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The multiple faces of dementia: a study of Alzheimer's, vascular dementia, and frontotemporal dementia.

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Title: The multiple faces of dementia: a study of Alzheimer's, vascular dementia, and frontotemporal dementia.
Alternate Title: Las múltiples caras de la demencia: un estudio de la demencia de Alzheimer, la demencia vascular y la demencia frontotemporal.
Authors: Pérez-García, Iker P.1 dr.ikerparis@gmail.com, Prieto-Palacios, María G. S.2, Basilio-Díaz, Sara3, Gómez-Pérez, Ricardo4, Salgado-Alemán, Yoko M.4, Valdez-Domínguez, Fernando3, Velázquez-Garita, María F.4
Source: Revista Mexicana de Neurociencia. May/Jun2026, Vol. 27 Issue 3, p145-159. 15p.
Subjects: ALZHEIMER'S disease, VASCULAR dementia, COGNITION disorders, THERAPEUTICS, DEMENTIA, FRONTOTEMPORAL dementia, DIAGNOSIS, DISEASE risk factors
Abstract (English): This narrative review explores dementia, a multifaceted clinical syndrome of neurodegenerative or vascular origin characterized by progressive cognitive decline affecting autonomy and quality of life. Given its rising global prevalence, particularly in developing countries, and the absence of a curative treatment, understanding this condition is of paramount importance. A structured but non-systematic search was conducted in PubMed, Scopus, and ScienceDirect for studies published between 2015 and 2025, focusing on systematic reviews, meta-analyses, clinical guidelines, and original research in English or Spanish. After applying inclusion and exclusion criteria, 50 high-quality studies were included. This review addresses key aspects, including modifiable and non-modifiable risk factors such as education, physical inactivity, hypertension, and pollution, as well as associated pathologies such as type 2 diabetes and traumatic brain injury. It delves into the distinct characteristics, pathophysiology, and clinical stages of Alzheimer's disease, vascular dementia, and frontotemporal dementia. This document also discusses diagnostic challenges and current symptomatic treatment approaches, emphasizing the critical role of prevention and early non-pharmacological interventions to improve patient outcomes and quality of life. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Esta revisión narrativa explora la demencia, un síndrome clínico multifacético de origen neurodegenerativo o vascular, caracterizado por un deterioro cognitivo progresivo que afecta la autonomía y la calidad de vida. Dada su creciente prevalencia mundial, especialmente en los países en desarrollo, y la ausencia de un tratamiento curativo, comprender esta condición resulta de suma importancia. Se realizó una búsqueda estructurada pero no sistemática en las bases de datos PubMed, Scopus y ScienceDirect, para identificar estudios publicados entre 2015 y 2025, con énfasis en revisiones sistemáticas, metaanálisis, guías clínicas y artículos originales en inglés o español. Tras aplicar los criterios de inclusión y exclusión, se incluyeron 50 estudios de alta calidad. Esta revisión aborda aspectos clave, entre ellos los factores de riesgo modificables y no modificables, como el nivel educativo, la inactividad física, la hipertensión arterial y la contaminación ambiental, así como patologías asociadas como la diabetes mellitus tipo 2 y el traumatismo craneoencefálico. Asimismo, analiza las características distintivas, la fisiopatología y las etapas clínicas de la enfermedad de Alzheimer, la demencia vascular y la demencia frontotemporal. Finalmente, se discuten los desafíos diagnósticos y los enfoques actuales de tratamiento sintomático, destacando el papel crítico de la prevención y de las intervenciones no farmacológicas tempranas para mejorar los resultados clínicos y la calidad de vida de los pacientes. [ABSTRACT FROM AUTHOR]
Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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  Data: The multiple faces of dementia: a study of Alzheimer's, vascular dementia, and frontotemporal dementia.
– Name: TitleAlt
  Label: Alternate Title
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  Data: Las múltiples caras de la demencia: un estudio de la demencia de Alzheimer, la demencia vascular y la demencia frontotemporal.
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  Data: <searchLink fieldCode="AR" term="%22Pérez-García%2C+Iker+P%2E%22">Pérez-García, Iker P.</searchLink><relatesTo>1</relatesTo><i> dr.ikerparis@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Prieto-Palacios%2C+María+G%2E+S%2E%22">Prieto-Palacios, María G. S.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Basilio-Díaz%2C+Sara%22">Basilio-Díaz, Sara</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Gómez-Pérez%2C+Ricardo%22">Gómez-Pérez, Ricardo</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Salgado-Alemán%2C+Yoko+M%2E%22">Salgado-Alemán, Yoko M.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Valdez-Domínguez%2C+Fernando%22">Valdez-Domínguez, Fernando</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Velázquez-Garita%2C+María+F%2E%22">Velázquez-Garita, María F.</searchLink><relatesTo>4</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Revista+Mexicana+de+Neurociencia%22">Revista Mexicana de Neurociencia</searchLink>. May/Jun2026, Vol. 27 Issue 3, p145-159. 15p.
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  Data: <searchLink fieldCode="DE" term="%22ALZHEIMER'S+disease%22">ALZHEIMER'S disease</searchLink><br /><searchLink fieldCode="DE" term="%22VASCULAR+dementia%22">VASCULAR dementia</searchLink><br /><searchLink fieldCode="DE" term="%22COGNITION+disorders%22">COGNITION disorders</searchLink><br /><searchLink fieldCode="DE" term="%22THERAPEUTICS%22">THERAPEUTICS</searchLink><br /><searchLink fieldCode="DE" term="%22DEMENTIA%22">DEMENTIA</searchLink><br /><searchLink fieldCode="DE" term="%22FRONTOTEMPORAL+dementia%22">FRONTOTEMPORAL dementia</searchLink><br /><searchLink fieldCode="DE" term="%22DIAGNOSIS%22">DIAGNOSIS</searchLink><br /><searchLink fieldCode="DE" term="%22DISEASE+risk+factors%22">DISEASE risk factors</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: This narrative review explores dementia, a multifaceted clinical syndrome of neurodegenerative or vascular origin characterized by progressive cognitive decline affecting autonomy and quality of life. Given its rising global prevalence, particularly in developing countries, and the absence of a curative treatment, understanding this condition is of paramount importance. A structured but non-systematic search was conducted in PubMed, Scopus, and ScienceDirect for studies published between 2015 and 2025, focusing on systematic reviews, meta-analyses, clinical guidelines, and original research in English or Spanish. After applying inclusion and exclusion criteria, 50 high-quality studies were included. This review addresses key aspects, including modifiable and non-modifiable risk factors such as education, physical inactivity, hypertension, and pollution, as well as associated pathologies such as type 2 diabetes and traumatic brain injury. It delves into the distinct characteristics, pathophysiology, and clinical stages of Alzheimer's disease, vascular dementia, and frontotemporal dementia. This document also discusses diagnostic challenges and current symptomatic treatment approaches, emphasizing the critical role of prevention and early non-pharmacological interventions to improve patient outcomes and quality of life. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Esta revisión narrativa explora la demencia, un síndrome clínico multifacético de origen neurodegenerativo o vascular, caracterizado por un deterioro cognitivo progresivo que afecta la autonomía y la calidad de vida. Dada su creciente prevalencia mundial, especialmente en los países en desarrollo, y la ausencia de un tratamiento curativo, comprender esta condición resulta de suma importancia. Se realizó una búsqueda estructurada pero no sistemática en las bases de datos PubMed, Scopus y ScienceDirect, para identificar estudios publicados entre 2015 y 2025, con énfasis en revisiones sistemáticas, metaanálisis, guías clínicas y artículos originales en inglés o español. Tras aplicar los criterios de inclusión y exclusión, se incluyeron 50 estudios de alta calidad. Esta revisión aborda aspectos clave, entre ellos los factores de riesgo modificables y no modificables, como el nivel educativo, la inactividad física, la hipertensión arterial y la contaminación ambiental, así como patologías asociadas como la diabetes mellitus tipo 2 y el traumatismo craneoencefálico. Asimismo, analiza las características distintivas, la fisiopatología y las etapas clínicas de la enfermedad de Alzheimer, la demencia vascular y la demencia frontotemporal. Finalmente, se discuten los desafíos diagnósticos y los enfoques actuales de tratamiento sintomático, destacando el papel crítico de la prevención y de las intervenciones no farmacológicas tempranas para mejorar los resultados clínicos y la calidad de vida de los pacientes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=194249341
RecordInfo BibRecord:
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        Value: 10.24875/RMN.25000048
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        Text: English
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        StartPage: 145
    Subjects:
      – SubjectFull: ALZHEIMER'S disease
        Type: general
      – SubjectFull: VASCULAR dementia
        Type: general
      – SubjectFull: COGNITION disorders
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      – SubjectFull: THERAPEUTICS
        Type: general
      – SubjectFull: DEMENTIA
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      – SubjectFull: FRONTOTEMPORAL dementia
        Type: general
      – SubjectFull: DIAGNOSIS
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      – SubjectFull: DISEASE risk factors
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              Text: May/Jun2026
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