MARCADORES DE REMODELACIÓN Y ESTRUCTURA ÓSEA EN DIFERENTES ETAPAS DE LA VIDA EN RATAS WISTAR.

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Bibliographic Details
Title:	MARCADORES DE REMODELACIÓN Y ESTRUCTURA ÓSEA EN DIFERENTES ETAPAS DE LA VIDA EN RATAS WISTAR.
Alternate Title:	MARKERS OF BONE REMODELLING AND BONE STRUCTURE AT DIFFERENT LIFE STAGES IN WISTAR RATS.
Authors:	Zeni Coronel, Estefanía M.¹ ezenicoronel@fvet.uba.ar, Bonanno, Marina S.¹, Mascías, Hernán¹, Longo, Morena¹, Zeni, Susana¹, Seijo, Mariana¹
Source:	Actualizaciones en Osteología. may-ago2025, Vol. 21 Issue 2, p138-149. 12p.
Subjects:	BONE remodeling, BONE densitometry, CANCELLOUS bone, BIOMECHANICS, BONE mechanics, LABORATORY rats, BONE metabolism, AGE groups
Abstract (English):	Introduction: bone mass undergoes dynamic changes throughout growth. The objective was to evaluate variations in bone remodeling markers, trabecular microarchitecture, and densitometric and biomechanical properties of the femur in female Wistar rats. Materials and methods: six age groups were studied (newborn, 21, 45, 90, 105, and 180 days; n=6/group). Serum levels of calcium (Ca), phosphorus (Pi), osteocalcin (OCN), and C-terminal telopeptide of type I collagen (CTX) were determined. Bone structure was evaluated by histomorphometry (BV/TV), density (BMDft), and femoral bone mineral content (BMOft) by densitometry (DXA), and biomechanics (CSMI, stiffness, fracture strength, Young’s modulus) by three-point bending test. Results: the results showed that Ca was highest at 21 and 180 days, and the lowest Pi value was observed at 90 days (p<0.05). OCN decreased and CTX increased from 21 to 180 days of age. BV/TV increased significantly from birth to 45 days. DMOft and CMOft increased up to 180 days. Biomechanical properties reached their maximum values in early adulthood. Discussion: taken together, these findings describe the physiological sequence of bone maturation, where bone turnover initially predominates, followed by a phase of structural gain and, finally, mechanical consolidation of the bone. Conclusions: these data may serve as a reference for experimental studies evaluating interventions on bone health during growth. [ABSTRACT FROM AUTHOR]
Abstract (Spanish):	Introducción: la masa ósea experimenta cambios dinámicos a lo largo del crecimiento. El objetivo fue evaluar variaciones en los marcadores de remodelación ósea, la microarquitectura trabecular y las propiedades densitométricas y biomecánicas del fémur en ratas Wistar hembras. Materiales y métodos: se estudiaron seis grupos etarios (recién nacidas, 21, 45, 90, 105 y 180 días; n=6/grupo). Se determinaron los niveles séricos de calcio (Ca), fósforo (Pi) osteocalcina (OCN) y telopéptido C-terminal del colágeno tipo I (CTX); se evaluó la estructura ósea mediante histomorfometría (BV/TV), densidad (DMOft) y contenido mineral óseo femoral (CMOft) mediante densitometría (DXA) y la biomecánica (CSMI, Rigidez, Fuerza de fractura, Módulo de Young) mediante ensayo de flexión a tres puntos. Resultados: los resultados mostraron que el Ca fue más alto a los 21 y 180 días y el menor valor de Pi se observó a los 90 días(p<0.05). La OCN disminuyó y el CTX aumentó desde 21 hasta 180 días de vida. El BV/TV aumentó significativamente desde el nacimiento hasta los 45 días. La DMOft y CMOft aumentaron hasta los 180 días. Las propiedades biomecánicas alcanzaron sus valores máximos en la adultez temprana. Discusión: en conjunto, estos hallazgos describen la secuencia fisiológica de maduración ósea, donde inicialmente predomina el recambio óseo, seguido por una fase de ganancia estructural y, finalmente, la consolidación mecánica del hueso. Conclusión: estos datos pueden servir como referencia para estudios experimentales que evalúen intervenciones sobre la salud ósea durante el crecimiento. [ABSTRACT FROM AUTHOR]
	Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	MedicLatina

Description
Abstract:	Introduction: bone mass undergoes dynamic changes throughout growth. The objective was to evaluate variations in bone remodeling markers, trabecular microarchitecture, and densitometric and biomechanical properties of the femur in female Wistar rats. Materials and methods: six age groups were studied (newborn, 21, 45, 90, 105, and 180 days; n=6/group). Serum levels of calcium (Ca), phosphorus (Pi), osteocalcin (OCN), and C-terminal telopeptide of type I collagen (CTX) were determined. Bone structure was evaluated by histomorphometry (BV/TV), density (BMDft), and femoral bone mineral content (BMOft) by densitometry (DXA), and biomechanics (CSMI, stiffness, fracture strength, Young’s modulus) by three-point bending test. Results: the results showed that Ca was highest at 21 and 180 days, and the lowest Pi value was observed at 90 days (p<0.05). OCN decreased and CTX increased from 21 to 180 days of age. BV/TV increased significantly from birth to 45 days. DMOft and CMOft increased up to 180 days. Biomechanical properties reached their maximum values in early adulthood. Discussion: taken together, these findings describe the physiological sequence of bone maturation, where bone turnover initially predominates, followed by a phase of structural gain and, finally, mechanical consolidation of the bone. Conclusions: these data may serve as a reference for experimental studies evaluating interventions on bone health during growth. [ABSTRACT FROM AUTHOR]
ISSN:	16698975