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Índice neutrófilo-linfocito y retinopatía en pacientes con diabetes mellitus tipo 2.

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Title: Índice neutrófilo-linfocito y retinopatía en pacientes con diabetes mellitus tipo 2.
Alternate Title: Neutrophil-lymphocyte ratio and retinopathy in patients with type 2 diabetes mellitus.
Authors: Cuevas-Acuña, María Tula1 maritca71@hotmail.com, Jiménez-Sánchez, José Alfredo2, Rosano-Carrasco, Ismael3
Source: Revista Medica del IMSS. may/jun2026, Vol. 64 Issue 3, p1-6. 6p.
Subjects: NEUTROPHIL lymphocyte ratio, DIABETIC retinopathy, INFLAMMATION, TYPE 2 diabetes, BLOOD sugar, BIOMARKERS, GLYCEMIC control
Abstract (English): Background: Diabetic retinopathy is a complication of type 2 diabetes mellitus. Inadequate glycemic control can promote a chronic inflammatory state. The Neutrophil-lymphocyte ratio has been used as a marker of systemic inflammation. Objective: To correlate the Neutrophil-lymphocyte ratio with the degree of retinopathy in patients with type 2 diabetes mellitus. Material and methods: Cross-sectional and analytical study. Patients with type 2 diabetes mellitus were included. The degree of retinopathy, glucose level, HbA1C, and neutrophil and lymphocyte counts were investigated to calculate the Neutrophil-lymphocyte ratio. To test the hypothesis, Fisher’s exact test, Mann Whitney U, Kruskal-Wallis, and Spearman’s Rho were used in the statistical analysis. A p < 0.05 was considered statistically significant. Results: 50 patients were included; their age was 65 ± 10 years. The mean Neutrophil-lymphocyte ratio was 2.5 ± 1.1. Mild nonproliferative retinopathy was present in 56% of the patients, moderate nonproliferative retinopathy in 14%, and high-risk proliferative retinopathy in 30%. A positive correlation was found between the Neutrophil-lymphocyte ratio and the degree of retinopathy (r = 0.532) (p = 0.000). Conclusions: Type 2 diabetes mellitus patients with a higher degree of diabetic retinopathy had a higher Neutrophillymphocyte ratio. A positive correlation was found between the Neutrophil-lymphocyte ratio and the degree of diabetic retinopathy. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: la retinopatía diabética es una complicación de la diabetes mellitus tipo 2. Un inadecuado control glucémico puede favorecer un estado inflamatorio crónico. El Índice neutrófilo-linfocito se ha utilizado como marcador de inflamación sistémica. Objetivo: correlacionar el Índice neutrófilo-linfocito con el grado de retinopatía en pacientes con diabetes mellitus tipo 2. Material y métodos: estudio transversal y analítico. Se incluyeron pacientes con diabetes mellitus tipo 2. Se investigó el grado de retinopatía, la cifra de glucosa, la HbA1C y el recuento de neutrófilos y linfocitos para calcular el Índice neutrófilo-linfocito. Para comprobar la hipótesis, en el análisis estadístico se utilizó prueba exacta de Fisher, U de Mann-Whitney, Kruskal-Wallis y Rho de Spearman. Se consideró significación estadística con una p < 0.05. Resultados: Se incluyeron 50 pacientes; edad 65 ± 10 años. La media del Índice neutrófilo-linfocito fue de 2.5 ± 1.1. El 56% de los pacientes presentó retinopatía no proliferativa leve, 14% no proliferativa moderada y 30% proliferativa de alto riesgo; se encontró correlación positiva entre el Índice neutrófilo-linfocito y el grado de retinopatía, r = 0.532 (p = 0.000). Conclusiones: los pacientes con diabetes mellitus tipo 2 con un mayor grado de retinopatía diabética presentaron un Índice neutrófilo-linfocito más elevado. Se encontró correlación positiva entre el Índice neutrófilo-linfocito y el grado de retinopatía diabética. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Background: Diabetic retinopathy is a complication of type 2 diabetes mellitus. Inadequate glycemic control can promote a chronic inflammatory state. The Neutrophil-lymphocyte ratio has been used as a marker of systemic inflammation. Objective: To correlate the Neutrophil-lymphocyte ratio with the degree of retinopathy in patients with type 2 diabetes mellitus. Material and methods: Cross-sectional and analytical study. Patients with type 2 diabetes mellitus were included. The degree of retinopathy, glucose level, HbA1C, and neutrophil and lymphocyte counts were investigated to calculate the Neutrophil-lymphocyte ratio. To test the hypothesis, Fisher’s exact test, Mann Whitney U, Kruskal-Wallis, and Spearman’s Rho were used in the statistical analysis. A p < 0.05 was considered statistically significant. Results: 50 patients were included; their age was 65 ± 10 years. The mean Neutrophil-lymphocyte ratio was 2.5 ± 1.1. Mild nonproliferative retinopathy was present in 56% of the patients, moderate nonproliferative retinopathy in 14%, and high-risk proliferative retinopathy in 30%. A positive correlation was found between the Neutrophil-lymphocyte ratio and the degree of retinopathy (r = 0.532) (p = 0.000). Conclusions: Type 2 diabetes mellitus patients with a higher degree of diabetic retinopathy had a higher Neutrophillymphocyte ratio. A positive correlation was found between the Neutrophil-lymphocyte ratio and the degree of diabetic retinopathy. [ABSTRACT FROM AUTHOR]
ISSN:04435117
DOI:10.5281/zenodo.18715301