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Factores asociados con la adherencia y respuesta al tratamiento en TDAH.

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Title: Factores asociados con la adherencia y respuesta al tratamiento en TDAH.
Alternate Title: Factors associated with ADHD medication adherence and treatment outcomes.
Authors: Temkin, Hali1 (AUTHOR), Daniel, Kerri L.1 (AUTHOR), Martinez, Diana1 (AUTHOR), Bennett, Julia C.1 (AUTHOR), Nix, Paris A.2 (AUTHOR), Nguyen, Linh (AUTHOR), Le, Yen-Chi (AUTHOR), Kluwe-Schiavon, Bruno1 (AUTHOR), Soutullo, Cesar A.1,2 (AUTHOR) Cesar.A.Soutullo@uth.tmc.edu
Source: Medicina (Buenos Aires). 2026 Supplement 1, Vol. 86, p49-57. 9p.
Subjects: PATIENT compliance, DRUG therapy, COMORBIDITY, TREATMENT effectiveness, ATTENTION-deficit hyperactivity disorder, SOCIODEMOGRAPHIC factors, CLINICAL medicine, FAMILY history (Medicine)
Abstract (English): Introduction : Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that affects 5 to 8% of youth and 2.5 to 4% of adults. Pharmacological treatments are among the most effective when treating ADHD, yet adherence to medication is still sub-optimal. We reviewed the literature on clinical and socio de mographic factors that may influence adherence and compared it to our clinical data. Methods : We conducted a targeted literature review on factors associated with ADHD medication adherence. These factors were compared within our sample of pa tients aged 3-18 with ADHD at the Child and Adolescent Mood Disorders Program (ChAMP) at (UT Health) - Houston. We assessed relations between measurement-based care (MBC) and socio demographic factors. Results : We found factors associated with adherence rates included patient age, level of parental involvement, psychiatric comorbidities, familial psychiatric history, and socioeconomic status. ADHD medication adher ence improved and symptom severity decreased over 24 months. Each additional year in age, multiple siblings, and ≥1 parent receiving psychiatric treatment were as sociated with greater symptom severity. Discussion : Results suggest that MBC is a useful method for reducing overall ADHD severity and improv ing medication adherence in children and adolescents. Additionally, MBC programs should consider screening for and addressing family psychiatric history and house hold structure as these relevant factors affect ADHD medication adherence. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción : El Trastorno por Déficit de Atención e Hiperactividad (TDAH) es un trastorno del neurodesa rrollo que afecta al 5-8 % de niños y adolescentes y al 2.5-4% de adultos. El tratamiento farmacológico del TDAH es seguro y eficaz, pero la adherencia al tratamiento es frecuentemente subóptima. Realizamos una revisión de la literatura sobre factores clínicos y socio-demográficos asociados que comparamos con nuestros datos clínicos. Métodos : Revisión bibliográfica dirigida de estudios sobre factores que afectan la adherencia a la medicación en TDAH. Estos factores se compararon en una muestra de pacientes con TDAH, de 3 a 18 años, atendidos en el Programa TDAH y en la Consulta ChAMP de la Univer sidad de Texas-Houston. Evaluamos la asociación entre resultados clínicos en pacientes, medidos mediante un modelo de atención basado en medidas (MBC) y factores socio demográficos. Resultados : Encontramos factores asociados a la adherencia, como edad, grado de implicación parental, comorbilidad psiquiátrica, antecedentes psiquiátricos familiares y nivel socioeconómico. La adherencia al tra tamiento mejoró y la gravedad de síntomas disminuyó a lo largo de 24 meses. Cada año de edad, tener varios hermanos y ≥1 padre recibiendo tratamiento psiquiátrico se asociaron con mayor gravedad de síntomas. Discusión : Nuestros resultados sugieren que la MBC es eficaz para reducir la gravedad global del TDAH y mejorar la adherencia a la medicación en niños y ado lescentes. Además, los programas MBC deberían con siderar la evaluación y tratamiento de antecedentes psiquiátricos familiares y la estructura del hogar, ya que estos factores inciden en la adherencia a la medicación del TDAH. [ABSTRACT FROM AUTHOR]
Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Factores asociados con la adherencia y respuesta al tratamiento en TDAH.
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  Data: Factors associated with ADHD medication adherence and treatment outcomes.
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  Data: <searchLink fieldCode="AR" term="%22Temkin%2C+Hali%22">Temkin, Hali</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Daniel%2C+Kerri+L%2E%22">Daniel, Kerri L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martinez%2C+Diana%22">Martinez, Diana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bennett%2C+Julia+C%2E%22">Bennett, Julia C.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nix%2C+Paris+A%2E%22">Nix, Paris A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Linh%22">Nguyen, Linh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Le%2C+Yen-Chi%22">Le, Yen-Chi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kluwe-Schiavon%2C+Bruno%22">Kluwe-Schiavon, Bruno</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soutullo%2C+Cesar+A%2E%22">Soutullo, Cesar A.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> Cesar.A.Soutullo@uth.tmc.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Medicina+%28Buenos+Aires%29%22">Medicina (Buenos Aires)</searchLink>. 2026 Supplement 1, Vol. 86, p49-57. 9p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22PATIENT+compliance%22">PATIENT compliance</searchLink><br /><searchLink fieldCode="DE" term="%22DRUG+therapy%22">DRUG therapy</searchLink><br /><searchLink fieldCode="DE" term="%22COMORBIDITY%22">COMORBIDITY</searchLink><br /><searchLink fieldCode="DE" term="%22TREATMENT+effectiveness%22">TREATMENT effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22ATTENTION-deficit+hyperactivity+disorder%22">ATTENTION-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22SOCIODEMOGRAPHIC+factors%22">SOCIODEMOGRAPHIC factors</searchLink><br /><searchLink fieldCode="DE" term="%22CLINICAL+medicine%22">CLINICAL medicine</searchLink><br /><searchLink fieldCode="DE" term="%22FAMILY+history+%28Medicine%29%22">FAMILY history (Medicine)</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction : Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that affects 5 to 8% of youth and 2.5 to 4% of adults. Pharmacological treatments are among the most effective when treating ADHD, yet adherence to medication is still sub-optimal. We reviewed the literature on clinical and socio de mographic factors that may influence adherence and compared it to our clinical data. Methods : We conducted a targeted literature review on factors associated with ADHD medication adherence. These factors were compared within our sample of pa tients aged 3-18 with ADHD at the Child and Adolescent Mood Disorders Program (ChAMP) at (UT Health) - Houston. We assessed relations between measurement-based care (MBC) and socio demographic factors. Results : We found factors associated with adherence rates included patient age, level of parental involvement, psychiatric comorbidities, familial psychiatric history, and socioeconomic status. ADHD medication adher ence improved and symptom severity decreased over 24 months. Each additional year in age, multiple siblings, and ≥1 parent receiving psychiatric treatment were as sociated with greater symptom severity. Discussion : Results suggest that MBC is a useful method for reducing overall ADHD severity and improv ing medication adherence in children and adolescents. Additionally, MBC programs should consider screening for and addressing family psychiatric history and house hold structure as these relevant factors affect ADHD medication adherence. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducción : El Trastorno por Déficit de Atención e Hiperactividad (TDAH) es un trastorno del neurodesa rrollo que afecta al 5-8 % de niños y adolescentes y al 2.5-4% de adultos. El tratamiento farmacológico del TDAH es seguro y eficaz, pero la adherencia al tratamiento es frecuentemente subóptima. Realizamos una revisión de la literatura sobre factores clínicos y socio-demográficos asociados que comparamos con nuestros datos clínicos. Métodos : Revisión bibliográfica dirigida de estudios sobre factores que afectan la adherencia a la medicación en TDAH. Estos factores se compararon en una muestra de pacientes con TDAH, de 3 a 18 años, atendidos en el Programa TDAH y en la Consulta ChAMP de la Univer sidad de Texas-Houston. Evaluamos la asociación entre resultados clínicos en pacientes, medidos mediante un modelo de atención basado en medidas (MBC) y factores socio demográficos. Resultados : Encontramos factores asociados a la adherencia, como edad, grado de implicación parental, comorbilidad psiquiátrica, antecedentes psiquiátricos familiares y nivel socioeconómico. La adherencia al tra tamiento mejoró y la gravedad de síntomas disminuyó a lo largo de 24 meses. Cada año de edad, tener varios hermanos y ≥1 padre recibiendo tratamiento psiquiátrico se asociaron con mayor gravedad de síntomas. Discusión : Nuestros resultados sugieren que la MBC es eficaz para reducir la gravedad global del TDAH y mejorar la adherencia a la medicación en niños y ado lescentes. Además, los programas MBC deberían con siderar la evaluación y tratamiento de antecedentes psiquiátricos familiares y la estructura del hogar, ya que estos factores inciden en la adherencia a la medicación del TDAH. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: PATIENT compliance
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              Text: 2026 Supplement 1
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