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Cirugía resectiva en epilepsia farmacorresistente.

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Title: Cirugía resectiva en epilepsia farmacorresistente.
Alternate Title: Resective surgery in drug-resistant epilepsy.
Authors: Alonso-Vanegas, Mario A.1 alonsomario@hotmail.com, Quintero-López, Eduardo1, Sentíes-Madrid, Horacio2, San Juan-Orta, Daniel3
Source: Revista Mexicana de Neurociencia. 2026 Supplement, Vol. 27, p196-208. 13p.
Abstract (English): Introduction: Drug-resistant epilepsy (DRE) is a condition associated with high morbidity and mortality. Resective epilepsy surgery is an effective and safe therapeutic alternative, although it remains underutilized. Objective: To synthesize the evidence on the efficacy, safety, and selection of candidates for resective epilepsy surgery, and to formulate clinical recommendations based on the GRADE approach. Method: A systematic review was conducted using the GRADE Adolopment methodology, including randomized controlled trials, systematic reviews, and meta-analyses. A PICOS-based search strategy was applied in Embase to identify relevant evidence. Results: Resective surgery, particularly in temporal lobe epilepsy, demonstrated greater efficacy in seizure control (≈ 60-75%) compared with medical treatment (< 10%), along with improvements in quality of life. Factors such as the presence of a lesion on MRI, EEG-imaging concordance, and complete resection were associated with better outcomes. Surgical mortality was low (< 1%), and adverse events were generally manageable. Conclusions: Resective epilepsy surgery is an effective and safe intervention in selected patients with DRE. Early referral and multidisciplinary evaluation optimize clinical outcomes. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: La epilepsia farmacorresistente (ERF) es una condición con alta morbilidad y mortalidad. La cirugía resectiva de epilepsia es una alternativa terapéutica efectiva y segura, aunque tradicionalmente infrautilizada. Objetivo: Sintetizar la evidencia sobre eficacia, seguridad y selección de candidatos para cirugía resectiva de epilepsia, y formular recomendaciones clínicas basadas en el enfoque GRADE. Método: Se realizó una revisión sistemática utilizando GRADE Adolopment, incluyendo ensayos clínicos aleatorizados, revisiones sistemáticas y metaanálisis. Se utilizó estrategia PICOS en Embase para identificar evidencia relevante. Resultados: La cirugía resectiva, especialmente en epilepsia del lóbulo temporal, demostró mayor eficacia en el control de crisis (≈ 60-75%) comparada con el tratamiento médico (< 10%) y mejoría en calidad de vida. Factores como lesión visible en IRM, concordancia EEG-imagen y resección completa se asocian a mejores resultados. La mortalidad quirúrgica es baja (< 1%) y eventos adversos son generalmente manejables. Conclusiones: La cirugía resectiva de epilepsia es una intervención efectiva y segura en pacientes seleccionados con ERF. La referencia temprana y evaluación multidisciplinaria optimizan los resultados clínicos. [ABSTRACT FROM AUTHOR]
Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Resective surgery in drug-resistant epilepsy.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alonso-Vanegas%2C+Mario+A%2E%22&quot;&gt;Alonso-Vanegas, Mario A.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; alonsomario@hotmail.com&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Quintero-L&#243;pez%2C+Eduardo%22&quot;&gt;Quintero-L&#243;pez, Eduardo&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sent&#237;es-Madrid%2C+Horacio%22&quot;&gt;Sent&#237;es-Madrid, Horacio&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22San+Juan-Orta%2C+Daniel%22&quot;&gt;San Juan-Orta, Daniel&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Revista+Mexicana+de+Neurociencia%22&quot;&gt;Revista Mexicana de Neurociencia&lt;/searchLink&gt;. 2026 Supplement, Vol. 27, p196-208. 13p.
– Name: Abstract
  Label: Abstract (English)
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  Data: Introduction: Drug-resistant epilepsy (DRE) is a condition associated with high morbidity and mortality. Resective epilepsy surgery is an effective and safe therapeutic alternative, although it remains underutilized. Objective: To synthesize the evidence on the efficacy, safety, and selection of candidates for resective epilepsy surgery, and to formulate clinical recommendations based on the GRADE approach. Method: A systematic review was conducted using the GRADE Adolopment methodology, including randomized controlled trials, systematic reviews, and meta-analyses. A PICOS-based search strategy was applied in Embase to identify relevant evidence. Results: Resective surgery, particularly in temporal lobe epilepsy, demonstrated greater efficacy in seizure control (≈ 60-75%) compared with medical treatment (&lt; 10%), along with improvements in quality of life. Factors such as the presence of a lesion on MRI, EEG-imaging concordance, and complete resection were associated with better outcomes. Surgical mortality was low (&lt; 1%), and adverse events were generally manageable. Conclusions: Resective epilepsy surgery is an effective and safe intervention in selected patients with DRE. Early referral and multidisciplinary evaluation optimize clinical outcomes. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducci&#243;n: La epilepsia farmacorresistente (ERF) es una condici&#243;n con alta morbilidad y mortalidad. La cirug&#237;a resectiva de epilepsia es una alternativa terap&#233;utica efectiva y segura, aunque tradicionalmente infrautilizada. Objetivo: Sintetizar la evidencia sobre eficacia, seguridad y selecci&#243;n de candidatos para cirug&#237;a resectiva de epilepsia, y formular recomendaciones cl&#237;nicas basadas en el enfoque GRADE. M&#233;todo: Se realiz&#243; una revisi&#243;n sistem&#225;tica utilizando GRADE Adolopment, incluyendo ensayos cl&#237;nicos aleatorizados, revisiones sistem&#225;ticas y metaan&#225;lisis. Se utiliz&#243; estrategia PICOS en Embase para identificar evidencia relevante. Resultados: La cirug&#237;a resectiva, especialmente en epilepsia del l&#243;bulo temporal, demostr&#243; mayor eficacia en el control de crisis (≈ 60-75%) comparada con el tratamiento m&#233;dico (&lt; 10%) y mejor&#237;a en calidad de vida. Factores como lesi&#243;n visible en IRM, concordancia EEG-imagen y resecci&#243;n completa se asocian a mejores resultados. La mortalidad quir&#250;rgica es baja (&lt; 1%) y eventos adversos son generalmente manejables. Conclusiones: La cirug&#237;a resectiva de epilepsia es una intervenci&#243;n efectiva y segura en pacientes seleccionados con ERF. La referencia temprana y evaluaci&#243;n multidisciplinaria optimizan los resultados cl&#237;nicos. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Revista Mexicana de Neurociencia is the property of Academia Mexicana de Neurologia and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Text: Spanish
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              Text: 2026 Supplement
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