Diagnostic performance of lung ultrasound for the detection of interstitial lung disease in patients with rheumatoid arthritis: comparison with risk scoring systems.
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| Title: | Diagnostic performance of lung ultrasound for the detection of interstitial lung disease in patients with rheumatoid arthritis: comparison with risk scoring systems. |
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| Authors: | Recalde-Reyes, J.1,2 jrecalder@unal.edu.co, Cortés, J. S.1,2, Cajas, L. J.1,2 |
| Source: | ARP Rheumatology. Apr-Jun2026, Vol. 5 Issue 2, p100-108. 9p. |
| Subjects: | Ultrasonic imaging, Rheumatoid arthritis, Medical screening, Tomography, Interstitial lung diseases, Clinical prediction rules, Disease risk factors |
| Abstract: | Introduction: Interstitial lung disease (ILD) is a frequent and severe complication of rheumatoid arthritis (RA), often remaining subclinical and associated with substantial morbidity and mortality. Given the limitations of high-resolution computed tomography (HRCT) for widespread screening, alternative tools for early detection are needed. Aim: The objective of this study was to assess the diagnostic performance of lung ultrasound (LUS) for the detection of ILD in patients with RA, compared with HRCT and established clinical risk scores, stratified by symptom status. Methods: A diagnostic test study was conducted in RA patients fulfilling the ACR 2010 criteria who had undergone HRCT within the previous six months. LUS was performed using a 14-point protocol, with abnormal findings defined as >5 B-lines or pleural irregularities in ≥2 windows. Two validated RA-ILD risk scores were applied. LUS findings were compared with HRCT, and logistic regression was used to identify clinical and imaging predictors of ILD. Results: A total of 147 patients were included (23.8% male; mean age 62.3 years; mean disease duration 12.3 years), of whom 68 had HRCT-confirmed ILD. Abnormal LUS findings were present in 58.5% of patients. Factors associated with RA-ILD included male sex (OR 2.8), dyspnea (OR 2.5), and velcro crackles (OR 47.5). Abnormal LUS (OR 59.8), >5 B-lines (OR 37.6), and pleural irregularities (OR 29.5) were strongly associated with ILD. In asymptomatic patients, LUS showed high sensitivity (95.4%) and specificity (77.7%), with a +LR of 4.3 and a −LR of 0.06. Risk scores showed limited diagnostic value (Spanish consensus ≥5: +LR 0.97; Juge et al. ≥25: +LR 1.45). Combining LUS with risk scores increased sensitivity to 100%. Conclusion: LUS outperforms clinical risk scores for the detection of RA-associated ILD, including in asymptomatic patients. Its integration with risk scores may optimize screening strategies for the early identification of RA-ILD. [ABSTRACT FROM AUTHOR] |
| Copyright of ARP Rheumatology is the property of Sociedade Portuguesa de Reumatologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 195258515 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Diagnostic performance of lung ultrasound for the detection of interstitial lung disease in patients with rheumatoid arthritis: comparison with risk scoring systems. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Recalde-Reyes%2C+J%2E%22">Recalde-Reyes, J.</searchLink><relatesTo>1,2</relatesTo><i> jrecalder@unal.edu.co</i><br /><searchLink fieldCode="AR" term="%22Cortés%2C+J%2E+S%2E%22">Cortés, J. S.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cajas%2C+L%2E+J%2E%22">Cajas, L. J.</searchLink><relatesTo>1,2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22ARP+Rheumatology%22">ARP Rheumatology</searchLink>. Apr-Jun2026, Vol. 5 Issue 2, p100-108. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ultrasonic+imaging%22">Ultrasonic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Rheumatoid+arthritis%22">Rheumatoid arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+screening%22">Medical screening</searchLink><br /><searchLink fieldCode="DE" term="%22Tomography%22">Tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Interstitial+lung+diseases%22">Interstitial lung diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+prediction+rules%22">Clinical prediction rules</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: Interstitial lung disease (ILD) is a frequent and severe complication of rheumatoid arthritis (RA), often remaining subclinical and associated with substantial morbidity and mortality. Given the limitations of high-resolution computed tomography (HRCT) for widespread screening, alternative tools for early detection are needed. Aim: The objective of this study was to assess the diagnostic performance of lung ultrasound (LUS) for the detection of ILD in patients with RA, compared with HRCT and established clinical risk scores, stratified by symptom status. Methods: A diagnostic test study was conducted in RA patients fulfilling the ACR 2010 criteria who had undergone HRCT within the previous six months. LUS was performed using a 14-point protocol, with abnormal findings defined as >5 B-lines or pleural irregularities in ≥2 windows. Two validated RA-ILD risk scores were applied. LUS findings were compared with HRCT, and logistic regression was used to identify clinical and imaging predictors of ILD. Results: A total of 147 patients were included (23.8% male; mean age 62.3 years; mean disease duration 12.3 years), of whom 68 had HRCT-confirmed ILD. Abnormal LUS findings were present in 58.5% of patients. Factors associated with RA-ILD included male sex (OR 2.8), dyspnea (OR 2.5), and velcro crackles (OR 47.5). Abnormal LUS (OR 59.8), >5 B-lines (OR 37.6), and pleural irregularities (OR 29.5) were strongly associated with ILD. In asymptomatic patients, LUS showed high sensitivity (95.4%) and specificity (77.7%), with a +LR of 4.3 and a −LR of 0.06. Risk scores showed limited diagnostic value (Spanish consensus ≥5: +LR 0.97; Juge et al. ≥25: +LR 1.45). Combining LUS with risk scores increased sensitivity to 100%. Conclusion: LUS outperforms clinical risk scores for the detection of RA-associated ILD, including in asymptomatic patients. Its integration with risk scores may optimize screening strategies for the early identification of RA-ILD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of ARP Rheumatology is the property of Sociedade Portuguesa de Reumatologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.63032/CUJE3036 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 100 Subjects: – SubjectFull: Ultrasonic imaging Type: general – SubjectFull: Rheumatoid arthritis Type: general – SubjectFull: Medical screening Type: general – SubjectFull: Tomography Type: general – SubjectFull: Interstitial lung diseases Type: general – SubjectFull: Clinical prediction rules Type: general – SubjectFull: Disease risk factors Type: general Titles: – TitleFull: Diagnostic performance of lung ultrasound for the detection of interstitial lung disease in patients with rheumatoid arthritis: comparison with risk scoring systems. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Recalde-Reyes, J. – PersonEntity: Name: NameFull: Cortés, J. S. – PersonEntity: Name: NameFull: Cajas, L. J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr-Jun2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 27954552 Numbering: – Type: volume Value: 5 – Type: issue Value: 2 Titles: – TitleFull: ARP Rheumatology Type: main |
| ResultId | 1 |
