Strongyloides stercoralis infection alters liver enzyme levels in alcoholic patients.
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| Title: | Strongyloides stercoralis infection alters liver enzyme levels in alcoholic patients. |
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| Alternate Title: | La infección por Strongyloides stercoralis altera los niveles de las enzimas hepáticas de pacientes alcohólicos. |
| Authors: | de Souza, Joelma Nascimento1, Costa Araújo, Weslei Almeida1, de Souza, Alex Bruno1, Aquino Teixeira, Márcia Cristina1, Soares, Neci Matos1 necisoares@gmail.com |
| Source: | Biomédica: Revista del Instituto Nacional de Salud. jun2026, Vol. 46 Issue 2, p246-253. 8p. |
| Subjects: | LIVER enzymes, STRONGYLOIDIASIS, PEOPLE with alcoholism, BIOMARKERS, WORMS, IMMUNOGLOBULIN E, INFECTION |
| Abstract (English): | Introduction. Strongyloides stercoralis infection can develop into a severe and lifethreatening condition in high-risk groups, such as alcoholics. However, few studies assess the effect of these comorbidities on patients’ health. Objective. To evaluate hematological, biochemical and hepatic biomarkers and the production of total immunoglobulin E in alcoholic patients infected with S. stercoralis. Materials and methods. This was a case-control study involving 240 alcoholic patients, 60 infected and 180 non-infected with S. stercoralis. Evaluation of blood biomarkers was performed using automated methods, commercial kits, or nephelometry. Results. A high frequency of low hemoglobin content was observed among alcoholics, but there was no significant difference between the infected and non-infected groups, 65.0% (39/60) and 62.8% (113/180), respectively. The frequency of eosinophilia, 58.3 % (35/60) and 26.1% (47/180) and the total immunoglobulin E concentration, 2882 and 1400 IU/ml, were significantly higher (p < 0.05) in S. stercoralis-infected than in non-infected individuals. ALT and AST levels were high in both groups compared to the reference values. However, the infected group presented lower AST levels, 61.5 ± 38.4 and 84.3 ± 84.6 U/L, and a lower frequency of individuals with high ALT levels, 26.7% (16/60) and 40.5% (73/180), respectively (p < 0.05). Moreover, AST levels were higher in individuals with a parasite load above 100 larvae/g of feces compared to those with less than 10 larvae/g of feces, 90.80 ± 39.9 and 56.42 ± 31.9 U/L (p < 0.05), respectively. A similar result was found for ALT. Conclusions. This study showed fewer alterations in liver enzyme levels in S. stercoralisinfected alcoholic patients compared to non-infected alcoholic patients, an effect that may depend on the parasite load. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Introducción. La estrongiloidiasis puede convertirse en una enfermedad grave en grupos de alto riesgo, como los alcohólicos. Sin embargo, pocos estudios evalúan el efecto de esta comorbilidad en la salud de los individuos. Objetivo. Evaluar biomarcadores hematológicos, bioquímicos y hepáticos y la producción de inmunoglobulina E total en pacientes alcohólicos infectados con S. stercoralis. Materiales y métodos. Se trata de un estudio de casos y controles con 240 pacientes alcohólicos, 60 infectados y 180 no infectados con S. stercoralis. Los biomarcadores sanguíneos se evaluaron mediante métodos automatizados, kits comerciales o nefelometría. Resultados. Se observó una alta frecuencia de alcohólicos con anemia, sin diferencia entre los grupos infectados y los no infectados, 65,0 % (39/60) y 62,8 % (113/180), respectivamente. La frecuencia de eosinofilia, 58,3 (35/60) y 26,1 % (47/180) y la concentración total de inmunoglobulina E, 2882 y 1400 UI/ml, fueron significativamente mayores (p < 0,05) en los individuos infectados con S. stercoralis en comparación con los no infectados. Los niveles de ALT y AST estuvieron elevados en ambos grupos. Sin embargo, en el grupo infectado se encontraron niveles más bajos de AST, 61,5 ± 38,4 comparado con 84,3 ± 84,6 U/L en no infectados y una menor frecuencia de individuos con niveles elevados de ALT, 26,7 % (16/60) comparado con 40,5 % (73/180) en pacientes infectados. Además, los niveles de AST fueron mayores en individuos con una carga parasitaria superior a 100 larvas/g de heces, en comparación con aquellos con una menor carga parasitaria (90,80 ± 39,9 y 56,42 ± 31,9 U/L (p < 0,05), respectivamente). Conclusiones: Este estudio demuestra una menor alteración de las enzimas hepáticas en alcohólicos infectados con S. stercoralis, lo cual podría depender de la carga parasitaria. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Strongyloides stercoralis infection alters liver enzyme levels in alcoholic patients. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: La infección por Strongyloides stercoralis altera los niveles de las enzimas hepáticas de pacientes alcohólicos. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22de+Souza%2C+Joelma+Nascimento%22">de Souza, Joelma Nascimento</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Costa+Araújo%2C+Weslei+Almeida%22">Costa Araújo, Weslei Almeida</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Souza%2C+Alex+Bruno%22">de Souza, Alex Bruno</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Aquino+Teixeira%2C+Márcia+Cristina%22">Aquino Teixeira, Márcia Cristina</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Soares%2C+Neci+Matos%22">Soares, Neci Matos</searchLink><relatesTo>1</relatesTo><i> necisoares@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomédica%3A+Revista+del+Instituto+Nacional+de+Salud%22">Biomédica: Revista del Instituto Nacional de Salud</searchLink>. jun2026, Vol. 46 Issue 2, p246-253. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22LIVER+enzymes%22">LIVER enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22STRONGYLOIDIASIS%22">STRONGYLOIDIASIS</searchLink><br /><searchLink fieldCode="DE" term="%22PEOPLE+with+alcoholism%22">PEOPLE with alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br /><searchLink fieldCode="DE" term="%22WORMS%22">WORMS</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOGLOBULIN+E%22">IMMUNOGLOBULIN E</searchLink><br /><searchLink fieldCode="DE" term="%22INFECTION%22">INFECTION</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Introduction. Strongyloides stercoralis infection can develop into a severe and lifethreatening condition in high-risk groups, such as alcoholics. However, few studies assess the effect of these comorbidities on patients’ health. Objective. To evaluate hematological, biochemical and hepatic biomarkers and the production of total immunoglobulin E in alcoholic patients infected with S. stercoralis. Materials and methods. This was a case-control study involving 240 alcoholic patients, 60 infected and 180 non-infected with S. stercoralis. Evaluation of blood biomarkers was performed using automated methods, commercial kits, or nephelometry. Results. A high frequency of low hemoglobin content was observed among alcoholics, but there was no significant difference between the infected and non-infected groups, 65.0% (39/60) and 62.8% (113/180), respectively. The frequency of eosinophilia, 58.3 % (35/60) and 26.1% (47/180) and the total immunoglobulin E concentration, 2882 and 1400 IU/ml, were significantly higher (p < 0.05) in S. stercoralis-infected than in non-infected individuals. ALT and AST levels were high in both groups compared to the reference values. However, the infected group presented lower AST levels, 61.5 ± 38.4 and 84.3 ± 84.6 U/L, and a lower frequency of individuals with high ALT levels, 26.7% (16/60) and 40.5% (73/180), respectively (p < 0.05). Moreover, AST levels were higher in individuals with a parasite load above 100 larvae/g of feces compared to those with less than 10 larvae/g of feces, 90.80 ± 39.9 and 56.42 ± 31.9 U/L (p < 0.05), respectively. A similar result was found for ALT. Conclusions. This study showed fewer alterations in liver enzyme levels in S. stercoralisinfected alcoholic patients compared to non-infected alcoholic patients, an effect that may depend on the parasite load. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Introducción. La estrongiloidiasis puede convertirse en una enfermedad grave en grupos de alto riesgo, como los alcohólicos. Sin embargo, pocos estudios evalúan el efecto de esta comorbilidad en la salud de los individuos. Objetivo. Evaluar biomarcadores hematológicos, bioquímicos y hepáticos y la producción de inmunoglobulina E total en pacientes alcohólicos infectados con S. stercoralis. Materiales y métodos. Se trata de un estudio de casos y controles con 240 pacientes alcohólicos, 60 infectados y 180 no infectados con S. stercoralis. Los biomarcadores sanguíneos se evaluaron mediante métodos automatizados, kits comerciales o nefelometría. Resultados. Se observó una alta frecuencia de alcohólicos con anemia, sin diferencia entre los grupos infectados y los no infectados, 65,0 % (39/60) y 62,8 % (113/180), respectivamente. La frecuencia de eosinofilia, 58,3 (35/60) y 26,1 % (47/180) y la concentración total de inmunoglobulina E, 2882 y 1400 UI/ml, fueron significativamente mayores (p < 0,05) en los individuos infectados con S. stercoralis en comparación con los no infectados. Los niveles de ALT y AST estuvieron elevados en ambos grupos. Sin embargo, en el grupo infectado se encontraron niveles más bajos de AST, 61,5 ± 38,4 comparado con 84,3 ± 84,6 U/L en no infectados y una menor frecuencia de individuos con niveles elevados de ALT, 26,7 % (16/60) comparado con 40,5 % (73/180) en pacientes infectados. Además, los niveles de AST fueron mayores en individuos con una carga parasitaria superior a 100 larvas/g de heces, en comparación con aquellos con una menor carga parasitaria (90,80 ± 39,9 y 56,42 ± 31,9 U/L (p < 0,05), respectivamente). Conclusiones: Este estudio demuestra una menor alteración de las enzimas hepáticas en alcohólicos infectados con S. stercoralis, lo cual podría depender de la carga parasitaria. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7705/biomedica.7735 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 246 Subjects: – SubjectFull: LIVER enzymes Type: general – SubjectFull: STRONGYLOIDIASIS Type: general – SubjectFull: PEOPLE with alcoholism Type: general – SubjectFull: BIOMARKERS Type: general – SubjectFull: WORMS Type: general – SubjectFull: IMMUNOGLOBULIN E Type: general – SubjectFull: INFECTION Type: general Titles: – TitleFull: Strongyloides stercoralis infection alters liver enzyme levels in alcoholic patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: de Souza, Joelma Nascimento – PersonEntity: Name: NameFull: Costa Araújo, Weslei Almeida – PersonEntity: Name: NameFull: de Souza, Alex Bruno – PersonEntity: Name: NameFull: Aquino Teixeira, Márcia Cristina – PersonEntity: Name: NameFull: Soares, Neci Matos IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: jun2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 01204157 Numbering: – Type: volume Value: 46 – Type: issue Value: 2 Titles: – TitleFull: Biomédica: Revista del Instituto Nacional de Salud Type: main |
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