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Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study.

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Title: Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study.
Alternate Title: ¿Tiene el licopeno algún efecto en la prevención de la formación de adherencias peritoneales en ratas? Un estudio experimental.
Authors: Bilgi, Ahmet1 (AUTHOR), Terek, Mustafa C.2 (AUTHOR), Yiğittürk, Gürkan3 (AUTHOR), Taşkıran, Dilek4 (AUTHOR), İlgen, Orkun5 (AUTHOR), Hortu, İsmet2 (AUTHOR), Yilmaz, Bulent6 (AUTHOR), Kart, Cavit7 (AUTHOR), Avcı, Fazıl1 (AUTHOR) fazilavci01@hotmail.com, Kulhan, Mehmet1 (AUTHOR)
Source: Cirugía y Cirujanos. may/jun2026, Vol. 94 Issue 3, p293-300. 8p.
Subjects: Lycopene, Tissue adhesions, Malondialdehyde, Vascular endothelial growth factors, Animal disease models, Oxidant status, Histopathology
Abstract (English): Objective: Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model. Methods: Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured. Results: There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group. Conclusions: Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Objetivo: Evaluar los fectos del licopeno en la prevención de la formación de adherencias intraabdominales en un modelo con ratas. Métodos: Veintiocho ratas se dividieron en cuatro grupos de siete cada uno: grupo 1, solo adhesión; grupo 2, adhesión más aceite de maíz; grupo 3, adhesión más 5 mg/kg de licopeno; y grupo 4, adhesión más 20 mg/kg de licopeno. Se midieron la puntuación de adherencia, la histopatología, la puntuación H del factor de crecimiento endotelial vascular (VEGF), el malondialdehído, la capacidad antioxidante total y los valores de VEGF. Resultados: Hubo puntuaciones de extensión, gravedad, grado y adhesión total significativamente más altas en los grupos control y con aceite de maíz que en el grupo con bajo y alto licopeno. Las puntuaciones VEGF H fueron significativamente más bajas en los grupos que recibieron licopeno, independientemente de la dosis. Cuando se compararon los grupos con niveles bajos y altos de licopeno en términos de puntuación H anti-VEGF, no se observaron diferencias significativas. Los niveles de malondialdehído fueron más bajos en los grupos de control y alto en licopeno, con una diferencia estadísticamente significativa. Conclusiones: Los parámetros bioquímicos, el examen histopatológico y la puntuación de adherencias revelaron que el licopeno redujo significativamente la formación de adherencias. [ABSTRACT FROM AUTHOR]
Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: MedicLatina
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Header DbId: lth
DbLabel: MedicLatina
An: 194842190
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: ¿Tiene el licopeno algún efecto en la prevención de la formación de adherencias peritoneales en ratas? Un estudio experimental.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bilgi%2C+Ahmet%22">Bilgi, Ahmet</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Terek%2C+Mustafa+C%2E%22">Terek, Mustafa C.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yiğittürk%2C+Gürkan%22">Yiğittürk, Gürkan</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taşkıran%2C+Dilek%22">Taşkıran, Dilek</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22İlgen%2C+Orkun%22">İlgen, Orkun</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hortu%2C+İsmet%22">Hortu, İsmet</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yilmaz%2C+Bulent%22">Yilmaz, Bulent</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kart%2C+Cavit%22">Kart, Cavit</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Avcı%2C+Fazıl%22">Avcı, Fazıl</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> fazilavci01@hotmail.com</i><br /><searchLink fieldCode="AR" term="%22Kulhan%2C+Mehmet%22">Kulhan, Mehmet</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Cirugía+y+Cirujanos%22">Cirugía y Cirujanos</searchLink>. may/jun2026, Vol. 94 Issue 3, p293-300. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Lycopene%22">Lycopene</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+adhesions%22">Tissue adhesions</searchLink><br /><searchLink fieldCode="DE" term="%22Malondialdehyde%22">Malondialdehyde</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+endothelial+growth+factors%22">Vascular endothelial growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+disease+models%22">Animal disease models</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidant+status%22">Oxidant status</searchLink><br /><searchLink fieldCode="DE" term="%22Histopathology%22">Histopathology</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective: Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model. Methods: Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured. Results: There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group. Conclusions: Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Objetivo: Evaluar los fectos del licopeno en la prevención de la formación de adherencias intraabdominales en un modelo con ratas. Métodos: Veintiocho ratas se dividieron en cuatro grupos de siete cada uno: grupo 1, solo adhesión; grupo 2, adhesión más aceite de maíz; grupo 3, adhesión más 5 mg/kg de licopeno; y grupo 4, adhesión más 20 mg/kg de licopeno. Se midieron la puntuación de adherencia, la histopatología, la puntuación H del factor de crecimiento endotelial vascular (VEGF), el malondialdehído, la capacidad antioxidante total y los valores de VEGF. Resultados: Hubo puntuaciones de extensión, gravedad, grado y adhesión total significativamente más altas en los grupos control y con aceite de maíz que en el grupo con bajo y alto licopeno. Las puntuaciones VEGF H fueron significativamente más bajas en los grupos que recibieron licopeno, independientemente de la dosis. Cuando se compararon los grupos con niveles bajos y altos de licopeno en términos de puntuación H anti-VEGF, no se observaron diferencias significativas. Los niveles de malondialdehído fueron más bajos en los grupos de control y alto en licopeno, con una diferencia estadísticamente significativa. Conclusiones: Los parámetros bioquímicos, el examen histopatológico y la puntuación de adherencias revelaron que el licopeno redujo significativamente la formación de adherencias. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.24875/CIRU.24000434
    Languages:
      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 293
    Subjects:
      – SubjectFull: Lycopene
        Type: general
      – SubjectFull: Tissue adhesions
        Type: general
      – SubjectFull: Malondialdehyde
        Type: general
      – SubjectFull: Vascular endothelial growth factors
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      – SubjectFull: Animal disease models
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      – SubjectFull: Oxidant status
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      – SubjectFull: Histopathology
        Type: general
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      – TitleFull: Is there any effect of lycopene's preventing peritoneal adhesion formation in rats: an experimental study.
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              M: 05
              Text: may/jun2026
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              Y: 2026
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