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The effect of ethyl pyruvate administration on intestinal mucosal damage in neonatal rat models of necrotizing enterocolitis.

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Title: The effect of ethyl pyruvate administration on intestinal mucosal damage in neonatal rat models of necrotizing enterocolitis.
Alternate Title: Efecto de la administración de piruvato de etilo sobre el daño de la mucosa intestinal en modelos de enterocolitis necrosante en ratas neonatas.
Authors: Merve-Orbay, Tugce1 (AUTHOR) orbaymerve@gmail.com, Celayir, Aysenur1 (AUTHOR), Yavuz, Hulya2 (AUTHOR)
Source: Cirugía y Cirujanos. may/jun2026, Vol. 94 Issue 3, p261-269. 9p.
Subjects: Neonatal necrotizing enterocolitis, Intestinal injuries, Biomarkers, Pyruvates, Animal models in research, Anti-inflammatory agents, Intraperitoneal injections
Abstract (English): Objective: The purpose of this study was to determine whether intraperitoneal administration of ethyl pyruvate (EP) affects intestinal mucosal damage in neonatal rats with a model of necrotizing enterocolitis (NEC). Methods: The study comprised 46 Sprague-Dawley newborn rats delivered on the 21st gestational day. The rats were divided into four groups: Sham Group (n = 10), EP Group (n = 10), NEC Group (n = 13), and NEC + EP Group (n = 13). Results: The mean body weights of rats in Sham and EP groups significantly increased (p < 0.05), whereas those in NEC groups significantly decreased (p < 0.05). The changes were similar between groups (p > 0.05). There was no significant difference in the clinical sickness score (CSS) between groups (p > 0.05). The CSS in the NEC groups showed an increase from day 1 to day 4. Based on the histopathological grading, there was a statistically significant difference (p < 0.001) observed between the Sham Group, the NEC Group, and the NEC + EP Group. The differences in biochemical values among the other groups were found to be statistically significant (p < 0.05) for all variables. Conclusions: The application of EP in high-mortality diseases such as NEC is expected to reduce surgical needs, establishing a basis for future studies on EP as an innovative anti-inflammatory agent. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Determinar si la administración intraperitoneal de piruvato de etilo (PE) afecta al daño de la mucosa intestinal en ratas neonatas con un modelo de enterocolitis necrosante (ECN). Métodos: El estudio incluyó 46 ratas recién nacidas Sprague-Dawley entregadas en el día gestacional 21. Las ratas se dividieron en cuatro grupos: grupo simulado (n = 10), grupo PE (n = 10), grupo ECN (n = 13) y grupo ECN + PE (n = 13). Resultados: El peso corporal medio de las ratas en los grupos simulado y PE aumentó significativamente (p < 0.05), mientras que en los grupos ECN disminuyó significativamente (p < 0.05). Los cambios fueron similares entre grupos (p > 0.05). No hubo diferencia significativa en el puntuación clínica de enfermedad (PCE) entre grupos (p > 0.05). El CSS en los grupos ECN mostró un aumento del día 1 al día 4. Según la clasificación histopatológica, se observó una diferencia estadísticamente significativa (p < 0.001) entre el grupo simulado, el grupo ECN y el grupo ECN + PE. Las diferencias en los valores bioquímicos entre los otros grupos resultaron ser estadísticamente significativas (p < 0.05) para todas las variables. Conclusiones: La aplicación de PE en enfermedades de alta mortalidad como la ECN se espera que reduzca las necesidades quirúrgicas, estableciendo una base para futuros estudios sobre el PE como un innovador agente antiinflamatorio. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Objective: The purpose of this study was to determine whether intraperitoneal administration of ethyl pyruvate (EP) affects intestinal mucosal damage in neonatal rats with a model of necrotizing enterocolitis (NEC). Methods: The study comprised 46 Sprague-Dawley newborn rats delivered on the 21st gestational day. The rats were divided into four groups: Sham Group (n = 10), EP Group (n = 10), NEC Group (n = 13), and NEC + EP Group (n = 13). Results: The mean body weights of rats in Sham and EP groups significantly increased (p < 0.05), whereas those in NEC groups significantly decreased (p < 0.05). The changes were similar between groups (p > 0.05). There was no significant difference in the clinical sickness score (CSS) between groups (p > 0.05). The CSS in the NEC groups showed an increase from day 1 to day 4. Based on the histopathological grading, there was a statistically significant difference (p < 0.001) observed between the Sham Group, the NEC Group, and the NEC + EP Group. The differences in biochemical values among the other groups were found to be statistically significant (p < 0.05) for all variables. Conclusions: The application of EP in high-mortality diseases such as NEC is expected to reduce surgical needs, establishing a basis for future studies on EP as an innovative anti-inflammatory agent. [ABSTRACT FROM AUTHOR]
ISSN:00097411
DOI:10.24875/CIRU.24000075