casos. La serie la componen tres pacientes masculinos con diagnóstico de metástasis cerebral única de localización supra tentorial (dos frontales derechas y una temporal iz quierda), con indicación quirúrgica por efecto de masa o necesidad diagnóstica (anatomía patológica) y que cumplían criterios para IORT. Los tumores primarios fueron en un caso adenocarcinoma colorrectal y en dos casos cáncer de pulmón de no-células pequeñas. En nuestra experiencia inicial, no documentamos ca sos de recurrencia local al seguimiento, ni evidencia de radionecrosis o diseminación leptomeníngea, los pacientes estaban vivos al cierre del análisis y sin pro gresión de enfermedad en el sistema nervioso central. La IORT resultó factible y segura, con resultados preli minares alentadores, que con futuros estudios podría consolidarse como alternativa al esquema clásico de cirugía más radioterapia postoperatoria. [ABSTRACT FROM AUTHOR]
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Radioterapia intraoperatoria para metástasis cerebrales: experiencia en Argentina.
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  Data: Intraoperative radiotherapy for brain metastases: an experience in Argentina.
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  Data: <searchLink fieldCode="AR" term="%22Saavedra+Azcona%2C+Tomás%22">Saavedra Azcona, Tomás</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> tomas.saavedra@hospitalitaliano.org.ar</i><br /><searchLink fieldCode="AR" term="%22Plou%2C+Pedro+L%2E%22">Plou, Pedro L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paolinelli%2C+Pablo%22">Paolinelli, Pablo</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Casto%2C+Florencia+B%2E%22">Casto, Florencia B.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jungberg%2C+Ezequiel%22">Jungberg, Ezequiel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tilano%2C+Nicolás%22">Tilano, Nicolás</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pazos%2C+Joan+Sebastian%22">Pazos, Joan Sebastian</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blettler%2C+William%22">Blettler, William</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garategui%2C+Gustavo+L%2E%22">Garategui, Gustavo L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ajler%2C+Pablo+M%2E%22">Ajler, Pablo M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Medicina+%28Buenos+Aires%29%22">Medicina (Buenos Aires)</searchLink>. ene/feb2026, Vol. 86 Issue 1, p260-265. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22INTRAOPERATIVE+radiotherapy%22">INTRAOPERATIVE radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22BRAIN+metastasis%22">BRAIN metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22NON-small-cell+lung+carcinoma%22">NON-small-cell lung carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22SURGICAL+excision%22">SURGICAL excision</searchLink><br /><searchLink fieldCode="DE" term="%22RADIOTHERAPY%22">RADIOTHERAPY</searchLink><br /><searchLink fieldCode="DE" term="%22STEREOTACTIC+radiosurgery%22">STEREOTACTIC radiosurgery</searchLink><br /><searchLink fieldCode="DE" term="%22COLORECTAL+cancer%22">COLORECTAL cancer</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22ARGENTINA%22">ARGENTINA</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Postoperative stereotactic radiosurgery or hypofrac tionated radiotherapy represent the standard local ad juvant treatment modality after surgical resection of single brain metastases. Intraoperative radiotherapy (IORT) offers the advantage of delivering an ablative dose during the same surgical procedure, avoiding delays and allowing early reinitiation of systemic therapies. This work describes our first national experience with IORT, with preliminary results from a case series. The series included three male patients diagnosed with a single supratentorial brain metastasis (two right frontal and one left temporal), with surgical indication due to mass effect or diagnostic need (pathology analysis) and who met criteria for IORT. The primary tumors were colorectal carcinoma in one case and non-small cell lung cancer in two cases. In our experience, we documented no cases of local recurrence at follow-up, nor evidence of radionecrosis or leptomeningeal dissemination, the patients were alive at the close of the analysis and with out central nervous system disease progression. IORT resulted feasible and safe, with encouraging preliminary results, which, with future studies, could consolidate it as an alternative to the traditional regimen of surgery plus postoperative radiotherapy. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: La radiocirugía estereotáctica o radioterapia hipo fraccionada postoperatorias representan la modalidad estándar de adyuvancia local tras la resección quirúr gica de metástasis cerebrales únicas. La radioterapia intraoperatoria (IORT) ofrece la ventaja de aplicar una dosis ablativa durante el mismo acto quirúrgico, evitando retrasos y permitiendo reinicio temprano de terapias sistémicas. Este trabajo describe nuestra primera experiencia nacional con IORT, con los resul tados preliminares de una serie de casos. La serie la componen tres pacientes masculinos con diagnóstico de metástasis cerebral única de localización supra tentorial (dos frontales derechas y una temporal iz quierda), con indicación quirúrgica por efecto de masa o necesidad diagnóstica (anatomía patológica) y que cumplían criterios para IORT. Los tumores primarios fueron en un caso adenocarcinoma colorrectal y en dos casos cáncer de pulmón de no-células pequeñas. En nuestra experiencia inicial, no documentamos ca sos de recurrencia local al seguimiento, ni evidencia de radionecrosis o diseminación leptomeníngea, los pacientes estaban vivos al cierre del análisis y sin pro gresión de enfermedad en el sistema nervioso central. La IORT resultó factible y segura, con resultados preli minares alentadores, que con futuros estudios podría consolidarse como alternativa al esquema clásico de cirugía más radioterapia postoperatoria. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Code: spa
        Text: Spanish
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        PageCount: 6
        StartPage: 260
    Subjects:
      – SubjectFull: INTRAOPERATIVE radiotherapy
        Type: general
      – SubjectFull: BRAIN metastasis
        Type: general
      – SubjectFull: NON-small-cell lung carcinoma
        Type: general
      – SubjectFull: SURGICAL excision
        Type: general
      – SubjectFull: RADIOTHERAPY
        Type: general
      – SubjectFull: STEREOTACTIC radiosurgery
        Type: general
      – SubjectFull: COLORECTAL cancer
        Type: general
      – SubjectFull: ARGENTINA
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      – TitleFull: Radioterapia intraoperatoria para metástasis cerebrales: experiencia en Argentina.
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              Text: ene/feb2026
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              Y: 2026
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