Validation of systemic lupus erythematosus disease activity score (SLE-DAS) in a Russian cohort of patients.
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| Title: | Validation of systemic lupus erythematosus disease activity score (SLE-DAS) in a Russian cohort of patients. |
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| Authors: | Shumilova, A. A.1 dr.anashumilova@gmail.com, Inês, L. Sousa2,3,4, Sholkina, P. A.1, Lila, A. M.1,5, Reshetnyak, T. M.1,5 |
| Source: | ARP Rheumatology. Apr-Jun2026, Vol. 5 Issue 2, p109-116. 8p. |
| Subjects: | Systemic lupus erythematosus, Patient monitoring, Medical research, Cohort analysis, Autoimmune diseases |
| Abstract: | Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by fluctuating activity affecting multiple organ systems. Timely and accurate assessment of disease activity is critical for guiding clinical decisions and implementing treat-to-target strategies. The Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) is a recently developed, continuous, and weighted index for disease activity, though it has not yet been validated in Russian patients. Objective: To validate SLE-DAS in a Russian cohort of patients with SLE. Methods: We prospectively enrolled 200 SLE patients followed for ≥12 months at the V.A. Nasonova Research Institute of Rheumatology. The median age was 35.0 [26.0–43.0] years; 84.5% were female. Median disease duration was 63.0 [22.0–158.0] months. Clinical and laboratory data were analyzed to assess SLE-DAS performance. Internal consistency of SLE-DAS was assessed using Cronbach’s alpha. Convergent validity was evaluated via correlation with the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Physician Global Assessment (PGA). To compare the ability of SLE-DAS and SLEDAI-2K to identify active SLE, we performed a receiver operating characteristic (ROC) analysis with determination of the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and Cohen’s kappa. Responsiveness was analyzed using the Wilcoxon test, SRM, and Cohen’s d. Results: At baseline, the median SLEDAI-2K was 8.0, PGA 0.99, and SLE-DAS 8.38. SLE-DAS showed excellent convergent validity (ρ = 0.878 with both SLEDAI-2K and PGA). Internal consistency was moderate for binary components (α = 0.663), while quantitative variables showed low agreement. According to DORIS remission framework, 90.5% of patients had active SLE. ROC analysis showed high diagnostic accuracy: AUC = 0.899 for SLEDAS and 0.870 for SLEDAI-2K. After reclassifying 23 patients on glucocorticoids >5 mg/day without clinical activity as inactive, SLE-DAS showed superior performance: AUC = 0.973, sensitivity 96.2%, specificity 97.6%, PPV 99.3%, NPV 82.4%, κ = 0.86. Responsiveness at 6 and 12 months was also confirmed (SRM = –0.78 and –0.66, both p < 0.0001). Conclusion: SLE-DAS is a valid, responsive, and accurate tool for assessing SLE activity in Russian patients and may improve clinical monitoring in routine practice. [ABSTRACT FROM AUTHOR] |
| Copyright of ARP Rheumatology is the property of Sociedade Portuguesa de Reumatologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: lth DbLabel: MedicLatina An: 195258516 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Validation of systemic lupus erythematosus disease activity score (SLE-DAS) in a Russian cohort of patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shumilova%2C+A%2E+A%2E%22">Shumilova, A. A.</searchLink><relatesTo>1</relatesTo><i> dr.anashumilova@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Inês%2C+L%2E+Sousa%22">Inês, L. Sousa</searchLink><relatesTo>2,3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Sholkina%2C+P%2E+A%2E%22">Sholkina, P. A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lila%2C+A%2E+M%2E%22">Lila, A. M.</searchLink><relatesTo>1,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Reshetnyak%2C+T%2E+M%2E%22">Reshetnyak, T. M.</searchLink><relatesTo>1,5</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22ARP+Rheumatology%22">ARP Rheumatology</searchLink>. Apr-Jun2026, Vol. 5 Issue 2, p109-116. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Systemic+lupus+erythematosus%22">Systemic lupus erythematosus</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+monitoring%22">Patient monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Autoimmune+diseases%22">Autoimmune diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by fluctuating activity affecting multiple organ systems. Timely and accurate assessment of disease activity is critical for guiding clinical decisions and implementing treat-to-target strategies. The Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) is a recently developed, continuous, and weighted index for disease activity, though it has not yet been validated in Russian patients. Objective: To validate SLE-DAS in a Russian cohort of patients with SLE. Methods: We prospectively enrolled 200 SLE patients followed for ≥12 months at the V.A. Nasonova Research Institute of Rheumatology. The median age was 35.0 [26.0–43.0] years; 84.5% were female. Median disease duration was 63.0 [22.0–158.0] months. Clinical and laboratory data were analyzed to assess SLE-DAS performance. Internal consistency of SLE-DAS was assessed using Cronbach’s alpha. Convergent validity was evaluated via correlation with the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and Physician Global Assessment (PGA). To compare the ability of SLE-DAS and SLEDAI-2K to identify active SLE, we performed a receiver operating characteristic (ROC) analysis with determination of the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and Cohen’s kappa. Responsiveness was analyzed using the Wilcoxon test, SRM, and Cohen’s d. Results: At baseline, the median SLEDAI-2K was 8.0, PGA 0.99, and SLE-DAS 8.38. SLE-DAS showed excellent convergent validity (ρ = 0.878 with both SLEDAI-2K and PGA). Internal consistency was moderate for binary components (α = 0.663), while quantitative variables showed low agreement. According to DORIS remission framework, 90.5% of patients had active SLE. ROC analysis showed high diagnostic accuracy: AUC = 0.899 for SLEDAS and 0.870 for SLEDAI-2K. After reclassifying 23 patients on glucocorticoids >5 mg/day without clinical activity as inactive, SLE-DAS showed superior performance: AUC = 0.973, sensitivity 96.2%, specificity 97.6%, PPV 99.3%, NPV 82.4%, κ = 0.86. Responsiveness at 6 and 12 months was also confirmed (SRM = –0.78 and –0.66, both p < 0.0001). Conclusion: SLE-DAS is a valid, responsive, and accurate tool for assessing SLE activity in Russian patients and may improve clinical monitoring in routine practice. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of ARP Rheumatology is the property of Sociedade Portuguesa de Reumatologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.63032/GBJD4295 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 109 Subjects: – SubjectFull: Systemic lupus erythematosus Type: general – SubjectFull: Patient monitoring Type: general – SubjectFull: Medical research Type: general – SubjectFull: Cohort analysis Type: general – SubjectFull: Autoimmune diseases Type: general Titles: – TitleFull: Validation of systemic lupus erythematosus disease activity score (SLE-DAS) in a Russian cohort of patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shumilova, A. A. – PersonEntity: Name: NameFull: Inês, L. Sousa – PersonEntity: Name: NameFull: Sholkina, P. A. – PersonEntity: Name: NameFull: Lila, A. M. – PersonEntity: Name: NameFull: Reshetnyak, T. M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr-Jun2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 27954552 Numbering: – Type: volume Value: 5 – Type: issue Value: 2 Titles: – TitleFull: ARP Rheumatology Type: main |
| ResultId | 1 |
