The architecture and hierarchical pathways in the subthalamic nucleus using isotropic imaging.
Saved in:
| Title: | The architecture and hierarchical pathways in the subthalamic nucleus using isotropic imaging. |
|---|---|
| Alternate Title: | ARQUITECTURA Y VÍAS DE LOS NÚCLEOS SUBTÁLAMICOS ESTUDIADAS POR IMAGEN DE ISÓTOPOS. |
| Authors: | Gómez-Acevedo, Héctor1, Salgado, Perla1, Alonso-Vanegas, Mario1, Pasalle, Erik1 |
| Source: | Archivos de Neurociencias. abr-jun2007, Vol. 12 Issue 2, p71-76. 6p. |
| Subjects: | DIFFUSION tensor imaging, CELL nuclei, PARKINSON'S disease, CENTRAL nervous system, SUBSTANTIA nigra, BRAIN stem, CORPUS callosum, BRAIN stimulation |
| Abstract (English): | Objective: the subthalamic nucleus (STN) has gained importance as a focus for histological, anatomical and imaging research due to its implications in modulation basal ganglia output and Parkinson's disease. Little is known about the intrinsic organization of the STN. More information is needed to understand its role in the central nervous system (CNS) and allow more accurate planning in Functional Neurosurgery. We describe a method capable of delineating the boundaries of gray matter that could be used to study the internal architecture of the STN. Methods: eighty-seven patients were randomly selected from a magnetic resonance (MR) diffusion tensor imaging (DTI) data bank. From these cases, we selected forty-four in which DTI showed the STN, but not the substantia nigra (SN) in the same image. After initial scrutiny, we excluded fourteen patients with tumors in the brain stem, mass effect, hydrocephalus or obvious malformations. We developed an algorithm by selecting the region of Interest in the STN as identified by the Isotropic Image instead of the Anisotropic one. Results: after reviewing these 30 studies, we identified regions of track concurrency (RTC). In all cases reviewed, RTC showed a hierarchical position from medial to lateral according to the longitudinal axis of the STN and the origin of the fibers. This arrangement revealed a more medial position of the fibers with connection to the parietal, frontal posterior and frontal polar cortex (Brodmann´s areas 7, 4 and 11), a central position for the fibers interacting with the corpus callosum and a lateral position of the fibers interacting with the frontal-medial cortex. Conclusion: the technique described allows fiber tracking in the gray matter, undetectable by other imaging methods. It has helped detail the description of STN architecture, evidencing a constant hierarchical position regarding its interconnections. This information helps elucidate the architectural complexity of this nucleus and may prove of use during implantation and programming procedures employed in Deep Brain Stimulation (DBS). [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): | Los núcleos subtálamicos son un foco importante de la investigación por que se consideran una estructura importante en la modulación de la actividad de los ganglios basales. Poco se conoce de la organización de estos núcleos (STN). Esta información se necesita para la planeación de la neurocirugía funcional. Con este método con el que se reconocen los límites de la sustancia gris se puede conocer la arquitectura interna de los núcleos subtálamicos. Se seleccionaron 90 pacientes al azar de imagen de resonancia magnetica e imagen de difusión y de ellos se seleccionaron 44 para el estudio donde no se visualiza la sustancia negra, otros 14 fueron excluidos por tener hidrocefalía, tumores o malformaciones. Después de revisar 30 pacientes identificamos regiones de concurrencia de tractos (RTC). En todos los casos revisados se encontró una posición jerárquica de mediano a lateral de acuerdo al eje longitudinal del núcleo subtalamico y del origen de las fibras. Este arreglo previo a una posición mas medial a las fibras con conexión a las regiones parietal frontal y una posición central a las conexión con el cuerpo calloso y la parte medio frontal. En conclusión se encontró una técnica de localización de fibras no posible anteriormente y esto ayuda a la comprensión de este complejo de núcleos lo cuál ayudará a la mejor implantación de electrodos y en la estimulación profunda (DBS). [ABSTRACT FROM AUTHOR] |
| Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: lth DbLabel: MedicLatina An: 25576281 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: The architecture and hierarchical pathways in the subthalamic nucleus using isotropic imaging. – Name: TitleAlt Label: Alternate Title Group: TiAlt Data: ARQUITECTURA Y VÍAS DE LOS NÚCLEOS SUBTÁLAMICOS ESTUDIADAS POR IMAGEN DE ISÓTOPOS. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gómez-Acevedo%2C+Héctor%22">Gómez-Acevedo, Héctor</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Salgado%2C+Perla%22">Salgado, Perla</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Alonso-Vanegas%2C+Mario%22">Alonso-Vanegas, Mario</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pasalle%2C+Erik%22">Pasalle, Erik</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Archivos+de+Neurociencias%22">Archivos de Neurociencias</searchLink>. abr-jun2007, Vol. 12 Issue 2, p71-76. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22DIFFUSION+tensor+imaging%22">DIFFUSION tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22CELL+nuclei%22">CELL nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22PARKINSON'S+disease%22">PARKINSON'S disease</searchLink><br /><searchLink fieldCode="DE" term="%22CENTRAL+nervous+system%22">CENTRAL nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22SUBSTANTIA+nigra%22">SUBSTANTIA nigra</searchLink><br /><searchLink fieldCode="DE" term="%22BRAIN+stem%22">BRAIN stem</searchLink><br /><searchLink fieldCode="DE" term="%22CORPUS+callosum%22">CORPUS callosum</searchLink><br /><searchLink fieldCode="DE" term="%22BRAIN+stimulation%22">BRAIN stimulation</searchLink> – Name: Abstract Label: Abstract (English) Group: Ab Data: Objective: the subthalamic nucleus (STN) has gained importance as a focus for histological, anatomical and imaging research due to its implications in modulation basal ganglia output and Parkinson's disease. Little is known about the intrinsic organization of the STN. More information is needed to understand its role in the central nervous system (CNS) and allow more accurate planning in Functional Neurosurgery. We describe a method capable of delineating the boundaries of gray matter that could be used to study the internal architecture of the STN. Methods: eighty-seven patients were randomly selected from a magnetic resonance (MR) diffusion tensor imaging (DTI) data bank. From these cases, we selected forty-four in which DTI showed the STN, but not the substantia nigra (SN) in the same image. After initial scrutiny, we excluded fourteen patients with tumors in the brain stem, mass effect, hydrocephalus or obvious malformations. We developed an algorithm by selecting the region of Interest in the STN as identified by the Isotropic Image instead of the Anisotropic one. Results: after reviewing these 30 studies, we identified regions of track concurrency (RTC). In all cases reviewed, RTC showed a hierarchical position from medial to lateral according to the longitudinal axis of the STN and the origin of the fibers. This arrangement revealed a more medial position of the fibers with connection to the parietal, frontal posterior and frontal polar cortex (Brodmann´s areas 7, 4 and 11), a central position for the fibers interacting with the corpus callosum and a lateral position of the fibers interacting with the frontal-medial cortex. Conclusion: the technique described allows fiber tracking in the gray matter, undetectable by other imaging methods. It has helped detail the description of STN architecture, evidencing a constant hierarchical position regarding its interconnections. This information helps elucidate the architectural complexity of this nucleus and may prove of use during implantation and programming procedures employed in Deep Brain Stimulation (DBS). [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Abstract (Spanish) Group: Ab Data: Los núcleos subtálamicos son un foco importante de la investigación por que se consideran una estructura importante en la modulación de la actividad de los ganglios basales. Poco se conoce de la organización de estos núcleos (STN). Esta información se necesita para la planeación de la neurocirugía funcional. Con este método con el que se reconocen los límites de la sustancia gris se puede conocer la arquitectura interna de los núcleos subtálamicos. Se seleccionaron 90 pacientes al azar de imagen de resonancia magnetica e imagen de difusión y de ellos se seleccionaron 44 para el estudio donde no se visualiza la sustancia negra, otros 14 fueron excluidos por tener hidrocefalía, tumores o malformaciones. Después de revisar 30 pacientes identificamos regiones de concurrencia de tractos (RTC). En todos los casos revisados se encontró una posición jerárquica de mediano a lateral de acuerdo al eje longitudinal del núcleo subtalamico y del origen de las fibras. Este arreglo previo a una posición mas medial a las fibras con conexión a las regiones parietal frontal y una posición central a las conexión con el cuerpo calloso y la parte medio frontal. En conclusión se encontró una técnica de localización de fibras no posible anteriormente y esto ayuda a la comprensión de este complejo de núcleos lo cuál ayudará a la mejor implantación de electrodos y en la estimulación profunda (DBS). [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Archivos de Neurociencias is the property of Instituto Nacional de Neurologia y Neurocirugia, Departamento de Publicaciones Cientificas and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=lth&AN=25576281 |
| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 71 Subjects: – SubjectFull: DIFFUSION tensor imaging Type: general – SubjectFull: CELL nuclei Type: general – SubjectFull: PARKINSON'S disease Type: general – SubjectFull: CENTRAL nervous system Type: general – SubjectFull: SUBSTANTIA nigra Type: general – SubjectFull: BRAIN stem Type: general – SubjectFull: CORPUS callosum Type: general – SubjectFull: BRAIN stimulation Type: general Titles: – TitleFull: The architecture and hierarchical pathways in the subthalamic nucleus using isotropic imaging. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gómez-Acevedo, Héctor – PersonEntity: Name: NameFull: Salgado, Perla – PersonEntity: Name: NameFull: Alonso-Vanegas, Mario – PersonEntity: Name: NameFull: Pasalle, Erik IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: abr-jun2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 10285938 Numbering: – Type: volume Value: 12 – Type: issue Value: 2 Titles: – TitleFull: Archivos de Neurociencias Type: main |
| ResultId | 1 |
