Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study.

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Title: Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study.
Alternate Title: ¿Tiene el licopeno algún efecto en la prevención de la formación de adherencias peritoneales en ratas? Un estudio experimental.
Authors: Bilgi, Ahmet1 (AUTHOR), Terek, Mustafa C.2 (AUTHOR), Yiğittürk, Gürkan3 (AUTHOR), Taşkıran, Dilek4 (AUTHOR), İlgen, Orkun5 (AUTHOR), Hortu, İsmet2 (AUTHOR), Yilmaz, Bulent6 (AUTHOR), Kart, Cavit7 (AUTHOR), Avcı, Fazıl1 (AUTHOR) fazilavci01@hotmail.com, Kulhan, Mehmet1 (AUTHOR)
Source: Cirugía y Cirujanos. may/jun2026, Vol. 94 Issue 3, p293-300. 8p.
Subjects: Lycopene, Tissue adhesions, Malondialdehyde, Vascular endothelial growth factors, Animal disease models, Oxidant status, Histopathology
Abstract (English): Objective: Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model. Methods: Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured. Results: There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group. Conclusions: Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Evaluar los fectos del licopeno en la prevención de la formación de adherencias intraabdominales en un modelo con ratas. Métodos: Veintiocho ratas se dividieron en cuatro grupos de siete cada uno: grupo 1, solo adhesión; grupo 2, adhesión más aceite de maíz; grupo 3, adhesión más 5 mg/kg de licopeno; y grupo 4, adhesión más 20 mg/kg de licopeno. Se midieron la puntuación de adherencia, la histopatología, la puntuación H del factor de crecimiento endotelial vascular (VEGF), el malondialdehído, la capacidad antioxidante total y los valores de VEGF. Resultados: Hubo puntuaciones de extensión, gravedad, grado y adhesión total significativamente más altas en los grupos control y con aceite de maíz que en el grupo con bajo y alto licopeno. Las puntuaciones VEGF H fueron significativamente más bajas en los grupos que recibieron licopeno, independientemente de la dosis. Cuando se compararon los grupos con niveles bajos y altos de licopeno en términos de puntuación H anti-VEGF, no se observaron diferencias significativas. Los niveles de malondialdehído fueron más bajos en los grupos de control y alto en licopeno, con una diferencia estadísticamente significativa. Conclusiones: Los parámetros bioquímicos, el examen histopatológico y la puntuación de adherencias revelaron que el licopeno redujo significativamente la formación de adherencias. [ABSTRACT FROM AUTHOR]
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Database: MedicLatina
Description
Abstract:Objective: Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model. Methods: Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured. Results: There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group. Conclusions: Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation. [ABSTRACT FROM AUTHOR]
ISSN:00097411
DOI:10.24875/CIRU.24000434