PREMIO NOBEL DE FISIOLOGÍA O MEDICINA 2024 AL DESCUBRIMIENTO DE LOS MICROARN Y SU PAPEL EN LA REGULACIÓN GÉNICA POSTRANSCRIPCIONAL.
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| Title: | PREMIO NOBEL DE FISIOLOGÍA O MEDICINA 2024 AL DESCUBRIMIENTO DE LOS MICROARN Y SU PAPEL EN LA REGULACIÓN GÉNICA POSTRANSCRIPCIONAL. |
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| Authors: | AZURMENDI, PABLO J.1 azurmendi.pablo@lanari.uba.ar, LÜTHY, ISABEL A.2 i.luthy@ibyme.org.ar |
| Source: | Medicina (Buenos Aires). 2024, Vol. 84 Issue 6, p1183-1186. 4p. |
| Subjects: | MICRORNA, GENETIC regulation, GENE expression, NOBEL Prizes, CAENORHABDITIS elegans, BIOMARKERS |
| Abstract (English): | The article focuses on the awarding of the 2024 Nobel Prize in Physiology or Medicine to Victor Ambros and Gary Ruvkun for the discovery of microRNAs (miRNAs) and their role in post-transcriptional gene regulation. miRNAs are small non-coding RNAs that regulate gene expression by binding to specific messenger RNAs, affecting their stability and translation, and are involved in multiple cellular processes. The discovery originated from studies with the nematode Caenorhabditis elegans, where the first miRNA, lin-4, was identified, followed by let-7, demonstrating the evolutionary conservation of these regulators. Additionally, miRNAs can be found in biological fluids and have potential as biomarkers for various diseases. This finding highlights the importance of basic research in model organisms for significant advances in biomedicine. [Extracted from the article] |
| Abstract (Spanish): | El artículo se centra en el otorgamiento del Premio Nobel de Fisiología o Medicina 2024 a Victor Ambros y Gary Ruvkun por el descubrimiento de los microARN (miARN) y su papel en la regulación génica postranscripcional. Los miARN son pequeños ARN no codificantes que regulan la expresión génica al unirse a ARN mensajeros específicos, afectando su estabilidad y traducción, y participan en múltiples procesos celulares. El descubrimiento se originó en estudios con el nematodo Caenorhabditis elegans, donde se identificó el primer miARN, lin-4, y posteriormente let-7, evidenciando la conservación evolutiva de estos reguladores. Además, los miARN pueden encontrarse en fluidos biológicos y tienen potencial como biomarcadores para diversas enfermedades. Este hallazgo destaca la importancia de la investigación básica en organismos modelo para avances significativos en biomedicina. [Extracted from the article] |
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| Database: | MedicLatina |
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| Abstract: | The article focuses on the awarding of the 2024 Nobel Prize in Physiology or Medicine to Victor Ambros and Gary Ruvkun for the discovery of microRNAs (miRNAs) and their role in post-transcriptional gene regulation. miRNAs are small non-coding RNAs that regulate gene expression by binding to specific messenger RNAs, affecting their stability and translation, and are involved in multiple cellular processes. The discovery originated from studies with the nematode Caenorhabditis elegans, where the first miRNA, lin-4, was identified, followed by let-7, demonstrating the evolutionary conservation of these regulators. Additionally, miRNAs can be found in biological fluids and have potential as biomarkers for various diseases. This finding highlights the importance of basic research in model organisms for significant advances in biomedicine. [Extracted from the article] |
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| ISSN: | 00257680 |
