SÍNDROME FEBRIL AGUDO INESPECÍFICO EN PACIENTES AMBULATORIOS: DIAGNÓSTICO DIFERENCIAL ENTRE DENGUE, ZIKA, FIEBRE HEMORRÁGICA ARGENTINA Y COVID-19.

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Bibliographic Details
Title: SÍNDROME FEBRIL AGUDO INESPECÍFICO EN PACIENTES AMBULATORIOS: DIAGNÓSTICO DIFERENCIAL ENTRE DENGUE, ZIKA, FIEBRE HEMORRÁGICA ARGENTINA Y COVID-19.
Alternate Title: Acute undifferentiated febrile illness among outpatients: differential diagnosis between dengue, zika, argentine hemorrhagic fever and COVID-19.
Authors: MELCON, MARIO O.1 finep.arg@gmail.com, GARCÍAS, CELESTE1
Source: Medicina (Buenos Aires). 2024, Vol. 84 Issue 6, p1215-1225. 11p.
Subjects: DIFFERENTIAL diagnosis, SERODIAGNOSIS, ZIKA virus, DENGUE, VIRUS diseases, HEMORRHAGIC fever, COVID-19
Abstract (English): The "acute undifferentiated febrile illness" (AUFI) encompasses a range of diseases characterized by the presence of fever, often prompting consultations in emergency services. During epidemics like COVID-19 or dengue, a surge in consultations occurs, resulting in long wait times for patients. Errors in first diagnosis can result in severe consequences. The objective is to provide a comprehensive review of the clinical approach to AUFI, focusing on certain viral infections (dengue, zika, Argentine hemorrhagic fever and COVID-19). This involves a detailed examination of the clinical presentation, laboratory and radiological findings, neurological manifestations, and definitive diagnosis through specific serological tests. AUFI is characterized by the onset of acute fever lasting less than seven days, accompanied by myalgia or headache without involvement of the upper respiratory tract and without a defined cause. Most cases are caused by common, self-limiting viral infections (e.g., influenza); however, they may also stem from more serious viral infections with a broad etiological spectrum. The differential diagnosis of acute febrile syndromes includes various infectious diseases, such as those previously mentioned. The definitive diagnosis is based on serological methods, PCR and IgM. Recommendations based on scientific evidence can help with early diagnosis and prevent possible serious complications. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): El "síndrome febril agudo inespecífico" (SFAI) abarca una variedad de enfermedades que se distinguen por la presencia de fiebre, convirtiéndose en una causa común de consulta en los servicios de urgencias. Durante epidemias como la del COVID-19 o dengue (brote epidémico), se observa un aumento significativo de consultas con larga fila de pacientes esperando ser atendidos. Errores u omisiones en el diagnóstico inicial pueden acarrear graves consecuencias. El objetivo es ofrecer una revisión exhaustiva del enfoque clínico del SFAI, centrándose en determinadas infecciones virales (dengue, zika, fiebre hemorrágica argentina y COVID-19). Se examina detalladamente la presentación clínica, los hallazgos de laboratorio y radiológicos, las manifestaciones neurológicas y el diagnóstico definitivo mediante pruebas serológicas específicas. El SFAI se caracteriza por la aparición de fiebre aguda que dura menos de siete días, acompañada de mialgia o dolor de cabeza, sin afectación de las vías respiratorias superiores y sin una causa definida. La mayoría de los casos se deben a infecciones virales comunes, que suelen ser autolimitadas (ej. influenza); sin embargo, también pueden ser el resultado de infecciones virales más graves con un amplio espectro etiológico. El diagnóstico diferencial de los síndromes febriles agudos abarca diversas enfermedades infecciosas, como las mencionadas previamente. El diagnóstico definitivo se basa en métodos serológicos, PCR e IgM. Las recomendaciones basadas en evidencia científica pueden ayudar a un diagnóstico temprano y prevenir serias complicaciones. [ABSTRACT FROM AUTHOR]
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