Enfermedad renal crónica de causas desconocidas en Mesoamérica. Análisis desde la perspectiva de la medicina geológica.
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| Title: | Enfermedad renal crónica de causas desconocidas en Mesoamérica. Análisis desde la perspectiva de la medicina geológica. |
|---|---|
| Alternate Title: | Chronic Kidney Disease of Unknown Causes in Mesoamerica. An Approach from the Perspective of Medical Geology. |
| Authors: | Montero-Campos, Virginia1 vmontero@itcr.ac.cr, Estrada-Zeledón, Javier A.2, Blanco-Castro, Diego3 |
| Source: | Nefrologia. Jun/Jul2026, Vol. 46 Issue 6, p1-8. 8p. |
| Subjects: | HEAVY metals, SANDY soils, MEDICAL geography, CHRONIC kidney failure, ENVIRONMENTAL risk, EPIDEMIOLOGY, PHYSIOGRAPHIC provinces, NEPHROTOXICOLOGY |
| Geographic Terms: | MESOAMERICAN region |
| Abstract (English): | In Mesoamerica, new cases of chronic kidney disease of unknown cause (CKDu) are increasing each year, including those requiring renal replacement therapy and deaths from this cause. It tends to manifest in younger people, who present symptoms late, in stages 4 and 5. Geographically, cases occur in specific well- recognized areas of Mesoamerica: low-lying areas associated with the Pacific coast, warm and dry regions with high wind traffic, volcanic activity and sandy soils. This comprehensive review was conducted without the use of generative AI (artificial intelligence) to provide novel criteria regarding potential environmental and epidemiological risk factors currently recognized in the global scientific literature. The factors investigated were approached from the novel perspective of medical geology, which addresses the risk to populations affected by different environmental variables specific to their living environment, presenting a similar risk under the same exposure scenario. According to the literature found related to CKDu, it is suggested that nephrotoxic heavy metals in medium and low doses present in sandy soils, typical of the specific areas of high prevalence of the disease in Mesoamerica, India and Sri Lanka contribute with genotoxic and epigenetic damage from various perspectives as common causal agents, which were quantified in some sites of prevalence of the disease. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | En Mesoamérica, los nuevos casos de enfermedad renal crónica de causas desconocidas (ERCcd) aumentan cada año, incluyendo las personas que necesitan terapia renal sustitutiva y las muertes por esta causa, con tendencia a manifestarse en personas de menor edad que presentan sintomatología de manera tardía en estados 4 y 5. Desde el punto de vista geográfico, los casos se presentan en zonas puntuales ya reconocidas de Mesoamérica, los cuales son lugares de baja altura asociados a la costa pacífica, zonas cálidas y secas, de alto tráfico de viento, asociadas a volcanes y de suelos de tipo arenoso. La presente revisión se realizó de forma exhaustiva, sin uso de IA (inteligencia artificial) generativa, con el objetivo de proporcionar criterios novedosos, sobre posibles factores de riesgo ambientales y epidemiológicos actualmente reconocidos en la literatura científica mundial. Los factores investigados fueron abordados desde la novedosa perspectiva de la medicina geológica, la cual se refiere al abordaje del riesgo de las poblaciones afectadas por diferentes variables ambientales propias del entorno donde viven, presentándose bajo un mismo riesgo en un escenario de exposición. De acuerdo con la literatura encontrada relacionada con ERCcd, se sugiere que metales pesados de naturaleza nefrotóxica en dosis medias y bajas presentes en los suelos arenosos, propios de las zonas específicas de alta prevalencia de la enfermedad en Mesoamérica, India y Sri Lanka, contribuyen con daño genotóxico y epigenético desde diversas perspectivas como agentes causales comunes, los cuales fueron cuantificados en algunos sitios de prevalencia de la enfermedad. [ABSTRACT FROM AUTHOR] |
| Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
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| Header | DbId: lth DbLabel: MedicLatina An: 194059860 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Enfermedad renal crónica de causas desconocidas en Mesoamérica. Análisis desde la perspectiva de la medicina geológica. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: Chronic Kidney Disease of Unknown Causes in Mesoamerica. An Approach from the Perspective of Medical Geology. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Montero-Campos%2C+Virginia%22">Montero-Campos, Virginia</searchLink><relatesTo>1</relatesTo><i> vmontero@itcr.ac.cr</i><br /><searchLink fieldCode="AR" term="%22Estrada-Zeledón%2C+Javier+A%2E%22">Estrada-Zeledón, Javier A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Blanco-Castro%2C+Diego%22">Blanco-Castro, Diego</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nefrologia%22">Nefrologia</searchLink>. Jun/Jul2026, Vol. 46 Issue 6, p1-8. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22HEAVY+metals%22">HEAVY metals</searchLink><br /><searchLink fieldCode="DE" term="%22SANDY+soils%22">SANDY soils</searchLink><br /><searchLink fieldCode="DE" term="%22MEDICAL+geography%22">MEDICAL geography</searchLink><br /><searchLink fieldCode="DE" term="%22CHRONIC+kidney+failure%22">CHRONIC kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22ENVIRONMENTAL+risk%22">ENVIRONMENTAL risk</searchLink><br /><searchLink fieldCode="DE" term="%22EPIDEMIOLOGY%22">EPIDEMIOLOGY</searchLink><br /><searchLink fieldCode="DE" term="%22PHYSIOGRAPHIC+provinces%22">PHYSIOGRAPHIC provinces</searchLink><br /><searchLink fieldCode="DE" term="%22NEPHROTOXICOLOGY%22">NEPHROTOXICOLOGY</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22MESOAMERICAN+region%22">MESOAMERICAN region</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: In Mesoamerica, new cases of chronic kidney disease of unknown cause (CKDu) are increasing each year, including those requiring renal replacement therapy and deaths from this cause. It tends to manifest in younger people, who present symptoms late, in stages 4 and 5. Geographically, cases occur in specific well- recognized areas of Mesoamerica: low-lying areas associated with the Pacific coast, warm and dry regions with high wind traffic, volcanic activity and sandy soils. This comprehensive review was conducted without the use of generative AI (artificial intelligence) to provide novel criteria regarding potential environmental and epidemiological risk factors currently recognized in the global scientific literature. The factors investigated were approached from the novel perspective of medical geology, which addresses the risk to populations affected by different environmental variables specific to their living environment, presenting a similar risk under the same exposure scenario. According to the literature found related to CKDu, it is suggested that nephrotoxic heavy metals in medium and low doses present in sandy soils, typical of the specific areas of high prevalence of the disease in Mesoamerica, India and Sri Lanka contribute with genotoxic and epigenetic damage from various perspectives as common causal agents, which were quantified in some sites of prevalence of the disease. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: En Mesoamérica, los nuevos casos de enfermedad renal crónica de causas desconocidas (ERCcd) aumentan cada año, incluyendo las personas que necesitan terapia renal sustitutiva y las muertes por esta causa, con tendencia a manifestarse en personas de menor edad que presentan sintomatología de manera tardía en estados 4 y 5. Desde el punto de vista geográfico, los casos se presentan en zonas puntuales ya reconocidas de Mesoamérica, los cuales son lugares de baja altura asociados a la costa pacífica, zonas cálidas y secas, de alto tráfico de viento, asociadas a volcanes y de suelos de tipo arenoso. La presente revisión se realizó de forma exhaustiva, sin uso de IA (inteligencia artificial) generativa, con el objetivo de proporcionar criterios novedosos, sobre posibles factores de riesgo ambientales y epidemiológicos actualmente reconocidos en la literatura científica mundial. Los factores investigados fueron abordados desde la novedosa perspectiva de la medicina geológica, la cual se refiere al abordaje del riesgo de las poblaciones afectadas por diferentes variables ambientales propias del entorno donde viven, presentándose bajo un mismo riesgo en un escenario de exposición. De acuerdo con la literatura encontrada relacionada con ERCcd, se sugiere que metales pesados de naturaleza nefrotóxica en dosis medias y bajas presentes en los suelos arenosos, propios de las zonas específicas de alta prevalencia de la enfermedad en Mesoamérica, India y Sri Lanka, contribuyen con daño genotóxico y epigenético desde diversas perspectivas como agentes causales comunes, los cuales fueron cuantificados en algunos sitios de prevalencia de la enfermedad. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.nefro.2026.501533 Languages: – Code: spa Text: Spanish PhysicalDescription: Pagination: PageCount: 8 StartPage: 1 Subjects: – SubjectFull: HEAVY metals Type: general – SubjectFull: SANDY soils Type: general – SubjectFull: MEDICAL geography Type: general – SubjectFull: CHRONIC kidney failure Type: general – SubjectFull: ENVIRONMENTAL risk Type: general – SubjectFull: EPIDEMIOLOGY Type: general – SubjectFull: PHYSIOGRAPHIC provinces Type: general – SubjectFull: NEPHROTOXICOLOGY Type: general – SubjectFull: MESOAMERICAN region Type: general Titles: – TitleFull: Enfermedad renal crónica de causas desconocidas en Mesoamérica. Análisis desde la perspectiva de la medicina geológica. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Montero-Campos, Virginia – PersonEntity: Name: NameFull: Estrada-Zeledón, Javier A. – PersonEntity: Name: NameFull: Blanco-Castro, Diego IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun/Jul2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 02116995 Numbering: – Type: volume Value: 46 – Type: issue Value: 6 Titles: – TitleFull: Nefrologia Type: main |
| ResultId | 1 |
